Home Neuronal Signaling NMDAR antagonist - PEAQX

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PEAQX NMDAR antagonist

Cat.No.E1050

PEAQX (NVP-AAM077) is an effective and orally available human NMDA antagonist, which shows preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over hNMDA 1A/2B receptors (IC50=29,600 nM).
PEAQX NMDAR antagonist Chemical Structure

Chemical Structure

Molecular Weight: 454.21

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Quality Control

Batch: E105001 DMSO]91 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 98.28%
98.28

Chemical Information, Storage & Stability

Molecular Weight 454.21 Formula

C17H17BrN3O5P

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 459836-30-7 -- Storage of Stock Solutions

Synonyms NVP-AAM077 Smiles CC(NC(C1=C2NC(=O)C(=O)NC2=CC=C1)[P;v5](O)(O)=O)C3=CC=C(Br)C=C3

Solubility

In vitro
Batch:

DMSO : 91 mg/mL (200.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
hNMDA 1A/2A [1]
270 nM
hNMDA 1A/2B [1]
29600 nM
References

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