Evodiamine

Catalog No.S2382 Batch:S238201

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Technical Data

Formula

C19H17N3O
Molecular Weight 303.36 CAS No. 518-17-2
Solubility (25°C)* In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells. It is shown to inhibit NF-κB activation through suppression of IkB kinase activity.
Targets
NF-κB [2]
In vitro Evodiamine (Isoevodiamine), an alkaloid extract from Evodiae Fructus exhibits antitumor activities against the human tumor cells. Evodiamine induces the substantial amount of apoptosis both in Bcl-2- and Akt-overexpressing U937 cells but not in human peripheral blood mononuclear cells via caspase-independent apoptotic pathways. [1] Evodiamine Evodiamine also inhibits tumor necrosis factor (TNF)-induced NF-kappaB and Akt activation but it has no effect on JNK or p38 MAPK activation. [2] In addition, Evodiamine is an human topoisomerase I inhibitor. [3]
In vivo LD50: Mice 77mg/kg (i.v.) [4]

Protocol (from reference)

Customer Product Validation

Data from [Data independently produced by , , Mol Med Rep, 2016, 14(5):4551-4558.]

Selleck's Evodiamine has been cited by 10 publications

Dietary Evodiamine Inhibits Atherosclerosis-Associated Changes in Vascular Smooth Muscle Cells [ Int J Mol Sci, 2023, 24(7)6653] PubMed: 37047626
Evodiamine induces ROS-Dependent cytotoxicity in human gastric cancer cells via TRPV1/Ca2+ pathway [ Chem Biol Interact, 2021, 351:109756] PubMed: 34808100
Evodiamine inhibits vasculogenic mimicry in HCT116 cells by suppressing hypoxia-inducible factor 1-alpha-mediated angiogenesis [ Anticancer Drugs, 2021, 32(3):314-322] PubMed: 33394687
Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis [ J Exp Clin Cancer Res, 2020, 39(1):249] PubMed: 33208183
Evodiamine inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells via the Hippo-Yes-Associated Protein signaling pathway. [ Life Sci, 2020, 10.1016/j.lfs.2020.117424] PubMed: 32057900
Evodiamine inhibits high-fat diet-induced colitis-associated cancer in mice through regulating the gut microbiota [ J Integr Med, 2020, S2095-4964(20)30128-X] PubMed: 33277208
Evodiamine inhibits migration and invasion by Sirt1-mediated post-translational modulations in colorectal cancer. [ Anticancer Drugs, 2019, 30(6):611-617] PubMed: 30789361
Evodiamine inhibits migration and invasion by Sirt1-mediated post-translational modulations in colorectal cancer [ Anticancer Drugs, 2019, 30(6):611-617] PubMed: 30789361
Evodiamine induces apoptosis and promotes hepatocellular carcinoma cell death induced by vorinostat via downregulating HIF-1α under hypoxia. [ Biochem Biophys Res Commun, 2018, 498(3):481-486] PubMed: 29505792
Evodiamine inhibits PDGF‑BB‑induced proliferation of rat vascular smooth muscle cells through the suppression of cell cycle progression and oxidative stress [Ge X, et al. Mol Med Rep, 2016, 14(5):4551-4558] PubMed: 27748810

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.