Triamterene

Synonyms: SKF8542

Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

Triamterene Chemical Structure

Triamterene Chemical Structure

CAS No. 396-01-0

Purity & Quality Control

Triamterene Related Products

Biological Activity

Description Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
Targets
ENaC [1] ENaCαS583 [1]
4.5 μM 23.9 μM
In vitro
In vitro Triamterene inhibits the epithelial sodium channels on principal cells in the late distal convoluted tubule and collecting tubule, which are responsible for 1-2% of total sodium reabsorption. Triamterene can achieve a modest amount of diuresis by decreasing the osmotic gradient necessary for water reabsorption from lumen to interstitium. Triamterene also has a potassium-sparing effect. Normally, the process of potassium excretion is driven by the electrochemical gradient produced by sodium reabsorption. As sodium is reabsorbed, it leaves a negative potential in the lumen, while producing a positive potential in the principal cell. This potential promotes potassium excretion through apical potassium channels. By inhibiting sodium reabsorption, triamterene also inhibits potassium excretion. [2]
In Vivo
In vivo 4'-hydroxylation of triamterene in humans appears to be mediated exclusively by CYP1A2. Inhibition or induction of CYP1A2 will change the time course of both triamterene and its active phase-II metabolite.[3]

Chemical Information & Solubility

Molecular Weight 253.26 Formula

C12H11N7

CAS No. 396-01-0 SDF Download Triamterene SDF
Smiles C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 5 mg/mL ( (19.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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