CAS No. 22144-77-0
Batch:
Purity:99.38
Chemical Structure
Check the
Cytochalasin D
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | [(1R,2R,3E,5R,7S,9E,11R,12S,14S,15R,16S)-16-benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-6,18-dioxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate | |
|---|---|---|
| CAS Number | 22144-77-0 | |
| Molecular Formula |
C30H37NO6 |
|
| Molecular Weight (MW) | 507.62 | |
| SMILES | CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O | |
| InChIKey | SDZRWUKZFQQKKV-JHADDHBZSA-N |
Biological Activity
Cytochalasin D is a cell-permeable fungal metabolite that acts as a potent actin polymerization inhibitor. By binding to the barbed ends of actin filaments, it disrupts actin filament dynamics and destabilizes the actin cytoskeleton. Consequently, disruption of the actin network impairs cell motility, modulates Hippo signaling by inducing phosphorylation and cytoplasmic retention of YAP, and inhibits cellular division.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(49.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
25 mg/mL
(49.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Jump to
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Note: Technical data last updated: Sep 1, 2026.