Quercitrin

Catalog No.S3824 Batch:S382401

Technical Data

Formula	C₂₁H₂₀O₁₁
Molecular Weight	448.38	CAS No.	522-12-3
Solubility (25°C)*	In vitro	DMSO	89 mg/mL (198.49 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Quercitrin (3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.
In vitro	Quercitrin ameliorates cytokine-impaired viability of RINm5F cells and improves Glucose-stimulated insulin secretion in cytokine-treated RINm5F cells. It also reduces production of cellular ROS from cytokines and restrains the enhancement of NO production caused by cytokines in RINm5F cells via inhibition of iNOS expression^[1].
In vivo	Quercitrin significantly suppresses the elevation of reactive oxygen species (ROS) production and malondialdehyde (MDA) content, reduces tissue plasminogen activator (t-PA) activity, enhances the antioxidant enzyme activities and abrogates cytochrome P450 2E1 (CYP2E1) induction in mouse brains. Quercitrin also prevents CCl4 induced cerebral function disorders associated with its ability to inhibit the activities of monoamine oxidase (MAO), acetylcholine esterase (AChE) and the N-methyl-D-aspartate receptor 2B subunit (NR2B). Quercitrin is known to have biological effects such as anti-oxidative, anti-inflammatory, and anti-apoptosis effects and it might be a more potent antioxidant and a neuroprotective agent than quercetin due to its high bioavailability in the digestive track. Quercitrin significantly reduces acute systemic inflammation in LPS-induced models as well as attenuates inflammation in the livers of mice. Quercitrin could also reduce inflammation and apoptosis in cytokine-induced models. In streptozotocin (STZ)-induced diabetic models, quercitrin displays organ protective properties in the pancreas, liver and kidney by improving the antioxidant status^[2].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines The insulin-secreting cell line RINm5F Concentrations 0, 5, 10 and 20 μM Incubation Time 2 h Method Cells are cultured in DMEM with 10% FBS, 100 U/ml penicillin, 100 μg/ml streptomycin, 2 mmol/l in a humidified atmosphere (5% CO2, 37°C). After starvation for 24 h, cells are treated with quercetin or quercitrin (0, 5, 10 and 20 μM) for 2 h, then co-incubated with TNF-α (10 ng/ml), IL-1β (5 ng/ml) and IFN-γ (1,000 U/ml) for 24 h.
Animal Study:^{^[2]}	Animal Models Male ICR mice Dosages 50 and 100 mg/kg Administration Oral gavage

Cell Assay:^{^[1]}

Cell lines
The insulin-secreting cell line RINm5F
Concentrations
0, 5, 10 and 20 μM
Incubation Time
2 h
Method
Cells are cultured in DMEM with 10% FBS, 100 U/ml penicillin, 100 μg/ml streptomycin, 2 mmol/l in a humidified atmosphere (5% CO2, 37°C). After starvation for 24 h, cells are treated with quercetin or quercitrin (0, 5, 10 and 20 μM) for 2 h, then co-incubated with TNF-α (10 ng/ml), IL-1β (5 ng/ml) and IFN-γ (1,000 U/ml) for 24 h.

Animal Study:^{^[2]}

Animal Models
Male ICR mice
Dosages
50 and 100 mg/kg
Administration
Oral gavage

References

Selleck's Quercitrin has been cited by 2 publications

The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling [ J Biol Chem, 2023, 299(6):104789]	PubMed: 37149146
Potential Inhibitors of Monkeypox Virus Revealed by Molecular Modeling Approach to Viral DNA Topoisomerase I [ Molecules, 2023, 28(3)1444]	PubMed: 36771105

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SHIPPING AND STORAGE
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