Pyrrolidinedithiocarbamate ammonium

Catalog No.S3633 Synonyms: APDC, PDTC

Pyrrolidinedithiocarbamate ammonium Chemical Structure

Molecular Weight(MW): 164.29

Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.

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Biological Activity

Description Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.
Targets
NF-κB [1]
()
In vitro

Ammonium pyrrolidine dithiocarbamate (PDTC) can inhibit the role of NF-κB by inhibiting IκB phosphorylation, thus blocking NF-κB translocation to the nucleus, reducing the expression of downstream cytokines[1].

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Sprague-Dawley rats
  • Formulation: Saline
  • Dosages: 50, 100, and 200 mg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 32 mg/mL (194.77 mM)
Water 32 mg/mL (194.77 mM)
Ethanol 32 mg/mL (194.77 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 164.29
Formula

C5H9NS2.H3N

CAS No. 5108-96-3
Storage powder
in solvent
Synonyms APDC, PDTC

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02503150 Not yet recruiting Metastatic Colorectal Cancer Second Military Medical University|Cancer Institute and Hospital Chinese Academy of Medical Sciences|Changhai Hospital|Xinhua Hospital Shanghai Jiao Tong University School of Medicine|Fudan University|Shanghai Changzheng Hospital|Zhejiang Cancer Hospital|Chinese PLA General Hospital|Beijing Cancer Hospital|Shanghai General Hospital Shanghai Jiao Tong University School of Medicine|RenJi Hospital|Second Affiliated Hospital School of Medicine Zhejiang University|First People''s Hospital of Hangzhou|The 307th Hospital of Chinese People`s Liberation Army|Huashan Hospital|Ruijin Hospital|Shanghai Haixin Biotechnology Co. Ltd July 2015 Phase 3
NCT02503150 Not yet recruiting Metastatic Colorectal Cancer Second Military Medical University|Cancer Institute and Hospital Chinese Academy of Medical Sciences|Changhai Hospital|Xinhua Hospital Shanghai Jiao Tong University School of Medicine|Fudan University|Shanghai Changzheng Hospital|Zhejiang Cancer Hospital|Chinese PLA General Hospital|Beijing Cancer Hospital|Shanghai General Hospital Shanghai Jiao Tong University School of Medicine|RenJi Hospital|Second Affiliated Hospital School of Medicine Zhejiang University|First People''s Hospital of Hangzhou|The 307th Hospital of Chinese People`s Liberation Army|Huashan Hospital|Ruijin Hospital|Shanghai Haixin Biotechnology Co. Ltd July 2015 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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NF-κB Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID