Chloroprocaine HCl

Catalog No.S4284

Chloroprocaine HCl is a local anesthetic during surgical procedures.

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Chloroprocaine HCl Chemical Structure

Chloroprocaine HCl Chemical Structure
Molecular Weight: 307.22

Validation & Quality Control

Quality Control & MSDS

Product Information

Product Description

Biological Activity

Description Chloroprocaine HCl is a local anesthetic during surgical procedures.
In vitro
In vivo
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-23)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02726620 Not yet recruiting Hypotension Vanderbilt University|UMC Utrecht May 2016 --
NCT02813382 Completed Anesthesia, Spinal|Ambulatory Surgical Procedures|Hernia, Inguinal|Hernia, Umbilical AZ St.-Dimpna Geel August 2015 --
NCT02481505 Completed Short Duration Lower Limb Surgery Via Spinal Anaesthesia Sintetica SA|Cross S.A. June 2015 Phase 2
NCT02385097 Recruiting Axillary Nerve Block Sintetica SA|Cross S.A. March 2015 Phase 3
NCT02282319 Recruiting Surgery Ambulatory University Hospital, Antwerp October 2014 Phase 4

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Chemical Information

Download Chloroprocaine HCl SDF
Molecular Weight (MW) 307.22
Formula

C13H20Cl2N2O2

CAS No. 3858-89-7
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 61 mg/mL (198.55 mM)
Water 61 mg/mL (198.55 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 4-amino-2-chloro-2-(diethylamino)ethyl benzoic acid ester,hydrochloride (1:1)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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