Research Area
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TAK-875 Chemical Structure
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Biological Activity
TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with an EC50 of 0.072 μM. TAK-875 is a new agent applied in the treatment of type 2 diabetes. TAK-875 not only elevated the levels of intra-cellular inositol monophosphate as well as calcium contents in rat insulinoma INS-1 833/15 cells but also improved the tolerance of glucose and amplified insulin secretion when orally administered in tolerance test. However, TAK-875 didn’t increase the secretion of insulin and cause hypoglycemia when 30 mg/kg dosage of TAK-875 was given in fasted normal Sprague Dawley rats. Conversely, TAK-875 with a dosage of 10 mg/kg (p.o.) not only significantly improved plasma insulin levels but also decreased fasting hyperglycemia in male Zucker diabetic fatty rats. [1][2]
References on TAK-875
- [1] J Pharmacol Exp Ther. 2011 Jul 13;
- [2] http://clinicaltrials.gov/ct2/show/NCT00949091 ;
Chemical Information
| Molecular Weight (WM): | 533.63 |
|---|---|
| Formula: | C29H32O7S.1/2H2O |
| CAS No.: | 1000413-72-8 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥105mg/mL |
| Water <1mg/mL | |
| Ethanol ≥11mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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