(R)-(-)-Ibuprofen

Catalog No.S5899 Synonyms: (R)-Ibuprofen

For research use only.

(R)-(-)-Ibuprofen ((R)-Ibuprofen) inhibits the activation of NF-κB in response to T-cell stimulation with IC50 of 121.8 μM. R(-)-ibuprofen exerts anti-inflammatory and antinociceptive effects.

(R)-(-)-Ibuprofen Chemical Structure

CAS No. 51146-57-7

Purity & Quality Control

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Biological Activity

Description (R)-(-)-Ibuprofen ((R)-Ibuprofen) inhibits the activation of NF-κB in response to T-cell stimulation with IC50 of 121.8 μM. R(-)-ibuprofen exerts anti-inflammatory and antinociceptive effects.
Targets
NF-κB [1]
(Cell-free assay)
121.8 μM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 41 mg/mL
(198.75 mM)
Water 41 mg/mL
(198.75 mM)
Ethanol ''''41 mg/mL

Chemical Information

Molecular Weight 206.28
Formula

C13H18O2

CAS No. 51146-57-7
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05013567 Not yet recruiting Drug: Ibuprofen gel|Other: Placebo Musculoskeletal Pain|Acute Pain|Stretch|Sprains Brainfarma Industria Química e Farmacêutica S/A March 2022 Phase 3
NCT05030324 Recruiting Drug: XC221 100 mg|Drug: XC221 200 mg|Drug: Placebo Influenza|Viral Respiratory Infection|Acute Viral Upper Respiratory Infections Valenta Pharm JSC October 1 2021 Phase 2
NCT04986839 Recruiting Drug: Paracetamol injection|Drug: Ibuprofen injection Patent Ductus Arteriosus Manchester University NHS Foundation Trust September 3 2021 Phase 2|Phase 3
NCT04942015 Not yet recruiting Drug: Honghuaruyi Wan|Drug: Placebo of Honghuaruyi Wan Endometriosis|Dysmenorrhea Beijing University of Chinese Medicine June 21 2021 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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