CAS No. 67227-57-0

Batch: Purity:99.96
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Fenoldopam mesylate Chemical Structure
Chemical Structure
Check the Fenoldopam mesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;methanesulfonic acid
CAS Number 67227-57-0
Molecular Formula

C16H16ClNO3.CH4O3S
Molecular Weight (MW) 401.86
SMILES CS(=O)(=O)O.C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O
InChIKey CVKUMNRCIJMVAR-UHFFFAOYSA-N

Ordering Information

Biological Activity

Fenoldopam mesylate is a selective dopamine-1 receptor (DA1) agonist with potent antihypertensive action. Upon binding to DA1 receptors, it stimulates adenylyl cyclase activity and increases intracellular cyclic AMP levels, promoting vascular smooth muscle relaxation. This signaling cascade leads to renal arteriolar vasodilation, significantly reducing systemic vascular resistance while enhancing urinary sodium and water excretion through downstream natriuretic and diuretic responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (199.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.