Curcumenol

Catalog No.S3874 Batch:S387402

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Technical Data

Formula

C15H22O2
Molecular Weight 234.33 CAS No. 19431-84-6
Solubility (25°C)* In vitro DMSO 47 mg/mL (200.57 mM)
Ethanol 47 mg/mL (200.57 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.
Targets
NF-κB [1] CYP3A4 [2]
12.6 μM
In vitro Curcumenol markedly decreases LPS-induced production of nitric oxide (NO), pro-inflammatory cytokines [(IL-6) and (TNF-α)] and pro-inflammatory proteins expression, iNOS and COX-2. Curcumenol has also been shown to exhibit hepatoprotective properties. Curcumenol can suppress the LPS-induced NF-κB activity by inhibiting the phosphorylation of Akt. Its treatment significantly inhibits LPS-induced phosphorylation of p38 MAPK but not JNK and ERK[1]. The activity of CYP3A4 is strongly inhibited by curcumenol with an IC50 value of 12.6 ± 1.3 μM. Kinetic analysis shows curcumenol competitively inhibits testosterone 6β-hydroxylation activity (CYP3A4) with Ki of 10.8 μM[2].

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    BV-2 cell line

  • Concentrations

    2.5–20 μM

  • Incubation Time

    2 h

  • Method

    BV-2 cells are seeded into a sterile flat bottom 96-well plate. The cells are then allowed to adhere overnight. The cells are pretreated with various concentrations of curcumenol for 2 h followed by LPS exposure (0.4 μg/mL) for 12 h to 24 h.

Selleck's Curcumenol has been cited by 3 publications

Curcumenol Mitigates the Inflammation and Ameliorates the Catabolism Status of the Intervertebral Discs In Vivo and In Vitro via Inhibiting the TNFα/NFκB Pathway [ Front Pharmacol, 2022, 13:905966] PubMed: 35795557
An Antioxidant Sesquiterpene Inhibits Osteoclastogenesis Via Blocking IPMK/TRAF6 and Counteracts OVX-Induced Osteoporosis in Mice [ J Bone Miner Res, 2021, 10.1002/jbmr.4328] PubMed: 33956362
Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice [ Int J Mol Med, 2021, 48(4)192] PubMed: 34435650

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.