CAS No. 2172652-48-9
Batch:
Purity:99.07
Chemical Structure
Check the
RMC-4630
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [6-[(2-amino-3-chloro-4-pyridinyl)sulfanyl]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl]methanol | |
|---|---|---|
| CAS Number | 2172652-48-9 | |
| Molecular Formula |
C20H27ClN6O2S |
|
| Molecular Weight (MW) | 450.99 | |
| InChIKey | HISJAYUQVHMWTA-BLLLJJGKSA-N |
Vociprotafib (RMC-4630) is a potent, selective, and orally bioavailable allosteric inhibitor of Src homology 2 domain-containing phosphatase 2 (SHP2). By target-binding and suppressing SHP2 activity, it effectively disrupts the downstream RAS-RAF-MEK-ERK signaling pathway. This inhibition impairs receptor tyrosine kinase-mediated signaling, leading to reduced cancer cell proliferation and marked anti-tumor phenotypes in preclinical cancer models. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
45 mg/mL
(99.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.