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Other Neuronal Signaling Related Inhibitors

Secretase GluR GABA Receptor Dopamine Receptor 5-HT Receptor P2 Receptor AChR Histamine Receptor MAO Beta Amyloid
Cat.No. Product Name Information Product Use Citations Product Validations
S4821 Glycine Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.
J Invest Dermatol, 2022, S0022-202X(22)00096-3
Free Radic Res, 2022, 1-13
E8008 QNZ46 QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). IC50 value: 3 μM (for NR2D), 6 μM (for NR2C), 229 μM (for NR2D NR2A)Target: NR2D, NR2C, NR2Ain vitro: QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC50 values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.
E7521 MDL-29951 MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.
S2876 (+)-Dizocilpine (MK 801) Maleate (+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.(+)-Dizocilpine (MK 801) Maleate can be used to induce animal models of Schizophrenia.
Frontiers in Cellular Neuroscience, September 14, 2022, 981190
Theranostics, June 09, 2025, 6901-6918
Theranostics, 2025, 15(14):6901-6918
S7072 NMDA (N-Methyl-D-aspartic acid) NMDA (N-Methyl-D-aspartic acid) is a specific agonist for the NMDA receptor, mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.
Theranostics, 2025, 15(14):6901-6918
Sci Rep, 2025, 15(1):17364
J Neurotrauma, 2025, 10.1177/08977151251374286
S1438 Topiramate Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
Anticancer Research, February 2021, 687-697
EMBO Molecular Medicine, December 23, 2025, 433-461
J Headache Pain, 2025, 26(1):182
S1334 Flupirtine maleate Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
Assay Drug Dev Technol, 2019, 17(7):310-321
Epilepsia, 2016 Jan, 79-88
eLife, 2015, e07242
S4091 Ifenprodil Tartrate Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.
J Immunother Cancer, 2024, 12(11)e009805
Cancer Sci, 2022, 113(8):2716-2726
Cancer Res, 2021, canres.1017.2021
Verified customer review of Ifenprodil Tartrate
S2251 (-)-Huperzine A (HupA) (-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.
Acta Pharmacologica Sinica, 2019 Nov, 1386-1393
Acta Pharmacologica Sinica, 2019, 1386-1393
Acta Pharmacol Sin, 2019, 10.1038/s41401-018-0206-4
S4721 L-Glutamic acid monosodium salt L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. This compound acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). It shows a direct activating effect on the release of DA from dopaminergic terminals.
Heliyon, 2024, e23945
Heliyon, 2024, 10(1):e23945
Acta Biomaterialia, 2022, 255-272