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PKUMDL-WQ-2101 Dehydrogenase inhibitor

Name: PKUMDL-WQ-2101
Brand: Selleck Chemicals
SKU: E6693
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E6693

PKUMDL‑WQ‑2101 is a non‑NAD⁺‑competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 34.8 μM. It exhibits antitumor activity, selectively inhibits de novo serine synthesis in cancer cells, and reduces tumor growth in vivo.

Chemical Structure

Molecular Weight: 317.25

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Cited in Nature Medicine for its top-tier quality
SDS
Datasheet

Related Targets	HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase
Other Dehydrogenase Inhibitors	Vorasidenib (AG-881) (R)-GNE-140 CPI-613 (Devimistat) Glycyrrhizin (Glycyrrhizic Acid, NSC 167409) Sodium Dichloroacetate (DCA) AGI-6780 Gossypol Acetate Emodin AGI-5198 Brequinar (DUP785)

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Mass	Concentration	Volume	Molecular Weight
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight	317.25	Formula	C₁₄H₁₁N₃O₆	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	304481-72-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/28042046/

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