ZCL278

ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.

ZCL278 Chemical Structure

ZCL278 Chemical Structure

CAS: 587841-73-4

Selleck's ZCL278 has been cited by 14 Publications

5 Customer Reviews

Purity & Quality Control

Batch: Purity: 99.45%
99.45

ZCL278 Related Products

Signaling Pathway

Choose Selective Rho Inhibitors

Biological Activity

Description ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
Targets
Cdc42 GTPase [1]
11.4 μM(Kd)
In vitro
In vitro ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity. [1]

Chemical Information & Solubility

Molecular Weight 584.89 Formula

C21H19BrClN5O4S2

CAS No. 587841-73-4 SDF Download ZCL278 SDF
Smiles CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=S)NC(=O)COC3=C(C=C(C=C3)Br)Cl)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (170.97 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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