For research use only. Not for use in humans.

Mipasetamab (Anti-AXL / UFO)

Synonyms: null Cat.No.A2774 Purity:99%

Mipasetamab (Anti-AXL / UFO) is a human monoclonal IgG1κ antibody targeting AXL, a tyrosine kinase receptor, and an TAM receptor, which involves the synthesis of ADCT-601 (Mipasetamab uzoptirine), an AXL-targeted antibody-drug conjugate (ADC). MW: 145.78 kD.

Quality Control

Batch: A277401 Purity: 99% Protein concentration: Endotoxin Level: ＜1EU/mg

Specificity

Name	Citation	Axl	Others
BMS-777607	62	++++	RON,Met,Tyro3
Bemcentinib (R428)	131	++
XL092	0	+++	VEGFR2,MER,MET
UNC2025	7	+++	FLT3,Mer,TrkA
Ningetinib	0	++++	VEGFR2,c-Met
Tamnorzatinib (ONO-7475)	4	++++	Mer,FLT3
RU-301	0	+
Sitravatinib (MGCD516)	6	++++	DDR2,EPHA3,Mer
CEP-40783 (RXDX-106)	7	+++	c-Met,Tyro3,MER
S49076	1	+++	Met,Mer,FGFR3
Merestinib (LY2801653)	10	+++	DDR1,Met,DDR2
SGI-7079	4	+	YES,Mer,Met
UNC2025 HCl	9	++	Mer,FLT3,Tyro3
Dubermatinib(TP-0903)	19	+
NPS-1034	3	++	Met
LDC1267	9	+	Mer,Tyro3
PF-07265807	0	✔	Mer

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Mipasetamab (Anti-AXL / UFO) is a human monoclonal IgG1κ antibody targeting AXL, a tyrosine kinase receptor, and an TAM receptor, which involves the synthesis of ADCT-601 (Mipasetamab uzoptirine), an AXL-targeted antibody-drug conjugate (ADC). MW: 145.78 kD.
References	https://pubmed.ncbi.nlm.nih.gov/35086955/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2361055-48-1
Molecular Weight	145.78
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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