LY-3381916

Catalog No.S8919 Synonyms: IDO1-IN-5

For research use only.

LY-3381916 (IDO1-IN-5) is a brain penetrated, potent and selective Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. LY-3381916 exhibits anti-tumor activity.

LY-3381916 Chemical Structure

CAS No. 2166616-75-5

Purity & Quality Control

Choose Selective IDO/TDO Inhibitors

Biological Activity

Description LY-3381916 (IDO1-IN-5) is a brain penetrated, potent and selective Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. LY-3381916 exhibits anti-tumor activity.
Targets
IDO1 [1]

Protocol (from reference)

Chemical Information

Molecular Weight 396.45
Formula
C23H25FN2O3
CAS No. 2166616-75-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C1=CC2=C(C=C1)N(CC2)C(=O)C3CCOCC3)NC(=O)C4=CC=C(C=C4)F

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03343613 Terminated Drug: LY3381916|Drug: LY3300054 Solid Tumor|Non Small Cell Lung Cancer|Renal Cell Carcinoma|Triple Negative Breast Cancer Eli Lilly and Company November 17 2017 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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