CAS No. 338-69-2
Batch:
Purity:99.87
Chemical Structure
Check the
D-Alanine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 338-69-2 | |
|---|---|---|
| Molecular Formula |
C3H7NO2 |
|
| Molecular Weight (MW) | 89.09 | |
| SMILES | CC(C(=O)O)N |
D-Alanine is an endogenous co-agonist that selectively binds to the glycine site of the N-methyl-D-aspartate (NMDA) receptor. By binding to the GluN1 subunit of the NMDA receptor complex, D-alanine facilitates glutamate-mediated channel opening, calcium influx, and downstream synaptic transmission. Activation of these NMDA receptor signaling pathways plays a critical role in regulating synaptic plasticity, long-term potentiation, and neurotransmission in the central nervous system. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 18 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.