Home Endocrinology & Hormones GPR agonist AS1269574 For research use only.

AS1269574

AS 1269574, a small-molecule G protein-coupled receptor 119 (GPR119) agonist, has an EC50 of 2.5 μM in HEK293 cells transiently expressing human GPR119 and enhances insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8 mM) conditions.

AS1269574 Chemical Structure

AS1269574 Chemical Structure

CAS: 330981-72-1

Purity & Quality Control

Batch: E034701 DMSO] 62 mg/mL] false] Ethanol] 62 mg/mL] false] Water] Insoluble] false Purity: 99.79%
99.79

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Biological Activity

Description AS 1269574, a small-molecule G protein-coupled receptor 119 (GPR119) agonist, has an EC50 of 2.5 μM in HEK293 cells transiently expressing human GPR119 and enhances insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8 mM) conditions.
Targets
IGF-1R [1] human GPR119 [1]
(in cAMP assay)
2.5 μM(EC50)

Chemical Information & Solubility

Molecular Weight 308.17 Formula

C13H14BrN3O
CAS No. 330981-72-1 SDF --
Smiles CC1=CC(=NC(=N1)C2=CC=C(Br)C=C2)NCCO
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 62 mg/mL ( (201.18 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 62 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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