CAS No. 86227-47-6

Batch: Purity:
Eicosapentaenoic acid ethyl ester Chemical Structure
Chemical Structure
Check the Eicosapentaenoic acid ethyl ester product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 86227-47-6
Molecular Formula

C22H34O2
Molecular Weight (MW) 330.50
SMILES CCOC(=O)CCC\C=C/C/C=C\C\C=C/C/C=C\C\C=C/CC

Biological Activity

Eicosapentaenoic acid ethyl ester is an omega-3 fatty acid derivative that functions as a lipid-regulating agent and PPAR modulator. It regulates lipid metabolism pathways by downregulating sterol regulatory element-binding protein 1c (SREBP-1c) expression and suppressing diacylglycerol acyltransferase activity. These mechanisms lead to reduced intracellular triglyceride synthesis, decreased lipid accumulation, and inhibition of pro-inflammatory NF-κB signaling in metabolic target tissues. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Journal of Lipid Research. 2003;44(2):437.

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Note: Technical data last updated: Sep 1, 2026.