CAS No. 51146-57-7
Batch:
Purity:99.94
Chemical Structure
Check the
(R)-(-)-Ibuprofen
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid | |
|---|---|---|
| CAS Number | 51146-57-7 | |
| Molecular Formula |
C13H18O2 |
|
| Molecular Weight (MW) | 206.28 | |
| SMILES | CC(C)CC1=CC=C(C=C1)C(C)C(O)=O | |
| InChIKey | HEFNNWSXXWATRW-SNVBAGLBSA-N |
(R)-(-)-Ibuprofen is an immunomodulatory non-steroidal compound that acts as a selective inhibitor of NF-κB activation (IC50 121.8 μM) in response to T-cell stimulation. By suppressing NF-κB signaling pathway activation, this enantiomer effectively downregulates the transcription of downstream pro-inflammatory mediators and cytokines, ultimately leading to marked cellular anti-inflammatory and antinociceptive phenotypic effects.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
41 mg/mL
(198.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 41 mg/mL |
| Ethanol | 41 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.