CAS No. 1456551-16-8

Batch: Purity:99.91
Check CoA
JG98 Chemical Structure
Chemical Structure
Check the JG98 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2Z,5E)-2-[(3-benzyl-1,3-thiazol-3-ium-2-yl)methylidene]-5-(6-chloro-3-methyl-1,3-benzothiazol-2-ylidene)-3-ethyl-1,3-thiazolidin-4-one chloride
CAS Number 1456551-16-8
Molecular Formula

C24H21Cl2N3OS3
Molecular Weight (MW) 534.54
SMILES CCN1C(=CC2=[N+](C=CS2)CC3=CC=CC=C3)SC(=C4N(C5=C(S4)C=C(C=C5)Cl)C)C1=O.[Cl-]
InChIKey AUPPGWXGMILTRB-HDPAMLMOSA-M

Ordering Information

Biological Activity

JG98 is an allosteric inhibitor of heat shock protein 70 (Hsp70) that binds tightly to a conserved deep pocket within the Hsp70 family. By inhibiting Hsp70 chaperone function, JG98 disrupts downstream oncogenic signaling and destabilizes client proteins, leading to classical apoptotic responses characterized by morphological changes and annexin V positivity. Consequently, JG98 exhibits potent anticancer activity and suppresses tumor cell proliferation across multiple cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 10 mg/mL (18.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.