IEM 1754 2HBr

Catalog No.S2860

IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.

Price Stock Quantity  
USD 140 In stock
USD 110 In stock
USD 470 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

IEM 1754 2HBr Chemical Structure

IEM 1754 2HBr Chemical Structure
Molecular Weight: 412.25

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

IEM 1754 2HBr is available in the following compound libraries:

Product Information

  • Compare GluR Chemicals
    Compare GluR Products
  • Research Area

Product Description

Biological Activity

Description IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
Targets GluR1 [1] GluR3 [1]
IC50 6 μM 6 μM
In vitro IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits. [1] IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization. [2]
In vivo

Protocol(Only for Reference)

Kinase Assay: [1]

Electrophysiological recording from oocytes Four to seven days after injection of GluR1, GluR2 and GluR3 mRNA, oocytes are placed in a Silicone tube of 2 mm diameter and continuously perfused with saline (120 mM NaCl, 2 mM KCI, 1.8 mM CaCl2 and 9.5 mM Hepes, pH 7.4) at 22-24 °C. Currents elicited by 100 μM kainite are measured using a conventional two-microelectrode voltage clamp. Each application of kainate lasts 20-40 s. When the current induced by this agonist reaches a steady state, the saline flow is switched to a solution containing the same concentration of kainate plus a given concentration of IEM-1754. Again, on reaching a steady state, the saline flow is returned to a solution containing kainate alone when recovery of the response to the agonist is recorded. This procedure is repeated several times, at not less than 5 min intervals, with different concentrations of the adamantane derivative. It is possible to conduct several experiments on a single oocyte. Unless otherwise noted, membrane currents are measured at a holding potential (Vh) of -80 mV. The voltage dependence of antagonism is estimated by ramping the membrane potential from -140 mV to +40 mV, the duration of the ramp being 20 s. Voltage and current responses are recorded on magnetic tape and post-analysed using in-house software.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Magazanik LG, et al. J Physiol, 1997, 505( Pt 3), 655-663.

[2] Tikhonov DB, et al. Br J Pharmacol, 2000, 129(2), 265-274.

Chemical Information

Download IEM 1754 2HBr SDF
Molecular Weight (MW) 412.25


CAS No. 162831-31-4
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 82 mg/mL (198.9 mM)
Water 82 mg/mL (198.9 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1,5-Pentanediamine, N1-(tricyclo[,7]dec-1-ylmethyl)-, hydrobromide (1:2)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related GluR Products

  • AZD3839

    AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.

  • Xanthohumol

    Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Phase 1.

  • A-438079 HCl

    A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

  • (-)-MK 801 maleate

    (-)-MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.

  • (+)-MK 801 maleate

    (+)-MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

  • MPEP

    MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.

    Features:Inactive against other group I/II/III metabotropic glutamate receptors.

  • Latrepirdine

    Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.

  • Ifenprodil Tartrate

    Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.

  • LY404039

    LY404039 is a potent agonist of recombinant human mGlu2/mGlu3 receptors with Ki of 149 nM/92 nM, shows >100-fold selectivity over ionotropic glutamate receptors, glutamate transporters, and other receptors. Phase 3.

    Features:Under investigation as an exciting new medicine that may herald the arrival of third-generation antipsychotic drugs.

  • CTEP (RO4956371)

    CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.

Recently Viewed Items

Tags: buy IEM 1754 2HBr | IEM 1754 2HBr supplier | purchase IEM 1754 2HBr | IEM 1754 2HBr cost | IEM 1754 2HBr manufacturer | order IEM 1754 2HBr | IEM 1754 2HBr distributor
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us