PDTC (Pyrrolidinedithiocarbamate ammonium)

Catalog No.S3633 Batch:S363305

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Technical Data

Formula

C5H9NS2.H3N
Molecular Weight 164.29 CAS No. 5108-96-3
Solubility (25°C)* In vitro DMSO 33 mg/mL (200.86 mM)
Water 33 mg/mL (200.86 mM)
Ethanol 11 mg/mL (66.95 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description PDTC (Pyrrolidinedithiocarbamate ammonium) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.
Targets
NF-κB [1]
In vitro Ammonium pyrrolidine dithiocarbamate (PDTC) can inhibit the role of NF-κB by inhibiting IκB phosphorylation, thus blocking NF-κB translocation to the nucleus, reducing the expression of downstream cytokines[1].

Protocol (from reference)

Animal Study:[1]
  • Animal Models

    Sprague-Dawley rats

  • Dosages

    50, 100, and 200 mg/kg

  • Administration

    i.v.

Selleck's PDTC (Pyrrolidinedithiocarbamate ammonium) has been cited by 83 publications

Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling [ Mol Metab, 2023, 75:101766] PubMed: 37406987
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release [ Oncogenesis, 2023, 12(1):18] PubMed: 36990991
Telmisartan inhibits microglia-induced neurotoxic A1 astrocyte conversion via PPARγ-mediated NF-κB/p65 degradation [ Int Immunopharmacol, 2023, 123:110761] PubMed: 37544025
Photobiomodulation reduces neuropathic pain after spinal cord injury by downregulating CXCL10 expression [ CNS Neurosci Ther, 2023, 10.1111/cns.14325] PubMed: 37475184
A novel lncRNA DFRV plays a dual function in influenza A virus infection [ Front Microbiol, 2023, 14:1171423] PubMed: 37303776
Baicalin Relieves LPS-Induced Lung Inflammation via the NF-κB and MAPK Pathways [ Molecules, 2023, 28(4)1873] PubMed: 36838858
Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis [ J Diabetes Res, 2023, 2023:7423661] PubMed: 37261217
GATA4 Forms a Positive Feedback Loop with CDX2 to Transactivate MUC2 in Bile Acids-Induced Gastric Intestinal Metaplasia [ Gut Liver, 2023, 10.5009/gnl220394] PubMed: 36860162
Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials [ Int J Oral Sci, 2023, 15(1):31] PubMed: 37532700
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma [ Signal Transduct Target Ther, 2022, 7(1):46] PubMed: 35169126

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.