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Technical Data
| Formula | C20H27N.C6H8O7 |
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| Molecular Weight | 473.56 | CAS No. | 5560-59-8 | |
| Solubility (25°C)* | In vitro | DMSO | 95 mg/mL (200.6 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. |
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| In vitro | In pharmacological studies, alverine citrate has been shown to exert an effect on intestinal motility and intestinal sensitivity, two factors recognized as involved in the onset of FBD, without exhibiting the potential drawbacks of a medication with systemic effects.Alverine citrate affects basal and stimulated motility via a calcium-dependent and -independent inhibition of neuronal excitability as well as direct inactivation of L-type Ca2+ of smooth muscle cells. Experimental findings support an antinociceptive action by selective receptor-mediated mechanisms. |
Protocol (from reference)
References
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Selleck's Alverine Citrate has been cited by 1 publication
| The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity. [ Am J Physiol Lung Cell Mol Physiol, 2018, 315(2):L133-L148] | PubMed: 29631359 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.