Home Neuronal Signaling iGluR

iGluR

Other Neuronal Signaling Related Inhibitors

Secretase GluR GABA Receptor Dopamine Receptor 5-HT Receptor P2 Receptor AChR Histamine Receptor MAO Beta Amyloid
Cat.No. Product Name Information Product Use Citations Product Validations
S4821 Glycine Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.
J Invest Dermatol, 2022, S0022-202X(22)00096-3
Free Radic Res, 2022, 1-13
E8008 QNZ46 QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). IC50 value: 3 μM (for NR2D), 6 μM (for NR2C), 229 μM (for NR2D NR2A)Target: NR2D, NR2C, NR2Ain vitro: QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC50 values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.
E7521 MDL-29951 MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.
S2876 (+)-Dizocilpine (MK 801) Maleate (+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.(+)-Dizocilpine (MK 801) Maleate can be used to induce animal models of Schizophrenia.
Theranostics, 2025, 15(14):6901-6918
Aging -Albany NY), 2023, 15(12):5698-5712
Aging (Albany NY), 2023, 15(12):5698-5712
S7072 NMDA (N-Methyl-D-aspartic acid) NMDA (N-Methyl-D-aspartic acid) is a specific agonist for the NMDA receptor, mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.
Theranostics, 2025, 15(14):6901-6918
Sci Rep, 2025, 15(1):17364
J Neurotrauma, 2025, 10.1177/08977151251374286
S1438 Topiramate Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
J Headache Pain, 2025, 26(1):182
Commun Biol, 2025, 8(1):28
Cell Rep, 2022, 40(5):111153
S4091 Ifenprodil Tartrate Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.
J Immunother Cancer, 2024, 12(11)e009805
Cancer Sci, 2022, 113(8):2716-2726
Cancer Res, 2021, canres.1017.2021
Verified customer review of Ifenprodil Tartrate
S2043 Memantine HCl Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.
Pharmaceuticals (Basel), 2023, 16(5)692
Front Genet, 2022, 13:942203
FASEB J, 2020, 10.1096/fj.202000534R
S6266 (S)-Glutamic acid (S)-Glutamic acid (L-Glutamic acid) is an endogenous, non-selective glutamate receptor agonist.
Cell Biosci, 2024, 14(1):135
Cancer Sci, 2022, 113-6:1955-1967
CHEM ENG J, 2021, 10.1016/j.cej.2021.130083
S1334 Flupirtine maleate Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
Assay Drug Dev Technol, 2019, 17(7):310-321
Elife, 2015, 4