Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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3 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MlnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGq2T3JKSzVyPUCuNFAxODByMEO1PUDPxE1? NViwc5ROW0GQR1XS
MV-4-11 M3HVdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLqTWM2OD1yLkCwNFA6PTZizszN MXfTRW5ITVJ?
MEG-01 M3T0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzOWJBKSzVyPUCuNFAxOTJ6IN88US=> M2rLfHNCVkeHUh?=
LAMA-84 M1nsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{T1[2lEPTB;MD6wNFAyPjVizszN NFTrT4tUSU6JRWK=
CGTH-W-1 NVjLc3VvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;QTWM2OD1yLkCwNVY6KM7:TR?= MYrTRW5ITVJ?
KASUMI-1 NGPMeFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfSeYdqUUN3ME2wMlAxOjF5IN88US=> NI\rcmxUSU6JRWK=
BE-13 NGXkRVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMECyOVkh|ryP MV7TRW5ITVJ?
CTV-1 M1PlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DrVGlEPTB;MD6wNFUzOSEQvF2= MnvsV2FPT0WU
NKM-1 NF\0TmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPvTWM2OD1yLkCwOlU2KM7:TR?= M1H3WXNCVkeHUh?=
MONO-MAC-6 NEPKZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLXTWM2OD1yLkCwPFM4KM7:TR?= M1vYdnNCVkeHUh?=
A204 NHq3N5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHO5U|VKSzVyPUCuNFEzOThizszN MYjTRW5ITVJ?
GDM-1 Moj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYiydVRnUUN3ME2wMlAyQDN|IN88US=> NIfnUldUSU6JRWK=
AN3-CA MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorBTWM2OD1yLkCxPFc{KM7:TR?= MVLTRW5ITVJ?
BL-70 Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2frUmlEPTB;MD6wNlE6QSEQvF2= M2npTHNCVkeHUh?=
Daudi NVrOVVZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHpXmZKSzVyPUCuNFI2OzdizszN NIr6bGRUSU6JRWK=
KU812 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEO0cFhKSzVyPUCuNFI5PDhizszN NXPJZYMxW0GQR1XS
KG-1 MoPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\tOGlEPTB;MD6wN|I6PCEQvF2= MoHlV2FPT0WU
DOHH-2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\ZW4RKSzVyPUCuNFQ5ODNizszN NIf4RY5USU6JRWK=
HuO9 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHwTWM2OD1yLkC1OFQ5KM7:TR?= NWXZdXU5W0GQR1XS
EB2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7kOXBGUUN3ME2wMlA2PTd4IN88US=> MUfTRW5ITVJ?
G-402 M1;zRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3yRVhKSzVyPUCuNFY{PDFizszN Mln0V2FPT0WU
SU-DHL-1 NVezVVZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn31TWM2OD1yLkC2N|c6KM7:TR?= MoTUV2FPT0WU
NCI-H719 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\Be5JFUUN3ME2wMlA4QDh6IN88US=> MXHTRW5ITVJ?
MLMA NHv5[VRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\jV2lEPTB;MD6wPVA3KM7:TR?= MkPLV2FPT0WU
KM12 Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4exT2lEPTB;MD6wPVc{PyEQvF2= NHfMfGhUSU6JRWK=
SUP-T1 NEH2RVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;Me2lEPTB;MD6wPVk5OiEQvF2= NI\EZXpUSU6JRWK=
MZ1-PC M{e4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMUGzN|Yh|ryP NXHUPHR5W0GQR1XS
MFE-296 MmTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3iTWM2OD1yLkGxPFM6KM7:TR?= NV:2TJBzW0GQR1XS
ALL-PO M3TpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPwTWM2OD1yLkGyOFQ{KM7:TR?= MYHTRW5ITVJ?
GB-1 NHTtNppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;5U3hKSzVyPUCuNVI2OTJizszN MWjTRW5ITVJ?
SIG-M5 NF7yTIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMUOzO{DPxE1? MmPLV2FPT0WU
P30-OHK MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLHSod5UUN3ME2wMlE2Pjd{IN88US=> MoTwV2FPT0WU
NCI-H716 Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfXWWxnUUN3ME2wMlE3OjZ4IN88US=> MUDTRW5ITVJ?
MPP-89 NHzLdlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;DTWM2OD1yLkG2PVM{KM7:TR?= MoHNV2FPT0WU
SF126 NUXhUos3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMUewOlMh|ryP M4jrWHNCVkeHUh?=
CTB-1 NYLVSIR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHWzcYFKSzVyPUCuNVc{OTZizszN NF\PSIRUSU6JRWK=
CA46 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\RTWM2OD1yLkG3OFg6KM7:TR?= MUjTRW5ITVJ?
NCI-H520 NHzWcWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMUe3N|Ih|ryP MnL4V2FPT0WU
CAL-85-1 NInxVYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3pbllSUUN3ME2wMlE4QTJ5IN88US=> NX2wPWdkW0GQR1XS
NCI-H2342 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3pXFNKSzVyPUCuNVg2PzdizszN M2XVOnNCVkeHUh?=
697 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLPTpJOUUN3ME2wMlE5QDdzIN88US=> MYnTRW5ITVJ?
NY M33semdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDOTWM2OD1yLkG5Nlg4KM7:TR?= MnLGV2FPT0WU
T98G MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMUmzNVgh|ryP MUnTRW5ITVJ?
NCI-H1703 NIDGWnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLkTWNKSzVyPUCuNVk3OTVizszN MoXhV2FPT0WU
NCI-H2087 NEDPemFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT1TWM2OD1yLkKwOFM6KM7:TR?= NWfwOlh2W0GQR1XS
PF-382 M4n5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHYOmJKSzVyPUCuNlA5PzNizszN Ml35V2FPT0WU
HCT-116 M2\PeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHXTWM2OD1yLkKxNFY6KM7:TR?= MmjZV2FPT0WU
CAKI-1 NGCzUGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfzWoNGUUN3ME2wMlIyPjZ4IN88US=> MnLRV2FPT0WU
CCF-STTG1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfEXWlKUUN3ME2wMlIzPDd3IN88US=> M4DMNnNCVkeHUh?=
D-392MG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3WwVGlEPTB;MD6yN|E4PyEQvF2= MVPTRW5ITVJ?
RT-112 NYjHUXpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWW1XpZGUUN3ME2wMlI{Pzl3IN88US=> NYS1XHZVW0GQR1XS
MES-SA M{j0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHDTWM2OD1yLkK0NVg4KM7:TR?= NYTQeVhbW0GQR1XS
LC-2-ad MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nzNWlEPTB;MD6yOFI3PSEQvF2= NUTuVXN[W0GQR1XS
NOS-1 NUDaOpgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMkSzOlch|ryP M37IcHNCVkeHUh?=
NALM-6 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\lPWlEPTB;MD6yOVU1OyEQvF2= MkjkV2FPT0WU
TE-15 M3nHV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofVTWM2OD1yLkK2NFkyKM7:TR?= MoiyV2FPT0WU
786-0 NEPQZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm4WmZKSzVyPUCuNlYzOjhizszN NGfrNXFUSU6JRWK=
IST-MES1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi3OmZKSzVyPUCuNlY5OjlizszN NFz6O5FUSU6JRWK=
KYSE-180 MlvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13vbmlEPTB;MD6yOlg6OSEQvF2= NXXEV4p5W0GQR1XS
YT MlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rrVWlEPTB;MD6yOlk4PCEQvF2= NFjF[GZUSU6JRWK=
A427 NHGzS4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMkeyOlQh|ryP MWPTRW5ITVJ?
KYSE-450 M1:2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrMTWM2OD1yLkK3N|I6KM7:TR?= MorTV2FPT0WU
HuH-7 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILCT|NKSzVyPUCuNlc4PjNizszN Mn3EV2FPT0WU
CAS-1 M{TDS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV62RppbUUN3ME2wMlI5OzB|IN88US=> MkjaV2FPT0WU
KURAMOCHI Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;CS4dJUUN3ME2wMlI5PDF7IN88US=> MXHTRW5ITVJ?
ACHN NV;CZ|dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3THNGlEPTB;MD6yPVMzOyEQvF2= MV7TRW5ITVJ?
HGC-27 NFXPZWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XwOGlEPTB;MD6yPVM2OyEQvF2= M33Xb3NCVkeHUh?=
A172 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKxfldpUUN3ME2wMlI6PTd5IN88US=> NXrWUmhKW0GQR1XS
SNU-449 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMkm5OlQh|ryP M2TIdXNCVkeHUh?=
SW982 MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rIemlEPTB;MD6yPVk4QCEQvF2= M3PsdHNCVkeHUh?=
EFO-21 NInURVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlK3TWM2OD1yLkOwOFEyKM7:TR?= NE\FR21USU6JRWK=
NCI-H2030 M1T3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\3OYFKSzVyPUCuN|EyPjRizszN NFvQbWtUSU6JRWK=
HT-144 M4DV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf0Uod2UUN3ME2wMlMyOjhizszN MX;TRW5ITVJ?
MFE-280 NV7YUm5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHETWM2OD1yLkOxOFU{KM7:TR?= MkDQV2FPT0WU
SK-LU-1 NEKz[WhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjzZm9KSzVyPUCuN|E1PjZizszN MVPTRW5ITVJ?
NCI-H2052 MlXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TPdGlEPTB;MD6zNVQ5PCEQvF2= MkXUV2FPT0WU
SK-HEP-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwM{OzOlgh|ryP NYHVU2l3W0GQR1XS
QIMR-WIL MnrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwM{O0NlQh|ryP MYTTRW5ITVJ?
A2780 M3e1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrWclZwUUN3ME2wMlM1OzB2IN88US=> M{\kbXNCVkeHUh?=
ACN NGjZU3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTrfpA5UUN3ME2wMlM1QDd|IN88US=> NEHIO25USU6JRWK=
BxPC-3 NUG4epd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\USGlEPTB;MD6zOFk5QSEQvF2= NFnUdoZUSU6JRWK=
BCPAP MljJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\NZZhKSzVyPUCuN|YxODFizszN MXPTRW5ITVJ?
HOP-62 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PpRWlEPTB;MD6zOlExPiEQvF2= NH7ZbYlUSU6JRWK=
SW1710 NHjERo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7BTWM2OD1yLkO2OFU2KM7:TR?= NFjLbHdUSU6JRWK=
OPM-2 M1e1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwM{[0O|Mh|ryP M4jZT3NCVkeHUh?=
DBTRG-05MG NG[yOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGToR3pKSzVyPUCuN|gxPTRizszN MlXmV2FPT0WU
SK-MEL-24 M4DQR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwM{m3PVEh|ryP NGDETFZUSU6JRWK=
8305C MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;KbJgxUUN3ME2wMlM6Pzl|IN88US=> M3TiN3NCVkeHUh?=
OVCAR-4 M1fDZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLxTWM2OD1yLkSxOVg3KM7:TR?= MYHTRW5ITVJ?
HLE NHrH[Y9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TFc2lEPTB;MD60NVg3KM7:TR?= MVfTRW5ITVJ?
NCI-H747 NGrWS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\WVGlEPTB;MD60NlE{PyEQvF2= NXz3WJF[W0GQR1XS
SW780 NH;rPXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XGcWlEPTB;MD60NlM1PiEQvF2= Ml3mV2FPT0WU
KYSE-150 NHXwV2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTzbJhKSzVyPUCuOFI1OTVizszN M1KwcXNCVkeHUh?=
H4 NYnDZY9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwNEK0OVEh|ryP MWrTRW5ITVJ?
SW1088 NHLIOnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH6NpNKSzVyPUCuOFQ{QSEQvF2= NIe2eHRUSU6JRWK=
SF268 Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNES4OkDPxE1? NXqwVYs2W0GQR1XS
RT4 NHL5c4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwNEWxNVEh|ryP NVX4TINJW0GQR1XS
NCI-H522 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwNEWyO{DPxE1? MlTTV2FPT0WU
LCLC-97TM1 M3PBS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTCNW9KSzVyPUCuOFYyQTVizszN NX\MWo15W0GQR1XS
CAL-39 M1TRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HkTGlEPTB;MD60OlUyQSEQvF2= NGPRblJUSU6JRWK=
CAL-120 NVyzVIlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjCcVlEUUN3ME2wMlQ4PjR|IN88US=> MVjTRW5ITVJ?
ESS-1 Ml;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPJTWM2OD1yLkS3PFIyKM7:TR?= MmriV2FPT0WU
KARPAS-45 MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD6SGpVUUN3ME2wMlQ5QTN|IN88US=> M13IZXNCVkeHUh?=
DU-4475 MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwNEm1NVEh|ryP M3P4T3NCVkeHUh?=
VMRC-RCZ M2PhWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PadWlEPTB;MD60PVkxPCEQvF2= NWjSdHBIW0GQR1XS
HOS NWjESI94T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;aTWM2OD1yLkWwN|Y2KM7:TR?= MX;TRW5ITVJ?
MOLT-16 MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrVTWM2OD1yLkWxPFA5KM7:TR?= M2T0enNCVkeHUh?=
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K052 NHX1OZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;uPXdKSzVyPUCuOVIyPCEQvF2= M{LqfHNCVkeHUh?=
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SK-MEL-2 NFvjOGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7HTWM2OD1zLkmwNlcyKM7:TR?= MoD6V2FPT0WU
OVCAR-5 NE\hOHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT2RXdKSzVyPUGuPVA3PzVizszN NV;YS|FpW0GQR1XS
SNG-M M1HLOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XReGlEPTB;MT65OVg2QCEQvF2= NEPCXotUSU6JRWK=
A673 M2Pvc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXO1R49NUUN3ME2xMlk4PTF4IN88US=> NFjxPGZUSU6JRWK=
L-428 NFu0ZodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO0TWM2OD1zLkm5NVc6KM7:TR?= M4XNbnNCVkeHUh?=
KM-H2 NXHDOmtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJwMEGwPUDPxE1? NEXyeGtUSU6JRWK=
MC-IXC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLzTWM2OD1{LkCyNlc{KM7:TR?= MUnTRW5ITVJ?
COLO-678 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPzV5dKSzVyPUKuNFQzODdizszN MYPTRW5ITVJ?
MEL-JUSO M{fkfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X2[GlEPTB;Mj6wO|g2OSEQvF2= NYW1OINJW0GQR1XS
HCC38 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrsXJhKSzVyPUKuNFg1OzNizszN M3q4TnNCVkeHUh?=
UACC-62 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoK4TWM2OD1{LkC4PFU2KM7:TR?= M1j0cnNCVkeHUh?=
OAW-42 MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVuyWHZEUUN3ME2yMlA6PzFzIN88US=> M1fLd3NCVkeHUh?=
LB996-RCC Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnmxTWM2OD1{LkGzPFE4KM7:TR?= MkfBV2FPT0WU
COR-L105 MoXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoS0TWM2OD1{LkG2N|c{KM7:TR?= M2r0bnNCVkeHUh?=
RCC10RGB NIfGTHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXMd4JKSzVyPUKuNVg2PzZizszN MlPIV2FPT0WU
A431 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnaTWM2OD1{LkG5NFE6KM7:TR?= MYHTRW5ITVJ?
NCI-H292 NX;UN2ZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jlOGlEPTB;Mj6yN|k2OSEQvF2= MoPjV2FPT0WU
SK-UT-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z5XmlEPTB;Mj6zN|E5PCEQvF2= NYCyNZIxW0GQR1XS
PANC-08-13 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoCzTWM2OD1{LkOzNlM2KM7:TR?= MofiV2FPT0WU
ST486 NXzjOFhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJwNEGwOFgh|ryP M4P3RXNCVkeHUh?=
SJSA-1 M{K5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXXb3FKSzVyPUKuOFEzPzFizszN Ml3UV2FPT0WU
RKO NW\6eYc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJwNEKwNlkh|ryP M{C4XnNCVkeHUh?=
NCI-H1793 M4XiUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPkWYluUUN3ME2yMlQ1ODJ7IN88US=> NYrTbpNxW0GQR1XS
639-V NXf2R5VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTJwNEWzPFIh|ryP NWTYbVVIW0GQR1XS
ES3 M2nzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPTeG83UUN3ME2yMlQ6PzN5IN88US=> NFjaPWdUSU6JRWK=
NCI-H1792 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjUO4dKSzVyPUKuOVY5OjZizszN NIL1OYNUSU6JRWK=
NCI-H1651 NEXBN5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJwNUiyNUDPxE1? NWq4W3N7W0GQR1XS
SN12C NV;QTHpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TRXmlEPTB;Mj61PFQ5PyEQvF2= MWLTRW5ITVJ?
COLO-679 NWPYcnFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfzTWM2OD1{LkW4OlA2KM7:TR?= NEfTeJRUSU6JRWK=
U-118-MG M1\FXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXhUW5KSzVyPUKuOVg5PzJizszN NXLhfogxW0GQR1XS
Ramos-2G6-4C10 MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfrPJNKSzVyPUKuOlQ5ODdizszN M{Xyb3NCVkeHUh?=
HCT-15 M2L1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTJwNki3PVIh|ryP NGPBVGJUSU6JRWK=
MDA-MB-157 M33Mcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTJwN{C3OFch|ryP MVfTRW5ITVJ?
K5 NGryXoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDmUXpKUUN3ME2yMlcyQDR3IN88US=> Mkj0V2FPT0WU
MKN45 MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvsTWM2OD1{LkezN|Y3KM7:TR?= NHH2fG9USU6JRWK=
DMS-273 M1vnRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJwN{W2N|Ih|ryP M362UnNCVkeHUh?=
C8166 NFznUYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\QTWM2OD1{Lke4OVE{KM7:TR?= NHPDU4RUSU6JRWK=
Calu-3 MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\aTWM2OD1{Lke4PVY6KM7:TR?= M1zqXnNCVkeHUh?=
SNB75 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P1R2lEPTB;Mj64PFU{PSEQvF2= MnjpV2FPT0WU
BFTC-905 M3:yS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX63TndlUUN3ME2yMlkxOTlzIN88US=> NUHMfXI6W0GQR1XS
C-4-II NY\wUXVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T0SWlEPTB;Mj65NVM2OyEQvF2= MVnTRW5ITVJ?
MS-1 MmXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJwOU[3Olkh|ryP NWDGVIR2W0GQR1XS
A375 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXi[pptUUN3ME2zMlA5OTh2IN88US=> MnXNV2FPT0WU
KYSE-70 NUftcVFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfLVlhKSzVyPUOuNFg5QDJizszN NELQXZhUSU6JRWK=
KYSE-510 NFXiSpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf4VY5pUUN3ME2zMlExQTl3IN88US=> Mo\kV2FPT0WU
LN-405 Moi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnXWFk{UUN3ME2zMlE{PTF6IN88US=> M{XCSHNCVkeHUh?=
BOKU MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LUbGlEPTB;Mz6xOFI2PiEQvF2= MkDJV2FPT0WU
TE-10 M3WxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ro[mlEPTB;Mz6xO|M3OiEQvF2= MW\TRW5ITVJ?
MKN1 M3PTWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHYTWM2OD1|LkG4OFg{KM7:TR?= MXvTRW5ITVJ?
M059J NVvKRXpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[3TWM2OD1|LkKwNVc{KM7:TR?= M2HPUnNCVkeHUh?=
GOTO MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;xTJNKSzVyPUOuNlIxOzlizszN NYrHNFdPW0GQR1XS
DK-MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTKTWM2OD1|LkK1PVc3KM7:TR?= NXOzbVB[W0GQR1XS
NCI-H727 MnXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzvTHFKSzVyPUOuNlY2QCEQvF2= M{jHXXNCVkeHUh?=
NB12 M2jyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHoTWM2OD1|LkOzNlI1KM7:TR?= MVnTRW5ITVJ?
DOK MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofqTWM2OD1|LkO2NVg3KM7:TR?= M4HFWHNCVkeHUh?=
KYSE-410 NXGySFVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTNwM{[yPFch|ryP Ml;5V2FPT0WU
AM-38 MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVizeFQyUUN3ME2zMlM5ODVzIN88US=> MlPsV2FPT0WU
GR-ST MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnMNppKSzVyPUOuOFU4OzJizszN NFjUNoRUSU6JRWK=
D-247MG MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPjTXRMUUN3ME2zMlQ5OjZ|IN88US=> M2HWWHNCVkeHUh?=
TE-8 MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrpbIM{UUN3ME2zMlQ6OzN|IN88US=> MYPTRW5ITVJ?
LS-411N M3fncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTNwNEm2PVIh|ryP NV[2XmtSW0GQR1XS
SK-MES-1 M2nhTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:2TWpKUUN3ME2zMlU3PDN|IN88US=> M1zoNnNCVkeHUh?=
SF295 MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrOTWM2OD1|Lk[xOVUzKM7:TR?= NXmxOo45W0GQR1XS
SK-MEL-30 NUDRemR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fZdWlEPTB;Mz62OVkzOSEQvF2= MYTTRW5ITVJ?
LB2241-RCC MmjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTNwNk[yOkDPxE1? NGL5O5hUSU6JRWK=
PC-14 MnL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mni2TWM2OD1|Lk[2OFM4KM7:TR?= NYXGVVV2W0GQR1XS
EW-7 M1myUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;EOJBKSzVyPUOuOlc3QTNizszN MYnTRW5ITVJ?
NMC-G1 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\HVJR6UUN3ME2zMlcyQDN5IN88US=> MljzV2FPT0WU
TE-441-T NFPQVotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHtZ2lKSzVyPUOuO|MxOjhizszN M{HMT3NCVkeHUh?=
NCI-H1618 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTNwOEG4O|Uh|ryP NY\4N4FLW0GQR1XS
PANC-03-27 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnaNno4UUN3ME2zMlgyQTF4IN88US=> NH7JXYlUSU6JRWK=
NCI-H2228 NHTjUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z1R2lEPTB;Mz64N|EzPiEQvF2= MojLV2FPT0WU
CAPAN-1 NILWWJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLRTWM2OD1|Lki3NFA6KM7:TR?= Mo\hV2FPT0WU
KLE M3nJUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\XXHFKSzVyPUOuPVA3PyEQvF2= M{HwTnNCVkeHUh?=
Becker M1fIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHjRolCUUN3ME2zMlkzQDR7IN88US=> Mmj6V2FPT0WU
SK-PN-DW NFq2dppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTRwMEe5O|Qh|ryP NXzHVHNGW0GQR1XS
Hs-578-T MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjuTWM2OD12LkC4N|A3KM7:TR?= NXLJVYl1W0GQR1XS
RS4-11 M{TQb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPGTWM2OD12LkGxNlU2KM7:TR?= MVXTRW5ITVJ?
D-502MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTRwMU[5PVch|ryP M2Xxc3NCVkeHUh?=
GI-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTRwMkiyPVkh|ryP MnLTV2FPT0WU
NCI-H209 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTRwM{O3PEDPxE1? M1TY[XNCVkeHUh?=
SK-OV-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C1bmlEPTB;ND60PFE1QSEQvF2= MoTiV2FPT0WU
LOUCY Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDJTWM2OD12LkS4OFMzKM7:TR?= NYm5VG5iW0GQR1XS
NCI-H69 NHLYSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L4Z2lEPTB;ND61NVc6OyEQvF2= NUDaWIpPW0GQR1XS
SCC-9 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DVNGlEPTB;ND61N|E4OiEQvF2= NEXi[ZZUSU6JRWK=
NCI-H526 NVvz[WtvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojuTWM2OD12LkW5Nlk{KM7:TR?= NF7abpRUSU6JRWK=
NCI-H2170 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDIPGdoUUN3ME20MlY3PzdzIN88US=> NFPyU5dUSU6JRWK=
SR NX32Z2h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnpXGx[UUN3ME20MlcxODR6IN88US=> NWrTUpJJW0GQR1XS
CMK NEnydItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ro[mlEPTB;ND63NlExOSEQvF2= MWTTRW5ITVJ?
COLO-829 NV7vfGJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LP[mlEPTB;ND63O|A1OyEQvF2= M1fVbnNCVkeHUh?=
HuO-3N1 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTRwOEOyPFEh|ryP NFflTllUSU6JRWK=
5637 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDKeo9KSzVyPUSuPVA1QDdizszN NF;ycJNUSU6JRWK=
A253 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv2[IhKSzVyPUSuPVc4ODhizszN MXrTRW5ITVJ?
NB10 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTVwMEe0PVch|ryP NUfY[lZjW0GQR1XS
SF539 M2DW[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzSWGNKSzVyPUWuNFk6PTlizszN NUnIUZp{W0GQR1XS
HAL-01 MnXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTVwMUS2OFUh|ryP MVzTRW5ITVJ?
MHH-ES-1 NXmwR4FCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\VVI1iUUN3ME21MlE3QTJ3IN88US=> NGnoNm1USU6JRWK=
DEL NFvlTmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n6[GlEPTB;NT6yO|U5OiEQvF2= M{fpcnNCVkeHUh?=
NCI-H1299 M4SySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHq[XJKSzVyPUWuN|UxODdizszN NWXMfYx6W0GQR1XS
ChaGo-K-1 MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjybG5KSzVyPUWuN|UyODdizszN NWrabXN5W0GQR1XS
HMV-II NUfZTmpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn64TWM2OD13LkO5OFMh|ryP MWrTRW5ITVJ?
NB69 NEDiSXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTVwM{m2N|Eh|ryP NIfvV49USU6JRWK=
NCI-H1882 M3ftN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTVwNEOzOlQh|ryP M3jG[HNCVkeHUh?=
SNU-475 NGrKTZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrSSmRKSzVyPUWuOFcyPzFizszN NH7CO|dUSU6JRWK=
RXF393 NWfH[20xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHCcmVYUUN3ME21MlQ5PDl2IN88US=> NXfacFJKW0GQR1XS
CAL-51 MoDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fJPWlEPTB;NT62Nlg2OyEQvF2= NXHDVlJqW0GQR1XS
SW1573 MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn1TWM2OD13Lk[zOVM1KM7:TR?= MYHTRW5ITVJ?
GCT NWPlbWJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTVwN{W5Nlkh|ryP NGPpS3dUSU6JRWK=
COR-L88 NWL1XZdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTVwN{[4OFYh|ryP MYPTRW5ITVJ?
MDA-MB-134-VI MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rJZWlEPTB;NT64O|U{PiEQvF2= Mlm5V2FPT0WU
NB5 NICzU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDxPItXUUN3ME21MlkzPDRizszN M2H5d3NCVkeHUh?=
GMS-10 NGDxSJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTVwOU[4OlEh|ryP Mn7sV2FPT0WU
CHP-212 Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv0TWM2OD14LkS4NlY4KM7:TR?= M3X1R3NCVkeHUh?=
TE-11 MnTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn5TWM2OD14LkW1NVgzKM7:TR?= MoTIV2FPT0WU
SW962 NWPkO3BET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4q0VWlEPTB;Nj62OVc4PCEQvF2= NXvRcFNvW0GQR1XS
MZ2-MEL MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPZbVVKSzVyPU[uPFIxOTFizszN M1fWOXNCVkeHUh?=
C-33-A M3u5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4POVWlEPTB;Nj65NVY5QCEQvF2= MVfTRW5ITVJ?
IGR-1 NXO0[2oxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfaVmxKSzVyPU[uPVc5OjZizszN NIDvV5NUSU6JRWK=
MOLT-4 MlfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TQOWlEPTB;Nz6xOVQxPiEQvF2= M3HSR3NCVkeHUh?=
NCI-H1650 MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTdwMkewOFYh|ryP NYfMUYlbW0GQR1XS
AsPC-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHkTWM2OD15LkK4OlA2KM7:TR?= M3;IPHNCVkeHUh?=
SNU-C2B MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn4[|dKSzVyPUeuNlk2PzFizszN MWLTRW5ITVJ?
MKN7 MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGOyS3JKSzVyPUeuN|czOzVizszN NYHTNpplW0GQR1XS
SW620 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTdwM{iyNFUh|ryP NIriWGdUSU6JRWK=
SK-MEL-28 MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;aeGJ3UUN3ME23MlQxPzl6IN88US=> NX6wOWZVW0GQR1XS
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HT-1080 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\mcGlEPTB;OD6xN|E4PSEQvF2= Ml\EV2FPT0WU
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EW-16 NFTk[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXPUlEyUUN3ME25MlQ1QDR6IN88US=> MmHvV2FPT0WU
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A388 Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfTTWM2OD1zND63OVU3KM7:TR?= NVfX[nlxW0GQR1XS
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HEL NHXqfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvjR4c3UUN3ME2xOE45QTl5IN88US=> M2jHN3NCVkeHUh?=
BEN NEnRZ2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXGXWp6UUN3ME2xOE46PzZ4IN88US=> MkSyV2FPT0WU
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IGROV-1 NHzwSIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF3LkKzNVch|ryP Mn25V2FPT0WU
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ABC-1 MkfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLOSJFNUUN3ME2xOU45ODN|IN88US=> NF;3Z25USU6JRWK=
EW-18 MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fjcWlEPTB;MUWuPVk4QSEQvF2= MkfUV2FPT0WU
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SCC-15 Ml[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPaenpHUUN3ME2xOk4zQDJ3IN88US=> MVnTRW5ITVJ?
TT NHmz[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XoNGlEPTB;MU[uOVg5QCEQvF2= MYDTRW5ITVJ?
KINGS-1 Mn3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M364emlEPTB;MU[uPFI4OyEQvF2= MYDTRW5ITVJ?
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NCI-H748 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TzXGlEPTB;MUeuO|A{PSEQvF2= M{TrUHNCVkeHUh?=
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CAL-33 Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTF6LkK3PFEh|ryP NFHicoRUSU6JRWK=
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CAL-72 NFG3WmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHkTWM2OD1zOT62O|M4KM7:TR?= NX7idG1{W0GQR1XS
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DB MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvGUGhtUUN3ME2yNU43OTR{IN88US=> MmjiV2FPT0WU
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COR-L23 MkPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\TTWM2OD1{MT64NFUyKM7:TR?= M3;JOXNCVkeHUh?=
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NCI-H630 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjtcIh{UUN3ME2yNk42OzZ|IN88US=> MV\TRW5ITVJ?
LU-165 MoPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJ{LkW1OEDPxE1? M2HkSnNCVkeHUh?=
COLO-792 NULhS|ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX6RWVuUUN3ME2yNk44OTFzIN88US=> NFHP[|FUSU6JRWK=
CAL-62 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknGTWM2OD1{Mj63OVE4KM7:TR?= MoDsV2FPT0WU
HCE-T NHu4UXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{foRmlEPTB;MkKuPFYxPiEQvF2= NUHBNJRZW0GQR1XS
BB65-RCC NXfWPI57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJ|LkCzOFQh|ryP NYCwXnV5W0GQR1XS
SiHa MmfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnUdmNDUUN3ME2yN{4{QTZ6IN88US=> MUXTRW5ITVJ?
NCI-H2081 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HIeGlEPTB;MkSuNFY1OSEQvF2= NUTDbHJ{W0GQR1XS
U251 NIrVTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\oPXhiUUN3ME2yOE4xPjZ6IN88US=> NEnXTI1USU6JRWK=
LoVo M3X1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJ2LkmyPFIh|ryP M1;0bXNCVkeHUh?=
GCIY MnrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJ3LkK4O|ch|ryP NFXsW4JUSU6JRWK=
NUGC-3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nnfmlEPTB;MkWuN|MyPiEQvF2= MY\TRW5ITVJ?
LNCaP-Clone-FGC M1fDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XsbGlEPTB;MkWuN|Q6QCEQvF2= NGfNNG1USU6JRWK=
PA-1 MmD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1GwcWlEPTB;MkWuOlg{OyEQvF2= MYPTRW5ITVJ?
OE33 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\2UWlEPTB;MkWuOlg2OyEQvF2= NIS1coRUSU6JRWK=
HT-29 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJ3Lke4O|kh|ryP MmXEV2FPT0WU
RCM-1 MnXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ3Lkm2OVYh|ryP M134fnNCVkeHUh?=
NCI-H1522 NEfL[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2yTWM2OD1{NT65PVEyKM7:TR?= NF7tTllUSU6JRWK=
LB373-MEL-D MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHO1d4FKSzVyPUK2MlE4ODhizszN M4DIWnNCVkeHUh?=
NCI-H1436 NITkfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHtW5Y2UUN3ME2yOk4zPzN6IN88US=> NW[2NHhZW0GQR1XS
COLO-824 NIrwd3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJ4LkSwNFIh|ryP MUjTRW5ITVJ?
CP50-MEL-B MnG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X4ZmlEPTB;Mk[uOVY4PSEQvF2= NVvuNG9HW0GQR1XS
EGI-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTNTWM2OD1{Nz6yOlk5KM7:TR?= NIPwc3JUSU6JRWK=
LAN-6 NU\oZ3IyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHyNldKSzVyPUK3MlM2QThizszN MWPTRW5ITVJ?
GAK Mn33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPzXHdxUUN3ME2yO{41OjJ3IN88US=> MnXUV2FPT0WU
MDA-MB-175-VII Ml\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnxTJByUUN3ME2yO{42ODV|IN88US=> MVPTRW5ITVJ?
JVM-2 NIPCVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX30PWN4UUN3ME2yO{43PjJ{IN88US=> NUOwdFhCW0GQR1XS
UACC-257 NX3peY9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPCTWM2OD1{Nz62PFc5KM7:TR?= NVfHco5rW0GQR1XS
SW1783 NYPkcnhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofDTWM2OD1{Nz63O|g{KM7:TR?= M4\SWHNCVkeHUh?=
HT-3 NID1eIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkO0TWM2OD1{OD6yNVY3KM7:TR?= M{XnTnNCVkeHUh?=
RL NYrobWNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XWWWlEPTB;MkiuOVkyOSEQvF2= M3HjSnNCVkeHUh?=
TK10 NH;Z[oVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTJ6Lk[1N|Uh|ryP NWfPPGZwW0GQR1XS
HT55 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJ7LkC1OlUh|ryP MUfTRW5ITVJ?
BT-20 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJ7LkC1PFYh|ryP M2e5b3NCVkeHUh?=
TGBC24TKB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmzV5VxUUN3ME2yPU4yQDNzIN88US=> MXnTRW5ITVJ?
HSC-2 NWq1NJJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\pUmxKSzVyPUK5MlMxODFizszN MlXyV2FPT0WU
COLO-205 NGftTYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfwdWM1UUN3ME2yPU4{QTR2IN88US=> NH33XYhUSU6JRWK=
GT3TKB NEnWXIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PKdmlEPTB;MkmuOlg4PyEQvF2= NFnvXVRUSU6JRWK=
T47D M1jNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DnRmlEPTB;MkmuPFU5OiEQvF2= NVPSOmlkW0GQR1XS
OMC-1 NYX2RWh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz6fWlVUUN3ME2zNE4yQTF7IN88US=> MWHTRW5ITVJ?
PFSK-1 Mmr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmxOW1jUUN3ME2zNU4zPjV7IN88US=> NFnBSWNUSU6JRWK=
JEG-3 MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf0TWM2OD1|MT6zOVYyKM7:TR?= MoXMV2FPT0WU
RD NXnj[WZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEmzd4pKSzVyPUOxMlUyOTVizszN MXPTRW5ITVJ?
NCI-H64 NIfNRYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW3TWM2OD1|Mj60NVc6KM7:TR?= NFT5dG9USU6JRWK=
DMS-114 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PWdWlEPTB;M{KuOFE5OiEQvF2= M4fSW3NCVkeHUh?=
NCI-H661 MlO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzjTWM2OD1|Mj62OVAyKM7:TR?= MVjTRW5ITVJ?
CAL-148 M2LhT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLTTWM2OD1|Mj62OlY2KM7:TR?= NGTiRmRUSU6JRWK=
HuP-T3 M{m5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXFTWM2OD1|Mj65N|M5KM7:TR?= NHOwWIpUSU6JRWK=
ES4 MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILQUmlKSzVyPUOzMlE4ODVizszN NILlVlRUSU6JRWK=
Ca9-22 NITrUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTN|LkS2NFEh|ryP NWfDVJdIW0GQR1XS
LP-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rNVWlEPTB;M{SuNFkh|ryP Mn;iV2FPT0WU
AU565 M2PkeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X6W2lEPTB;M{SuOVA3QSEQvF2= MVrTRW5ITVJ?
MDA-MB-453 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TLOmlEPTB;M{WuNVQzPiEQvF2= NUP6cGRmW0GQR1XS
SNU-C1 NHH2TFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XZWmlEPTB;M{WuNVcyKM7:TR?= M1nBUXNCVkeHUh?=
SW13 M3TDOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTN3LkSwO|Yh|ryP MU\TRW5ITVJ?
NCI-H2122 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HiVWlEPTB;M{WuOVU6QCEQvF2= MnX3V2FPT0WU
NCI-H1395 M3XzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfpNZZFUUN3ME2zOU43PjlzIN88US=> MWnTRW5ITVJ?
J-RT3-T3-5 M4K0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXJdotKSzVyPUO2MlAzQTRizszN NYXPcZFGW0GQR1XS
COR-L279 Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\WTWM2OD1|Nj6xPVgyKM7:TR?= NEXCNHVUSU6JRWK=
ATN-1 NF3vO49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LVTWlEPTB;M{[uPFUyPiEQvF2= MV7TRW5ITVJ?
HCC2998 M2TxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDmV5k{UUN3ME2zOk45PTdzIN88US=> M3TyfnNCVkeHUh?=
UM-UC-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjWbWRKSzVyPUO2Mlg3PzVizszN NWi1UopyW0GQR1XS
DV-90 NEPEWXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfGb|hKSzVyPUO2MlkxPjdizszN NWe2c5FNW0GQR1XS
ES8 M4LjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjxW|dKSzVyPUO2Mlk{OThizszN M1jqZnNCVkeHUh?=
YAPC MlHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfBTWM2OD1|Nj65OlU1KM7:TR?= NUG2e2FZW0GQR1XS
HCC1599 M3TaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETqeVJKSzVyPUO3MlE3OThizszN MYPTRW5ITVJ?
UMC-11 NYnXXmh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTN5LkK1NFMh|ryP M1rLVXNCVkeHUh?=
THP-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf3TWM2OD1|Nz6yPFY5KM7:TR?= MYPTRW5ITVJ?
OCUB-M MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTN5LkK4PVEh|ryP MV;TRW5ITVJ?
NCI-H1693 M1\j[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH34bG1KSzVyPUO3MlMzOzNizszN NGf0U3JUSU6JRWK=
NCI-H345 NYjFPFNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\LNmlKSzVyPUO3MlM3OjRizszN NWHB[mViW0GQR1XS
COLO-800 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG3fZFpUUN3ME2zO{42PjdizszN Mnn2V2FPT0WU
COLO-320-HSR MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPrTVJ[UUN3ME2zPE4{PDl{IN88US=> NVv3TpE1W0GQR1XS
NCI-H596 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLKTWM2OD1|OD60OFg6KM7:TR?= NISxVGhUSU6JRWK=
NCI-H187 NY\MVWJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTN6LkezOFQh|ryP MnfOV2FPT0WU
ECC4 NGHXcWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv4TWM2OD1|OT6wPFE1KM7:TR?= M17TW3NCVkeHUh?=
KP-4 NFH2OVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVWwV5JnUUN3ME2zPU4yOjN3IN88US=> MUfTRW5ITVJ?
NCI-H2227 MoHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHiVYtKSzVyPUO5MlM6PDlizszN M1;0XnNCVkeHUh?=
22RV1 M{PTfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLiTWM2OD1|OT64N|k5KM7:TR?= NYLBXHZ1W0GQR1XS
SAS NEWxNWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTRyLkC5OkDPxE1? M4rn[3NCVkeHUh?=
PANC-10-05 MmfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjhclJKSzVyPUSwMlE5OjhizszN NX;Y[5VYW0GQR1XS
MDA-MB-468 NXHrN5RGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1WxVWlEPTB;NECuOVM1PiEQvF2= MlrLV2FPT0WU
RPMI-7951 NXLwe4dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWGwelZZUUN3ME20NU4zODd3IN88US=> M3\E[3NCVkeHUh?=
BB49-HNC M3Ti[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTRzLkKxO|kh|ryP NEe5U5FUSU6JRWK=
23132-87 MkfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPFVWFGUUN3ME20NU4zPzN{IN88US=> NFvKe2dUSU6JRWK=
HCC1569 Ml\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrKenE1UUN3ME20NU4zQDh3IN88US=> NEDTZnRUSU6JRWK=
CP66-MEL NGfYWY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3y3b2lEPTB;NEKuNVg5PiEQvF2= MXnTRW5ITVJ?
K-562 MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTR{LkK4OVQh|ryP Mo\WV2FPT0WU
OCI-AML2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPmRWNxUUN3ME20Nk45QTd2IN88US=> M4fFOHNCVkeHUh?=
SW756 NYSxPFVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXFO3JKSzVyPUSzMlA{QDhizszN NHPOSJNUSU6JRWK=
M14 NYi0fGZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTR|LkOxPFkh|ryP MYrTRW5ITVJ?
NCI-H1623 NFTkb5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPNOnRKSzVyPUSzMlQ3PCEQvF2= MXjTRW5ITVJ?
KNS-81-FD MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTR|Lke2NkDPxE1? NGXpZ2RUSU6JRWK=
TGBC1TKB M2X6fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTR|LkmwPVkh|ryP M1jPSnNCVkeHUh?=
RERF-LC-MS M1zNNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTR|LkmyPFEh|ryP M4LoVXNCVkeHUh?=
PC-3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnENHhkUUN3ME20OE41OzR5IN88US=> MlXIV2FPT0WU
HuP-T4 M2Syemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjiTWM2OD12ND60OFc1KM7:TR?= MlLpV2FPT0WU
NCI-H510A MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4CzXGlEPTB;NESuO|A5KM7:TR?= NEPub3hUSU6JRWK=
LB2518-MEL NGjVXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zLcGlEPTB;NESuO|k{PyEQvF2= NELiVWtUSU6JRWK=
TE-5 Mny1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nqPWlEPTB;NEWuPVU5OSEQvF2= NUey[|BDW0GQR1XS
EW-24 Mnr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIr5[IZKSzVyPUS2MlE4OjNizszN NUKwRYVQW0GQR1XS
LB647-SCLC NVXhcVNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTR4LkKxOVUh|ryP M2fUfHNCVkeHUh?=
NCI-H524 NEHMWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD3e|NKSzVyPUS2MlcyQDVizszN NYnMN|Z{W0GQR1XS
EW-11 MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\oNWZKSzVyPUS2Mlk{PzNizszN M1TaTHNCVkeHUh?=
KALS-1 MmDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vMdGlEPTB;NEeuNlA3PiEQvF2= NGPEXHZUSU6JRWK=
BT-474 NFmzRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPUSWRKSzVyPUS3MlQzOTZizszN M1HvPXNCVkeHUh?=
SK-N-AS NUfUbY06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nNbmlEPTB;NEeuPFg5KM7:TR?= MmfpV2FPT0WU
HCC2157 M4LUdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj2NXB4UUN3ME20PE4xPzZizszN MYrTRW5ITVJ?
HCC1954 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnhOVBWUUN3ME20PE4yPzB2IN88US=> MXPTRW5ITVJ?
FADU NYf4bIZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH6zWplKSzVyPUS4MlMxOzFizszN NVnNNGVTW0GQR1XS
S-117 M2[0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTR6LkO4NVUh|ryP NVfR[nFRW0GQR1XS
LS-1034 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEOxdWhKSzVyPUS4MlcxPjdizszN M2LjUHNCVkeHUh?=
CAMA-1 M4PoZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ixS2lEPTB;NEmuOVU1OyEQvF2= M17McHNCVkeHUh?=
LU-134-A MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\0UmV6UUN3ME20PU45ODh3IN88US=> NGrHZWhUSU6JRWK=
NCI-H1838 Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;pN2lEPTB;NEmuPFA5PyEQvF2= MWrTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
+ Expand

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
+ Expand
  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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