Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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4 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NVywTVJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXmeWVKSzVyPUCuNFAxODByMEO1PUDPxE1? MXvTRW5ITVJ?
MV-4-11 MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFSwe3FKSzVyPUCuNFAxODl3NjFOwG0> MXfTRW5ITVJ?
MEG-01 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\VTWM2OD1yLkCwNFEzQCEQvF2= M3y2dnNCVkeHUh?=
LAMA-84 NHvNdmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnpTWM2OD1yLkCwNFE3PSEQvF2= MYXTRW5ITVJ?
CGTH-W-1 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXleHFLUUN3ME2wMlAxOTZ7IN88US=> NHvyUXFUSU6JRWK=
KASUMI-1 NGfBVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3u2XmlEPTB;MD6wNFIyPyEQvF2= NEXIRnJUSU6JRWK=
BE-13 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWns[nh{UUN3ME2wMlAxOjV7IN88US=> M1\ue3NCVkeHUh?=
CTV-1 MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H5bWlEPTB;MD6wNFUzOSEQvF2= M1TqdXNCVkeHUh?=
NKM-1 MorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\3NnZKSzVyPUCuNFA3PTVizszN NV\tOYJEW0GQR1XS
MONO-MAC-6 M3TE[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLNTWM2OD1yLkCwPFM4KM7:TR?= NVHwSYJIW0GQR1XS
A204 NX6yVnB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEGyNVgh|ryP NIDCcZpUSU6JRWK=
GDM-1 NYr4eXc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEG4N|Mh|ryP MlzsV2FPT0WU
AN3-CA NWTXTWRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7TTWM2OD1yLkCxPFc{KM7:TR?= MlTFV2FPT0WU
BL-70 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y4SGlEPTB;MD6wNlE6QSEQvF2= M4rNZnNCVkeHUh?=
Daudi MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjjR|lKSzVyPUCuNFI2OzdizszN MV;TRW5ITVJ?
KU812 M3m3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDhTWM2OD1yLkCyPFQ5KM7:TR?= Mn\nV2FPT0WU
KG-1 M1L5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXCZ2tKSzVyPUCuNFMzQTRizszN MVXTRW5ITVJ?
DOHH-2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLpTWM2OD1yLkC0PFA{KM7:TR?= M2rwNnNCVkeHUh?=
HuO9 M3rlWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTJTWM2OD1yLkC1OFQ5KM7:TR?= MnPZV2FPT0WU
EB2 M17TNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjKendYUUN3ME2wMlA2PTd4IN88US=> M4\kW3NCVkeHUh?=
G-402 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXGZo5KSzVyPUCuNFY{PDFizszN NFqxOpFUSU6JRWK=
SU-DHL-1 NX3mNpFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLtTWM2OD1yLkC2N|c6KM7:TR?= NH\2eVNUSU6JRWK=
NCI-H719 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\6UItKSzVyPUCuNFc5QDhizszN MVHTRW5ITVJ?
MLMA MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33MO2lEPTB;MD6wPVA3KM7:TR?= MYnTRW5ITVJ?
KM12 Mn71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7iXZRRUUN3ME2wMlA6PzN5IN88US=> NFPCUWlUSU6JRWK=
SUP-T1 MnHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFr0XotKSzVyPUCuNFk6QDJizszN NUC5VVVzW0GQR1XS
MZ1-PC NYXBTZFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLPTWM2OD1yLkGxN|M3KM7:TR?= MoLQV2FPT0WU
MFE-296 Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHaTWM2OD1yLkGxPFM6KM7:TR?= MVfTRW5ITVJ?
ALL-PO MoTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe1T2NOUUN3ME2wMlEzPDR|IN88US=> MkjkV2FPT0WU
GB-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMUK1NVIh|ryP MWPTRW5ITVJ?
SIG-M5 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXse29IUUN3ME2wMlE{OzdizszN NYPuTXNtW0GQR1XS
P30-OHK NXXzcm5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnwPXhKSzVyPUCuNVU3PzJizszN M2TGNHNCVkeHUh?=
NCI-H716 M{eyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMU[yOlYh|ryP MkfOV2FPT0WU
MPP-89 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrWdGlyUUN3ME2wMlE3QTN|IN88US=> MX;TRW5ITVJ?
SF126 Ml\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\BNpUzUUN3ME2wMlE4ODZ|IN88US=> NFyyOFhUSU6JRWK=
CTB-1 NGmwNmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknPTWM2OD1yLkG3N|E3KM7:TR?= MmCyV2FPT0WU
CA46 MnjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMUe0PFkh|ryP NHjYc5hUSU6JRWK=
NCI-H520 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ToVGlEPTB;MD6xO|c{OiEQvF2= M1;r[3NCVkeHUh?=
CAL-85-1 NYPJfHhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYr1dZhFUUN3ME2wMlE4QTJ5IN88US=> M1;YdnNCVkeHUh?=
NCI-H2342 MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnINoZkUUN3ME2wMlE5PTd5IN88US=> NFi3NVhUSU6JRWK=
697 M3v2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDVZ3BkUUN3ME2wMlE5QDdzIN88US=> M2PQUXNCVkeHUh?=
NY NVTK[ohGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMUmyPFch|ryP M3Oz[HNCVkeHUh?=
T98G MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\McmlEPTB;MD6xPVMyQCEQvF2= Ml;SV2FPT0WU
NCI-H1703 M2n6b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfjPGlKSzVyPUCuNVk3OTVizszN NHjmc3dUSU6JRWK=
NCI-H2087 MmrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nMT2lEPTB;MD6yNFQ{QSEQvF2= NFL3W4tUSU6JRWK=
PF-382 NX\tfnMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHr6bHRKSzVyPUCuNlA5PzNizszN Mk\uV2FPT0WU
HCT-116 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v2cmlEPTB;MD6yNVA3QSEQvF2= MmeyV2FPT0WU
CAKI-1 NVjzRXJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTiTWM2OD1yLkKxOlY3KM7:TR?= M3LWNnNCVkeHUh?=
CCF-STTG1 NF;LbGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMkK0O|Uh|ryP NVz4N2ZzW0GQR1XS
D-392MG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LaZ2lEPTB;MD6yN|E4PyEQvF2= NUP0eWxLW0GQR1XS
RT-112 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M370WmlEPTB;MD6yN|c6PSEQvF2= NFrEd4pUSU6JRWK=
MES-SA NFrqRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[0TWlEPTB;MD6yOFE5PyEQvF2= NFzyc2tUSU6JRWK=
LC-2-ad M4XJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMkSyOlUh|ryP MXHTRW5ITVJ?
NOS-1 Mn7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUj2W4liUUN3ME2wMlI1OzZ5IN88US=> M{TwSnNCVkeHUh?=
NALM-6 NYfxWGNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLRTWM2OD1yLkK1OVQ{KM7:TR?= MWfTRW5ITVJ?
TE-15 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMk[wPVEh|ryP MVfTRW5ITVJ?
786-0 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojHTWM2OD1yLkK2NlI5KM7:TR?= MnjXV2FPT0WU
IST-MES1 M3\0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTmTWM2OD1yLkK2PFI6KM7:TR?= NVS0dIpqW0GQR1XS
KYSE-180 NUjObmdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zyN2lEPTB;MD6yOlg6OSEQvF2= M13TfHNCVkeHUh?=
YT M{HrNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPufopYUUN3ME2wMlI3QTd2IN88US=> NWfTNnNTW0GQR1XS
A427 MkfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TVe2lEPTB;MD6yO|I3PCEQvF2= NIPBeXBUSU6JRWK=
KYSE-450 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;0TWM2OD1yLkK3N|I6KM7:TR?= MYnTRW5ITVJ?
HuH-7 M4qwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HqZWlEPTB;MD6yO|c3OyEQvF2= M1PCWHNCVkeHUh?=
CAS-1 MnLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMkizNFMh|ryP MUXTRW5ITVJ?
KURAMOCHI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\ueXZKSzVyPUCuNlg1OTlizszN NFH1W2lUSU6JRWK=
ACHN NXXjPGhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnVTWM2OD1yLkK5N|I{KM7:TR?= MX;TRW5ITVJ?
HGC-27 NYDXeZNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M374RmlEPTB;MD6yPVM2OyEQvF2= NInWVItUSU6JRWK=
A172 NUDVOpFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:5TWM2OD1yLkK5OVc4KM7:TR?= NYe0Z4t7W0GQR1XS
SNU-449 NHjtO49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LZN2lEPTB;MD6yPVk3PCEQvF2= M1PVfXNCVkeHUh?=
SW982 M{fTd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMkm5O|gh|ryP M1PoNnNCVkeHUh?=
EFO-21 MmPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYqyV2ZKUUN3ME2wMlMxPDFzIN88US=> NHe5VYhUSU6JRWK=
NCI-H2030 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPSTWM2OD1yLkOxNVY1KM7:TR?= MVHTRW5ITVJ?
HT-144 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP2VWNKSzVyPUCuN|EzQCEQvF2= M3WyZnNCVkeHUh?=
MFE-280 NHLwSlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwM{G0OVMh|ryP NHSzRYJUSU6JRWK=
SK-LU-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrJNI94UUN3ME2wMlMyPDZ4IN88US=> M2jZ[HNCVkeHUh?=
NCI-H2052 M4e1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzFbWw6UUN3ME2wMlMyPDh2IN88US=> M4nuR3NCVkeHUh?=
SK-HEP-1 MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvSSJMyUUN3ME2wMlM{OzZ6IN88US=> M33VfHNCVkeHUh?=
QIMR-WIL MmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj0TWM2OD1yLkOzOFI1KM7:TR?= NIq4dYdUSU6JRWK=
A2780 NWTxVIRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4m4VmlEPTB;MD6zOFMxPCEQvF2= MlvBV2FPT0WU
ACN M{X4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6yTWM2OD1yLkO0PFc{KM7:TR?= NXfaZlN6W0GQR1XS
BxPC-3 M{jBNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fBS2lEPTB;MD6zOFk5QSEQvF2= NGjEN|ZUSU6JRWK=
BCPAP M3P0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TicGlEPTB;MD6zOlAxOSEQvF2= MnjRV2FPT0WU
HOP-62 NX6zbWJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwM{[xNFYh|ryP MlHzV2FPT0WU
SW1710 NVHWWm5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfBdllKSzVyPUCuN|Y1PTVizszN MmnnV2FPT0WU
OPM-2 NYn2eJpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnkTWM2OD1yLkO2OFc{KM7:TR?= Mo\OV2FPT0WU
DBTRG-05MG M{Oxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XRcmlEPTB;MD6zPFA2PCEQvF2= NEXtbGlUSU6JRWK=
SK-MEL-24 NGj4T2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4mwTmlEPTB;MD6zPVc6OSEQvF2= MojNV2FPT0WU
8305C NGTmcHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETvNnpKSzVyPUCuN|k4QTNizszN M4i0NHNCVkeHUh?=
OVCAR-4 M3TSNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\DWmlEPTB;MD60NVU5PiEQvF2= NHjOOZlUSU6JRWK=
HLE NHO5fWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorJTWM2OD1yLkSxPFYh|ryP NV7QSlBiW0GQR1XS
NCI-H747 NH;KXnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PKN2lEPTB;MD60NlE{PyEQvF2= MnPBV2FPT0WU
SW780 NEnodFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv5TWM2OD1yLkSyN|Q3KM7:TR?= MVjTRW5ITVJ?
KYSE-150 NHvOUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XFOWlEPTB;MD60NlQyPSEQvF2= Mn;RV2FPT0WU
H4 NH7ySXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLFTWM2OD1yLkSyOFUyKM7:TR?= NW\OWlYyW0GQR1XS
SW1088 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPFNmpMUUN3ME2wMlQ1OzlizszN NYPCXoZHW0GQR1XS
SF268 MnLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlWyTWM2OD1yLkS0PFYh|ryP NFrNelZUSU6JRWK=
RT4 M{HEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwNEWxNVEh|ryP MlfRV2FPT0WU
NCI-H522 M1vEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XMbmlEPTB;MD60OVI4KM7:TR?= MXnTRW5ITVJ?
LCLC-97TM1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfKbY1JUUN3ME2wMlQ3OTl3IN88US=> MVfTRW5ITVJ?
CAL-39 MonWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwNE[1NVkh|ryP NXy2Upo4W0GQR1XS
CAL-120 NUP5eY9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\xRXRCUUN3ME2wMlQ4PjR|IN88US=> M3vFOHNCVkeHUh?=
ESS-1 NX\JSFcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TmcWlEPTB;MD60O|gzOSEQvF2= MlezV2FPT0WU
KARPAS-45 M{D2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7kc5lKSzVyPUCuOFg6OzNizszN NWjDSINRW0GQR1XS
DU-4475 NV;5VHAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHDTWM2OD1yLkS5OVEyKM7:TR?= NIXHTIlUSU6JRWK=
VMRC-RCZ M2TSU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf3VI57UUN3ME2wMlQ6QTB2IN88US=> M2jZS3NCVkeHUh?=
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KNS-42 M2C5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwOE[yOlYh|ryP MXnTRW5ITVJ?
NCI-H2452 M{fTO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXxTWM2OD1zLki5NFc1KM7:TR?= NXHTe5R1W0GQR1XS
SK-MEL-2 MlvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrtTWM2OD1zLkmwNlcyKM7:TR?= MoX5V2FPT0WU
OVCAR-5 MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\zXZczUUN3ME2xMlkxPjd3IN88US=> M3PSTnNCVkeHUh?=
SNG-M NWTPOHluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fXe2lEPTB;MT65OVg2QCEQvF2= MWjTRW5ITVJ?
A673 NFfzd2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUCwbFNoUUN3ME2xMlk4PTF4IN88US=> MVLTRW5ITVJ?
L-428 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTFwOUmxO|kh|ryP NI\FeWlUSU6JRWK=
KM-H2 M2XDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nnUWlEPTB;Mj6wNVA6KM7:TR?= NHS3RllUSU6JRWK=
MC-IXC M1P4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJwMEKyO|Mh|ryP M{ToT3NCVkeHUh?=
COLO-678 NIrQ[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjP[pNGUUN3ME2yMlA1OjB5IN88US=> NYHTV3dOW0GQR1XS
MEL-JUSO M{\0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC2NJdKSzVyPUKuNFc5PTFizszN NI[xSGVUSU6JRWK=
HCC38 NHvF[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mny0TWM2OD1{LkC4OFM{KM7:TR?= MmftV2FPT0WU
UACC-62 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvSTWM2OD1{LkC4PFU2KM7:TR?= NUPh[HFIW0GQR1XS
OAW-42 NYnNb3R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJwMEm3NVEh|ryP NITKRopUSU6JRWK=
LB996-RCC NUfqXVI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTJwMUO4NVch|ryP NVy3VWVrW0GQR1XS
COR-L105 MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTJwMU[zO|Mh|ryP M{HHdHNCVkeHUh?=
RCC10RGB Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvufFhvUUN3ME2yMlE5PTd4IN88US=> MmPnV2FPT0WU
A431 M1iz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJwMUmwNVkh|ryP NFjLWJhUSU6JRWK=
NCI-H292 M{e0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHlbGRKSzVyPUKuNlM6PTFizszN Ml7IV2FPT0WU
SK-UT-1 NG\0enFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjTU4FqUUN3ME2yMlM{OTh2IN88US=> MYTTRW5ITVJ?
PANC-08-13 NH;sOG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXoZ3drUUN3ME2yMlM{OjN3IN88US=> NHjKWFBUSU6JRWK=
ST486 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f1b2lEPTB;Mj60NVA1QCEQvF2= MYLTRW5ITVJ?
SJSA-1 NUP6S4dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPkTWM2OD1{LkSxNlcyKM7:TR?= M1fFTXNCVkeHUh?=
RKO MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\pXmxKSzVyPUKuOFIxOjlizszN NWDtU3Z4W0GQR1XS
NCI-H1793 NXK1N49JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe4R2dDUUN3ME2yMlQ1ODJ7IN88US=> MmHrV2FPT0WU
639-V NV3JTlVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJwNEWzPFIh|ryP NIG0RVBUSU6JRWK=
ES3 M1jJ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnZfIhDUUN3ME2yMlQ6PzN5IN88US=> NHvibHdUSU6JRWK=
NCI-H1792 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjMdIhHUUN3ME2yMlU3QDJ4IN88US=> NUSyOHZNW0GQR1XS
NCI-H1651 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\WRWpLUUN3ME2yMlU5OjFizszN NGn6SZdUSU6JRWK=
SN12C NYryN4c{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP4RnJKSzVyPUKuOVg1QDdizszN M12zdnNCVkeHUh?=
COLO-679 NVXqeopvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jtWmlEPTB;Mj61PFYxPSEQvF2= MnfkV2FPT0WU
U-118-MG NXK3V|RlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJwNUi4O|Ih|ryP NYrwcHNSW0GQR1XS
Ramos-2G6-4C10 NV;6fmt3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4L5TWlEPTB;Mj62OFgxPyEQvF2= MoCyV2FPT0WU
HCT-15 MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv6TWM2OD1{Lk[4O|kzKM7:TR?= MYfTRW5ITVJ?
MDA-MB-157 MlLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvPUGJ3UUN3ME2yMlcxPzR5IN88US=> NIr3[|lUSU6JRWK=
K5 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DT[GlEPTB;Mj63NVg1PSEQvF2= M12wSHNCVkeHUh?=
MKN45 NWj4R2prT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7pTWM2OD1{LkezN|Y3KM7:TR?= NH;ybFJUSU6JRWK=
DMS-273 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;WXHR1UUN3ME2yMlc2PjN{IN88US=> MU\TRW5ITVJ?
C8166 NX3nWo5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n0WmlEPTB;Mj63PFUyOyEQvF2= NULRdGRkW0GQR1XS
Calu-3 NVXIVoVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\v[ZdKSzVyPUKuO|g6PjlizszN MWrTRW5ITVJ?
SNB75 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXCTWM2OD1{Lki4OVM2KM7:TR?= M{[1enNCVkeHUh?=
BFTC-905 M3jvOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;yeWlKSzVyPUKuPVAyQTFizszN NUf5XZBnW0GQR1XS
C-4-II Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPvPJlSUUN3ME2yMlkyOzV|IN88US=> NGLBe5VUSU6JRWK=
MS-1 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEL4NJNKSzVyPUKuPVY4PjlizszN NIrmTZhUSU6JRWK=
A375 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzPXGRKSzVyPUOuNFgyQDRizszN MlPLV2FPT0WU
KYSE-70 NIjjV3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTjOpNjUUN3ME2zMlA5QDh{IN88US=> MUPTRW5ITVJ?
KYSE-510 MkHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rWdWlEPTB;Mz6xNFk6PSEQvF2= Ml;WV2FPT0WU
LN-405 MoPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T6eGlEPTB;Mz6xN|UyQCEQvF2= NFTvOo5USU6JRWK=
BOKU M3TjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTNwMUSyOVYh|ryP NUDZVoVxW0GQR1XS
TE-10 NYCyPHN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[ybGFKSzVyPUOuNVc{PjJizszN MWnTRW5ITVJ?
MKN1 Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTFeVhKSzVyPUOuNVg1QDNizszN NITDXY1USU6JRWK=
M059J MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXDTWM2OD1|LkKwNVc{KM7:TR?= MlzRV2FPT0WU
GOTO M1j4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PTRmlEPTB;Mz6yNlA{QSEQvF2= NHfIZlRUSU6JRWK=
DK-MG MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP2TYdnUUN3ME2zMlI2QTd4IN88US=> NIPPeHNUSU6JRWK=
NCI-H727 NFPHXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLjTlNwUUN3ME2zMlI3PThizszN NFmzTlZUSU6JRWK=
NB12 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTWeZpFUUN3ME2zMlM{OjJ2IN88US=> MkTZV2FPT0WU
DOK NWrQUVZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPrTWM2OD1|LkO2NVg3KM7:TR?= NX[zfnpkW0GQR1XS
KYSE-410 MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LsZWlEPTB;Mz6zOlI5PyEQvF2= M37y[3NCVkeHUh?=
AM-38 NU\ESVlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfwd5lKSzVyPUOuN|gxPTFizszN M1n0VnNCVkeHUh?=
GR-ST MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTNwNEW3N|Ih|ryP NIHlZ5BUSU6JRWK=
D-247MG M{\3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD6[XlyUUN3ME2zMlQ5OjZ|IN88US=> NF3ISFRUSU6JRWK=
TE-8 MmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn6S2xKSzVyPUOuOFk{OzNizszN MUjTRW5ITVJ?
LS-411N NGL2d2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC3TWM2OD1|LkS5OlkzKM7:TR?= MWrTRW5ITVJ?
SK-MES-1 NXnjbWRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17SNWlEPTB;Mz61OlQ{OyEQvF2= NGW4WZNUSU6JRWK=
SF295 NV7BT3M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu1TWM2OD1|Lk[xOVUzKM7:TR?= NX3q[INpW0GQR1XS
SK-MEL-30 NYnwSZkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILBU5FKSzVyPUOuOlU6OjFizszN MV;TRW5ITVJ?
LB2241-RCC NEnRd5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHiXIRwUUN3ME2zMlY3OjZizszN NHfJRpVUSU6JRWK=
PC-14 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvSO2dKSzVyPUOuOlY1OzdizszN NXHDfJhMW0GQR1XS
EW-7 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHie4FKSzVyPUOuOlc3QTNizszN M4\v[HNCVkeHUh?=
NMC-G1 MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf2WINKSzVyPUOuO|E5OzdizszN M4jwbXNCVkeHUh?=
TE-441-T MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXOydm56UUN3ME2zMlc{ODJ6IN88US=> NWP1b|VsW0GQR1XS
NCI-H1618 NIL4PJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTNwOEG4O|Uh|ryP M4eyeXNCVkeHUh?=
PANC-03-27 MnzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HIfmlEPTB;Mz64NVkyPiEQvF2= MljOV2FPT0WU
NCI-H2228 NH\sS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\lU3hKSzVyPUOuPFMyOjZizszN MUfTRW5ITVJ?
CAPAN-1 M2nJZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TKW2lEPTB;Mz64O|AxQSEQvF2= NFP2W5pUSU6JRWK=
KLE NITXUGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDaUJlKSzVyPUOuPVA3PyEQvF2= M{LZbXNCVkeHUh?=
Becker MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES5VHhKSzVyPUOuPVI5PDlizszN MkDGV2FPT0WU
SK-PN-DW MoP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTTN5BvUUN3ME20MlA4QTd2IN88US=> NULGUFlXW0GQR1XS
Hs-578-T NFn3U5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXaeZNKSzVyPUSuNFg{ODZizszN MXXTRW5ITVJ?
RS4-11 NWfwNodxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fVc2lEPTB;ND6xNVI2PSEQvF2= Mn3vV2FPT0WU
D-502MG MnyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTRwMU[5PVch|ryP MoDQV2FPT0WU
GI-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;vTWM2OD12LkK4Nlk6KM7:TR?= NEG4[IpUSU6JRWK=
NCI-H209 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW5TlZCUUN3ME20MlM{PzhizszN NWH1XmJYW0GQR1XS
SK-OV-3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf4emNCUUN3ME20MlQ5OTR7IN88US=> NFSyflhUSU6JRWK=
LOUCY M4HBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzRTWM2OD12LkS4OFMzKM7:TR?= MkPLV2FPT0WU
NCI-H69 NHjDcWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof5TWM2OD12LkWxO|k{KM7:TR?= MYTTRW5ITVJ?
SCC-9 Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlruTWM2OD12LkWzNVczKM7:TR?= MXTTRW5ITVJ?
NCI-H526 NUTvVoE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PxPGlEPTB;ND61PVI6OyEQvF2= M13ucXNCVkeHUh?=
NCI-H2170 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTRwNk[3O|Eh|ryP NEfLbYJUSU6JRWK=
SR MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:yfmlEPTB;ND63NFA1QCEQvF2= NGLtOYlUSU6JRWK=
CMK NEXJeZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XZNGlEPTB;ND63NlExOSEQvF2= MljiV2FPT0WU
COLO-829 NYHjemxyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\0UY1KSzVyPUSuO|cxPDNizszN MX7TRW5ITVJ?
HuO-3N1 NIfwRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPiTWM2OD12LkizNlgyKM7:TR?= MnTUV2FPT0WU
5637 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1W4UWlEPTB;ND65NFQ5PyEQvF2= MVjTRW5ITVJ?
A253 M3z6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT0dJBpUUN3ME20Mlk4PzB6IN88US=> MX7TRW5ITVJ?
NB10 NHjTcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP2V3RKSzVyPUWuNFc1QTdizszN MojUV2FPT0WU
SF539 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PYWWlEPTB;NT6wPVk2QSEQvF2= NXLsPG5NW0GQR1XS
HAL-01 NY[2WZNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXSwflJTUUN3ME21MlE1PjR3IN88US=> NHn6WYJUSU6JRWK=
MHH-ES-1 M4HmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPZTWM2OD13LkG2PVI2KM7:TR?= M2XHPXNCVkeHUh?=
DEL NITlbnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPlfFFXUUN3ME21MlI4PTh{IN88US=> NHPMXVVUSU6JRWK=
NCI-H1299 NULv[FQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HXdWlEPTB;NT6zOVAxPyEQvF2= M1y3[XNCVkeHUh?=
ChaGo-K-1 M{LhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3xTWM2OD13LkO1NVA4KM7:TR?= MmCxV2FPT0WU
HMV-II MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[zNoFzUUN3ME21MlM6PDNizszN NVzEbHp4W0GQR1XS
NB69 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHRN41{UUN3ME21MlM6PjNzIN88US=> M2PSPHNCVkeHUh?=
NCI-H1882 NVnIc|M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTVwNEOzOlQh|ryP NYHkc3ZQW0GQR1XS
SNU-475 MoXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTVwNEexO|Eh|ryP MV;TRW5ITVJ?
RXF393 MoexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTVwNEi0PVQh|ryP NVXDNmdyW0GQR1XS
CAL-51 M{XjdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTVwNkK4OVMh|ryP Mk\BV2FPT0WU
SW1573 M2P4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPEbVZQUUN3ME21MlY{PTN2IN88US=> NWPhXnNvW0GQR1XS
GCT NHvrW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTDTWM2OD13Lke1PVI6KM7:TR?= M4LtOHNCVkeHUh?=
COR-L88 MmLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTqTWM2OD13Lke2PFQ3KM7:TR?= MYLTRW5ITVJ?
MDA-MB-134-VI NF;sRnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHyTWM2OD13Lki3OVM3KM7:TR?= NUfj[2tiW0GQR1XS
NB5 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTVwOUK0OEDPxE1? MXzTRW5ITVJ?
GMS-10 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW1Z5hKSzVyPUWuPVY5PjFizszN NE\ZZoNUSU6JRWK=
CHP-212 M374VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\yRnBRUUN3ME22MlQ5OjZ5IN88US=> NFXQU29USU6JRWK=
TE-11 NXrwOo1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvWTWM2OD14LkW1NVgzKM7:TR?= M2PORnNCVkeHUh?=
SW962 M3[4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTZwNkW3O|Qh|ryP MWTTRW5ITVJ?
MZ2-MEL M3G1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTZwOEKwNVEh|ryP M2rhbXNCVkeHUh?=
C-33-A NVLPfHRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIn2Z3dKSzVyPU[uPVE3QDhizszN NEWxPFdUSU6JRWK=
IGR-1 MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTZwOUe4NlYh|ryP NUPqWYZzW0GQR1XS
MOLT-4 MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTdwMUW0NFYh|ryP NWj2VG9kW0GQR1XS
NCI-H1650 NGLwcZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzIcZRKSzVyPUeuNlcxPDZizszN MXTTRW5ITVJ?
AsPC-1 M1;OPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkL2TWM2OD15LkK4OlA2KM7:TR?= NULhS5dSW0GQR1XS
SNU-C2B NYLyNZdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTdwMkm1O|Eh|ryP M2rXUXNCVkeHUh?=
MKN7 MoD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPTeVRKSzVyPUeuN|czOzVizszN MnrsV2FPT0WU
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CAL-62 NUHKdW5lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTJ{Lke1NVch|ryP MVTTRW5ITVJ?
HCE-T NHvVT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nnbWlEPTB;MkKuPFYxPiEQvF2= M2KwW3NCVkeHUh?=
BB65-RCC M4TCbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfUTWM2OD1{Mz6wN|Q1KM7:TR?= NYD1bodUW0GQR1XS
SiHa NID5NGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXlfZJKSzVyPUKzMlM6PjhizszN NIfEWpVUSU6JRWK=
NCI-H2081 NHv3[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJ2LkC2OFEh|ryP NFeyN4FUSU6JRWK=
U251 MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnvRm9QUUN3ME2yOE4xPjZ6IN88US=> MXPTRW5ITVJ?
LoVo M3nqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\wTWM2OD1{ND65NlgzKM7:TR?= MojFV2FPT0WU
GCIY MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvUWmFKSzVyPUK1MlI5PzdizszN NW[0fIw6W0GQR1XS
NUGC-3 M2HvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv1NolzUUN3ME2yOU4{OzF4IN88US=> M3TVfHNCVkeHUh?=
LNCaP-Clone-FGC MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHMeYFKSzVyPUK1MlM1QThizszN NInGOWZUSU6JRWK=
PA-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK2cHhKSzVyPUK1MlY5OzNizszN MoLVV2FPT0WU
OE33 NVKyTJlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn36TWM2OD1{NT62PFU{KM7:TR?= M163VHNCVkeHUh?=
HT-29 M4CyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPlTWM2OD1{NT63PFc6KM7:TR?= NHLtclRUSU6JRWK=
RCM-1 NE[2eGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TzUGlEPTB;MkWuPVY2PiEQvF2= M{LnS3NCVkeHUh?=
NCI-H1522 NWjCfGJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ3Lkm5NVEh|ryP MmjBV2FPT0WU
LB373-MEL-D MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnFTWM2OD1{Nj6xO|A5KM7:TR?= MmC1V2FPT0WU
NCI-H1436 M{HYfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH1TWM2OD1{Nj6yO|M5KM7:TR?= NYn2cGptW0GQR1XS
COLO-824 M17GNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJ4LkSwNFIh|ryP MXPTRW5ITVJ?
CP50-MEL-B NH[5fmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoKwTWM2OD1{Nj61Olc2KM7:TR?= M3P4VHNCVkeHUh?=
EGI-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkD0TWM2OD1{Nz6yOlk5KM7:TR?= MUjTRW5ITVJ?
LAN-6 M2S4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vpWmlEPTB;MkeuN|U6QCEQvF2= MXHTRW5ITVJ?
GAK MnW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[0TWM2OD1{Nz60NlI2KM7:TR?= MmrYV2FPT0WU
MDA-MB-175-VII Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvYcY9KSzVyPUK3MlUxPTNizszN M3;kcnNCVkeHUh?=
JVM-2 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfkTWM2OD1{Nz62OlIzKM7:TR?= MX\TRW5ITVJ?
UACC-257 Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fkPWlEPTB;MkeuOlg4QCEQvF2= MXXTRW5ITVJ?
SW1783 Mlm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJ5Lke3PFMh|ryP NF7ZWZJUSU6JRWK=
HT-3 MlLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXITWM2OD1{OD6yNVY3KM7:TR?= MnnkV2FPT0WU
RL NXLDfFl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK1SZRKSzVyPUK4MlU6OTFizszN MnW3V2FPT0WU
TK10 MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTJ6Lk[1N|Uh|ryP NFLuPY5USU6JRWK=
HT55 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;2UXRKSzVyPUK5MlA2PjVizszN M4XOZXNCVkeHUh?=
BT-20 NF3aZo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DVdWlEPTB;MkmuNFU5PiEQvF2= MlfHV2FPT0WU
TGBC24TKB Ml\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnaTWM2OD1{OT6xPFMyKM7:TR?= NEL1[5FUSU6JRWK=
HSC-2 NH;QcYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LoT2lEPTB;MkmuN|AxOSEQvF2= MX\TRW5ITVJ?
COLO-205 MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfETWFlUUN3ME2yPU4{QTR2IN88US=> NYfTZYFFW0GQR1XS
GT3TKB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:xdZlLUUN3ME2yPU43QDd5IN88US=> NUDqTHNGW0GQR1XS
T47D MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoGwTWM2OD1{OT64OVgzKM7:TR?= NVfGPYVHW0GQR1XS
OMC-1 M2roOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPZTWM2OD1|MD6xPVE6KM7:TR?= NGXTbItUSU6JRWK=
PFSK-1 M2K3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGCxNlJKSzVyPUOxMlI3PTlizszN NGfEXmRUSU6JRWK=
JEG-3 M1;IbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVj5ZnBxUUN3ME2zNU4{PTZzIN88US=> MV3TRW5ITVJ?
RD NV3hOINMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjPbZVKSzVyPUOxMlUyOTVizszN NIHtXJhUSU6JRWK=
NCI-H64 NF;y[5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli5TWM2OD1|Mj60NVc6KM7:TR?= MVfTRW5ITVJ?
DMS-114 MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr2OYxlUUN3ME2zNk41OTh{IN88US=> NXTxU|ExW0GQR1XS
NCI-H661 Mn21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPPXmY3UUN3ME2zNk43PTBzIN88US=> MX;TRW5ITVJ?
CAL-148 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTp[lhKSzVyPUOyMlY3PjVizszN MoXaV2FPT0WU
HuP-T3 NX3sepYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTN{LkmzN|gh|ryP MkPRV2FPT0WU
ES4 MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTN|LkG3NFUh|ryP MWTTRW5ITVJ?
Ca9-22 NVXh[JBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTN|LkS2NFEh|ryP NXfHZ4c{W0GQR1XS
LP-1 M{\6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonWTWM2OD1|ND6wPUDPxE1? MljNV2FPT0WU
AU565 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDsTWM2OD1|ND61NFY6KM7:TR?= M3e1V3NCVkeHUh?=
MDA-MB-453 NY[2fnRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nMRmlEPTB;M{WuNVQzPiEQvF2= Mkf5V2FPT0WU
SNU-C1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HaSWlEPTB;M{WuNVcyKM7:TR?= MkjEV2FPT0WU
SW13 M1LWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n4fWlEPTB;M{WuOFA4PiEQvF2= MUXTRW5ITVJ?
NCI-H2122 NUPKNZdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\ZSmRKSzVyPUO1MlU2QThizszN Ml3IV2FPT0WU
NCI-H1395 M3zlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nPdGlEPTB;M{WuOlY6OSEQvF2= MUXTRW5ITVJ?
J-RT3-T3-5 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWyTWM2OD1|Nj6wNlk1KM7:TR?= NETzZWJUSU6JRWK=
COR-L279 M3;pUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYm0T|ZSUUN3ME2zOk4yQThzIN88US=> NYLoUog1W0GQR1XS
ATN-1 Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPibWdKSzVyPUO2Mlg2OTZizszN M3jiRXNCVkeHUh?=
HCC2998 Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnToTWM2OD1|Nj64OVcyKM7:TR?= NGDSfnhUSU6JRWK=
UM-UC-3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLTb|RKSzVyPUO2Mlg3PzVizszN MY\TRW5ITVJ?
DV-90 M2S4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTN4LkmwOlch|ryP NFjMNXNUSU6JRWK=
ES8 NG\UXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjqTJJKSzVyPUO2Mlk{OThizszN NFe4[mxUSU6JRWK=
YAPC M33WVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3THVWlEPTB;M{[uPVY2PCEQvF2= NGT5TnBUSU6JRWK=
HCC1599 M1ruNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT1TWM2OD1|Nz6xOlE5KM7:TR?= MYDTRW5ITVJ?
UMC-11 NUeySXF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXRTWM2OD1|Nz6yOVA{KM7:TR?= NW\RN3lGW0GQR1XS
THP-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzkTWM2OD1|Nz6yPFY5KM7:TR?= MnvMV2FPT0WU
OCUB-M NGThem1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzESW9qUUN3ME2zO{4zQDlzIN88US=> NVjtSYRtW0GQR1XS
NCI-H1693 M4Ti[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET1NJVKSzVyPUO3MlMzOzNizszN NXjCfo9PW0GQR1XS
NCI-H345 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3X3RWlEPTB;M{euN|YzPCEQvF2= MXfTRW5ITVJ?
COLO-800 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPnRW9KSzVyPUO3MlU3PyEQvF2= MWHTRW5ITVJ?
COLO-320-HSR M3Luemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLLTWM2OD1|OD6zOFkzKM7:TR?= NYLMV5h4W0GQR1XS
NCI-H596 M1HDS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmCwTWM2OD1|OD60OFg6KM7:TR?= MYXTRW5ITVJ?
NCI-H187 Mnn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzhTWM2OD1|OD63N|Q1KM7:TR?= MknOV2FPT0WU
ECC4 NUntNnRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDzbGc6UUN3ME2zPU4xQDF2IN88US=> M4qyTXNCVkeHUh?=
KP-4 MkHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K2UWlEPTB;M{muNVI{PSEQvF2= M3[1cXNCVkeHUh?=
NCI-H2227 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnYeVBKSzVyPUO5MlM6PDlizszN NIjUcWJUSU6JRWK=
22RV1 NVfkVVVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTQdYpjUUN3ME2zPU45Ozl6IN88US=> MX3TRW5ITVJ?
SAS MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmO5TWM2OD12MD6wPVYh|ryP NXi1clZJW0GQR1XS
PANC-10-05 M3e0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXmOWREUUN3ME20NE4yQDJ6IN88US=> NWK5eG8zW0GQR1XS
MDA-MB-468 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;I[YdKSzVyPUSwMlU{PDZizszN MV3TRW5ITVJ?
RPMI-7951 MoWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3KTWM2OD12MT6yNFc2KM7:TR?= MoHxV2FPT0WU
BB49-HNC NIrD[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3K2bGlEPTB;NEGuNlE4QSEQvF2= NGDsOphUSU6JRWK=
23132-87 NWfJe|Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTRzLkK3N|Ih|ryP NVHpcZFUW0GQR1XS
HCC1569 NIfTPVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTnO5dKSzVyPUSxMlI5QDVizszN M4HC[HNCVkeHUh?=
CP66-MEL Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvYeIJKSzVyPUSyMlE5QDZizszN MoXBV2FPT0WU
K-562 NVr1SHVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDNXGcxUUN3ME20Nk4zQDV2IN88US=> M1PJenNCVkeHUh?=
OCI-AML2 NXzWOFZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\RcWlEPTB;NEKuPFk4PCEQvF2= NIrpTVJUSU6JRWK=
SW756 M1LHfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O0OWlEPTB;NEOuNFM5QCEQvF2= M3jhUXNCVkeHUh?=
M14 NYTNfZVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHyToJKSzVyPUSzMlMyQDlizszN MWDTRW5ITVJ?
NCI-H1623 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHCNJhPUUN3ME20N{41PjRizszN M1nrcHNCVkeHUh?=
KNS-81-FD MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4C5V2lEPTB;NEOuO|YzKM7:TR?= MWfTRW5ITVJ?
TGBC1TKB MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17HbmlEPTB;NEOuPVA6QSEQvF2= M{e3[3NCVkeHUh?=
RERF-LC-MS NUTOSJdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorRTWM2OD12Mz65NlgyKM7:TR?= MlLIV2FPT0WU
PC-3 Mo\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n5OmlEPTB;NESuOFM1PyEQvF2= M3TxTHNCVkeHUh?=
HuP-T4 NWnDU4ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHRN|lKSzVyPUS0MlQ1PzRizszN M3faXnNCVkeHUh?=
NCI-H510A MkjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnJW2hKSzVyPUS0MlcxQCEQvF2= MV3TRW5ITVJ?
LB2518-MEL Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH2xRo9KSzVyPUS0Mlc6OzdizszN NIjFU45USU6JRWK=
TE-5 M3;wVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLpTWM2OD12NT65OVgyKM7:TR?= M1P5fXNCVkeHUh?=
EW-24 M4Xke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTR4LkG3NlMh|ryP NGPySYNUSU6JRWK=
LB647-SCLC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTR4LkKxOVUh|ryP MlzSV2FPT0WU
NCI-H524 M2X6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojuTWM2OD12Nj63NVg2KM7:TR?= NWe2XZNjW0GQR1XS
EW-11 NUjmfWVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTqTWM2OD12Nj65N|c{KM7:TR?= MYLTRW5ITVJ?
KALS-1 M4nDNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DFWGlEPTB;NEeuNlA3PiEQvF2= M{LQenNCVkeHUh?=
BT-474 NYrQWms4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPx[3RKSzVyPUS3MlQzOTZizszN M{HSZXNCVkeHUh?=
SK-N-AS NWnNW2V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYSwXZEzUUN3ME20O{45QDhizszN NYTPbFF{W0GQR1XS
HCC2157 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HWd2lEPTB;NEiuNFc3KM7:TR?= MY\TRW5ITVJ?
HCC1954 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTR6LkG3NFQh|ryP MVjTRW5ITVJ?
FADU NYKzXJVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknnTWM2OD12OD6zNFMyKM7:TR?= NXfmRWFHW0GQR1XS
S-117 MlHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT1[29nUUN3ME20PE4{QDF3IN88US=> NGrKSoNUSU6JRWK=
LS-1034 M3i3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDwTWM2OD12OD63NFY4KM7:TR?= NECx[IpUSU6JRWK=
CAMA-1 MmK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfwTWM2OD12OT61OVQ{KM7:TR?= MUDTRW5ITVJ?
LU-134-A NYXVT25qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1H2TGlEPTB;NEmuPFA5PSEQvF2= M1fubnNCVkeHUh?=
NCI-H1838 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPz[IdrUUN3ME20PU45ODh5IN88US=> M{L4VHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID