L-Glutamic acid monosodium salt

Catalog No.S4721 Synonyms: Monosodium glutamate, MSG

For research use only.

L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

L-Glutamic acid monosodium salt Chemical Structure

CAS No. 142-47-2

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Biological Activity

Description L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
In vitro

Monosodium glutamate(MSG) induces apoptosis in human B cells. It has a more potent apoptotic effect in naïve B cells compared to memory B cell population[3]. Low doses of L-monosodium glutamate promote neuronal growth and differentiation in vitro[4].

In vivo Daily monosodium glutamate(MSG) dietary consumption reduces pancreatic β-cell mass and enhances hemorrhages and fibrosis, but does not affect glucose homeostasis. High dietary MSG intake may exert a negative effect on the pancreas and such effect might become functionally significant in the presence or susceptibility to diabetes or NaCl. Parenteral MSG causes various changes in pancreatic islets such as hypertrophy, hyperplasia, decrease in acinar cells, α-cells and somatostatin cells and increase in fibrosis[1]. MSG may have some deleterious effects on the testes of Wistar rats and by extension may contribute to the causes of male infertility[2].

Protocol (from reference)

Cell Research:[3]
  • Cell lines: human B cells
  • Concentrations: 1-100 mM
  • Incubation Time: 24 h
  • Method: B cells are cultured with and with out increasing concentrations of MSG(1-100 mM) for 24 h. The number of early apoptotic cells and necrotic cells is determined using Annexin-V FITC/PI staining.
Animal Research:[1]
  • Animal Models: Adult male Wistar rats
  • Dosages: 2 mg/g 
  • Administration: Oral administration

Solubility (25°C)

In vitro

Water 33 mg/mL
(195.13 mM)
DMSO Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 169.11
Formula

C5H8NO4.Na

CAS No. 142-47-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CC(=O)O)C(C(=O)[O-])N.[Na+]

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04876716 Recruiting Drug: Azole|Drug: Anidulafungin Invasive Aspergillosis Erasmus Medical Center|ZonMw: The Netherlands Organisation for Health Research and Development|Stichting Hemato-Oncologie voor Volwassenen Nederland May 11 2021 Phase 3
NCT04024995 Recruiting -- Invasive Fungal Infections Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne September 1 2019 --
NCT03299608 Unknown status Diagnostic Test: Breath analysis Respiratory Tract Infections|Hematologic Diseases Universitaire Ziekenhuizen Leuven June 21 2019 --
NCT02981615 Unknown status Drug: Levofloxacin|Drug: Placebo Oral Tablet Prevention Sheba Medical Center August 1 2017 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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