Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NUTIdXNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvwTWM2OD1yLkCwNFAxODB|NUmg{txO M37UT3NCVkeHUh?=
MV-4-11 Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMECwNFk2PiEQvF2= MYDTRW5ITVJ?
MEG-01 NHnIWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMECwNVI5KM7:TR?= MUTTRW5ITVJ?
LAMA-84 NGLI[FlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUT1Z3BRUUN3ME2wMlAxODF4NTFOwG0> M1zVTnNCVkeHUh?=
CGTH-W-1 NVHDfJA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfNfFlsUUN3ME2wMlAxOTZ7IN88US=> NX7keY9OW0GQR1XS
KASUMI-1 M4\PS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvTUGpsUUN3ME2wMlAxOjF5IN88US=> MoTKV2FPT0WU
BE-13 NGftcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\mOGx6UUN3ME2wMlAxOjV7IN88US=> MWjTRW5ITVJ?
CTV-1 NUHkOFF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\YfHZKSzVyPUCuNFA2OjFizszN MlXnV2FPT0WU
NKM-1 MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX4UmRKSzVyPUCuNFA3PTVizszN M{HCOXNCVkeHUh?=
MONO-MAC-6 M3HVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUH2NpprUUN3ME2wMlAxQDN5IN88US=> MWDTRW5ITVJ?
A204 M2\BZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrJTWM2OD1yLkCxNlE5KM7:TR?= NFL3TllUSU6JRWK=
GDM-1 NFvXeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;sWpRKSzVyPUCuNFE5OzNizszN MVXTRW5ITVJ?
AN3-CA NWjQOFU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTITWM2OD1yLkCxPFc{KM7:TR?= MXvTRW5ITVJ?
BL-70 M2\zWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;NWHZKSzVyPUCuNFIyQTlizszN NHP5OHlUSU6JRWK=
Daudi Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nmdGlEPTB;MD6wNlU{PyEQvF2= NX\V[nNnW0GQR1XS
KU812 NVPwUWpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rFS2lEPTB;MD6wNlg1QCEQvF2= NIDkdlZUSU6JRWK=
KG-1 MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETi[|lKSzVyPUCuNFMzQTRizszN MYrTRW5ITVJ?
DOHH-2 M{ewdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\MTWM2OD1yLkC0PFA{KM7:TR?= NWXGboF5W0GQR1XS
HuO9 Mk\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEW0OFgh|ryP NXzUW2FqW0GQR1XS
EB2 MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoD3TWM2OD1yLkC1OVc3KM7:TR?= M1\QTnNCVkeHUh?=
G-402 M1fGbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33s[WlEPTB;MD6wOlM1OSEQvF2= MkHTV2FPT0WU
SU-DHL-1 NWrZ[2dVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\5O4l7UUN3ME2wMlA3Ozd7IN88US=> MVjTRW5ITVJ?
NCI-H719 NX63dplqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPDd2RFUUN3ME2wMlA4QDh6IN88US=> NWnXdHZkW0GQR1XS
MLMA MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEmwOkDPxE1? M4jHfHNCVkeHUh?=
KM12 NEX5OHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nQcmlEPTB;MD6wPVc{PyEQvF2= NIfHTnpUSU6JRWK=
SUP-T1 NX7IRoFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEm5PFIh|ryP NWL0T5JLW0GQR1XS
MZ1-PC NYfkNW1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2KxVmlEPTB;MD6xNVM{PiEQvF2= M2rRWHNCVkeHUh?=
MFE-296 NWLhSJdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2m0dWlEPTB;MD6xNVg{QSEQvF2= NXTHNZF5W0GQR1XS
ALL-PO NH7PNHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH3T2pKSzVyPUCuNVI1PDNizszN NWrpVHJuW0GQR1XS
GB-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\hTWM2OD1yLkGyOVEzKM7:TR?= MorQV2FPT0WU
SIG-M5 NV62VZdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi1TWM2OD1yLkGzN|ch|ryP NUewVYFTW0GQR1XS
P30-OHK M{DCPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlruTWM2OD1yLkG1OlczKM7:TR?= M1nRVHNCVkeHUh?=
NCI-H716 M1jTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnLNJJNUUN3ME2wMlE3OjZ4IN88US=> NXrRZmJsW0GQR1XS
MPP-89 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;ReGVlUUN3ME2wMlE3QTN|IN88US=> NGDWNlNUSU6JRWK=
SF126 MofsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\C[3lKSzVyPUCuNVcxPjNizszN NGjHeWxUSU6JRWK=
CTB-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMUezNVYh|ryP NGjQbFJUSU6JRWK=
CA46 NYnxNpFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMUe0PFkh|ryP MXPTRW5ITVJ?
NCI-H520 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnrTWM2OD1yLkG3O|MzKM7:TR?= NFHGbHhUSU6JRWK=
CAL-85-1 M4rGNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjCeHhKSzVyPUCuNVc6OjdizszN MU\TRW5ITVJ?
NCI-H2342 M1vQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe5dpZKSzVyPUCuNVg2PzdizszN M1z2bXNCVkeHUh?=
697 M3;UdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jGRWlEPTB;MD6xPFg4OSEQvF2= M{m5SnNCVkeHUh?=
NY NHrSOZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS4XnJKSzVyPUCuNVkzQDdizszN M3faN3NCVkeHUh?=
T98G NUKxU|ZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1OyW2lEPTB;MD6xPVMyQCEQvF2= M3XTNnNCVkeHUh?=
NCI-H1703 NGXQe|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMUm2NVUh|ryP MVXTRW5ITVJ?
NCI-H2087 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHJXZBKSzVyPUCuNlA1OzlizszN MUjTRW5ITVJ?
PF-382 NWjBVmE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTOUI5KSzVyPUCuNlA5PzNizszN NYfNUZFUW0GQR1XS
HCT-116 MkTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMkGwOlkh|ryP NIPuTpZUSU6JRWK=
CAKI-1 NHLae|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{P2NmlEPTB;MD6yNVY3PiEQvF2= M4XuPXNCVkeHUh?=
CCF-STTG1 M2HHeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfke4hKSzVyPUCuNlI1PzVizszN NEjTUXlUSU6JRWK=
D-392MG NVOweJVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnXTWM2OD1yLkKzNVc4KM7:TR?= NUnX[FgyW0GQR1XS
RT-112 Mlz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHGTWM2OD1yLkKzO|k2KM7:TR?= M4TycXNCVkeHUh?=
MES-SA MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli5TWM2OD1yLkK0NVg4KM7:TR?= M1HnOnNCVkeHUh?=
LC-2-ad MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUn0V5V4UUN3ME2wMlI1OjZ3IN88US=> M362TnNCVkeHUh?=
NOS-1 M1zWbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\1TWM2OD1yLkK0N|Y4KM7:TR?= MkLuV2FPT0WU
NALM-6 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnlOHZKSzVyPUCuNlU2PDNizszN MVHTRW5ITVJ?
TE-15 NV:1XIJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\Jd5dVUUN3ME2wMlI3ODlzIN88US=> NHXvb4tUSU6JRWK=
786-0 NFnyOFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DmcmlEPTB;MD6yOlIzQCEQvF2= NFvlb3BUSU6JRWK=
IST-MES1 MkWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXWTlJFUUN3ME2wMlI3QDJ7IN88US=> MYXTRW5ITVJ?
KYSE-180 M1PZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K4TGlEPTB;MD6yOlg6OSEQvF2= NXryPWhXW0GQR1XS
YT NV3hO|NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjmV2xKSzVyPUCuNlY6PzRizszN NVTPO4ZyW0GQR1XS
A427 M4nUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMkeyOlQh|ryP M{LsbHNCVkeHUh?=
KYSE-450 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPCOI5KSzVyPUCuNlc{OjlizszN MkLMV2FPT0WU
HuH-7 MmPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jFNGlEPTB;MD6yO|c3OyEQvF2= M1PqS3NCVkeHUh?=
CAS-1 NHXJd|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMkizNFMh|ryP NH3sZVdUSU6JRWK=
KURAMOCHI MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMki0NVkh|ryP MXjTRW5ITVJ?
ACHN MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMkmzNlMh|ryP NHrsc2RUSU6JRWK=
HGC-27 NVnpR4hNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vFTGlEPTB;MD6yPVM2OyEQvF2= M3PsV3NCVkeHUh?=
A172 NFPsN|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMkm1O|ch|ryP NXfIXGFYW0GQR1XS
SNU-449 MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMkm5OlQh|ryP MXrTRW5ITVJ?
SW982 NUL0S2JjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMkm5O|gh|ryP MYXTRW5ITVJ?
EFO-21 M362SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUH2TXZsUUN3ME2wMlMxPDFzIN88US=> NUHuZYxCW0GQR1XS
NCI-H2030 NWDFdXc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvQTWM2OD1yLkOxNVY1KM7:TR?= Ml3jV2FPT0WU
HT-144 NWr4[GFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HTcGlEPTB;MD6zNVI5KM7:TR?= MmjPV2FPT0WU
MFE-280 M4W1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W0c2lEPTB;MD6zNVQ2OyEQvF2= NY\LT4RyW0GQR1XS
SK-LU-1 NXu5VJlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Hrc2lEPTB;MD6zNVQ3PiEQvF2= MVHTRW5ITVJ?
NCI-H2052 Mm\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTEPIxzUUN3ME2wMlMyPDh2IN88US=> MYTTRW5ITVJ?
SK-HEP-1 MmTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwM{OzOlgh|ryP M2LKWnNCVkeHUh?=
QIMR-WIL NXnURnlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwM{O0NlQh|ryP NHTtNodUSU6JRWK=
A2780 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[5UIY6UUN3ME2wMlM1OzB2IN88US=> M4\CbXNCVkeHUh?=
ACN MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXjOJpKSzVyPUCuN|Q5PzNizszN MVvTRW5ITVJ?
BxPC-3 NGDx[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvVN3FKSzVyPUCuN|Q6QDlizszN M4DIWHNCVkeHUh?=
BCPAP MnrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PkdGlEPTB;MD6zOlAxOSEQvF2= MWHTRW5ITVJ?
HOP-62 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUCzbG1OUUN3ME2wMlM3OTB4IN88US=> MnrCV2FPT0WU
SW1710 NUTV[Jc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPoSYxSUUN3ME2wMlM3PDV3IN88US=> NGnQRnBUSU6JRWK=
OPM-2 NV\BWZFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPYV3llUUN3ME2wMlM3PDd|IN88US=> NXnqfo1qW0GQR1XS
DBTRG-05MG M4Xy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS3XVVOUUN3ME2wMlM5ODV2IN88US=> NU\zfnd4W0GQR1XS
SK-MEL-24 NVHiTXhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLSTWM2OD1yLkO5O|kyKM7:TR?= MXnTRW5ITVJ?
8305C NWDHVXZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HTe2lEPTB;MD6zPVc6OyEQvF2= M3XZSXNCVkeHUh?=
OVCAR-4 MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwNEG1PFYh|ryP NYHxe25qW0GQR1XS
HLE M1T2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rGNGlEPTB;MD60NVg3KM7:TR?= MmTxV2FPT0WU
NCI-H747 MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwNEKxN|ch|ryP NIe0XGFUSU6JRWK=
SW780 NIfHUmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fpc2lEPTB;MD60NlM1PiEQvF2= M3\IO3NCVkeHUh?=
KYSE-150 MoHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n0PGlEPTB;MD60NlQyPSEQvF2= NHTkXFFUSU6JRWK=
H4 NEe0TYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3niS2lEPTB;MD60NlQ2OSEQvF2= NI\KXHhUSU6JRWK=
SW1088 NID1endIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M135b2lEPTB;MD60OFM6KM7:TR?= MUPTRW5ITVJ?
SF268 M3XHWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfiVo9SUUN3ME2wMlQ1QDZizszN NX6xPZZQW0GQR1XS
RT4 NFvQ[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PTZmlEPTB;MD60OVEyOSEQvF2= M4LVWnNCVkeHUh?=
NCI-H522 NGPtd21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7sXnVbUUN3ME2wMlQ2OjdizszN NYDBWXJRW0GQR1XS
LCLC-97TM1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwNE[xPVUh|ryP Mn7UV2FPT0WU
CAL-39 M1TSSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwNE[1NVkh|ryP MonkV2FPT0WU
CAL-120 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzXTWM2OD1yLkS3OlQ{KM7:TR?= MWXTRW5ITVJ?
ESS-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGSySmJKSzVyPUCuOFc5OjFizszN NVzmclB6W0GQR1XS
KARPAS-45 M2f5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjjTWM2OD1yLkS4PVM{KM7:TR?= NEj3[2xUSU6JRWK=
DU-4475 M4T3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fW[mlEPTB;MD60PVUyOSEQvF2= NV63eWFiW0GQR1XS
VMRC-RCZ M3vRTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwNEm5NFQh|ryP NG\GTYZUSU6JRWK=
HOS MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33s[2lEPTB;MD61NFM3PSEQvF2= MnPGV2FPT0WU
MOLT-16 M3zG[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwNUG4NFgh|ryP M4HPbnNCVkeHUh?=
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NCI-H2452 NGLCdGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGT1b2pKSzVyPUGuPFkxPzRizszN NX70XVM{W0GQR1XS
SK-MEL-2 NUjtd5NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXi[pdUUUN3ME2xMlkxOjdzIN88US=> MXTTRW5ITVJ?
OVCAR-5 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jre2lEPTB;MT65NFY4PSEQvF2= MWPTRW5ITVJ?
SNG-M NEfJbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK5TWM2OD1zLkm1PFU5KM7:TR?= NX;iVVFNW0GQR1XS
A673 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTFwOUe1NVYh|ryP NHiyO2xUSU6JRWK=
L-428 NH;ldZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPqTWM2OD1zLkm5NVc6KM7:TR?= MVnTRW5ITVJ?
KM-H2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfKZ3BKSzVyPUKuNFExQSEQvF2= MVLTRW5ITVJ?
MC-IXC MmDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrWSnQ1UUN3ME2yMlAzOjd|IN88US=> NEHVXFdUSU6JRWK=
COLO-678 M32w[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;EfWFnUUN3ME2yMlA1OjB5IN88US=> NYCxV4xoW0GQR1XS
MEL-JUSO MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPxRoFiUUN3ME2yMlA4QDVzIN88US=> NUTsWlJQW0GQR1XS
HCC38 MmraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJwMEi0N|Mh|ryP NHOyPJRUSU6JRWK=
UACC-62 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3oTWM2OD1{LkC4PFU2KM7:TR?= NWPwN|hbW0GQR1XS
OAW-42 MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTJwMEm3NVEh|ryP M33ZfXNCVkeHUh?=
LB996-RCC MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\NOFhKSzVyPUKuNVM5OTdizszN MkexV2FPT0WU
COR-L105 NFXrWYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XNc2lEPTB;Mj6xOlM4OyEQvF2= NHfZfFVUSU6JRWK=
RCC10RGB M4DHW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjOe|B[UUN3ME2yMlE5PTd4IN88US=> M2H0O3NCVkeHUh?=
A431 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvqTWM2OD1{LkG5NFE6KM7:TR?= NH;UTldUSU6JRWK=
NCI-H292 NF;oSHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\PSGlEPTB;Mj6yN|k2OSEQvF2= M3XxXHNCVkeHUh?=
SK-UT-1 NX\3TFdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnUNYFKSzVyPUKuN|MyQDRizszN M2fMfHNCVkeHUh?=
PANC-08-13 M37CN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jnZ2lEPTB;Mj6zN|I{PSEQvF2= MVXTRW5ITVJ?
ST486 M1nzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe4PJR2UUN3ME2yMlQyODR6IN88US=> MlzaV2FPT0WU
SJSA-1 M4TyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jncGlEPTB;Mj60NVI4OSEQvF2= M{nO[nNCVkeHUh?=
RKO M{nXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LNbWlEPTB;Mj60NlAzQSEQvF2= MofmV2FPT0WU
NCI-H1793 M17nfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnmOGlKSzVyPUKuOFQxOjlizszN NHP2W4VUSU6JRWK=
639-V MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJwNEWzPFIh|ryP MmmzV2FPT0WU
ES3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnYeHNKSzVyPUKuOFk4OzdizszN Mn7vV2FPT0WU
NCI-H1792 NVHCcJpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJwNU[4NlYh|ryP MX\TRW5ITVJ?
NCI-H1651 MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jmNmlEPTB;Mj61PFIyKM7:TR?= NVznNZBIW0GQR1XS
SN12C Mm\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXlTWM2OD1{LkW4OFg4KM7:TR?= M3fNSXNCVkeHUh?=
COLO-679 NEDXeHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXiybYlDUUN3ME2yMlU5PjB3IN88US=> NGPKUZJUSU6JRWK=
U-118-MG MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDoWXRKSzVyPUKuOVg5PzJizszN M131UnNCVkeHUh?=
Ramos-2G6-4C10 NFK2cZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTUXHZ5UUN3ME2yMlY1QDB5IN88US=> M3\YVHNCVkeHUh?=
HCT-15 NF\ObYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrRRYtKSzVyPUKuOlg4QTJizszN MV\TRW5ITVJ?
MDA-MB-157 NXTCeFZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;TfWlEPTB;Mj63NFc1PyEQvF2= MXrTRW5ITVJ?
K5 M1LkUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnOPYYxUUN3ME2yMlcyQDR3IN88US=> NEPWT2JUSU6JRWK=
MKN45 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWexdnZnUUN3ME2yMlc{OzZ4IN88US=> NX22dFJ2W0GQR1XS
DMS-273 NX\kOnpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnQZYpnUUN3ME2yMlc2PjN{IN88US=> MkPmV2FPT0WU
C8166 NXrBXol3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUixXJo4UUN3ME2yMlc5PTF|IN88US=> MofRV2FPT0WU
Calu-3 NH7UN|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\NZ2lEPTB;Mj63PFk3QSEQvF2= NWrRZndtW0GQR1XS
SNB75 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LLdGlEPTB;Mj64PFU{PSEQvF2= MnTYV2FPT0WU
BFTC-905 NGjNcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vYZmlEPTB;Mj65NFE6OSEQvF2= MUTTRW5ITVJ?
C-4-II M2XHZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPLOHcxUUN3ME2yMlkyOzV|IN88US=> MY\TRW5ITVJ?
MS-1 NIDFPJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITIO4pKSzVyPUKuPVY4PjlizszN MlLUV2FPT0WU
A375 NF25b5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[2TWM2OD1|LkC4NVg1KM7:TR?= NEfhXphUSU6JRWK=
KYSE-70 MkfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX3ZZdJUUN3ME2zMlA5QDh{IN88US=> MXnTRW5ITVJ?
KYSE-510 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvBV2JKSzVyPUOuNVA6QTVizszN M{\2OnNCVkeHUh?=
LN-405 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTNwMUO1NVgh|ryP M4S1dHNCVkeHUh?=
BOKU NUXEb3hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rwbGlEPTB;Mz6xOFI2PiEQvF2= NIrFWWRUSU6JRWK=
TE-10 NHvqNIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrkW5ZKSzVyPUOuNVc{PjJizszN M{DjOHNCVkeHUh?=
MKN1 NETPXWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHXPFNNUUN3ME2zMlE5PDh|IN88US=> NYDCXYdXW0GQR1XS
M059J M1Lo[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L3RmlEPTB;Mz6yNFE4OyEQvF2= NXT1eVVuW0GQR1XS
GOTO M121OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTNwMkKwN|kh|ryP M2Pxe3NCVkeHUh?=
DK-MG NEnMPW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorOTWM2OD1|LkK1PVc3KM7:TR?= MUPTRW5ITVJ?
NCI-H727 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnLTWM2OD1|LkK2OVgh|ryP NHrtdpRUSU6JRWK=
NB12 M4j4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzCSog2UUN3ME2zMlM{OjJ2IN88US=> MknmV2FPT0WU
DOK M3KwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTNwM{[xPFYh|ryP MXjTRW5ITVJ?
KYSE-410 M2OyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D0WmlEPTB;Mz6zOlI5PyEQvF2= MoT4V2FPT0WU
AM-38 M1\o[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojBTWM2OD1|LkO4NFUyKM7:TR?= MVXTRW5ITVJ?
GR-ST MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDqUpl7UUN3ME2zMlQ2PzN{IN88US=> MYPTRW5ITVJ?
D-247MG M1fTT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\wdYlKSzVyPUOuOFgzPjNizszN NFG1TYJUSU6JRWK=
TE-8 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP6e2pKSzVyPUOuOFk{OzNizszN NIPDd|dUSU6JRWK=
LS-411N M3\1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNwNEm2PVIh|ryP MXXTRW5ITVJ?
SK-MES-1 NEP0UWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jRVmlEPTB;Mz61OlQ{OyEQvF2= MUnTRW5ITVJ?
SF295 NWG1OYdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTNwNkG1OVIh|ryP MmPHV2FPT0WU
SK-MEL-30 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHnfpdZUUN3ME2zMlY2QTJzIN88US=> NVrJc|hDW0GQR1XS
LB2241-RCC M{izbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHSTWM2OD1|Lk[2NlYh|ryP Mn33V2FPT0WU
PC-14 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTNwNk[0N|ch|ryP NHHHSVJUSU6JRWK=
EW-7 M2P6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\zR4cyUUN3ME2zMlY4Pjl|IN88US=> MVfTRW5ITVJ?
NMC-G1 MmC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3uzbWlEPTB;Mz63NVg{PyEQvF2= MnLCV2FPT0WU
TE-441-T MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTNwN{OwNlgh|ryP MY\TRW5ITVJ?
NCI-H1618 MmHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELIcYtKSzVyPUOuPFE5PzVizszN NVLicHY2W0GQR1XS
PANC-03-27 NFjOWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTNwOEG5NVYh|ryP MU\TRW5ITVJ?
NCI-H2228 M2TRTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTTTWM2OD1|LkizNVI3KM7:TR?= NYnpZ3NEW0GQR1XS
CAPAN-1 NFvK[HFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmCxTWM2OD1|Lki3NFA6KM7:TR?= MmPnV2FPT0WU
KLE MljxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W0W2lEPTB;Mz65NFY4KM7:TR?= M33x[HNCVkeHUh?=
Becker NUKx[lRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3ufVk{UUN3ME2zMlkzQDR7IN88US=> Mo\MV2FPT0WU
SK-PN-DW MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXUd2h[UUN3ME20MlA4QTd2IN88US=> NVr0Z445W0GQR1XS
Hs-578-T MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTRO3BbUUN3ME20MlA5OzB4IN88US=> NGrIW4NUSU6JRWK=
RS4-11 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLwW4lTUUN3ME20MlEyOjV3IN88US=> NEm1fGRUSU6JRWK=
D-502MG M3PsXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLKTWM2OD12LkG2PVk4KM7:TR?= MXnTRW5ITVJ?
GI-1 NWjZV4h2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPmNnpKSzVyPUSuNlgzQTlizszN M{XZU3NCVkeHUh?=
NCI-H209 M33EbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7ST|RDUUN3ME20MlM{PzhizszN NEjpcYxUSU6JRWK=
SK-OV-3 NI\pOpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37PdWlEPTB;ND60PFE1QSEQvF2= M4nC[HNCVkeHUh?=
LOUCY MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnpdW5KSzVyPUSuOFg1OzJizszN NH;FclZUSU6JRWK=
NCI-H69 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TXSmlEPTB;ND61NVc6OyEQvF2= MnHKV2FPT0WU
SCC-9 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTRwNUOxO|Ih|ryP MYTTRW5ITVJ?
NCI-H526 MojzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfoUYZYUUN3ME20MlU6Ojl|IN88US=> NIe0O4ZUSU6JRWK=
NCI-H2170 NFrsfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTRwNk[3O|Eh|ryP M4Tz[nNCVkeHUh?=
SR Mmn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfOTWM2OD12LkewNFQ5KM7:TR?= M3\nenNCVkeHUh?=
CMK M{XSfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlGwTWM2OD12LkeyNVAyKM7:TR?= M3fqOHNCVkeHUh?=
COLO-829 M3vpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInlU49KSzVyPUSuO|cxPDNizszN NXXy[4FXW0GQR1XS
HuO-3N1 M1LITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;WZmlEPTB;ND64N|I5OSEQvF2= M1vTbXNCVkeHUh?=
5637 NH;1[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm2TWM2OD12LkmwOFg4KM7:TR?= NYDPTHhxW0GQR1XS
A253 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fVVGlEPTB;ND65O|cxQCEQvF2= NHy2[W5USU6JRWK=
NB10 NV7hNoZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTVwMEe0PVch|ryP NIDlVJpUSU6JRWK=
SF539 MnXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXDU3ZKSzVyPUWuNFk6PTlizszN NFfWdHRUSU6JRWK=
HAL-01 M1q1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTZTWM2OD13LkG0OlQ2KM7:TR?= M3PZcHNCVkeHUh?=
MHH-ES-1 NGGxcVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTVwMU[5NlUh|ryP MkexV2FPT0WU
DEL Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWq5XId4UUN3ME21MlI4PTh{IN88US=> MUDTRW5ITVJ?
NCI-H1299 M{\OO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n3ZWlEPTB;NT6zOVAxPyEQvF2= NIfGTpJUSU6JRWK=
ChaGo-K-1 M{TZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTVwM{WxNFch|ryP NIjR[pdUSU6JRWK=
HMV-II MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTVwM{m0N{DPxE1? NY\tU3FCW0GQR1XS
NB69 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnX2TWM2OD13LkO5OlMyKM7:TR?= NUS4bIh5W0GQR1XS
NCI-H1882 M4\IXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r2c2lEPTB;NT60N|M3PCEQvF2= NF[1[WlUSU6JRWK=
SNU-475 Ml\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTVwNEexO|Eh|ryP MmmwV2FPT0WU
RXF393 M37RTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTVwNEi0PVQh|ryP NIq3NFJUSU6JRWK=
CAL-51 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGWzO|BKSzVyPUWuOlI5PTNizszN MlqzV2FPT0WU
SW1573 M2CwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjLZY9KSzVyPUWuOlM2OzRizszN MlXxV2FPT0WU
GCT NFvOb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVW1OHZsUUN3ME21Mlc2QTJ7IN88US=> NUD2[IhJW0GQR1XS
COR-L88 NWn6OmpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDQfmJtUUN3ME21Mlc3QDR4IN88US=> M{DyXnNCVkeHUh?=
MDA-MB-134-VI M2qwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX2xVZR7UUN3ME21Mlg4PTN4IN88US=> M{TUenNCVkeHUh?=
NB5 NUm4SlZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\wTWM2OD13LkmyOFQh|ryP MmnhV2FPT0WU
GMS-10 NHe3UpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTVwOU[4OlEh|ryP NInDbXVUSU6JRWK=
CHP-212 M3\hSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvYTWM2OD14LkS4NlY4KM7:TR?= NFm1Z|VUSU6JRWK=
TE-11 NGjTS2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnWTWM2OD14LkW1NVgzKM7:TR?= NIj5NZNUSU6JRWK=
SW962 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HYSmlEPTB;Nj62OVc4PCEQvF2= MV3TRW5ITVJ?
MZ2-MEL NWnaPXhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTZwOEKwNVEh|ryP NGK0W5pUSU6JRWK=
C-33-A NF;rVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrDUGNKSzVyPU[uPVE3QDhizszN Ml7XV2FPT0WU
IGR-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTZwOUe4NlYh|ryP NInRSGpUSU6JRWK=
MOLT-4 M4HWbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3yxO2lEPTB;Nz6xOVQxPiEQvF2= NY\MPI4xW0GQR1XS
NCI-H1650 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\Oe21KSzVyPUeuNlcxPDZizszN MoTzV2FPT0WU
AsPC-1 M{m4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LSO2lEPTB;Nz6yPFYxPSEQvF2= Mlr4V2FPT0WU
SNU-C2B M4TRUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;XWIpKUUN3ME23MlI6PTdzIN88US=> NIDsbGNUSU6JRWK=
MKN7 Ml7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLUTWM2OD15LkO3NlM2KM7:TR?= NXrDe2RtW0GQR1XS
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CAL-62 NELKVVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3joZWlEPTB;MkKuO|UyPyEQvF2= MmrKV2FPT0WU
HCE-T NVPlNmtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7Ib2VyUUN3ME2yNk45PjB4IN88US=> MornV2FPT0WU
BB65-RCC NGHKNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJ|LkCzOFQh|ryP NXXaWXpjW0GQR1XS
SiHa MonOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PrNGlEPTB;MkOuN|k3QCEQvF2= NIT2PVVUSU6JRWK=
NCI-H2081 MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJ2LkC2OFEh|ryP MWrTRW5ITVJ?
U251 NELFZmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJ2LkC2Olgh|ryP NUe1PXpLW0GQR1XS
LoVo M{\Ve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFv5SGdKSzVyPUK0MlkzQDJizszN MoL5V2FPT0WU
GCIY MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjSOYd1UUN3ME2yOU4zQDd5IN88US=> M3HlUHNCVkeHUh?=
NUGC-3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDsWGZKUUN3ME2yOU4{OzF4IN88US=> NWHGWmFJW0GQR1XS
LNCaP-Clone-FGC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJ3LkO0PVgh|ryP NXrVeZFGW0GQR1XS
PA-1 MnTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJ3Lk[4N|Mh|ryP NF\nXJNUSU6JRWK=
OE33 MlT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml76TWM2OD1{NT62PFU{KM7:TR?= NGfzcItUSU6JRWK=
HT-29 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rqRWlEPTB;MkWuO|g4QSEQvF2= MXXTRW5ITVJ?
RCM-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\vTWM2OD1{NT65OlU3KM7:TR?= NWrSPHNjW0GQR1XS
NCI-H1522 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rDRWlEPTB;MkWuPVkyOSEQvF2= MWjTRW5ITVJ?
LB373-MEL-D NWLWdZMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX1NY5YUUN3ME2yOk4yPzB6IN88US=> NFHmPXJUSU6JRWK=
NCI-H1436 MmLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T3cGlEPTB;Mk[uNlc{QCEQvF2= NY\z[oZTW0GQR1XS
COLO-824 NFvV[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVWwR5FIUUN3ME2yOk41ODB{IN88US=> MkXyV2FPT0WU
CP50-MEL-B MoDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLZTWM2OD1{Nj61Olc2KM7:TR?= M3WxZnNCVkeHUh?=
EGI-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPxTWM2OD1{Nz6yOlk5KM7:TR?= NUjKN5hDW0GQR1XS
LAN-6 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJ5LkO1PVgh|ryP M1vBZ3NCVkeHUh?=
GAK MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG5eHl1UUN3ME2yO{41OjJ3IN88US=> NIPkUFNUSU6JRWK=
MDA-MB-175-VII MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXjVVNKSzVyPUK3MlUxPTNizszN MlnRV2FPT0WU
JVM-2 M3uyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJ5Lk[2NlIh|ryP M4O1VXNCVkeHUh?=
UACC-257 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnVN2U2UUN3ME2yO{43QDd6IN88US=> NWiydnlSW0GQR1XS
SW1783 NHTORlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorITWM2OD1{Nz63O|g{KM7:TR?= MmL0V2FPT0WU
HT-3 Ml:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[3TWM2OD1{OD6yNVY3KM7:TR?= MnmxV2FPT0WU
RL NUf6OXBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NViwRo54UUN3ME2yPE42QTFzIN88US=> M2XpVnNCVkeHUh?=
TK10 MnS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHIV4Z1UUN3ME2yPE43PTN3IN88US=> NYXzd4x5W0GQR1XS
HT55 Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPjenR2UUN3ME2yPU4xPTZ3IN88US=> M{G2ZnNCVkeHUh?=
BT-20 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJ7LkC1PFYh|ryP M3XafHNCVkeHUh?=
TGBC24TKB NWfMZYR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJ7LkG4N|Eh|ryP NVzuRWg3W0GQR1XS
HSC-2 M2XIZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7xfmR1UUN3ME2yPU4{ODBzIN88US=> M2TrZ3NCVkeHUh?=
COLO-205 NHjvXFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjMTWM2OD1{OT6zPVQ1KM7:TR?= NH\BU2pUSU6JRWK=
GT3TKB NWrYTGlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nBNmlEPTB;MkmuOlg4PyEQvF2= M2jCZ3NCVkeHUh?=
T47D NUXiVXB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zSVGlEPTB;MkmuPFU5OiEQvF2= MnfjV2FPT0WU
OMC-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTNyLkG5NVkh|ryP Mn7VV2FPT0WU
PFSK-1 NYXQXFIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTNzLkK2OVkh|ryP Ml\qV2FPT0WU
JEG-3 NWLwR4hNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTNzLkO1OlEh|ryP NYnKVol3W0GQR1XS
RD MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XwV2lEPTB;M{GuOVEyPSEQvF2= M1j5OnNCVkeHUh?=
NCI-H64 M1z6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnIb2VKSzVyPUOyMlQyPzlizszN NXvq[nBPW0GQR1XS
DMS-114 Mm\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrHfolKSzVyPUOyMlQyQDJizszN NFvTelNUSU6JRWK=
NCI-H661 NUizb2E4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDYTWM2OD1|Mj62OVAyKM7:TR?= NUXKN3hzW0GQR1XS
CAL-148 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPXfndKSzVyPUOyMlY3PjVizszN NITDclRUSU6JRWK=
HuP-T3 NXvCdGJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;1V3RKSzVyPUOyMlk{OzhizszN MnroV2FPT0WU
ES4 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLJZWNIUUN3ME2zN{4yPzB3IN88US=> MlviV2FPT0WU
Ca9-22 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zicmlEPTB;M{OuOFYxOSEQvF2= M3HhU3NCVkeHUh?=
LP-1 NX3MUHlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TId2lEPTB;M{SuNFkh|ryP NH36O3RUSU6JRWK=
AU565 MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj4TWM2OD1|ND61NFY6KM7:TR?= NUTkfmtsW0GQR1XS
MDA-MB-453 NFjpV3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\0UG9KSzVyPUO1MlE1OjZizszN Mn60V2FPT0WU
SNU-C1 NXnpVopzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LuUWlEPTB;M{WuNVcyKM7:TR?= MVnTRW5ITVJ?
SW13 NGOwelJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\tZmlEPTB;M{WuOFA4PiEQvF2= NYGwVJNwW0GQR1XS
NCI-H2122 MmXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPifnpKSzVyPUO1MlU2QThizszN NYHhdYQ3W0GQR1XS
NCI-H1395 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTN3Lk[2PVEh|ryP NVzie4lbW0GQR1XS
J-RT3-T3-5 NY\UdGtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7pTWM2OD1|Nj6wNlk1KM7:TR?= NI\jSGtUSU6JRWK=
COR-L279 M1vBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDydndQUUN3ME2zOk4yQThzIN88US=> NEfiNY1USU6JRWK=
ATN-1 MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPEZ|FGUUN3ME2zOk45PTF4IN88US=> NWrYNFIzW0GQR1XS
HCC2998 NFnW[lRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTN4Lki1O|Eh|ryP M3e5O3NCVkeHUh?=
UM-UC-3 NIXHflFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTN4Lki2O|Uh|ryP NV;1UFZRW0GQR1XS
DV-90 M{LacWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETzRZlKSzVyPUO2MlkxPjdizszN NUP5fnVyW0GQR1XS
ES8 MkWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVv1SmVZUUN3ME2zOk46OzF6IN88US=> MX7TRW5ITVJ?
YAPC M4LhRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlywTWM2OD1|Nj65OlU1KM7:TR?= M1vaZnNCVkeHUh?=
HCC1599 NVzF[Y86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HCcWlEPTB;M{euNVYyQCEQvF2= MoXuV2FPT0WU
UMC-11 NE\BeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD6NWRuUUN3ME2zO{4zPTB|IN88US=> MmfPV2FPT0WU
THP-1 MmHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTN5LkK4Olgh|ryP NXfvOXA2W0GQR1XS
OCUB-M NULydW9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLUVoFKSzVyPUO3MlI5QTFizszN M3q2VHNCVkeHUh?=
NCI-H1693 M4L5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TBO2lEPTB;M{euN|I{OyEQvF2= NUX2SHpZW0GQR1XS
NCI-H345 NEfzXHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTN5LkO2NlQh|ryP NEjWSmZUSU6JRWK=
COLO-800 M3v5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHLd5d5UUN3ME2zO{42PjdizszN Moi2V2FPT0WU
COLO-320-HSR NGC3RpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfxTWM2OD1|OD6zOFkzKM7:TR?= Mnv2V2FPT0WU
NCI-H596 NGXWdGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTN6LkS0PFkh|ryP MmrwV2FPT0WU
NCI-H187 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nLUmlEPTB;M{iuO|M1PCEQvF2= NVnYenBlW0GQR1XS
ECC4 Mnf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPvdWVKSzVyPUO5MlA5OTRizszN MnzBV2FPT0WU
KP-4 NEnwTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvrXJhKSzVyPUO5MlEzOzVizszN NYfQUFZTW0GQR1XS
NCI-H2227 M1LXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkL2TWM2OD1|OT6zPVQ6KM7:TR?= Ml7CV2FPT0WU
22RV1 M1\LXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTN7LkizPVgh|ryP NHnGRVZUSU6JRWK=
SAS M1;kSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33kXGlEPTB;NECuNFk3KM7:TR?= M17KV3NCVkeHUh?=
PANC-10-05 M3\mNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPFZ4VKSzVyPUSwMlE5OjhizszN M2HT[nNCVkeHUh?=
MDA-MB-468 NIPS[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknuTWM2OD12MD61N|Q3KM7:TR?= NGG3fmxUSU6JRWK=
RPMI-7951 M1nVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTRzLkKwO|Uh|ryP M4L4eXNCVkeHUh?=
BB49-HNC M1m0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zE[mlEPTB;NEGuNlE4QSEQvF2= M4DrRXNCVkeHUh?=
23132-87 M{jhU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LjNGlEPTB;NEGuNlc{OiEQvF2= MXLTRW5ITVJ?
HCC1569 M2PiW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr4cXBKSzVyPUSxMlI5QDVizszN NWjufpVTW0GQR1XS
CP66-MEL NGHCWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjUNm9KSzVyPUSyMlE5QDZizszN NELue3NUSU6JRWK=
K-562 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ewfWlEPTB;NEKuNlg2PCEQvF2= M4rHfnNCVkeHUh?=
OCI-AML2 NHjEWHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK4TWM2OD12Mj64PVc1KM7:TR?= NUfSPINVW0GQR1XS
SW756 NETtRlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTR|LkCzPFgh|ryP M4HEV3NCVkeHUh?=
M14 NV\6fVFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTR|LkOxPFkh|ryP M3zMd3NCVkeHUh?=
NCI-H1623 MnLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPmZXdKSzVyPUSzMlQ3PCEQvF2= M1K0WnNCVkeHUh?=
KNS-81-FD MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTR|Lke2NkDPxE1? MmLVV2FPT0WU
TGBC1TKB MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTR|LkmwPVkh|ryP NGXISW9USU6JRWK=
RERF-LC-MS NF;WTHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTR|LkmyPFEh|ryP NWq2OY1rW0GQR1XS
PC-3 Ml7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe2NphKSzVyPUS0MlQ{PDdizszN MUTTRW5ITVJ?
HuP-T4 NX\Jdmg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXWUoxYUUN3ME20OE41PDd2IN88US=> M4P6WHNCVkeHUh?=
NCI-H510A NI[0TlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTR2LkewPEDPxE1? M2PFTXNCVkeHUh?=
LB2518-MEL MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;FN21KSzVyPUS0Mlc6OzdizszN MoPUV2FPT0WU
TE-5 M3fRVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjXUIFKSzVyPUS1Mlk2QDFizszN M4nEOHNCVkeHUh?=
EW-24 MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\kO2FKSzVyPUS2MlE4OjNizszN MkDTV2FPT0WU
LB647-SCLC M4nseWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzaTWM2OD12Nj6yNVU2KM7:TR?= NIm3eGVUSU6JRWK=
NCI-H524 M3;QN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1i4TWlEPTB;NE[uO|E5PSEQvF2= M4rs[nNCVkeHUh?=
EW-11 M3r0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXacWZKSzVyPUS2Mlk{PzNizszN NWrPcGs6W0GQR1XS
KALS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTR5LkKwOlYh|ryP MVfTRW5ITVJ?
BT-474 NY\y[|NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nvcWlEPTB;NEeuOFIyPiEQvF2= NHjFN4dUSU6JRWK=
SK-N-AS NXfNe5B5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTR5Lki4PEDPxE1? NIXCPGZUSU6JRWK=
HCC2157 MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDpWYx5UUN3ME20PE4xPzZizszN NHrQTYFUSU6JRWK=
HCC1954 M4HFVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy1TJQ6UUN3ME20PE4yPzB2IN88US=> NH;Nb5hUSU6JRWK=
FADU NEPpe|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEf0RXpKSzVyPUS4MlMxOzFizszN MUjTRW5ITVJ?
S-117 MkOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;XU3ZKSzVyPUS4MlM5OTVizszN NF\U[oJUSU6JRWK=
LS-1034 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T1cWlEPTB;NEiuO|A3PyEQvF2= MknFV2FPT0WU
CAMA-1 NEm3U4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrUTWNKSzVyPUS5MlU2PDNizszN MkW2V2FPT0WU
LU-134-A MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnP4TWM2OD12OT64NFg2KM7:TR?= M1fJdXNCVkeHUh?=
NCI-H1838 M1fr[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LC[GlEPTB;NEmuPFA5PyEQvF2= M4\wN3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID