Research Area
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Nutlin-3 Chemical Structure
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Biological Activity
Nutlin-3 is a MDM-2 antagonist with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.[1][2]
References on Nutlin-3
- [1] Neoplasia. 2007 Oct;;9(10):853-61.
- [2] Science. 303(5659):844-8.;2004 Feb 6;
Chemical Information
| Molecular Weight (WM): | 581.5 |
|---|---|
| Formula: | C30H30Cl2N4O4 |
| CAS No.: | 548472-68-0 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥116mg/mL |
| Water <1mg/mL | |
| Ethanol ≥116mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
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Selleck's high quality products have been used in several published research findings, including the following:
Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.
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