CAS No. 1079043-55-2

Batch: Purity:99.94
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Deudextromethorphan (AVP-786) Chemical Structure
Chemical Structure
Check the Deudextromethorphan (AVP-786) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1079043-55-2
Molecular Formula

C18H19D6NO
Molecular Weight (MW) 277.43
SMILES C(OC1=CC=C2CC3C4CCCCC4(CCN3C([2H])([2H])[2H])C2=C1)([2H])([2H])[2H]

Ordering Information

Biological Activity

Deudextromethorphan (AVP-786) is a deuterated small-molecule compound that acts as an active N-methyl-D-aspartate (NMDA) receptor antagonist. By blocking NMDA receptor-mediated ion channel activation and glutamate-induced neurotransmission, it attenuates intracellular calcium ion influx and modulates downstream central signaling pathways. This target inhibition leads to reduced neuronal excitotoxicity and exhibits significant neuroprotective activity within the central nervous system.[1]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 55 mg/mL (198.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 55 mg/mL
Water 14 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.