Naringenin

Catalog No.S2394 Synonyms: NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol

Naringenin Chemical Structure

Molecular Weight(MW): 272.25

Naringenin is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.

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  • (d) Antiviral activity of SZA on assembly and release. Huh7 cells were electroporated with JFH-1 RNA of HCV, followed by 4 h treatment of the indicated concentrations of SZA. At 48 h after electroporation, cells were subjected to three cycles of freeze and thaw to test the intracellular viral infectivity; supernatants of the electroporated cells were collected for the detection of extracellular viral infectivity. 100 μM naringenin was introduced as a positive control. Results are shown as relative HCV infectivity compared to DMSO treated group. Data shown as mean ± SD of three independent experiments.

    Scientific Reports 6, 2016, Article number: 27268 . Naringenin purchased from Selleck.

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Biological Activity

Description Naringenin is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
Targets
CYP1A2 [1]
In vitro

Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Naringenin is the predominant flavanone in grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2, which can change pharmacokinetics in a human (or orthologous) host of several popular agents in an adverse manner, even resulting in carcinogens of otherwise harmless substances. [1]

In vivo Intragastrically administered Naringenin (50 mg/kg) induces a significant decrease in plasma glucose in normoglycaemic and non-insulin-dependent diabetes mellitus (NIDDM) rat models. LD50: Mice >5g/kg; Rats >5g/kg. [2]

Protocol

Solubility (25°C)

In vitro DMSO 54 mg/mL (198.34 mM)
Ethanol 5 mg/mL (18.36 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 272.25
Formula

C15H12O5

CAS No. 480-41-1
Storage powder
in solvent
Synonyms NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03582553 Completed Safety Issues|Pharmacokinetics Pennington Biomedical Research Center|Louisiana Clinical and Translational Science Center May 25 2018 Early Phase 1
NCT03582553 Completed Safety Issues|Pharmacokinetics Pennington Biomedical Research Center|Louisiana Clinical and Translational Science Center May 25 2018 Early Phase 1
NCT01091077 Completed Hepatitis C Virus|HCV Infection|Chronic HCV|Hepatitis C Massachusetts General Hospital|Harvard University June 2009 Phase 1
NCT01091077 Completed Hepatitis C Virus|HCV Infection|Chronic HCV|Hepatitis C Massachusetts General Hospital|Harvard University June 2009 Phase 1

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P450 (e.g. CYP17) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID