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iGluR Antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S2876 (+)-Dizocilpine (MK 801) Maleate (+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.(+)-Dizocilpine (MK 801) Maleate can be used to induce animal models of Schizophrenia.
Frontiers in Cellular Neuroscience, September 14, 2022, 981190
Theranostics, June 09, 2025, 6901-6918
Theranostics, 2025, 15(14):6901-6918
S4091 Ifenprodil Tartrate Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.
J Immunother Cancer, 2024, 12(11)e009805
Cancer Sci, 2022, 113(8):2716-2726
Cancer Res, 2021, canres.1017.2021
Verified customer review of Ifenprodil Tartrate
S1334 Flupirtine maleate Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
eLife, August 27, 2015, e07242
Assay Drug Dev Technol, 2019, 17(7):310-321
Epilepsia, 2016 Jan, 79-88
S2043 Memantine HCl Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.
Pharmaceuticals (Basel), 2023, 16(5)692
Front Genet, 2022, 13:942203
FASEB J, 2020, 10.1096/fj.202000534R
E0484 CNQX CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) is an AMPA and kainate receptor antagonist with IC50 values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively. This compound is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). It shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.
Advanced Science, November 21, 2025, e05663
Frontiers in Cellular Neuroscience, March 06, 2020, 24
S5032 Mephenesin Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.
Cell Rep Methods, 2023, 3(10):100599
S0509 NMDAR antagonist 1 NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective antagonist of NMDAR. It has neuroprotective activity.
E1259 DNQX DNQX is an AMPA receptor antagonist that prevents excess calcium influx via voltage-gated calcium channels.
E1246 D-AP5 D-AP5 (D-APV; D-2-Amino-5-phosphonovaleric acid) is a selective and competitive NMDA receptor antagonist that inhibits the glutamate binding site of NMDA receptors.
S4957 Linalool Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.
S4745 L-Phenylalanine L-Phenylalanine is an essential amino acid and a competitive antagonist against NMDAR glycine- and glutamate-binding sites with a Kb of 573 μM. It is widely used in food flavor and pharmaceutical production.
E1050 PEAQX PEAQX (NVP-AAM077) is an effective and orally available human NMDA antagonist, which shows preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over hNMDA 1A/2B receptors (IC50=29,600 nM).
S5664 Orphenadrine Hydrochloride Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.
S9686 NBQX (FG9202) NBQX (FG9202, NNC 079202) is a highly selective and competitive antagonist of AMPA receptor (AMPAR) with anti-epileptic effect.