CAS No. 213819-48-8
Batch:
Purity:99.76
Chemical Structure
Check the
Belotecan (CKD-602) hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (19S)-19-ethyl-19-hydroxy-10-[2-(propan-2-ylamino)ethyl]-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione;hydrochloride | |
|---|---|---|
| CAS Number | 213819-48-8 | |
| Molecular Formula |
C25H28ClN3O4 |
|
| Molecular Weight (MW) | 469.96 | |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O.Cl | |
| InChIKey | SJKBXKKZBKCHET-UQIIZPHYSA-N |
Belotecan (CKD-602) hydrochloride is a synthetic camptothecin derivative functioning as a potent DNA topoisomerase I inhibitor. By binding to the topoisomerase I-DNA complex, it stabilizes reversible single-strand cleavage intermediates, preventing DNA religation during replication. This accumulation of cleavable complexes induces replication fork collapse, double-strand DNA breaks, cell cycle arrest, and apoptotic death in sensitive cancer cell lines. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
47 mg/mL
(100.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 4 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Belotecan (CKD-602) hydrochloride Clinical Trials
- Belotecan (CKD-602) hydrochloride Solubility in DMSO
- Belotecan (CKD-602) hydrochloride Stock Solution
- Belotecan (CKD-602) hydrochloride Storage
- Belotecan (CKD-602) hydrochloride Stability
- Belotecan (CKD-602) hydrochloride Molecular Weight
- Belotecan (CKD-602) hydrochloride SMILES
- Belotecan (CKD-602) hydrochloride Chemical Structure (2D and 3D)
- Belotecan (CKD-602) hydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.