CAS No. 3064599-36-3
Chemical Structure
Check the
GSK4418959
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1R,2S,6R)-2-[4-[(1,2-dimethylbenzimidazol-5-yl)sulfonyl-methylamino]phenyl]-6-[[2-fluoro-4-(trifluoromethyl)phenyl]carbamoyl]cyclohexane-1-carboxylic acid | |
|---|---|---|
| CAS Number | 3064599-36-3 | |
| Molecular Formula | C31H30F4N4O5S | |
| Molecular Weight (MW) | 646.65 | |
| SMILES | O=C(NC1=CC=C(C(F)(F)F)C=C1F)[C@@H]2CCC[C@H](C3=CC=C(N(C)S(=O)(C4=CC(N=C(C)N5C)=C5C=C4)=O)C=C3)[C@H]2C(O)=O | |
| InChIKey | CPNRNECAIBPHJF-MVOZIGHISA-N |
GSK4418959 (IDE275) is a non-covalent, reversible, selective, and orally bioavailable inhibitor of Werner syndrome ATP-dependent helicase (WRN). It exhibits ATP-competitive inhibition of WRN ATPase activity and DNA unwinding function. By targeting WRN helicase, GSK4418959 impairs DNA replication fork progression and DNA repair mechanisms, leading to double-strand breaks and synthetic lethality specifically in microsatellite instability-high (MSI-H) cancer cells. [1]
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Note: Technical data last updated: Sep 1, 2026.