Catalog No.S7293

ZCL278 Chemical Structure

Molecular Weight(MW): 584.89

2 Customer Reviews

  • Cell Physiol Biochem, 2015, 36(4):1613-27.. ZCL278 purchased from Selleck.

    b The graph indicates rat cerebellar astrocytes exposed to NaAsO2 (30 μM) with ZCL278 or NSC23766 groups decreased significantly compared with those of NaAsO2 treatment group. Data are expressed as mean±SD from at least four independent experiments. c Rat cerebellar astrocytes in 96-well plates were treated by 0 and 30 μMNaAsO2 for 24 h with or without ZCL278 (an inhibitor of Cdc42) pretreatment for 1 h, or a Rac1 inhibitor NSC23766 pretreatment for 12 h, and assessed by a CCK-8. ZCL278 and NSC23766 increased rat astrocytes viability exposed to NaAsO2. All statistical results are expressed as means±SD from at least three independent experiments. **P<0.01 for 30 μM NaAsO2 treatment group, NSC23766 and ZCL278 with 0 μM NaAsO2 treatment group compared with control. &&P<0.01 for NSC23766 and ZCL278 with 30 μM NaAsO2 treatment group compared with 30 μM NaAsO2 treatment group.

    Biol Trace Elem Res, 2016, 170(1):173-82. ZCL278 purchased from Selleck.

Purity & Quality Control

Choose Selective Rho Inhibitors

Biological Activity

Description ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
Cdc42 GTPase [1]
11.4 μM(Kd)
In vitro

ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity. [1]


Solubility (25°C)

In vitro DMSO 100 mg/mL (170.97 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 584.89


CAS No. 587841-73-4
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Rho Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID