Isovaleramide

Synonyms: 3-Methylbutanamide

Isovaleramide(3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.

Isovaleramide Chemical Structure

Isovaleramide Chemical Structure

CAS: 541-46-8

Purity & Quality Control

Batch: S411601 DMSO] 20 mg/mL] false] Water] 20 mg/mL] false] Ethanol] 20 mg/mL] false Purity: >97%
97

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Biological Activity

Description Isovaleramide(3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.
Targets
alcohol dehydrogenase [4]
In vitro
In vitro

Isovaleramide is isolated from the most active fraction of Valeriana pavonii. Isovaleramide (300 µM) exhibits a 42% of inhibition of the binding of ³H-FNZ to its sites in the in vitro assay. [1] Isovaleramide is without effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied. [2] Isovaleramide (0.15%) induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3. [3]

In Vivo
In vivo

Isovaleramide (100 mg/Kg, p.o) evidences a 90% index protection against the maximal electroshock seizure in mice (MES). [1] Isovaleramide produces a consistent pattern of signs at relatively high doses in extensive safety studies in rats, rabbits, and dogs. Isovaleramide shows a significantly lower potential for reproductive toxicity than VPA in several reproductive toxicity studies conducted in mice, rats and rabbits. [2]

Chemical Information & Solubility

Molecular Weight 101.15 Formula

C5H11NO

CAS No. 541-46-8 SDF Download Isovaleramide SDF
Smiles CC(C)CC(=O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 20 mg/mL ( (197.72 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 20 mg/mL

Ethanol : 20 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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