Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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3 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NFq3[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TT[2lEPTB;MD6wNFAxODByM{W5JO69VQ>? NIS1Zm5USU6JRWK=
MV-4-11 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMECwNFk2PiEQvF2= NUm1WmM2W0GQR1XS
MEG-01 NVzXTYFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDOTWM2OD1yLkCwNFEzQCEQvF2= Mk\oV2FPT0WU
LAMA-84 MofaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\NfWVKSzVyPUCuNFAxOTZ3IN88US=> Mm\SV2FPT0WU
CGTH-W-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMECxOlkh|ryP MWrTRW5ITVJ?
KASUMI-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMECyNVch|ryP MU\TRW5ITVJ?
BE-13 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf5S|RKSzVyPUCuNFAzPTlizszN M3;NUHNCVkeHUh?=
CTV-1 MnfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4OyT2lEPTB;MD6wNFUzOSEQvF2= Mle5V2FPT0WU
NKM-1 NXi0fYc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;iTWM2OD1yLkCwOlU2KM7:TR?= NFH1U4ZUSU6JRWK=
MONO-MAC-6 NInXcVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:1TWM2OD1yLkCwPFM4KM7:TR?= MUXTRW5ITVJ?
A204 NYXmTlBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PRNmlEPTB;MD6wNVIyQCEQvF2= NXfMWYJyW0GQR1XS
GDM-1 NHjoUYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\sSYhKSzVyPUCuNFE5OzNizszN M{jRSXNCVkeHUh?=
AN3-CA MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEG4O|Mh|ryP NUG1WpJXW0GQR1XS
BL-70 NVq4Xo9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfhfGhKSzVyPUCuNFIyQTlizszN M4e4eHNCVkeHUh?=
Daudi NUPoeldyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWGyUlYyUUN3ME2wMlAzPTN5IN88US=> M1XvfHNCVkeHUh?=
KU812 NX[zUWN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlyxTWM2OD1yLkCyPFQ5KM7:TR?= NIXZRVdUSU6JRWK=
KG-1 NWPjZ5plT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi0OWdKSzVyPUCuNFMzQTRizszN NFHQW|ZUSU6JRWK=
DOHH-2 NHjWPFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXucIFOUUN3ME2wMlA1QDB|IN88US=> Mk\3V2FPT0WU
HuO9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjlUWRSUUN3ME2wMlA2PDR6IN88US=> MV;TRW5ITVJ?
EB2 NU[0dHpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:y[Zk4UUN3ME2wMlA2PTd4IN88US=> NUL4S3ZIW0GQR1XS
G-402 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXKXIFUUUN3ME2wMlA3OzRzIN88US=> NYTC[HAxW0GQR1XS
SU-DHL-1 NIrDPZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX6doxLUUN3ME2wMlA3Ozd7IN88US=> MYPTRW5ITVJ?
NCI-H719 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjINIlKSzVyPUCuNFc5QDhizszN NX3RZVdbW0GQR1XS
MLMA NEm0XHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMEmwOkDPxE1? MVPTRW5ITVJ?
KM12 NIrqe4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMEm3N|ch|ryP MWnTRW5ITVJ?
SUP-T1 NEfaOGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnrTWM2OD1yLkC5PVgzKM7:TR?= NHLqfY1USU6JRWK=
MZ1-PC M{\Ke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TEWWlEPTB;MD6xNVM{PiEQvF2= M3vCXnNCVkeHUh?=
MFE-296 NFnvZplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMUG4N|kh|ryP MmTIV2FPT0WU
ALL-PO MmDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHi1WW5KSzVyPUCuNVI1PDNizszN MljyV2FPT0WU
GB-1 MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnWfVZ1UUN3ME2wMlEzPTF{IN88US=> NWHYSlA1W0GQR1XS
SIG-M5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3sdVlzUUN3ME2wMlE{OzdizszN NFLJR3FUSU6JRWK=
P30-OHK NUHL[I5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\sdnRbUUN3ME2wMlE2Pjd{IN88US=> NFzaeYJUSU6JRWK=
NCI-H716 Ml;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFW4OnNKSzVyPUCuNVYzPjZizszN MmTHV2FPT0WU
MPP-89 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33YRWlEPTB;MD6xOlk{OyEQvF2= MkLYV2FPT0WU
SF126 NVjSSm9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLsNWVSUUN3ME2wMlE4ODZ|IN88US=> M{T0bHNCVkeHUh?=
CTB-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvPTWM2OD1yLkG3N|E3KM7:TR?= NWWwTo17W0GQR1XS
CA46 M{jrPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nvOGlEPTB;MD6xO|Q5QSEQvF2= MXzTRW5ITVJ?
NCI-H520 NF7JOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;hVY9tUUN3ME2wMlE4PzN{IN88US=> M1vKVXNCVkeHUh?=
CAL-85-1 M{\vSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vVWGlEPTB;MD6xO|kzPyEQvF2= NVziUmN2W0GQR1XS
NCI-H2342 NX22[G4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvqSHJmUUN3ME2wMlE5PTd5IN88US=> NFjEOlBUSU6JRWK=
697 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mke2TWM2OD1yLkG4PFcyKM7:TR?= NXqxUGJ7W0GQR1XS
NY M4fjSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMUmyPFch|ryP M1rWdXNCVkeHUh?=
T98G NFnycVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXSPJRKSzVyPUCuNVk{OThizszN Mlj0V2FPT0WU
NCI-H1703 NYnMclFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrCTWM2OD1yLkG5OlE2KM7:TR?= MXrTRW5ITVJ?
NCI-H2087 NFPWN41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDWcWtKSzVyPUCuNlA1OzlizszN MnnMV2FPT0WU
PF-382 NYDncJhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfqSmhKSzVyPUCuNlA5PzNizszN NEfJSGJUSU6JRWK=
HCT-116 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PCPWlEPTB;MD6yNVA3QSEQvF2= MV\TRW5ITVJ?
CAKI-1 NEnyfopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMkG2OlYh|ryP NV:xU3JEW0GQR1XS
CCF-STTG1 MlLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P6S2lEPTB;MD6yNlQ4PSEQvF2= M2TISXNCVkeHUh?=
D-392MG NWPBNIUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoriTWM2OD1yLkKzNVc4KM7:TR?= M{jpT3NCVkeHUh?=
RT-112 M1nCfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\DZmlEPTB;MD6yN|c6PSEQvF2= M4XBOXNCVkeHUh?=
MES-SA MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlO0TWM2OD1yLkK0NVg4KM7:TR?= NVPQOIVrW0GQR1XS
LC-2-ad M{jOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMkSyOlUh|ryP MlzkV2FPT0WU
NOS-1 NVy2NVh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7C[GVKSzVyPUCuNlQ{PjdizszN NGX5dG1USU6JRWK=
NALM-6 M2nSNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1OyUmlEPTB;MD6yOVU1OyEQvF2= MYPTRW5ITVJ?
TE-15 NH\4TVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\MemlEPTB;MD6yOlA6OSEQvF2= NUnTR|RFW0GQR1XS
786-0 NFW0dFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGzTXdOUUN3ME2wMlI3OjJ6IN88US=> M{LVPHNCVkeHUh?=
IST-MES1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjGUHBKSzVyPUCuNlY5OjlizszN NWHXPWdEW0GQR1XS
KYSE-180 NGe2cI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMk[4PVEh|ryP NGDuUWVUSU6JRWK=
YT NFPYRodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrtVIxDUUN3ME2wMlI3QTd2IN88US=> NU\oXZNqW0GQR1XS
A427 NFTaZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTZTWM2OD1yLkK3NlY1KM7:TR?= NILIOY1USU6JRWK=
KYSE-450 Mn\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u4dmlEPTB;MD6yO|MzQSEQvF2= MX;TRW5ITVJ?
HuH-7 M2rXOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMke3OlMh|ryP M3\GZnNCVkeHUh?=
CAS-1 M{nwZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\lOWlEPTB;MD6yPFMxOyEQvF2= M{PETHNCVkeHUh?=
KURAMOCHI NYXnelVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;iZZJCUUN3ME2wMlI5PDF7IN88US=> Ml70V2FPT0WU
ACHN NGLKcW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnoTWM2OD1yLkK5N|I{KM7:TR?= Ml;5V2FPT0WU
HGC-27 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMkmzOVMh|ryP NWP4VZNNW0GQR1XS
A172 NGjMcJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG1eodKSzVyPUCuNlk2PzdizszN NI\EcIxUSU6JRWK=
SNU-449 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n5ZmlEPTB;MD6yPVk3PCEQvF2= NUmyfGRFW0GQR1XS
SW982 NVrLR3VmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljyTWM2OD1yLkK5PVc5KM7:TR?= NFTjbJRUSU6JRWK=
EFO-21 NF2yUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\jdnpKSzVyPUCuN|A1OTFizszN MnvOV2FPT0WU
NCI-H2030 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T0NmlEPTB;MD6zNVE3PCEQvF2= NWi4SpFFW0GQR1XS
HT-144 MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf2U|hKSzVyPUCuN|EzQCEQvF2= NVvBV4NzW0GQR1XS
MFE-280 NIjCT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwM{G0OVMh|ryP NWDVdFh1W0GQR1XS
SK-LU-1 M1u5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzCeFVKSzVyPUCuN|E1PjZizszN M2TTd3NCVkeHUh?=
NCI-H2052 NILmdoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwM{G0PFQh|ryP MlPJV2FPT0WU
SK-HEP-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\qTWM2OD1yLkOzN|Y5KM7:TR?= MYPTRW5ITVJ?
QIMR-WIL NUflfosxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\5c4ZyUUN3ME2wMlM{PDJ2IN88US=> MoH3V2FPT0WU
A2780 NHTkdlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\DVYlKSzVyPUCuN|Q{ODRizszN M17HS3NCVkeHUh?=
ACN NEfrXZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PHT2lEPTB;MD6zOFg4OyEQvF2= M3[w[nNCVkeHUh?=
BxPC-3 M2fIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37hW2lEPTB;MD6zOFk5QSEQvF2= M17QSHNCVkeHUh?=
BCPAP MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfFSnJKSzVyPUCuN|YxODFizszN Ml7JV2FPT0WU
HOP-62 MljHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLxOppuUUN3ME2wMlM3OTB4IN88US=> M33RU3NCVkeHUh?=
SW1710 NGXtbIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwM{[0OVUh|ryP M3HIVHNCVkeHUh?=
OPM-2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\YT5hCUUN3ME2wMlM3PDd|IN88US=> NHro[YVUSU6JRWK=
DBTRG-05MG NYfaVnhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;3VFNKSzVyPUCuN|gxPTRizszN NHvEeZdUSU6JRWK=
SK-MEL-24 NHXQNYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDwSmQyUUN3ME2wMlM6PzlzIN88US=> M3y0Z3NCVkeHUh?=
8305C Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3nSYZKSzVyPUCuN|k4QTNizszN MVjTRW5ITVJ?
OVCAR-4 NFnqeWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnOZpRuUUN3ME2wMlQyPTh4IN88US=> M1fLUXNCVkeHUh?=
HLE NFPDdpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjwW3FKSzVyPUCuOFE5PiEQvF2= NXPWVoJRW0GQR1XS
NCI-H747 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLkTWM2OD1yLkSyNVM4KM7:TR?= MnXjV2FPT0WU
SW780 NGracm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[1RndKSzVyPUCuOFI{PDZizszN MljvV2FPT0WU
KYSE-150 NVPPWmY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfy[FduUUN3ME2wMlQzPDF3IN88US=> MnrpV2FPT0WU
H4 M1LqPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwNEK0OVEh|ryP NXXxWng3W0GQR1XS
SW1088 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHuTWM2OD1yLkS0N|kh|ryP NE[xeG5USU6JRWK=
SF268 MkD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXH[25KSzVyPUCuOFQ5PiEQvF2= NH3oRnNUSU6JRWK=
RT4 NHfzN3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TrdGlEPTB;MD60OVEyOSEQvF2= NUjrNWJSW0GQR1XS
NCI-H522 M3TwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfjTWM2OD1yLkS1Nlch|ryP MlXMV2FPT0WU
LCLC-97TM1 NFrERXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPkTWM2OD1yLkS2NVk2KM7:TR?= MYnTRW5ITVJ?
CAL-39 NUHyOXFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r6XmlEPTB;MD60OlUyQSEQvF2= MUTTRW5ITVJ?
CAL-120 M1HZc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfrZW5RUUN3ME2wMlQ4PjR|IN88US=> NEHBXVRUSU6JRWK=
ESS-1 NUC3SI1{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXyVFhKSzVyPUCuOFc5OjFizszN NGL3S2ZUSU6JRWK=
KARPAS-45 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInGSHpKSzVyPUCuOFg6OzNizszN MmPIV2FPT0WU
DU-4475 NF:2VXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwNEm1NVEh|ryP MmjlV2FPT0WU
VMRC-RCZ NYTJVpozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH75[lhKSzVyPUCuOFk6ODRizszN M3roZ3NCVkeHUh?=
HOS NIPpWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwNUCzOlUh|ryP NFXRcHpUSU6JRWK=
MOLT-16 MoDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\iTWM2OD1yLkWxPFA5KM7:TR?= NGHzV4dUSU6JRWK=
RPMI-6666 MojES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTLTWM2OD1yLkWyNVM2KM7:TR?= NGTu[5BUSU6JRWK=
K052 MkH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13YO2lEPTB;MD61NlE1KM7:TR?= NV7rbHFiW0GQR1XS
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SK-MEL-2 M4\uOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULRZW1kUUN3ME2xMlkxOjdzIN88US=> NEK0fWNUSU6JRWK=
OVCAR-5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoiyTWM2OD1zLkmwOlc2KM7:TR?= NHrrTIJUSU6JRWK=
SNG-M NIDoUHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojQTWM2OD1zLkm1PFU5KM7:TR?= MUjTRW5ITVJ?
A673 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HCOGlEPTB;MT65O|UyPiEQvF2= MVPTRW5ITVJ?
L-428 NVvqPHdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu1RnVCUUN3ME2xMlk6OTd7IN88US=> MnTSV2FPT0WU
KM-H2 M1q4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjXPFBKSzVyPUKuNFExQSEQvF2= MkHhV2FPT0WU
MC-IXC NHH1RVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT3c2JQUUN3ME2yMlAzOjd|IN88US=> MX7TRW5ITVJ?
COLO-678 NV;hTVRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDNdHRKSzVyPUKuNFQzODdizszN MV;TRW5ITVJ?
MEL-JUSO NFTZflFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDPTWM2OD1{LkC3PFUyKM7:TR?= NY\FUIVMW0GQR1XS
HCC38 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HqUGlEPTB;Mj6wPFQ{OyEQvF2= MoHRV2FPT0WU
UACC-62 Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\PZ5JKSzVyPUKuNFg5PTVizszN NYi1b|RmW0GQR1XS
OAW-42 M1ToRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPTdI1KSzVyPUKuNFk4OTFizszN NITDeG5USU6JRWK=
LB996-RCC MkfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NID4bYhKSzVyPUKuNVM5OTdizszN MYfTRW5ITVJ?
COR-L105 NGPPWnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJwMU[zO|Mh|ryP NHnLclBUSU6JRWK=
RCC10RGB MlrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorZTWM2OD1{LkG4OVc3KM7:TR?= M2rXbnNCVkeHUh?=
A431 NITZ[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnaOnVKSzVyPUKuNVkxOTlizszN NFTa[3ZUSU6JRWK=
NCI-H292 MkjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuybYtKSzVyPUKuNlM6PTFizszN NXjjWFdpW0GQR1XS
SK-UT-1 MoHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:wVm5iUUN3ME2yMlM{OTh2IN88US=> NIrIN3pUSU6JRWK=
PANC-08-13 NV;nTJVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnYVGlKSzVyPUKuN|MzOzVizszN M321SXNCVkeHUh?=
ST486 M1rWfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoD2TWM2OD1{LkSxNFQ5KM7:TR?= M{ewWnNCVkeHUh?=
SJSA-1 NVPxU3pYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnEUGxTUUN3ME2yMlQyOjdzIN88US=> MXLTRW5ITVJ?
RKO MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPwb5ZjUUN3ME2yMlQzODJ7IN88US=> M3H3dXNCVkeHUh?=
NCI-H1793 MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHTOoQ{UUN3ME2yMlQ1ODJ7IN88US=> M{HiR3NCVkeHUh?=
639-V M3rm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXzdmVQUUN3ME2yMlQ2Ozh{IN88US=> MmThV2FPT0WU
ES3 M1mwdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nLZWlEPTB;Mj60PVc{PyEQvF2= NEnOPZdUSU6JRWK=
NCI-H1792 M1rQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJwNU[4NlYh|ryP MnvVV2FPT0WU
NCI-H1651 NFj2S4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\zZpRKSzVyPUKuOVgzOSEQvF2= MUPTRW5ITVJ?
SN12C NGHGbVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzXTWM2OD1{LkW4OFg4KM7:TR?= MUfTRW5ITVJ?
COLO-679 MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLZTWM2OD1{LkW4OlA2KM7:TR?= NUG3NlM6W0GQR1XS
U-118-MG M{GyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\qTWM2OD1{LkW4PFczKM7:TR?= MlHUV2FPT0WU
Ramos-2G6-4C10 M1zNSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2OzWGlEPTB;Mj62OFgxPyEQvF2= NXrwOJRiW0GQR1XS
HCT-15 NEjkeHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\yXIhKSzVyPUKuOlg4QTJizszN NVz1[ppsW0GQR1XS
MDA-MB-157 NFi3c|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzQTWM2OD1{LkewO|Q4KM7:TR?= NYX3Z4pIW0GQR1XS
K5 NEnnT5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTFTWM2OD1{LkexPFQ2KM7:TR?= NUTnTlA4W0GQR1XS
MKN45 NV7hUZlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXsPFhtUUN3ME2yMlc{OzZ4IN88US=> MUnTRW5ITVJ?
DMS-273 NUTHZoNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrGTWM2OD1{Lke1OlMzKM7:TR?= MXzTRW5ITVJ?
C8166 NEW2OndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnITWM2OD1{Lke4OVE{KM7:TR?= M1P2UXNCVkeHUh?=
Calu-3 NIjmXJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTJwN{i5Olkh|ryP NH\5cY5USU6JRWK=
SNB75 NGHPO2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXtVHdpUUN3ME2yMlg5PTN3IN88US=> NI\NUGZUSU6JRWK=
BFTC-905 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3zdY5{UUN3ME2yMlkxOTlzIN88US=> Mme2V2FPT0WU
C-4-II MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwOUGzOVMh|ryP MlP4V2FPT0WU
MS-1 M2PhSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfoclNKSzVyPUKuPVY4PjlizszN MX;TRW5ITVJ?
A375 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTNwMEixPFQh|ryP M17ETnNCVkeHUh?=
KYSE-70 M2j4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3TTWM2OD1|LkC4PFgzKM7:TR?= NX3CVWszW0GQR1XS
KYSE-510 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnLZYF[UUN3ME2zMlExQTl3IN88US=> M{HmcXNCVkeHUh?=
LN-405 M1nuTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[zVpZWUUN3ME2zMlE{PTF6IN88US=> NVLJXFJTW0GQR1XS
BOKU MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHGWJVKSzVyPUOuNVQzPTZizszN M{HuXHNCVkeHUh?=
TE-10 NYP3RWZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13FeGlEPTB;Mz6xO|M3OiEQvF2= NE\3T3lUSU6JRWK=
MKN1 NH[wUFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7oPFN[UUN3ME2zMlE5PDh|IN88US=> NHexWXZUSU6JRWK=
M059J NFHtTI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jSPWlEPTB;Mz6yNFE4OyEQvF2= NUDCUmRWW0GQR1XS
GOTO NYnx[4pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;mZoxKSzVyPUOuNlIxOzlizszN NFHFXWRUSU6JRWK=
DK-MG NFvHfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7GTWM2OD1|LkK1PVc3KM7:TR?= MUPTRW5ITVJ?
NCI-H727 NGTuNVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf4TWM2OD1|LkK2OVgh|ryP M1O2fnNCVkeHUh?=
NB12 MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTNwM{OyNlQh|ryP NUfGdJFWW0GQR1XS
DOK NXvSNJhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTNwM{[xPFYh|ryP MkHKV2FPT0WU
KYSE-410 Mm\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrkTWM2OD1|LkO2Nlg4KM7:TR?= MXnTRW5ITVJ?
AM-38 Mn3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17VUWlEPTB;Mz6zPFA2OSEQvF2= MXnTRW5ITVJ?
GR-ST NUfyU|JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLOTWM2OD1|LkS1O|MzKM7:TR?= M4XOenNCVkeHUh?=
D-247MG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu4RVRwUUN3ME2zMlQ5OjZ|IN88US=> M3fjSHNCVkeHUh?=
TE-8 NUfEcYZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm2WFh2UUN3ME2zMlQ6OzN|IN88US=> NEjyc|dUSU6JRWK=
LS-411N MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTNwNEm2PVIh|ryP M2O1SXNCVkeHUh?=
SK-MES-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoS2TWM2OD1|LkW2OFM{KM7:TR?= M4O2eXNCVkeHUh?=
SF295 Ml\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrrTWM2OD1|Lk[xOVUzKM7:TR?= NYj3fldTW0GQR1XS
SK-MEL-30 MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHQNHlwUUN3ME2zMlY2QTJzIN88US=> Mon4V2FPT0WU
LB2241-RCC MlrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLu[YlwUUN3ME2zMlY3OjZizszN MUTTRW5ITVJ?
PC-14 M3LDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv0[YNKSzVyPUOuOlY1OzdizszN MkfqV2FPT0WU
EW-7 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3FNJFKSzVyPUOuOlc3QTNizszN M1u0OnNCVkeHUh?=
NMC-G1 NFfRbY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYW3b2pYUUN3ME2zMlcyQDN5IN88US=> MWTTRW5ITVJ?
TE-441-T M4fnTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PxXmlEPTB;Mz63N|AzQCEQvF2= MojlV2FPT0WU
NCI-H1618 MorvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTNwOEG4O|Uh|ryP NVexcnpVW0GQR1XS
PANC-03-27 MlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTNwOEG5NVYh|ryP MVXTRW5ITVJ?
NCI-H2228 M2SxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGGxeGJKSzVyPUOuPFMyOjZizszN M{TNVnNCVkeHUh?=
CAPAN-1 MnfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\5VYxMUUN3ME2zMlg4ODB7IN88US=> MYfTRW5ITVJ?
KLE MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TKfWlEPTB;Mz65NFY4KM7:TR?= MnTQV2FPT0WU
Becker MojGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXvTWM2OD1|LkmyPFQ6KM7:TR?= MUTTRW5ITVJ?
SK-PN-DW MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfSeIM3UUN3ME20MlA4QTd2IN88US=> MmfRV2FPT0WU
Hs-578-T NXjYd4Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjVTWM2OD12LkC4N|A3KM7:TR?= NXWzOFFKW0GQR1XS
RS4-11 NITSPIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTRwMUGyOVUh|ryP NEWwXJZUSU6JRWK=
D-502MG NGO5Z|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLBTWM2OD12LkG2PVk4KM7:TR?= MojOV2FPT0WU
GI-1 MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnMTWM2OD12LkK4Nlk6KM7:TR?= MkDaV2FPT0WU
NCI-H209 NW\BeYJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3XW5hbUUN3ME20MlM{PzhizszN NVXWXlFMW0GQR1XS
SK-OV-3 NUTiW5R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PzbGlEPTB;ND60PFE1QSEQvF2= NHr6OIxUSU6JRWK=
LOUCY MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTRwNEi0N|Ih|ryP MYHTRW5ITVJ?
NCI-H69 M3PvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXONVNiUUN3ME20MlUyPzl|IN88US=> MkfDV2FPT0WU
SCC-9 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTRwNUOxO|Ih|ryP NHrNbFFUSU6JRWK=
NCI-H526 M4[zeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkKzTWM2OD12LkW5Nlk{KM7:TR?= NXrGfHBoW0GQR1XS
NCI-H2170 MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTRwNk[3O|Eh|ryP NGfSOGZUSU6JRWK=
SR M3j0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTRwN{CwOFgh|ryP MkPWV2FPT0WU
CMK M1TJ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DXVmlEPTB;ND63NlExOSEQvF2= MV7TRW5ITVJ?
COLO-829 M4L4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvQU4FKSzVyPUSuO|cxPDNizszN NGDLN3pUSU6JRWK=
HuO-3N1 NE\CcGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHJVGpkUUN3ME20Mlg{OjhzIN88US=> NHm0OXZUSU6JRWK=
5637 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MortTWM2OD12LkmwOFg4KM7:TR?= MXXTRW5ITVJ?
A253 MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jwXGlEPTB;ND65O|cxQCEQvF2= NUewXIFsW0GQR1XS
NB10 M{fzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXwTWM2OD13LkC3OFk4KM7:TR?= MVPTRW5ITVJ?
SF539 NFzBdGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVj6dHRuUUN3ME21MlA6QTV7IN88US=> MnLHV2FPT0WU
HAL-01 NX65Nm9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFu1b2pKSzVyPUWuNVQ3PDVizszN NYDMdFRFW0GQR1XS
MHH-ES-1 NWHjOG13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLWfoFKSzVyPUWuNVY6OjVizszN M{P4ZnNCVkeHUh?=
DEL NXTjbVVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3VSm1tUUN3ME21MlI4PTh{IN88US=> MnvSV2FPT0WU
NCI-H1299 M3L3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vlUGlEPTB;NT6zOVAxPyEQvF2= M4fQZnNCVkeHUh?=
ChaGo-K-1 MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nVNmlEPTB;NT6zOVExPyEQvF2= M2Dqe3NCVkeHUh?=
HMV-II NV\OfnpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL4TWM2OD13LkO5OFMh|ryP MYTTRW5ITVJ?
NB69 Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjRSXBKSzVyPUWuN|k3OzFizszN MVTTRW5ITVJ?
NCI-H1882 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXweYNKSzVyPUWuOFM{PjRizszN NYT0fXpCW0GQR1XS
SNU-475 NWTkOnExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfQeHdlUUN3ME21MlQ4OTdzIN88US=> NH\3ZYtUSU6JRWK=
RXF393 NEL4cWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrJTWM2OD13LkS4OFk1KM7:TR?= NHXUdHFUSU6JRWK=
CAL-51 MkfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn5VHZKSzVyPUWuOlI5PTNizszN NEPE[|BUSU6JRWK=
SW1573 NFTDNFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjsRopKSzVyPUWuOlM2OzRizszN M3TBSnNCVkeHUh?=
GCT NUHoeYxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG0T3ZlUUN3ME21Mlc2QTJ7IN88US=> MWrTRW5ITVJ?
COR-L88 NWXofmlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTVwN{[4OFYh|ryP M2K1NnNCVkeHUh?=
MDA-MB-134-VI Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTVwOEe1N|Yh|ryP M1LGXXNCVkeHUh?=
NB5 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jyWmlEPTB;NT65NlQ1KM7:TR?= M3LlVnNCVkeHUh?=
GMS-10 NHPrWHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTVwOU[4OlEh|ryP Ml;xV2FPT0WU
CHP-212 M1n6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvDTHRKSzVyPU[uOFgzPjdizszN NEjxZnRUSU6JRWK=
TE-11 M37hemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUi1cZVRUUN3ME22MlU2OTh{IN88US=> MUjTRW5ITVJ?
SW962 NVHte5NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTZwNkW3O|Qh|ryP MXTTRW5ITVJ?
MZ2-MEL NI\jT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTZwOEKwNVEh|ryP M2izeXNCVkeHUh?=
C-33-A M2DlS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;lSIF[UUN3ME22MlkyPjh6IN88US=> NYHGe2RyW0GQR1XS
IGR-1 MkPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTZwOUe4NlYh|ryP NGe1OGpUSU6JRWK=
MOLT-4 NX3IUXRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\1T2lEPTB;Nz6xOVQxPiEQvF2= MmHrV2FPT0WU
NCI-H1650 MkKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrvVo5KSzVyPUeuNlcxPDZizszN M4DEPHNCVkeHUh?=
AsPC-1 M1H3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTdwMki2NFUh|ryP NVHVcXNJW0GQR1XS
SNU-C2B NYXoWFNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTdwMkm1O|Eh|ryP Mon2V2FPT0WU
MKN7 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTdwM{eyN|Uh|ryP M{njcHNCVkeHUh?=
SW620 NG\T[2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHUTWM2OD15LkO4NlA2KM7:TR?= MnLlV2FPT0WU
SK-MEL-28 NFHmeJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTdwNEC3PVgh|ryP NIi1fpJUSU6JRWK=
TE-6 MnjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnvXYR6UUN3ME23MlQ1QTB6IN88US=> MXfTRW5ITVJ?
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BB65-RCC NGOyV|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHiVVlKSzVyPUKzMlA{PDRizszN M3vzR3NCVkeHUh?=
SiHa MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLZTWM2OD1{Mz6zPVY5KM7:TR?= NGPBeVlUSU6JRWK=
NCI-H2081 M4e2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTIPIVrUUN3ME2yOE4xPjRzIN88US=> NGK4O4hUSU6JRWK=
U251 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2flWmlEPTB;MkSuNFY3QCEQvF2= MnzuV2FPT0WU
LoVo MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LnZmlEPTB;MkSuPVI5OiEQvF2= M3\qV3NCVkeHUh?=
GCIY MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJ3LkK4O|ch|ryP MnO1V2FPT0WU
NUGC-3 NH:yfHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJ3LkOzNVYh|ryP M1fReHNCVkeHUh?=
LNCaP-Clone-FGC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXWTWM2OD1{NT6zOFk5KM7:TR?= Mn31V2FPT0WU
PA-1 M33Ncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJ3Lk[4N|Mh|ryP MWjTRW5ITVJ?
OE33 NX3Nd3pzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJ3Lk[4OVMh|ryP M33j[HNCVkeHUh?=
HT-29 NFj1[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrNTWM2OD1{NT63PFc6KM7:TR?= NWrm[YI{W0GQR1XS
RCM-1 NELtZXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjSbXFKSzVyPUK1Mlk3PTZizszN MUfTRW5ITVJ?
NCI-H1522 M3nFeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjvSFZKSzVyPUK1Mlk6OTFizszN MWPTRW5ITVJ?
LB373-MEL-D M3rON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\zTWM2OD1{Nj6xO|A5KM7:TR?= MmXjV2FPT0WU
NCI-H1436 MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTJ4LkK3N|gh|ryP M2i4V3NCVkeHUh?=
COLO-824 M13iPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XLW2lEPTB;Mk[uOFAxOiEQvF2= M4SwVnNCVkeHUh?=
CP50-MEL-B NIfFSVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJ4LkW2O|Uh|ryP MonoV2FPT0WU
EGI-1 M37LbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfo[Y1KSzVyPUK3MlI3QThizszN MXjTRW5ITVJ?
LAN-6 NYG0O5ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJ5LkO1PVgh|ryP NVHoUmRPW0GQR1XS
GAK NWPJeVB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXITWM2OD1{Nz60NlI2KM7:TR?= MXvTRW5ITVJ?
MDA-MB-175-VII NVK0dmtFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPPTWM2OD1{Nz61NFU{KM7:TR?= MYPTRW5ITVJ?
JVM-2 MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnqR41oUUN3ME2yO{43PjJ{IN88US=> NUH2NZgxW0GQR1XS
UACC-257 NYjXWZZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJ5Lk[4O|gh|ryP NVrJRmRlW0GQR1XS
SW1783 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXBV|FKSzVyPUK3Mlc4QDNizszN MoHCV2FPT0WU
HT-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\kVIhHUUN3ME2yPE4zOTZ4IN88US=> NH[yfZhUSU6JRWK=
RL NF7DUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJ6LkW5NVEh|ryP Mki3V2FPT0WU
TK10 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJ6Lk[1N|Uh|ryP MYLTRW5ITVJ?
HT55 NGjETlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJ7LkC1OlUh|ryP NEDvWZhUSU6JRWK=
BT-20 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi4XodbUUN3ME2yPU4xPTh4IN88US=> MlvuV2FPT0WU
TGBC24TKB NXn1fIJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTJ7LkG4N|Eh|ryP NX;VN3ZwW0GQR1XS
HSC-2 NWjUOpVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXMUI9KSzVyPUK5MlMxODFizszN MX\TRW5ITVJ?
COLO-205 MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ7LkO5OFQh|ryP MUfTRW5ITVJ?
GT3TKB NIr6PZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvTVlNpUUN3ME2yPU43QDd5IN88US=> MV3TRW5ITVJ?
T47D M4f5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHFTWM2OD1{OT64OVgzKM7:TR?= MY\TRW5ITVJ?
OMC-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXrO5dKSzVyPUOwMlE6OTlizszN NYXpeId1W0GQR1XS
PFSK-1 NFHyb|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnPVItDUUN3ME2zNU4zPjV7IN88US=> NVvJWYxNW0GQR1XS
JEG-3 M4TuVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTNzLkO1OlEh|ryP NIGwd4dUSU6JRWK=
RD MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTNzLkWxNVUh|ryP NXTQeJZiW0GQR1XS
NCI-H64 Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO2U|VKSzVyPUOyMlQyPzlizszN M1LtXnNCVkeHUh?=
DMS-114 NFjFeWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXVTWM2OD1|Mj60NVgzKM7:TR?= NV;UWFRYW0GQR1XS
NCI-H661 MoPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfuRoZKSzVyPUOyMlY2ODFizszN NFq0cJJUSU6JRWK=
CAL-148 NFzk[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPqTGJKSzVyPUOyMlY3PjVizszN NFzqV|BUSU6JRWK=
HuP-T3 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\pNXpNUUN3ME2zNk46OzN6IN88US=> MX7TRW5ITVJ?
ES4 Mlj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LMXGlEPTB;M{OuNVcxPSEQvF2= MnfSV2FPT0WU
Ca9-22 M1GzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvwTXlvUUN3ME2zN{41PjBzIN88US=> NYf5dWM3W0GQR1XS
LP-1 M3X3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTN2LkC5JO69VQ>? M4e3[XNCVkeHUh?=
AU565 NFPTSYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHoU4V{UUN3ME2zOE42ODZ7IN88US=> M2TFd3NCVkeHUh?=
MDA-MB-453 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDGZmVnUUN3ME2zOU4yPDJ4IN88US=> MX\TRW5ITVJ?
SNU-C1 Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTSOFZjUUN3ME2zOU4yPzFizszN MXLTRW5ITVJ?
SW13 NWi4dYNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rzOWlEPTB;M{WuOFA4PiEQvF2= NYX5TnVIW0GQR1XS
NCI-H2122 NX7PTWJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfsTWM2OD1|NT61OVk5KM7:TR?= NWfjeJdZW0GQR1XS
NCI-H1395 NYTWXmtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjtUI41UUN3ME2zOU43PjlzIN88US=> M33ERnNCVkeHUh?=
J-RT3-T3-5 NXi4bnl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzKTWM2OD1|Nj6wNlk1KM7:TR?= M4rmXXNCVkeHUh?=
COR-L279 Mn7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTN4LkG5PFEh|ryP MYTTRW5ITVJ?
ATN-1 M3LyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILJU2pKSzVyPUO2Mlg2OTZizszN NWf2XZVEW0GQR1XS
HCC2998 M2LiTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTN4Lki1O|Eh|ryP NXK3N4lXW0GQR1XS
UM-UC-3 MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFS5emRKSzVyPUO2Mlg3PzVizszN NELCZXlUSU6JRWK=
DV-90 NFzkW5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfkdHpKSzVyPUO2MlkxPjdizszN NHniSmZUSU6JRWK=
ES8 Mor0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;JRW1UUUN3ME2zOk46OzF6IN88US=> MWfTRW5ITVJ?
YAPC NFX1cZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH32TJBKSzVyPUO2Mlk3PTRizszN M3XUOXNCVkeHUh?=
HCC1599 M1e3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTN5LkG2NVgh|ryP NHrpVXpUSU6JRWK=
UMC-11 NHXLfWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LqWmlEPTB;M{euNlUxOyEQvF2= NH;zcpFUSU6JRWK=
THP-1 NWnB[5F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\LTWM2OD1|Nz6yPFY5KM7:TR?= NYLjWFZCW0GQR1XS
OCUB-M Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELBOINKSzVyPUO3MlI5QTFizszN NVTUflRPW0GQR1XS
NCI-H1693 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jLfmlEPTB;M{euN|I{OyEQvF2= M4KyTnNCVkeHUh?=
NCI-H345 MlPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPITWM2OD1|Nz6zOlI1KM7:TR?= MnLIV2FPT0WU
COLO-800 M{fEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTN5LkW2O{DPxE1? NWLUOItRW0GQR1XS
COLO-320-HSR MkTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTN6LkO0PVIh|ryP MlLJV2FPT0WU
NCI-H596 NHrtSGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq1N5pTUUN3ME2zPE41PDh7IN88US=> NIrXOZhUSU6JRWK=
NCI-H187 NH7wfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTN6LkezOFQh|ryP M3Ly[XNCVkeHUh?=
ECC4 Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTN7LkC4NVQh|ryP NIrNcXRUSU6JRWK=
KP-4 MnzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\hc2lEPTB;M{muNVI{PSEQvF2= NV[xbnV4W0GQR1XS
NCI-H2227 NFfWTnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTN7LkO5OFkh|ryP NVf4OHhXW0GQR1XS
22RV1 MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHNTWM2OD1|OT64N|k5KM7:TR?= M3HMNnNCVkeHUh?=
SAS M3LCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrRTWM2OD12MD6wPVYh|ryP NF:3RppUSU6JRWK=
PANC-10-05 M4fUfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz4OFV7UUN3ME20NE4yQDJ6IN88US=> NFjzVJpUSU6JRWK=
MDA-MB-468 M{CzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTRyLkWzOFYh|ryP M2TQRXNCVkeHUh?=
RPMI-7951 Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHH3VmlKSzVyPUSxMlIxPzVizszN MV7TRW5ITVJ?
BB49-HNC MnG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTRzLkKxO|kh|ryP M3uyc3NCVkeHUh?=
23132-87 MmDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTRzLkK3N|Ih|ryP NF;tb|NUSU6JRWK=
HCC1569 Ml;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTRzLkK4PFUh|ryP M{fEUnNCVkeHUh?=
CP66-MEL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjYNIExUUN3ME20Nk4yQDh4IN88US=> NIXrZXFUSU6JRWK=
K-562 NY\NWJNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnONlBpUUN3ME20Nk4zQDV2IN88US=> MUjTRW5ITVJ?
OCI-AML2 M{fmRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1SzWWlEPTB;NEKuPFk4PCEQvF2= NYHO[po5W0GQR1XS
SW756 NFz2W3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTR|LkCzPFgh|ryP NV\qUWVbW0GQR1XS
M14 NUXGZYR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTR|LkOxPFkh|ryP NGrQdXZUSU6JRWK=
NCI-H1623 NH7Hd4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rRVmlEPTB;NEOuOFY1KM7:TR?= MnjzV2FPT0WU
KNS-81-FD NIXwOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXOUIFKSzVyPUSzMlc3OiEQvF2= MkPQV2FPT0WU
TGBC1TKB M{LxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFSyWlNKSzVyPUSzMlkxQTlizszN MorNV2FPT0WU
RERF-LC-MS NVz4PVBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrSO4tKSzVyPUSzMlkzQDFizszN M2P6fHNCVkeHUh?=
PC-3 Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13zc2lEPTB;NESuOFM1PyEQvF2= MXnTRW5ITVJ?
HuP-T4 MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PEWmlEPTB;NESuOFQ4PCEQvF2= M3vm[HNCVkeHUh?=
NCI-H510A MlS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13L[mlEPTB;NESuO|A5KM7:TR?= M{DiR3NCVkeHUh?=
LB2518-MEL M4fMOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTR2Lke5N|ch|ryP M1zqZ3NCVkeHUh?=
TE-5 M4jobWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTsTWM2OD12NT65OVgyKM7:TR?= Mn3JV2FPT0WU
EW-24 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP6c2pKSzVyPUS2MlE4OjNizszN M3\mTHNCVkeHUh?=
LB647-SCLC MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkWyTWM2OD12Nj6yNVU2KM7:TR?= MVjTRW5ITVJ?
NCI-H524 NInYZm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG3TWM2OD12Nj63NVg2KM7:TR?= NF61bVVUSU6JRWK=
EW-11 M4ryXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULMb5FLUUN3ME20Ok46Ozd|IN88US=> MWPTRW5ITVJ?
KALS-1 M4PKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoToTWM2OD12Nz6yNFY3KM7:TR?= M{PKfnNCVkeHUh?=
BT-474 Mn7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzvcI1[UUN3ME20O{41OjF4IN88US=> MkXZV2FPT0WU
SK-N-AS NWG5NYxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrsXpR5UUN3ME20O{45QDhizszN MkDpV2FPT0WU
HCC2157 NGfH[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjvTolTUUN3ME20PE4xPzZizszN MlK5V2FPT0WU
HCC1954 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTR6LkG3NFQh|ryP MXrTRW5ITVJ?
FADU MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zLO2lEPTB;NEiuN|A{OSEQvF2= NHjaVplUSU6JRWK=
S-117 Ml;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofkTWM2OD12OD6zPFE2KM7:TR?= NHS2SFFUSU6JRWK=
LS-1034 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTR6LkewOlch|ryP M3TKT3NCVkeHUh?=
CAMA-1 M37CN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LRR2lEPTB;NEmuOVU1OyEQvF2= NG[2ZoVUSU6JRWK=
LU-134-A NXvNeJk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XEZWlEPTB;NEmuPFA5PSEQvF2= NW\PfndMW0GQR1XS
NCI-H1838 M37oTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fVZmlEPTB;NEmuPFA5PyEQvF2= NHrMVVRUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
+ Expand

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
+ Expand
  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water slightly soluble or insoluble
Ethanol slightly soluble or insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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