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RAAS Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2051 Captopril Captopril (SQ 14225,Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.
Frontiers in Pharmacology, March 18, 2022, 837756
bioRxiv, January 29, 2024, nan
Molecular Medicine Reports, August 27, 2019, 4433-4448
S2099 Temocapril HCl Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
J Immunother Cancer, 2024, 12(11)e009805
Human Cell, 2024, 854-864
J Pers Med, 2022, 12(2)258
S1657 Enalaprilat Dihydrate Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
Drug Metabolism and Disposition, November 2017, 1149-1155
Drug Metabolism and Disposition, April 2016, 554-559
J Immunother Cancer, 2024, 12(11)e009805
S1941 Enalapril Maleate Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
ACS Omega, July 12, 2021, 18610-18622
J Immunother Cancer, 2024, 12(11)e009805
BMC Pharmacol Toxicol, 2024, 25(1):25
S2199 Aliskiren Hemifumarate Aliskiren hemifumarate(CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate) is a direct renin inhibitor with IC50 of 1.5 nM.
European Journal of Pharmaceutical Sciences, September 20 2016, 22-27
Frontiers in Pharmacology, April 08 2025, 1539032
J Immunother Cancer, 2024, 12(11)e009805
S7382 Phosphoramidon Disodium Salt Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.
Diagnostics (Basel), 2022, 2710
Diagnostics, 2022, 12(11)
Diagnostics, 2022, 2710
S5767 Aliskiren Aliskiren(CGP 60536) is a renin inhibitor with antihypertensive activity.
Front Pharmacol, 2025, 16:1539032
Angiogenesis, 2017, 20(1):175-181
Am J Physiol Heart Circ Physiol, 2016, 311(3):H849-54
S5938 Benazepril Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. This compound is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
Frontiers in Pharmacology, 2021, 740529
Front Pharmacol, 2021, 12:740529
Anticancer Research, 2021, 6179-6190
S1506 Perindopril Erbumine Perindopril Erbumine (S9490-3) is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite, a potent ACE inhibitor with IC50 of 1.05 nM. This compound is used for in vivo studies and Perindoprilat is recommened for in vitro research.
J Immunother Cancer, 2024, 12(11)e009805
Neurotherapeutics, 2018, 15(2):500-510
S1793 Ramipril Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
Communications Medicine, 2025, 420
J Immunother Cancer, 2024, 12(11)e009805
S2076 Lisinopril dihydrate Lisinopril dihydrate(MK-521 dihydrate) is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
bioRxiv, 2025, Preprint
J Immunother Cancer, 2024, 12(11)e009805
S2581 Quinapril HCl Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.
Chemical & Pharmaceutical Bulletin, 2025, 857-867
J Immunother Cancer, 2024, 12(11)e009805
S2079 Moexipril HCl Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.
J Cell Biochem, 2022, 10.1002/jcb.30213
S2109 Imidapril HCl Imidapril HCl(TA-6366) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
J Immunother Cancer, 2024, 12(11)e009805
S2488 VTP-27999 TFA VTP-27999 TFA (VTP-27999 Trifluoroacetate, VTP-27999 2,2,2-trifluoroacetate) is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.
ProQuest , 2023, 30489399
S6468 Trandolapril Trandolapril(RU44570) is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.
J Immunother Cancer, 2024, 12(11)e009805
S2095 Fosinopril Sodium Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
J Immunother Cancer, 2024, 12(11)e009805
S9820 Angiotensin (1-7) Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. This compound is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
Int J Biol Sci, 2023, 19(8):2613-2629
S2100 Temocapril Temocapril (CS-622,temocaprilum) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
S5728 Delapril Hydrochloride Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
S5712 Zofenopril calcium Zofenopril calcium (SQ-26991) is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.