Home Neuronal Signaling GluR agonist L-Glutamic acid monosodium salt For research use only.

L-Glutamic acid monosodium salt

Synonyms: Monosodium glutamate, MSG

L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

L-Glutamic acid monosodium salt Chemical Structure

L-Glutamic acid monosodium salt Chemical Structure

CAS: 142-47-2

Selleck's L-Glutamic acid monosodium salt has been cited by 2 publications

Purity & Quality Control

Batch: S472101 Water] 33 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.62%
99.62

L-Glutamic acid monosodium salt Related Products

Signaling Pathway

GluR Signaling Pathways

GluR Signaling Pathway

Choose Selective GluR Inhibitors

Biological Activity

Description L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
In vitro
In vitro Monosodium glutamate(MSG) induces apoptosis in human B cells. It has a more potent apoptotic effect in naïve B cells compared to memory B cell population[3]. Low doses of L-monosodium glutamate promote neuronal growth and differentiation in vitro[4].
Cell Research Cell lines human B cells
Concentrations 1-100 mM
Incubation Time 24 h
Method B cells are cultured with and with out increasing concentrations of MSG(1-100 mM) for 24 h. The number of early apoptotic cells and necrotic cells is determined using Annexin-V FITC/PI staining.
In Vivo
In vivo Daily monosodium glutamate(MSG) dietary consumption reduces pancreatic β-cell mass and enhances hemorrhages and fibrosis, but does not affect glucose homeostasis. High dietary MSG intake may exert a negative effect on the pancreas and such effect might become functionally significant in the presence or susceptibility to diabetes or NaCl. Parenteral MSG causes various changes in pancreatic islets such as hypertrophy, hyperplasia, decrease in acinar cells, α-cells and somatostatin cells and increase in fibrosis[1]. MSG may have some deleterious effects on the testes of Wistar rats and by extension may contribute to the causes of male infertility[2].
Animal Research Animal Models Adult male Wistar rats
Dosages 2 mg/g 
Administration Oral administration
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04876716 Recruiting
Invasive Aspergillosis
Erasmus Medical Center|ZonMw: The Netherlands Organisation for Health Research and Development|Stichting Hemato-Oncologie voor Volwassenen Nederland
 May 11 2021 Phase 3
NCT04024995 Completed
Invasive Fungal Infections
Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne
 September 1 2019 --
NCT03299608 Unknown status
Respiratory Tract Infections|Hematologic Diseases
Universitaire Ziekenhuizen KU Leuven
 June 21 2019 --

Chemical Information & Solubility

Molecular Weight 169.11 Formula

C5H8NO4.Na
CAS No. 142-47-2 SDF Download L-Glutamic acid monosodium salt SDF
Smiles C(CC(=O)O)C(C(=O)[O-])N.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

Water : 33 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy L-Glutamic acid monosodium salt | L-Glutamic acid monosodium salt supplier | purchase L-Glutamic acid monosodium salt | L-Glutamic acid monosodium salt cost | L-Glutamic acid monosodium salt manufacturer | order L-Glutamic acid monosodium salt | L-Glutamic acid monosodium salt distributor