Pyrrolidinedithiocarbamate ammonium

Catalog No.S3633 Synonyms: APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt

For research use only.

Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.

Pyrrolidinedithiocarbamate ammonium Chemical Structure

CAS No. 5108-96-3

Selleck's Pyrrolidinedithiocarbamate ammonium has been cited by 66 publications

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Biological Activity

Description Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.
Targets
NF-κB [1]
In vitro

Ammonium pyrrolidine dithiocarbamate (PDTC) can inhibit the role of NF-κB by inhibiting IκB phosphorylation, thus blocking NF-κB translocation to the nucleus, reducing the expression of downstream cytokines[1].

Assay
Methods Test Index PMID
Western blot p-p65 / p65 / p50 ; p-IKKβ / IKKβ / p-IκBα / IκBα ; CCR2 / CCR5 / CXCR4 29956738 10716998
Immunofluorescence p65 / p50 29956738

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Sprague-Dawley rats
  • Dosages: 50, 100, and 200 mg/kg
  • Administration: i.v.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 164.29
Formula

C5H9NS2.H3N

CAS No. 5108-96-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CCN(C1)C(=S)[S-].[NH4+]

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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