CAS No. 929978-58-5
Batch:
Purity:99.32
Chemical Structure
Check the
Fasnall
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(1-benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine | |
|---|---|---|
| CAS Number | 929978-58-5 | |
| Molecular Formula |
C19H22N4S |
|
| Molecular Weight (MW) | 338.47 | |
| SMILES | CC1=C(C)C2=C(NC3CCN(C3)CC4=CC=CC=C4)N=CN=C2S1 | |
| InChIKey | VSXRMURGJRAOCU-UHFFFAOYSA-N |
Fasnall is a selective thiophenopyrimidine-based fatty acid synthase (FASN) inhibitor that exhibits potent antitumor activity. By targeting FASN, Fasnall disrupts de novo lipogenesis, leading to the inhibition of cancer cell proliferation and impairment of cell membrane biosynthesis. This disruption significantly decreases lipid accumulation, suppresses tumor growth, and induces apoptosis in preclinical models of HER2-positive breast cancer. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 25 mg/mL |
| DMSO |
13 mg/mL
(38.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.