Pramipexole dihydrochloride

Catalog No.S5066 Batch:S506601

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Technical Data

Formula

C10H17N3S.2HCl
Molecular Weight 284.25 CAS No. 104632-25-9
Solubility (25°C)* In vitro DMSO 56 mg/mL (197.0 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.
Targets
D3 receptor [1]
(Cell-free)		 D2L Receptor [1]
(Cell-free)		 D2S Receptor [1]
(Cell-free)		 D4 receptor [1]
(Cell-free)
0.5 nM(Ki) 2.2 nM(Ki) 3.9 nM(Ki) 5.1 nM(Ki)
In vivo In mice, pramipexole (0.001-1 mg/kg s.c.) reduced exploratory locomotor activity. In rats with unilateral striatal lesions, only weak ipsilateral rotation was produced by pramipexole at the highest dose. However, in rats with unilateral lesions of the medial forebrain bundle, pramipexole potently induced contralateral circling (ED50 0.026 mg/kg s.c). In the N-mcthyl-4-phenyl-l,2,3,6 tetrahydropyridine (MPTP) monkey model, pramipexole also had potent stimulatory effects[2]. Pramipexole is, at least in part, transported across the BBB by an organic cation-sensitive transporter. The pramipexole transport is pH-dependent, but sodium- and membrane potential-independent[3].

Protocol (from reference)

Animal Study:

[2]
  • Animal Models

    Male mice

  • Dosages

    0.001-1 mg/kg

  • Administration

    p.o.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.