Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7CPGk3UUN3ME2wMlAxODByMECzOVkh|ryP NXOxVnA2W0GQR1XS
MV-4-11 Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjmZZV3UUN3ME2wMlAxODB7NU[g{txO MULTRW5ITVJ?
MEG-01 Mo\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nUUWlEPTB;MD6wNFAyOjhizszN NXPUS|VHW0GQR1XS
LAMA-84 NX\xXohxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\CWld2UUN3ME2wMlAxODF4NTFOwG0> M1y5dHNCVkeHUh?=
CGTH-W-1 M3n3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMECxOlkh|ryP MnfJV2FPT0WU
KASUMI-1 NVnMUmt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYS1cGhEUUN3ME2wMlAxOjF5IN88US=> MkeyV2FPT0WU
BE-13 MnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUniRmhHUUN3ME2wMlAxOjV7IN88US=> Mo\3V2FPT0WU
CTV-1 MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInnb5pKSzVyPUCuNFA2OjFizszN M3TLTHNCVkeHUh?=
NKM-1 MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\RdWlEPTB;MD6wNFY2PSEQvF2= M2PtPXNCVkeHUh?=
MONO-MAC-6 M3HrNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPyTWM2OD1yLkCwPFM4KM7:TR?= NU\EN2c4W0GQR1XS
A204 MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3mOHptUUN3ME2wMlAyOjF6IN88US=> M1LXcHNCVkeHUh?=
GDM-1 M17hXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vTRWlEPTB;MD6wNVg{OyEQvF2= NXLN[FBKW0GQR1XS
AN3-CA MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEG4O|Mh|ryP NYTyWZlXW0GQR1XS
BL-70 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XFNGlEPTB;MD6wNlE6QSEQvF2= MXHTRW5ITVJ?
Daudi NXmyfYVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XFWmlEPTB;MD6wNlU{PyEQvF2= NYHOWmNnW0GQR1XS
KU812 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HKXmlEPTB;MD6wNlg1QCEQvF2= MVjTRW5ITVJ?
KG-1 NXP1dVhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\pXnoyUUN3ME2wMlA{Ojl2IN88US=> M3W3W3NCVkeHUh?=
DOHH-2 NEjTSJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMES4NFMh|ryP M{i1WnNCVkeHUh?=
HuO9 NFLxe|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33RPWlEPTB;MD6wOVQ1QCEQvF2= M2fYd3NCVkeHUh?=
EB2 M2fYcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvaTWM2OD1yLkC1OVc3KM7:TR?= NVXwb|E{W0GQR1XS
G-402 Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwME[zOFEh|ryP MXvTRW5ITVJ?
SU-DHL-1 NGTzXG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrEdm4xUUN3ME2wMlA3Ozd7IN88US=> M3LUSXNCVkeHUh?=
NCI-H719 NF\wc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLQUFN{UUN3ME2wMlA4QDh6IN88US=> NFnlN5lUSU6JRWK=
MLMA MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37mT2lEPTB;MD6wPVA3KM7:TR?= MYDTRW5ITVJ?
KM12 NF\GXYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TYZ2lEPTB;MD6wPVc{PyEQvF2= NXn0UVY2W0GQR1XS
SUP-T1 NUDEbHZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrMTIJDUUN3ME2wMlA6QTh{IN88US=> MU\TRW5ITVJ?
MZ1-PC M{HzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LPT2lEPTB;MD6xNVM{PiEQvF2= NVfoNYNzW0GQR1XS
MFE-296 M4Hp[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFyxSFBKSzVyPUCuNVE5OzlizszN NVXCV5k5W0GQR1XS
ALL-PO NGPNdplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLSVHlGUUN3ME2wMlEzPDR|IN88US=> MYHTRW5ITVJ?
GB-1 MoTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTL[pk3UUN3ME2wMlEzPTF{IN88US=> NFHwTYFUSU6JRWK=
SIG-M5 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1n2V2lEPTB;MD6xN|M4KM7:TR?= MYXTRW5ITVJ?
P30-OHK M1TiS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzoOWs{UUN3ME2wMlE2Pjd{IN88US=> M2DjR3NCVkeHUh?=
NCI-H716 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe2V4pKSzVyPUCuNVYzPjZizszN MWrTRW5ITVJ?
MPP-89 NF24PFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMU[5N|Mh|ryP NUjBcnVRW0GQR1XS
SF126 M3z5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXySYF3UUN3ME2wMlE4ODZ|IN88US=> MkS4V2FPT0WU
CTB-1 M1nKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMUezNVYh|ryP NFTDVYVUSU6JRWK=
CA46 NEPuZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MomzTWM2OD1yLkG3OFg6KM7:TR?= MW\TRW5ITVJ?
NCI-H520 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG3Zo9NUUN3ME2wMlE4PzN{IN88US=> M4HCd3NCVkeHUh?=
CAL-85-1 NXqwdpV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G3bWlEPTB;MD6xO|kzPyEQvF2= MlP4V2FPT0WU
NCI-H2342 M3nMfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMUi1O|ch|ryP NFm1V|dUSU6JRWK=
697 NGS0NIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofVTWM2OD1yLkG4PFcyKM7:TR?= NFXKZY5USU6JRWK=
NY NV3XcZBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHIUYdKSzVyPUCuNVkzQDdizszN NYT1N3VbW0GQR1XS
T98G Ml\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMUmzNVgh|ryP MV;TRW5ITVJ?
NCI-H1703 NX\h[nhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[wXm1KSzVyPUCuNVk3OTVizszN MYLTRW5ITVJ?
NCI-H2087 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q5XmlEPTB;MD6yNFQ{QSEQvF2= NIXQV|dUSU6JRWK=
PF-382 NXLZTZhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M333WWlEPTB;MD6yNFg4OyEQvF2= MnzLV2FPT0WU
HCT-116 MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMkGwOlkh|ryP NEDhUnJUSU6JRWK=
CAKI-1 M2DxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfCcoRKSzVyPUCuNlE3PjZizszN Mny1V2FPT0WU
CCF-STTG1 M3zVOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1T0NGlEPTB;MD6yNlQ4PSEQvF2= NWDSTGYzW0GQR1XS
D-392MG NYPtZZJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe1[3RiUUN3ME2wMlI{OTd5IN88US=> M4nKWnNCVkeHUh?=
RT-112 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjCPXhKSzVyPUCuNlM4QTVizszN MnS2V2FPT0WU
MES-SA NUD3NoxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMkSxPFch|ryP MWLTRW5ITVJ?
LC-2-ad NFzGSnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfuXFFVUUN3ME2wMlI1OjZ3IN88US=> MmTpV2FPT0WU
NOS-1 NHvJSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTje4pMUUN3ME2wMlI1OzZ5IN88US=> NHnjZndUSU6JRWK=
NALM-6 Moq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnOU4lKSzVyPUCuNlU2PDNizszN M3y5cHNCVkeHUh?=
TE-15 M4XIUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv0bopUUUN3ME2wMlI3ODlzIN88US=> NET0dlFUSU6JRWK=
786-0 NIS0[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[zXG5KSzVyPUCuNlYzOjhizszN NGDYPYdUSU6JRWK=
IST-MES1 MmL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDMTWM2OD1yLkK2PFI6KM7:TR?= NXzke5dRW0GQR1XS
KYSE-180 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfpTWM2OD1yLkK2PFkyKM7:TR?= MX;TRW5ITVJ?
YT Ml[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{WyXWlEPTB;MD6yOlk4PCEQvF2= NFjsT3ZUSU6JRWK=
A427 M1\rWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPWTWM2OD1yLkK3NlY1KM7:TR?= NETn[45USU6JRWK=
KYSE-450 MlvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzYd|ZKSzVyPUCuNlc{OjlizszN NHXkcI1USU6JRWK=
HuH-7 NF\KdlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK2S5dKSzVyPUCuNlc4PjNizszN M4CxS3NCVkeHUh?=
CAS-1 M4nufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfsTpNKSzVyPUCuNlg{ODNizszN NXHjfo9tW0GQR1XS
KURAMOCHI MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMki0NVkh|ryP NGTpV4NUSU6JRWK=
ACHN M17VXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMkmzNlMh|ryP MkDCV2FPT0WU
HGC-27 NUnMSYdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P2XmlEPTB;MD6yPVM2OyEQvF2= MoXjV2FPT0WU
A172 M4fXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEW5PINKSzVyPUCuNlk2PzdizszN MUHTRW5ITVJ?
SNU-449 NUPCT5JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH1TWM2OD1yLkK5PVY1KM7:TR?= M4\Jb3NCVkeHUh?=
SW982 NX3LfGY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMkm5O|gh|ryP NFTQ[VZUSU6JRWK=
EFO-21 NXf0ZYtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIn3XndKSzVyPUCuN|A1OTFizszN MWHTRW5ITVJ?
NCI-H2030 M{fBbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwM{GxOlQh|ryP MUHTRW5ITVJ?
HT-144 NETtN5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fZOGlEPTB;MD6zNVI5KM7:TR?= NF7PSnJUSU6JRWK=
MFE-280 NXzMWXNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rudWlEPTB;MD6zNVQ2OyEQvF2= MlfDV2FPT0WU
SK-LU-1 M{LGeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fIZmlEPTB;MD6zNVQ3PiEQvF2= NV;OUJlQW0GQR1XS
NCI-H2052 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDUNWhKSzVyPUCuN|E1QDRizszN Mny3V2FPT0WU
SK-HEP-1 MmPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorkTWM2OD1yLkOzN|Y5KM7:TR?= MVrTRW5ITVJ?
QIMR-WIL M1P2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwM{O0NlQh|ryP MYfTRW5ITVJ?
A2780 Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkniTWM2OD1yLkO0N|A1KM7:TR?= MkThV2FPT0WU
ACN M3zSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPXR5dvUUN3ME2wMlM1QDd|IN88US=> NFT2TlBUSU6JRWK=
BxPC-3 NF:1cm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTpTWM2OD1yLkO0PVg6KM7:TR?= NYO3eG81W0GQR1XS
BCPAP NFL6dmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rFOmlEPTB;MD6zOlAxOSEQvF2= MVLTRW5ITVJ?
HOP-62 M4PRNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwM{[xNFYh|ryP MUXTRW5ITVJ?
SW1710 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwM{[0OVUh|ryP NWf1N5p4W0GQR1XS
OPM-2 NGHCfZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHQTWM2OD1yLkO2OFc{KM7:TR?= MoTIV2FPT0WU
DBTRG-05MG NHXEVI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjmTWM2OD1yLkO4NFU1KM7:TR?= Mnn2V2FPT0WU
SK-MEL-24 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iyT2lEPTB;MD6zPVc6OSEQvF2= MojBV2FPT0WU
8305C M2\SbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml35TWM2OD1yLkO5O|k{KM7:TR?= NInFbGtUSU6JRWK=
OVCAR-4 NXX4UpNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moj4TWM2OD1yLkSxOVg3KM7:TR?= MkHBV2FPT0WU
HLE M1;GPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnUZoFKSzVyPUCuOFE5PiEQvF2= NX;6VpFCW0GQR1XS
NCI-H747 M1\3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXGbXlzUUN3ME2wMlQzOTN5IN88US=> NUfOeZdZW0GQR1XS
SW780 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHaTWM2OD1yLkSyN|Q3KM7:TR?= MVHTRW5ITVJ?
KYSE-150 NHXHcmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq5THQ{UUN3ME2wMlQzPDF3IN88US=> NFvJUHpUSU6JRWK=
H4 NV7zSo45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzqWm9KSzVyPUCuOFI1PTFizszN MXLTRW5ITVJ?
SW1088 NYDLT4dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPXS|VKSzVyPUCuOFQ{QSEQvF2= M{DvTnNCVkeHUh?=
SF268 NXm4OYFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPOZ5FKSzVyPUCuOFQ5PiEQvF2= NG\mSVVUSU6JRWK=
RT4 MnPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDCUXBKSzVyPUCuOFUyOTFizszN NVXYV2d2W0GQR1XS
NCI-H522 NWDjdo9OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwNEWyO{DPxE1? NX3Pe5dIW0GQR1XS
LCLC-97TM1 M3;Nbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TlXGlEPTB;MD60OlE6PSEQvF2= MUPTRW5ITVJ?
CAL-39 MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDGTWM2OD1yLkS2OVE6KM7:TR?= NH3tfWdUSU6JRWK=
CAL-120 NX;XcIhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn5doRKSzVyPUCuOFc3PDNizszN M{PMb3NCVkeHUh?=
ESS-1 NVPvWXRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlT2TWM2OD1yLkS3PFIyKM7:TR?= MUfTRW5ITVJ?
KARPAS-45 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLRTWM2OD1yLkS4PVM{KM7:TR?= NFzjbmlUSU6JRWK=
DU-4475 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HBXWlEPTB;MD60PVUyOSEQvF2= MYnTRW5ITVJ?
VMRC-RCZ NWLVVGpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwNEm5NFQh|ryP MXzTRW5ITVJ?
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KNS-42 M2fjPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHIS5RKSzVyPUGuPFYzPjZizszN Mnv5V2FPT0WU
NCI-H2452 NIH1OJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTqTWM2OD1zLki5NFc1KM7:TR?= M32yO3NCVkeHUh?=
SK-MEL-2 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnyTFlwUUN3ME2xMlkxOjdzIN88US=> NUfpXG0zW0GQR1XS
OVCAR-5 NGfGXYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XpNGlEPTB;MT65NFY4PSEQvF2= NYTaO4luW0GQR1XS
SNG-M NFfIOWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nIOGlEPTB;MT65OVg2QCEQvF2= Mon5V2FPT0WU
A673 M3fNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvsTWM2OD1zLkm3OVE3KM7:TR?= MXHTRW5ITVJ?
L-428 NYf2cG1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfOc2JKSzVyPUGuPVkyPzlizszN MYnTRW5ITVJ?
KM-H2 NHvQUVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHaTWM2OD1{LkCxNFkh|ryP MnyzV2FPT0WU
MC-IXC NYXC[Gd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDKNphKSzVyPUKuNFIzPzNizszN MYHTRW5ITVJ?
COLO-678 NEnoW|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH5NXpKSzVyPUKuNFQzODdizszN MXrTRW5ITVJ?
MEL-JUSO MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJwMEe4OVEh|ryP NXHVOWg6W0GQR1XS
HCC38 Mlv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzoTWM2OD1{LkC4OFM{KM7:TR?= NXT5OlZSW0GQR1XS
UACC-62 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPqWWtoUUN3ME2yMlA5QDV3IN88US=> NHPTelVUSU6JRWK=
OAW-42 NFqwN2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHFUYV{UUN3ME2yMlA6PzFzIN88US=> NV2z[WhoW0GQR1XS
LB996-RCC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{e0WWlEPTB;Mj6xN|gyPyEQvF2= NIXz[XJUSU6JRWK=
COR-L105 M13Jd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJwMU[zO|Mh|ryP MX\TRW5ITVJ?
RCC10RGB MmLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJwMUi1O|Yh|ryP M3r6eHNCVkeHUh?=
A431 NF3ZNmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnTcpoxUUN3ME2yMlE6ODF7IN88US=> Mmn2V2FPT0WU
NCI-H292 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXx[I5KSzVyPUKuNlM6PTFizszN NFHsWVhUSU6JRWK=
SK-UT-1 M3jGSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e4b2lEPTB;Mj6zN|E5PCEQvF2= MWXTRW5ITVJ?
PANC-08-13 NXu2[oV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPMe3FKSzVyPUKuN|MzOzVizszN Mmm3V2FPT0WU
ST486 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHOxXppKSzVyPUKuOFExPDhizszN MYrTRW5ITVJ?
SJSA-1 NGPXWoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1SybGlEPTB;Mj60NVI4OSEQvF2= NXTHdHQ4W0GQR1XS
RKO NU\RZnVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W0[mlEPTB;Mj60NlAzQSEQvF2= MnPZV2FPT0WU
NCI-H1793 NH3UbFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJwNESwNlkh|ryP NFHxTJdUSU6JRWK=
639-V MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrVRpNVUUN3ME2yMlQ2Ozh{IN88US=> MoTvV2FPT0WU
ES3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH22fllKSzVyPUKuOFk4OzdizszN NF\SOpFUSU6JRWK=
NCI-H1792 NXvUcG1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrNfJpKSzVyPUKuOVY5OjZizszN M3TTenNCVkeHUh?=
NCI-H1651 NEPlb3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJwNUiyNUDPxE1? NYrNeIoxW0GQR1XS
SN12C MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP0TWM2OD1{LkW4OFg4KM7:TR?= NFH2VXNUSU6JRWK=
COLO-679 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfOdZpUUUN3ME2yMlU5PjB3IN88US=> M1rDNXNCVkeHUh?=
U-118-MG NUjaO3huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13BSmlEPTB;Mj61PFg4OiEQvF2= MlO2V2FPT0WU
Ramos-2G6-4C10 NWTFflh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvhZ4s2UUN3ME2yMlY1QDB5IN88US=> M1vV[nNCVkeHUh?=
HCT-15 M3;EOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJwNki3PVIh|ryP M{nwe3NCVkeHUh?=
MDA-MB-157 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\3SlhKSzVyPUKuO|A4PDdizszN M1rNVHNCVkeHUh?=
K5 M1GxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\LW5RKSzVyPUKuO|E5PDVizszN NHv6TFJUSU6JRWK=
MKN45 MoDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLqTWM2OD1{LkezN|Y3KM7:TR?= NVuycXZVW0GQR1XS
DMS-273 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PpWGlEPTB;Mj63OVY{OiEQvF2= MV7TRW5ITVJ?
C8166 NVXVNXRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjZSXdKSzVyPUKuO|g2OTNizszN NXPyNlVTW0GQR1XS
Calu-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTKTWM2OD1{Lke4PVY6KM7:TR?= MnHkV2FPT0WU
SNB75 M2m4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK0TWM2OD1{Lki4OVM2KM7:TR?= M{TOcHNCVkeHUh?=
BFTC-905 NVToTIFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHyTWM2OD1{LkmwNVkyKM7:TR?= M2rrPXNCVkeHUh?=
C-4-II NGLWXIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPqUYFKSzVyPUKuPVE{PTNizszN NWjlSYlOW0GQR1XS
MS-1 M{nGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJwOU[3Olkh|ryP MVnTRW5ITVJ?
A375 NYDiUFlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jOfGlEPTB;Mz6wPFE5PCEQvF2= NUnJPWhZW0GQR1XS
KYSE-70 NFrBOVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWniRnN6UUN3ME2zMlA5QDh{IN88US=> NVzRfHpnW0GQR1XS
KYSE-510 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFm5PXFKSzVyPUOuNVA6QTVizszN NYnVXIhpW0GQR1XS
LN-405 NIrQOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTNwMUO1NVgh|ryP NF3wO5ZUSU6JRWK=
BOKU MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\MNHBKSzVyPUOuNVQzPTZizszN NETLV2lUSU6JRWK=
TE-10 MlTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfsZm1KSzVyPUOuNVc{PjJizszN NHHzfG1USU6JRWK=
MKN1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\kbYdyUUN3ME2zMlE5PDh|IN88US=> MYfTRW5ITVJ?
M059J MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTNwMkCxO|Mh|ryP Ml;0V2FPT0WU
GOTO NVTlTnp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXUTWM2OD1|LkKyNFM6KM7:TR?= MkXZV2FPT0WU
DK-MG M17INmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTNwMkW5O|Yh|ryP NFjGUI9USU6JRWK=
NCI-H727 M4XKb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTHTWM2OD1|LkK2OVgh|ryP MVrTRW5ITVJ?
NB12 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrZPYNIUUN3ME2zMlM{OjJ2IN88US=> MUXTRW5ITVJ?
DOK NUi0W2lYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTNwM{[xPFYh|ryP NEH4elRUSU6JRWK=
KYSE-410 NGHVV5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTNwM{[yPFch|ryP Mo\lV2FPT0WU
AM-38 M4T0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jJTGlEPTB;Mz6zPFA2OSEQvF2= MkT3V2FPT0WU
GR-ST M{nnTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HWdmlEPTB;Mz60OVc{OiEQvF2= M4fvWHNCVkeHUh?=
D-247MG Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH2TWM2OD1|LkS4NlY{KM7:TR?= MkS1V2FPT0WU
TE-8 NWLwZnVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTNwNEmzN|Mh|ryP MmCzV2FPT0WU
LS-411N NGXPWWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHJWmhKSzVyPUOuOFk3QTJizszN Mm\oV2FPT0WU
SK-MES-1 NI\1XVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjrTWM2OD1|LkW2OFM{KM7:TR?= MoHPV2FPT0WU
SF295 M4XZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;nTWM2OD1|Lk[xOVUzKM7:TR?= NHGzdWtUSU6JRWK=
SK-MEL-30 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L6RmlEPTB;Mz62OVkzOSEQvF2= NWTvVm9QW0GQR1XS
LB2241-RCC MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe3Z4FKSzVyPUOuOlYzPiEQvF2= M1jNfnNCVkeHUh?=
PC-14 M4\lcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDYTWM2OD1|Lk[2OFM4KM7:TR?= MXfTRW5ITVJ?
EW-7 MoXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG3VmNKSzVyPUOuOlc3QTNizszN NUPBWJJ4W0GQR1XS
NMC-G1 MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUC4SJdpUUN3ME2zMlcyQDN5IN88US=> M3zxXnNCVkeHUh?=
TE-441-T M33aOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHBXJd{UUN3ME2zMlc{ODJ6IN88US=> NWq3XmdmW0GQR1XS
NCI-H1618 NH\ySpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYiyUJpWUUN3ME2zMlgyQDd3IN88US=> MlmzV2FPT0WU
PANC-03-27 NF\hc2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzRTWM2OD1|LkixPVE3KM7:TR?= NIjPUXdUSU6JRWK=
NCI-H2228 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTNwOEOxNlYh|ryP MmHiV2FPT0WU
CAPAN-1 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTNwOEewNFkh|ryP NFPqW4ZUSU6JRWK=
KLE M3nhWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLGTWM2OD1|LkmwOlch|ryP Mlf0V2FPT0WU
Becker NYnJbpVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH0TWM2OD1|LkmyPFQ6KM7:TR?= NHjpTJhUSU6JRWK=
SK-PN-DW MmTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfUTWM2OD12LkC3PVc1KM7:TR?= MX7TRW5ITVJ?
Hs-578-T M3rkT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PlR2lEPTB;ND6wPFMxPiEQvF2= Ml7WV2FPT0WU
RS4-11 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVixXZlsUUN3ME20MlEyOjV3IN88US=> MX3TRW5ITVJ?
D-502MG MortS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTRwMU[5PVch|ryP MVjTRW5ITVJ?
GI-1 NH62NlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nTZ2lEPTB;ND6yPFI6QSEQvF2= MnvuV2FPT0WU
NCI-H209 MkDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlu5TWM2OD12LkOzO|gh|ryP NGrO[2JUSU6JRWK=
SK-OV-3 NVmybHVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILSXHNKSzVyPUSuOFgyPDlizszN MlLyV2FPT0WU
LOUCY M4ewPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzTPJZKSzVyPUSuOFg1OzJizszN MUHTRW5ITVJ?
NCI-H69 NWTzbHZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTEVVNKSzVyPUSuOVE4QTNizszN M{XHV3NCVkeHUh?=
SCC-9 NUXxZph5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;zN2lEPTB;ND61N|E4OiEQvF2= MWrTRW5ITVJ?
NCI-H526 NHrXWpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPaPGYzUUN3ME20MlU6Ojl|IN88US=> MluxV2FPT0WU
NCI-H2170 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGL2b3NKSzVyPUSuOlY4PzFizszN MX3TRW5ITVJ?
SR NYfQd|lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXuVVZ1UUN3ME20MlcxODR6IN88US=> NFvEeoNUSU6JRWK=
CMK NGLtbI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXiTWM2OD12LkeyNVAyKM7:TR?= NEW5TXdUSU6JRWK=
COLO-829 NVzjOXVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\ITWM2OD12Lke3NFQ{KM7:TR?= M2Dt[nNCVkeHUh?=
HuO-3N1 M4TJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTRwOEOyPFEh|ryP MVTTRW5ITVJ?
5637 M4LQSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;SU|BKSzVyPUSuPVA1QDdizszN NXTDV4xyW0GQR1XS
A253 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W0dWlEPTB;ND65O|cxQCEQvF2= NF7WR2pUSU6JRWK=
NB10 MnTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTMVGZKSzVyPUWuNFc1QTdizszN NYrEUlZyW0GQR1XS
SF539 NUjGdo1ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTVwMEm5OVkh|ryP NXTSc5ZzW0GQR1XS
HAL-01 M{XWZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfPbGNTUUN3ME21MlE1PjR3IN88US=> NWDDZZVMW0GQR1XS
MHH-ES-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XTTWlEPTB;NT6xOlkzPSEQvF2= M1T6VnNCVkeHUh?=
DEL NInsNnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP2TWM2OD13LkK3OVgzKM7:TR?= NWTE[lNuW0GQR1XS
NCI-H1299 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jY[2lEPTB;NT6zOVAxPyEQvF2= NGjBcXBUSU6JRWK=
ChaGo-K-1 M1njcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTVwM{WxNFch|ryP MVvTRW5ITVJ?
HMV-II MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTVwM{m0N{DPxE1? MofmV2FPT0WU
NB69 NVTqOo4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTaRZJ7UUN3ME21MlM6PjNzIN88US=> NFnHeW5USU6JRWK=
NCI-H1882 MmDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrEXo9KSzVyPUWuOFM{PjRizszN MYHTRW5ITVJ?
SNU-475 NVXCSFF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13Cd2lEPTB;NT60O|E4OSEQvF2= M3nCbXNCVkeHUh?=
RXF393 M3X2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTVwNEi0PVQh|ryP NI\FeIRUSU6JRWK=
CAL-51 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PMVmlEPTB;NT62Nlg2OyEQvF2= MWfTRW5ITVJ?
SW1573 Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnRWmdPUUN3ME21MlY{PTN2IN88US=> M4noTHNCVkeHUh?=
GCT Mn\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH0TWM2OD13Lke1PVI6KM7:TR?= MoPMV2FPT0WU
COR-L88 MkjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3kTWM2OD13Lke2PFQ3KM7:TR?= Ml;HV2FPT0WU
MDA-MB-134-VI NWHtUoJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvJXZJKSzVyPUWuPFc2OzZizszN Mor4V2FPT0WU
NB5 M4\PXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLoS|hKSzVyPUWuPVI1PCEQvF2= NFfoS2FUSU6JRWK=
GMS-10 NGW1U|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW4TWM2OD13Lkm2PFYyKM7:TR?= NG[2eWZUSU6JRWK=
CHP-212 M3Tmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnXTWM2OD14LkS4NlY4KM7:TR?= NXTG[XhmW0GQR1XS
TE-11 NY\LeGdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTZwNUWxPFIh|ryP NED1N2JUSU6JRWK=
SW962 NXfBTIpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf2U2pKSzVyPU[uOlU4PzRizszN NUezOnZTW0GQR1XS
MZ2-MEL NXG1bXZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTZwOEKwNVEh|ryP M1LocHNCVkeHUh?=
C-33-A MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTZwOUG2PFgh|ryP Mo\pV2FPT0WU
IGR-1 M175WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;FcZFZUUN3ME22Mlk4QDJ4IN88US=> NV;YPZF3W0GQR1XS
MOLT-4 NInLd2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHRNYRGUUN3ME23MlE2PDB4IN88US=> MVTTRW5ITVJ?
NCI-H1650 NFjONVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nLfmlEPTB;Nz6yO|A1PiEQvF2= MnXSV2FPT0WU
AsPC-1 M3y0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHyNFNKSzVyPUeuNlg3ODVizszN MXXTRW5ITVJ?
SNU-C2B NFK2VGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTdwMkm1O|Eh|ryP M{XYWHNCVkeHUh?=
MKN7 NG\PfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTdwM{eyN|Uh|ryP NFnoO2tUSU6JRWK=
SW620 NUj3SnF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrU[2xuUUN3ME23MlM5OjB3IN88US=> M4P0T3NCVkeHUh?=
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COLO-792 NYXpXYR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XC[mlEPTB;MkKuO|EyOSEQvF2= Mn;nV2FPT0WU
CAL-62 NFfyOHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJ{Lke1NVch|ryP MYTTRW5ITVJ?
HCE-T Mk\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PsO2lEPTB;MkKuPFYxPiEQvF2= MkK3V2FPT0WU
BB65-RCC NUPKUG97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn6yTWM2OD1{Mz6wN|Q1KM7:TR?= NH[0UnFUSU6JRWK=
SiHa MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTQUpZKSzVyPUKzMlM6PjhizszN NXLPNJZWW0GQR1XS
NCI-H2081 M3HvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O0NGlEPTB;MkSuNFY1OSEQvF2= M4O2W3NCVkeHUh?=
U251 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHkTIZKSzVyPUK0MlA3PjhizszN NHuySohUSU6JRWK=
LoVo NF3QUVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrve|FKSzVyPUK0MlkzQDJizszN MUfTRW5ITVJ?
GCIY M2TkO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJ3LkK4O|ch|ryP NUTpRZlNW0GQR1XS
NUGC-3 MlO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTJ3LkOzNVYh|ryP NESzSGJUSU6JRWK=
LNCaP-Clone-FGC NVTj[5p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJ3LkO0PVgh|ryP M1TUbXNCVkeHUh?=
PA-1 M1vMNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInpOndKSzVyPUK1MlY5OzNizszN M13KcHNCVkeHUh?=
OE33 NE[0d2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[zR4I2UUN3ME2yOU43QDV|IN88US=> Mn7GV2FPT0WU
HT-29 M2C5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ3Lke4O|kh|ryP MoTtV2FPT0WU
RCM-1 MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJ3Lkm2OVYh|ryP MXrTRW5ITVJ?
NCI-H1522 NVfuO3BZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrBOoF4UUN3ME2yOU46QTFzIN88US=> MVLTRW5ITVJ?
LB373-MEL-D M{npc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfLdYlVUUN3ME2yOk4yPzB6IN88US=> MojOV2FPT0WU
NCI-H1436 MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3izUmlEPTB;Mk[uNlc{QCEQvF2= NF3wfWtUSU6JRWK=
COLO-824 NVn1fFFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrBdnRKSzVyPUK2MlQxODJizszN MUPTRW5ITVJ?
CP50-MEL-B MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofqTWM2OD1{Nj61Olc2KM7:TR?= M4r6ZXNCVkeHUh?=
EGI-1 M1;k[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDROFdjUUN3ME2yO{4zPjl6IN88US=> MlHaV2FPT0WU
LAN-6 Mn;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJ5LkO1PVgh|ryP NF3CdVhUSU6JRWK=
GAK NUfsdIV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfQWHBKSzVyPUK3MlQzOjVizszN MWXTRW5ITVJ?
MDA-MB-175-VII MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3UNoFKSzVyPUK3MlUxPTNizszN MWPTRW5ITVJ?
JVM-2 M4HlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jte2lEPTB;MkeuOlYzOiEQvF2= MWjTRW5ITVJ?
UACC-257 NETrSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlztTWM2OD1{Nz62PFc5KM7:TR?= M365[XNCVkeHUh?=
SW1783 MkjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjSc|RKSzVyPUK3Mlc4QDNizszN M1X2THNCVkeHUh?=
HT-3 MmfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXJTWM2OD1{OD6yNVY3KM7:TR?= NWCwT5RiW0GQR1XS
RL MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;vWWlEPTB;MkiuOVkyOSEQvF2= MYTTRW5ITVJ?
TK10 NIPYTFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJ6Lk[1N|Uh|ryP Mn23V2FPT0WU
HT55 NYP4SZBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf3V5Z3UUN3ME2yPU4xPTZ3IN88US=> MXjTRW5ITVJ?
BT-20 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJ7LkC1PFYh|ryP NWLtcGJ{W0GQR1XS
TGBC24TKB MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW5bpF4UUN3ME2yPU4yQDNzIN88US=> MmHRV2FPT0WU
HSC-2 NXy0bI16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTJ7LkOwNFEh|ryP NX:z[WRCW0GQR1XS
COLO-205 NF3xO3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHMdWVKUUN3ME2yPU4{QTR2IN88US=> M1\TU3NCVkeHUh?=
GT3TKB NUf0W2NwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCwNmExUUN3ME2yPU43QDd5IN88US=> MnLiV2FPT0WU
T47D NWfre492T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJ7Lki1PFIh|ryP MnfiV2FPT0WU
OMC-1 M3nkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmG4TWM2OD1|MD6xPVE6KM7:TR?= Ml;sV2FPT0WU
PFSK-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Htc2lEPTB;M{GuNlY2QSEQvF2= MnTNV2FPT0WU
JEG-3 NGmxfGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LIXWlEPTB;M{GuN|U3OSEQvF2= M3eye3NCVkeHUh?=
RD NFmxR49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDPTWM2OD1|MT61NVE2KM7:TR?= M2WxZXNCVkeHUh?=
NCI-H64 NXmxSG5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTSTWM2OD1|Mj60NVc6KM7:TR?= NH7mUoZUSU6JRWK=
DMS-114 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTN{LkSxPFIh|ryP NUnBfY8xW0GQR1XS
NCI-H661 NHfxXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTN{Lk[1NFEh|ryP MljBV2FPT0WU
CAL-148 M4fGb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;vfnptUUN3ME2zNk43PjZ3IN88US=> NGL0UGdUSU6JRWK=
HuP-T3 NV7rcoJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPkb4NKSzVyPUOyMlk{OzhizszN Mkf5V2FPT0WU
ES4 MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoCxTWM2OD1|Mz6xO|A2KM7:TR?= MoWwV2FPT0WU
Ca9-22 NHP2UZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTN|LkS2NFEh|ryP Mn3ZV2FPT0WU
LP-1 NUfqcYE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljjTWM2OD1|ND6wPUDPxE1? Mn7nV2FPT0WU
AU565 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTN2LkWwOlkh|ryP MmfFV2FPT0WU
MDA-MB-453 NIDaOIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTN3LkG0NlYh|ryP MYDTRW5ITVJ?
SNU-C1 NEGwR2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPucZNKSzVyPUO1MlE4OSEQvF2= NXPpXXRJW0GQR1XS
SW13 MoXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PiU2lEPTB;M{WuOFA4PiEQvF2= NUC1OYlMW0GQR1XS
NCI-H2122 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTN3LkW1PVgh|ryP MkDtV2FPT0WU
NCI-H1395 NVTNbW1IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHSWYVtUUN3ME2zOU43PjlzIN88US=> NEDXOVZUSU6JRWK=
J-RT3-T3-5 NHzGOm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLvTWM2OD1|Nj6wNlk1KM7:TR?= M1;QbnNCVkeHUh?=
COR-L279 M2TCSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jmVmlEPTB;M{[uNVk5OSEQvF2= Mn3OV2FPT0WU
ATN-1 NXvxOmppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3OPXNKSzVyPUO2Mlg2OTZizszN NYH1[5Z{W0GQR1XS
HCC2998 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX5UotKSzVyPUO2Mlg2PzFizszN NYG3RpRqW0GQR1XS
UM-UC-3 NEK1Z5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjNNJpKSzVyPUO2Mlg3PzVizszN NXrse4JKW0GQR1XS
DV-90 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrxVo9WUUN3ME2zOk46ODZ5IN88US=> M2rEO3NCVkeHUh?=
ES8 M1LVdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonFTWM2OD1|Nj65N|E5KM7:TR?= NFP1SnpUSU6JRWK=
YAPC NHfzPI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrPdFJKSzVyPUO2Mlk3PTRizszN NHnJcHZUSU6JRWK=
HCC1599 NYK0eWpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfZfJdKSzVyPUO3MlE3OThizszN MljMV2FPT0WU
UMC-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTN5LkK1NFMh|ryP M2G4RXNCVkeHUh?=
THP-1 NV\adWdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVznPHBwUUN3ME2zO{4zQDZ6IN88US=> MkLKV2FPT0WU
OCUB-M NEn0V|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\zTWM2OD1|Nz6yPFkyKM7:TR?= NVjvdodRW0GQR1XS
NCI-H1693 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTN5LkOyN|Mh|ryP M4S4OnNCVkeHUh?=
NCI-H345 NYDlUWlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonTTWM2OD1|Nz6zOlI1KM7:TR?= M{LjdHNCVkeHUh?=
COLO-800 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPQXndKSzVyPUO3MlU3PyEQvF2= NHji[YNUSU6JRWK=
COLO-320-HSR Mn7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7vcpVKSzVyPUO4MlM1QTJizszN NWrGPG9SW0GQR1XS
NCI-H596 NX[3bGFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHSTWM2OD1|OD60OFg6KM7:TR?= NEHYRlFUSU6JRWK=
NCI-H187 MoDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULibmt[UUN3ME2zPE44OzR2IN88US=> MUPTRW5ITVJ?
ECC4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL2TWM2OD1|OT6wPFE1KM7:TR?= NVKxcpd5W0GQR1XS
KP-4 M3PuVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX1TYFtUUN3ME2zPU4yOjN3IN88US=> NFXWdXZUSU6JRWK=
NCI-H2227 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLlTWM2OD1|OT6zPVQ6KM7:TR?= M375[nNCVkeHUh?=
22RV1 M3LHVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknhTWM2OD1|OT64N|k5KM7:TR?= NHXYW4ZUSU6JRWK=
SAS MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\JPYxKSzVyPUSwMlA6PiEQvF2= M4P4N3NCVkeHUh?=
PANC-10-05 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUniV451UUN3ME20NE4yQDJ6IN88US=> MX\TRW5ITVJ?
MDA-MB-468 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofYTWM2OD12MD61N|Q3KM7:TR?= MmLyV2FPT0WU
RPMI-7951 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojaTWM2OD12MT6yNFc2KM7:TR?= NGDFTJZUSU6JRWK=
BB49-HNC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTRzLkKxO|kh|ryP M37FSHNCVkeHUh?=
23132-87 NFf6d2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTRzLkK3N|Ih|ryP MX7TRW5ITVJ?
HCC1569 MofmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fseWlEPTB;NEGuNlg5PSEQvF2= NY\nfYxIW0GQR1XS
CP66-MEL MlHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X2bGlEPTB;NEKuNVg5PiEQvF2= M3jaeXNCVkeHUh?=
K-562 M4D6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nhPGlEPTB;NEKuNlg2PCEQvF2= M2jUSXNCVkeHUh?=
OCI-AML2 M{mxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTR{Lki5O|Qh|ryP NHzGPHVUSU6JRWK=
SW756 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjF[lFKSzVyPUSzMlA{QDhizszN M{fHPXNCVkeHUh?=
M14 M2jxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoWzTWM2OD12Mz6zNVg6KM7:TR?= NGDqWnNUSU6JRWK=
NCI-H1623 NVrkXGVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HFVGlEPTB;NEOuOFY1KM7:TR?= NYjmWXprW0GQR1XS
KNS-81-FD NWLMclZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTR|Lke2NkDPxE1? NInIWVZUSU6JRWK=
TGBC1TKB M1nlVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r0fmlEPTB;NEOuPVA6QSEQvF2= M13iZXNCVkeHUh?=
RERF-LC-MS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXoSpRXUUN3ME20N{46OjhzIN88US=> NGL1doZUSU6JRWK=
PC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTR2LkSzOFch|ryP M1vXd3NCVkeHUh?=
HuP-T4 NH:1cldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHsTWM2OD12ND60OFc1KM7:TR?= MXfTRW5ITVJ?
NCI-H510A M1XsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4e4[WlEPTB;NESuO|A5KM7:TR?= MkHiV2FPT0WU
LB2518-MEL Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmmyTWM2OD12ND63PVM4KM7:TR?= MX\TRW5ITVJ?
TE-5 NHXxNIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3L[WpKSzVyPUS1Mlk2QDFizszN M1W5ZnNCVkeHUh?=
EW-24 NVrBeJpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTXRmxKSzVyPUS2MlE4OjNizszN NWTObIt[W0GQR1XS
LB647-SCLC NVe0N3BQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\ITWM2OD12Nj6yNVU2KM7:TR?= NV62ephmW0GQR1XS
NCI-H524 M3LoT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHDN|JyUUN3ME20Ok44OTh3IN88US=> MmLPV2FPT0WU
EW-11 MnjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG3e|hKSzVyPUS2Mlk{PzNizszN MofuV2FPT0WU
KALS-1 NHjMcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml20TWM2OD12Nz6yNFY3KM7:TR?= M{PjWnNCVkeHUh?=
BT-474 NFLxVIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH0TWM2OD12Nz60NlE3KM7:TR?= NFzySpdUSU6JRWK=
SK-N-AS MoLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLlS4tKSzVyPUS3Mlg5QCEQvF2= Mn7FV2FPT0WU
HCC2157 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2qxNGlEPTB;NEiuNFc3KM7:TR?= NXTISm5MW0GQR1XS
HCC1954 NGLzXmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzmNGF2UUN3ME20PE4yPzB2IN88US=> M2rwNnNCVkeHUh?=
FADU NWHn[oZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[1RW1nUUN3ME20PE4{ODNzIN88US=> NHzMR4pUSU6JRWK=
S-117 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXKTWM2OD12OD6zPFE2KM7:TR?= MWDTRW5ITVJ?
LS-1034 NGLyPVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq5TWM2OD12OD63NFY4KM7:TR?= NIKyVFFUSU6JRWK=
CAMA-1 NF;CRW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj6TWM2OD12OT61OVQ{KM7:TR?= NULUe|BqW0GQR1XS
LU-134-A Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fPRWlEPTB;NEmuPFA5PSEQvF2= M1[wOXNCVkeHUh?=
NCI-H1838 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH61XFhKSzVyPUS5MlgxQDdizszN NU\uWVl7W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
+ Expand

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
+ Expand
  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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