Piperine

Catalog No.S2344 Synonyms: 1-Piperoylpiperidine

For research use only.

Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.

Piperine Chemical Structure

CAS No. 94-62-2

Selleck's Piperine has been cited by 1 Publication

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Biological Activity

Description Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.
Targets
CYP3A4 [1]
In vitro

Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide. Piperine has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. [1] Piperine is found to be cytotoxic towards DLA and EAC cells at a concentration of 250 μ g/ml. Piperine (1.14 mg/dose/animal) could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor. [2]

In vivo LD50: Mice 15.1mg/kg (i.v.), 43mg/kg (i.p.), 200mg/kg (s.c.), 330mg/kg (i.g.); Rats 33.5mg/kg (i.p.), 514mg/kg (i.g.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 285.34
Formula

C17H19NO3

CAS No. 94-62-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04731844 Recruiting Drug: Curcumin plus Piperine Prostate Cancer|Multiple Myeloma|Smoldering Multiple Myeloma (SMM)|Monoclonal Gammopathy of Undetermined Significance University of Rochester December 14 2021 Phase 2
NCT00181662 Completed Drug: Curcumin Healthy Massachusetts General Hospital August 2005 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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