CAS No. 131602-53-4

Batch: Purity:99.08
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β-Amyloid (25-35) Chemical Structure
Chemical Structure
Check the β-Amyloid (25-35) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[2-[[2-[[2-[[2-[2-[[2-[[6-amino-2-[[4-amino-2-[[2-[(2-aminoacetyl)amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]acetyl]amino]propanoylamino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid
CAS Number 131602-53-4
Molecular Formula

C45H81N13O14S
Molecular Weight (MW) 1060.27
InChIKey WIHBNMPFWRHGDF-UHFFFAOYSA-N

Biological Activity

β-Amyloid (25-35) is a cytotoxic synthetic derivative of amyloid beta-peptide that forms fibrillar aggregates involved in Alzheimer's disease pathogenesis. Upon aggregation, this peptide triggers apoptotic signaling pathways, induces mitochondrial dysfunction, and increases oxidative stress in neuronal cells. These cellular alterations impair synaptic plasticity and promote neurodegeneration, making it a widely utilized peptide model for studying amyloid toxicity and neurodegenerative mechanisms.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (94.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Pike CJ, et al. J Neurochem. 1995;64(1):253-265.

[2] Varadarajan S, et al. J Am Chem Soc. 2001;123(24):5625-5631.

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Note: Technical data last updated: Sep 1, 2026.