(R)-(-)-Ibuprofen

For research use only.

Catalog No.S5899 Synonyms: (R)-Ibuprofen

(R)-(-)-Ibuprofen Chemical Structure

CAS No. 51146-57-7

(R)-(-)-Ibuprofen ((R)-Ibuprofen) inhibits the activation of NF-κB in response to T-cell stimulation with IC50 of 121.8 μM. R(-)-ibuprofen exerts anti-inflammatory and antinociceptive effects.

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Biological Activity

Description (R)-(-)-Ibuprofen ((R)-Ibuprofen) inhibits the activation of NF-κB in response to T-cell stimulation with IC50 of 121.8 μM. R(-)-ibuprofen exerts anti-inflammatory and antinociceptive effects.
Targets
NF-κB [1]
(Cell-free assay)
121.8 μM

Protocol

Solubility (25°C)

In vitro DMSO 41 mg/mL (198.75 mM)
Water 41 mg/mL (198.75 mM)
Ethanol ''''41 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 206.28
Formula

C13H18O2

CAS No. 51146-57-7
Storage powder
in solvent
Synonyms (R)-Ibuprofen

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05013567 Not yet recruiting Drug: Ibuprofen gel|Other: Placebo Musculoskeletal Pain|Acute Pain|Stretch|Sprains Brainfarma Industria Química e Farmacêutica S/A March 2022 Phase 3
NCT04986839 Not yet recruiting Drug: Paracetamol injection|Drug: Ibuprofen injection Patent Ductus Arteriosus Manchester University NHS Foundation Trust October 1 2021 Phase 2|Phase 3
NCT05030324 Not yet recruiting Drug: XC221 100 mg|Drug: XC221 200 mg|Drug: Placebo Influenza|Viral Respiratory Infection|Acute Viral Upper Respiratory Infections Valenta Pharm JSC September 2021 Phase 2
NCT04942015 Not yet recruiting Drug: Honghuaruyi Wan|Drug: Placebo of Honghuaruyi Wan Endometriosis|Dysmenorrhea Beijing University of Chinese Medicine June 21 2021 Phase 4
NCT04723394 Active not recruiting Drug: AZD7442|Drug: Placebo COVID-19 AstraZeneca January 28 2021 Phase 3

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NF-κB Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID