Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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3 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnYTWM2OD1yLkCwNFAxODB|NUmg{txO MnvSV2FPT0WU
MV-4-11 MoXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[0V3hvUUN3ME2wMlAxODB7NU[g{txO Ml;XV2FPT0WU
MEG-01 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrsTWM2OD1yLkCwNFEzQCEQvF2= MVLTRW5ITVJ?
LAMA-84 NYXMeYV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMECwNVY2KM7:TR?= NHK1bHZUSU6JRWK=
CGTH-W-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnFTWM2OD1yLkCwNVY6KM7:TR?= MVTTRW5ITVJ?
KASUMI-1 NVmyeVh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{flSmlEPTB;MD6wNFIyPyEQvF2= M{HTfHNCVkeHUh?=
BE-13 M3HSfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMECyOVkh|ryP MXXTRW5ITVJ?
CTV-1 NHO5VHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn36TWM2OD1yLkCwOVIyKM7:TR?= NVflZ|JlW0GQR1XS
NKM-1 NWn6Z5JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnj6TWM2OD1yLkCwOlU2KM7:TR?= MUXTRW5ITVJ?
MONO-MAC-6 NEG4WHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEC4N|ch|ryP M2HIb3NCVkeHUh?=
A204 MlfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v5OGlEPTB;MD6wNVIyQCEQvF2= MYfTRW5ITVJ?
GDM-1 MmTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMEG4N|Mh|ryP M3rLU3NCVkeHUh?=
AN3-CA MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjVTWM2OD1yLkCxPFc{KM7:TR?= M4TRcHNCVkeHUh?=
BL-70 NFvWSGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjpU5JKSzVyPUCuNFIyQTlizszN M3fKe3NCVkeHUh?=
Daudi NX;WR5J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7DdlJKSzVyPUCuNFI2OzdizszN MWrTRW5ITVJ?
KU812 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDlZllKSzVyPUCuNFI5PDhizszN MXrTRW5ITVJ?
KG-1 M1;IbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MluzTWM2OD1yLkCzNlk1KM7:TR?= MXjTRW5ITVJ?
DOHH-2 MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTwTWM2OD1yLkC0PFA{KM7:TR?= MorzV2FPT0WU
HuO9 NVrGWHR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XBZmlEPTB;MD6wOVQ1QCEQvF2= MoXsV2FPT0WU
EB2 NHTVVFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zZdWlEPTB;MD6wOVU4PiEQvF2= NFmy[mtUSU6JRWK=
G-402 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfN[VNKSzVyPUCuNFY{PDFizszN NXHBfJN6W0GQR1XS
SU-DHL-1 NWnvVHdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\hS4p7UUN3ME2wMlA3Ozd7IN88US=> MWHTRW5ITVJ?
NCI-H719 NVfReVlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMEe4PFgh|ryP NVP2dXRsW0GQR1XS
MLMA M1fEOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;lN2lEPTB;MD6wPVA3KM7:TR?= NHrXcJVUSU6JRWK=
KM12 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;RU3FKSzVyPUCuNFk4OzdizszN MoPtV2FPT0WU
SUP-T1 NUK1b3Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEm5PFIh|ryP M1HRXnNCVkeHUh?=
MZ1-PC M2XJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMUGzN|Yh|ryP MlrPV2FPT0WU
MFE-296 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrkS3BKSzVyPUCuNVE5OzlizszN MkD1V2FPT0WU
ALL-PO NIfPTJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf6TWM2OD1yLkGyOFQ{KM7:TR?= NYXLTYNPW0GQR1XS
GB-1 NGP1ZYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPrTWM2OD1yLkGyOVEzKM7:TR?= M{Hse3NCVkeHUh?=
SIG-M5 NH:xUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu1WnlKSzVyPUCuNVM{PyEQvF2= M3\EUXNCVkeHUh?=
P30-OHK MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfKVmxkUUN3ME2wMlE2Pjd{IN88US=> Ml3ZV2FPT0WU
NCI-H716 NE\NTnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfNTWM2OD1yLkG2NlY3KM7:TR?= M{fzdnNCVkeHUh?=
MPP-89 M1fVOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TlcmlEPTB;MD6xOlk{OyEQvF2= NXi1WnM2W0GQR1XS
SF126 MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWO0[201UUN3ME2wMlE4ODZ|IN88US=> NETLO5NUSU6JRWK=
CTB-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7mcItlUUN3ME2wMlE4OzF4IN88US=> MWnTRW5ITVJ?
CA46 Ml\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XLc2lEPTB;MD6xO|Q5QSEQvF2= NYfRT2dsW0GQR1XS
NCI-H520 Mkf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnMTWM2OD1yLkG3O|MzKM7:TR?= MXnTRW5ITVJ?
CAL-85-1 MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi0UIM1UUN3ME2wMlE4QTJ5IN88US=> NIq2NJVUSU6JRWK=
NCI-H2342 M4PZPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMUi1O|ch|ryP NFuxbJlUSU6JRWK=
697 Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTnenR4UUN3ME2wMlE5QDdzIN88US=> NIPmeVlUSU6JRWK=
NY NXfzR3l{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjNOGZKSzVyPUCuNVkzQDdizszN NY\hOmJvW0GQR1XS
T98G NYXacWc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHy[ZFKSzVyPUCuNVk{OThizszN NEjYRWlUSU6JRWK=
NCI-H1703 NF;OWnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMUm2NVUh|ryP NYr3XG1kW0GQR1XS
NCI-H2087 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:4fmlEPTB;MD6yNFQ{QSEQvF2= NIDKdXBUSU6JRWK=
PF-382 Mlm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT3Wmg3UUN3ME2wMlIxQDd|IN88US=> NIjmNXpUSU6JRWK=
HCT-116 MlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37uUmlEPTB;MD6yNVA3QSEQvF2= MlG2V2FPT0WU
CAKI-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMkG2OlYh|ryP NV3ncoNFW0GQR1XS
CCF-STTG1 Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13HcWlEPTB;MD6yNlQ4PSEQvF2= M3y0WXNCVkeHUh?=
D-392MG NHHRZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\3O|RCUUN3ME2wMlI{OTd5IN88US=> MkXGV2FPT0WU
RT-112 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\FOppUUUN3ME2wMlI{Pzl3IN88US=> MYHTRW5ITVJ?
MES-SA NH7XenJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIe2eJRKSzVyPUCuNlQyQDdizszN MlTmV2FPT0WU
LC-2-ad MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rBOGlEPTB;MD6yOFI3PSEQvF2= MU\TRW5ITVJ?
NOS-1 MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIO4[pJKSzVyPUCuNlQ{PjdizszN M2rhVnNCVkeHUh?=
NALM-6 M3;aOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XqTmlEPTB;MD6yOVU1OyEQvF2= NWTTbpJpW0GQR1XS
TE-15 M3zq[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHSO|dKSzVyPUCuNlYxQTFizszN NGWwbplUSU6JRWK=
786-0 MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLhd4hKSzVyPUCuNlYzOjhizszN MYnTRW5ITVJ?
IST-MES1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP4OlJKSzVyPUCuNlY5OjlizszN M2LMe3NCVkeHUh?=
KYSE-180 Mo\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G3fGlEPTB;MD6yOlg6OSEQvF2= NXfnO41DW0GQR1XS
YT M3HPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;ZRWlEPTB;MD6yOlk4PCEQvF2= NHSwdmZUSU6JRWK=
A427 M3rCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMkeyOlQh|ryP NIe5c29USU6JRWK=
KYSE-450 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPKTWM2OD1yLkK3N|I6KM7:TR?= MoPlV2FPT0WU
HuH-7 MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;yeGdxUUN3ME2wMlI4PzZ|IN88US=> MV7TRW5ITVJ?
CAS-1 MnLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjPTHNKSzVyPUCuNlg{ODNizszN NYDVTo5qW0GQR1XS
KURAMOCHI NV3nW4F[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LmcWlEPTB;MD6yPFQyQSEQvF2= NXTFb3g3W0GQR1XS
ACHN M2Pjc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXqwWXpHUUN3ME2wMlI6OzJ|IN88US=> M33xfHNCVkeHUh?=
HGC-27 MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnsdYg5UUN3ME2wMlI6OzV|IN88US=> NHf3T21USU6JRWK=
A172 MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMkm1O|ch|ryP MlfUV2FPT0WU
SNU-449 M2rrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnVWWtKSzVyPUCuNlk6PjRizszN MlvBV2FPT0WU
SW982 NUjSdFZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMkm5O|gh|ryP NW\0dIM3W0GQR1XS
EFO-21 M4m4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTWUHZuUUN3ME2wMlMxPDFzIN88US=> MU\TRW5ITVJ?
NCI-H2030 M4j2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnPbphKSzVyPUCuN|EyPjRizszN NGHvWINUSU6JRWK=
HT-144 M{PZXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwM{GyPEDPxE1? MVTTRW5ITVJ?
MFE-280 NVLLXYRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwM{G0OVMh|ryP MlLZV2FPT0WU
SK-LU-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\ycmlEPTB;MD6zNVQ3PiEQvF2= M4jUcnNCVkeHUh?=
NCI-H2052 NEn2W2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXZTWM2OD1yLkOxOFg1KM7:TR?= NY\2T3pMW0GQR1XS
SK-HEP-1 M2exfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfyWJBKSzVyPUCuN|M{PjhizszN MV;TRW5ITVJ?
QIMR-WIL MnX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTsTWM2OD1yLkOzOFI1KM7:TR?= M2\FT3NCVkeHUh?=
A2780 Mn7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwM{SzNFQh|ryP NVi5bopqW0GQR1XS
ACN NVvUb2F5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwM{S4O|Mh|ryP M4PWSnNCVkeHUh?=
BxPC-3 M4fwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwM{S5PFkh|ryP MUXTRW5ITVJ?
BCPAP M4qzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfZTGdoUUN3ME2wMlM3ODBzIN88US=> M{XGenNCVkeHUh?=
HOP-62 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjQ[JRKSzVyPUCuN|YyODZizszN NG\tSZBUSU6JRWK=
SW1710 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XicGlEPTB;MD6zOlQ2PSEQvF2= NX72fFU5W0GQR1XS
OPM-2 NIDs[ZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrPSGxKSzVyPUCuN|Y1PzNizszN M2Lke3NCVkeHUh?=
DBTRG-05MG MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGriNoFKSzVyPUCuN|gxPTRizszN NU\KXIpVW0GQR1XS
SK-MEL-24 NELKfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwM{m3PVEh|ryP NX3vemIzW0GQR1XS
8305C MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHX1eFhKSzVyPUCuN|k4QTNizszN MVvTRW5ITVJ?
OVCAR-4 NV\HXGVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwNEG1PFYh|ryP NGfEeYVUSU6JRWK=
HLE MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\oTI01UUN3ME2wMlQyQDZizszN MkTDV2FPT0WU
NCI-H747 M1vROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHLTWM2OD1yLkSyNVM4KM7:TR?= M3jBPXNCVkeHUh?=
SW780 M1zkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvsOG9KSzVyPUCuOFI{PDZizszN MXfTRW5ITVJ?
KYSE-150 M3PMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjXUYtKSzVyPUCuOFI1OTVizszN MmD4V2FPT0WU
H4 MkHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{S0VWlEPTB;MD60NlQ2OSEQvF2= MoC0V2FPT0WU
SW1088 NIXYV|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrwcnVSUUN3ME2wMlQ1OzlizszN MXPTRW5ITVJ?
SF268 NWrxSVhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\kTWM2OD1yLkS0PFYh|ryP NETtSFlUSU6JRWK=
RT4 NInTVGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwNEWxNVEh|ryP NIX5N3FUSU6JRWK=
NCI-H522 M1vXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwNEWyO{DPxE1? MlzjV2FPT0WU
LCLC-97TM1 NET2N49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XuRWlEPTB;MD60OlE6PSEQvF2= MV\TRW5ITVJ?
CAL-39 NHXmUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjRd2dKSzVyPUCuOFY2OTlizszN MWDTRW5ITVJ?
CAL-120 NWH4UYNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHyfW5KSzVyPUCuOFc3PDNizszN NVO5OI1GW0GQR1XS
ESS-1 NGj3foJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoiyTWM2OD1yLkS3PFIyKM7:TR?= NWXsUVhnW0GQR1XS
KARPAS-45 NFHGOHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnub5VKSzVyPUCuOFg6OzNizszN MnjmV2FPT0WU
DU-4475 M4e0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTlTWhKSzVyPUCuOFk2OTFizszN M2PhXHNCVkeHUh?=
VMRC-RCZ NFjZ[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme3TWM2OD1yLkS5PVA1KM7:TR?= NFvQZ3VUSU6JRWK=
HOS Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;wTWM2OD1yLkWwN|Y2KM7:TR?= M17qRnNCVkeHUh?=
MOLT-16 NF\GbGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzZTWM2OD1yLkWxPFA5KM7:TR?= MomwV2FPT0WU
RPMI-6666 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwNUKxN|Uh|ryP MXfTRW5ITVJ?
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NCI-H2009 NHSyUYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7NcpU6UUN3ME2xMlc6PzJzIN88US=> Mk\JV2FPT0WU
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NCI-H2452 NUj2UYZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfpTWM2OD1zLki5NFc1KM7:TR?= NIXGS|RUSU6JRWK=
SK-MEL-2 M4Lxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3kc|hKSzVyPUGuPVAzPzFizszN Mn21V2FPT0WU
OVCAR-5 NGiyXWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC3fI1KSzVyPUGuPVA3PzVizszN NUGyPG8yW0GQR1XS
SNG-M M17h[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PXcWlEPTB;MT65OVg2QCEQvF2= MWDTRW5ITVJ?
A673 NWLOO4pJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVL5RlV{UUN3ME2xMlk4PTF4IN88US=> NHf4V|ZUSU6JRWK=
L-428 NIjHemlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTFwOUmxO|kh|ryP NFXpc5BUSU6JRWK=
KM-H2 Mmf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInPb2pKSzVyPUKuNFExQSEQvF2= NGPGT4lUSU6JRWK=
MC-IXC NFruTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTJwMEKyO|Mh|ryP NFT0XWVUSU6JRWK=
COLO-678 Ml3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7B[VhOUUN3ME2yMlA1OjB5IN88US=> NW\rPIJ4W0GQR1XS
MEL-JUSO M{OyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLybWYxUUN3ME2yMlA4QDVzIN88US=> NUezZoJHW0GQR1XS
HCC38 MmXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJwMEi0N|Mh|ryP NGjO[5BUSU6JRWK=
UACC-62 NWfle4VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fyU2lEPTB;Mj6wPFg2PSEQvF2= NUPRO2t[W0GQR1XS
OAW-42 NYPjWHVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrxS|FKSzVyPUKuNFk4OTFizszN MnvpV2FPT0WU
LB996-RCC NYSwVpFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJwMUO4NVch|ryP MVvTRW5ITVJ?
COR-L105 NXPh[JRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\ZOGlEPTB;Mj6xOlM4OyEQvF2= MknLV2FPT0WU
RCC10RGB NFj3cJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rCV2lEPTB;Mj6xPFU4PiEQvF2= MUXTRW5ITVJ?
A431 NFLRWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e3OmlEPTB;Mj6xPVAyQSEQvF2= NFHTc3pUSU6JRWK=
NCI-H292 M4O3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Tjb2lEPTB;Mj6yN|k2OSEQvF2= M1\BXnNCVkeHUh?=
SK-UT-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlqxTWM2OD1{LkOzNVg1KM7:TR?= NEDHUFJUSU6JRWK=
PANC-08-13 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfmZ49KSzVyPUKuN|MzOzVizszN M4XDRnNCVkeHUh?=
ST486 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T6eGlEPTB;Mj60NVA1QCEQvF2= MX3TRW5ITVJ?
SJSA-1 NH70U5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4niOGlEPTB;Mj60NVI4OSEQvF2= Ml:zV2FPT0WU
RKO MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJwNEKwNlkh|ryP MUnTRW5ITVJ?
NCI-H1793 M3qwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTJwNESwNlkh|ryP Ml7SV2FPT0WU
639-V MorMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDnXYNKSzVyPUKuOFU{QDJizszN MUPTRW5ITVJ?
ES3 MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LuTWlEPTB;Mj60PVc{PyEQvF2= NUHhTnZRW0GQR1XS
NCI-H1792 M3ThW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrOOWhXUUN3ME2yMlU3QDJ4IN88US=> MlHqV2FPT0WU
NCI-H1651 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q5VGlEPTB;Mj61PFIyKM7:TR?= NW\Lcm9SW0GQR1XS
SN12C MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjUXHVKSzVyPUKuOVg1QDdizszN Mm\qV2FPT0WU
COLO-679 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXITWM2OD1{LkW4OlA2KM7:TR?= MWnTRW5ITVJ?
U-118-MG Mn[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJwNUi4O|Ih|ryP NEjhNWJUSU6JRWK=
Ramos-2G6-4C10 NVvFZZdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLSRZVJUUN3ME2yMlY1QDB5IN88US=> NUixSnl1W0GQR1XS
HCT-15 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfYTWM2OD1{Lk[4O|kzKM7:TR?= MkewV2FPT0WU
MDA-MB-157 NGn4TYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XOOWlEPTB;Mj63NFc1PyEQvF2= NEXsRlhUSU6JRWK=
K5 MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWj6N45XUUN3ME2yMlcyQDR3IN88US=> MWnTRW5ITVJ?
MKN45 NVrRZYdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHMW2RKSzVyPUKuO|M{PjZizszN NEfEO|FUSU6JRWK=
DMS-273 NYnLdGY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjidpg1UUN3ME2yMlc2PjN{IN88US=> NVzvVGo3W0GQR1XS
C8166 NEnMfI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPwVG9jUUN3ME2yMlc5PTF|IN88US=> NEnFWW1USU6JRWK=
Calu-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjrXJF2UUN3ME2yMlc5QTZ7IN88US=> M2[0c3NCVkeHUh?=
SNB75 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPiUGRGUUN3ME2yMlg5PTN3IN88US=> MXrTRW5ITVJ?
BFTC-905 M1HuT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nVe2lEPTB;Mj65NFE6OSEQvF2= NIj6dYxUSU6JRWK=
C-4-II M{e3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjwOFRRUUN3ME2yMlkyOzV|IN88US=> MkG4V2FPT0WU
MS-1 NUfjOolsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\QTGlEPTB;Mj65Olc3QSEQvF2= Mn3xV2FPT0WU
A375 MlvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorkTWM2OD1|LkC4NVg1KM7:TR?= NEPFWJZUSU6JRWK=
KYSE-70 NH\XZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWOyNHByUUN3ME2zMlA5QDh{IN88US=> MoTBV2FPT0WU
KYSE-510 NVfQS3NYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTNwMUC5PVUh|ryP NXL3TXNyW0GQR1XS
LN-405 NIGyWG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S4TWlEPTB;Mz6xN|UyQCEQvF2= M4T0NXNCVkeHUh?=
BOKU NUHBPVBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnoTWM2OD1|LkG0NlU3KM7:TR?= NXG1UHRrW0GQR1XS
TE-10 NYnhTINDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP0Wo5KSzVyPUOuNVc{PjJizszN NImzd5lUSU6JRWK=
MKN1 M4XVcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHtTWM2OD1|LkG4OFg{KM7:TR?= M2rtTXNCVkeHUh?=
M059J MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXruVnZZUUN3ME2zMlIxOTd|IN88US=> NHnRSIhUSU6JRWK=
GOTO NVPHXpdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LNNWlEPTB;Mz6yNlA{QSEQvF2= M{PmbnNCVkeHUh?=
DK-MG NGPVWpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT3TWM2OD1|LkK1PVc3KM7:TR?= MWDTRW5ITVJ?
NCI-H727 NYnwTm1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTNwMk[1PEDPxE1? M3jCSXNCVkeHUh?=
NB12 M3Ptemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf3[4hKSzVyPUOuN|MzOjRizszN NYG0VJB5W0GQR1XS
DOK M1LX[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHy0SnZKSzVyPUOuN|YyQDZizszN MmS0V2FPT0WU
KYSE-410 M1zZdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2S2cGlEPTB;Mz6zOlI5PyEQvF2= NEHYNWNUSU6JRWK=
AM-38 M{\hUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\FeVRDUUN3ME2zMlM5ODVzIN88US=> M3L2bHNCVkeHUh?=
GR-ST NVTUS3hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LoOWlEPTB;Mz60OVc{OiEQvF2= MmTXV2FPT0WU
D-247MG NGTXSmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\2ZmlEPTB;Mz60PFI3OyEQvF2= MUfTRW5ITVJ?
TE-8 MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnQSGpKSzVyPUOuOFk{OzNizszN MWPTRW5ITVJ?
LS-411N M2Dle2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zMRmlEPTB;Mz60PVY6OiEQvF2= NV\TfnR7W0GQR1XS
SK-MES-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELjSG1KSzVyPUOuOVY1OzNizszN NYriVFl7W0GQR1XS
SF295 M1jxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHyTWM2OD1|Lk[xOVUzKM7:TR?= MXHTRW5ITVJ?
SK-MEL-30 MkH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3K[pkyUUN3ME2zMlY2QTJzIN88US=> M{DiXnNCVkeHUh?=
LB2241-RCC NX34SmRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTNwNk[yOkDPxE1? M1XnZnNCVkeHUh?=
PC-14 NEnHZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT3TWM2OD1|Lk[2OFM4KM7:TR?= MWTTRW5ITVJ?
EW-7 M1TkWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D0Z2lEPTB;Mz62O|Y6OyEQvF2= M1i3fnNCVkeHUh?=
NMC-G1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37wcmlEPTB;Mz63NVg{PyEQvF2= MXLTRW5ITVJ?
TE-441-T M2rxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33ST2lEPTB;Mz63N|AzQCEQvF2= NH7YWlBUSU6JRWK=
NCI-H1618 NInYeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH4TWM2OD1|LkixPFc2KM7:TR?= MmfHV2FPT0WU
PANC-03-27 NEjhNmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fVOGlEPTB;Mz64NVkyPiEQvF2= MU\TRW5ITVJ?
NCI-H2228 NX:0cnRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHV[JRKSzVyPUOuPFMyOjZizszN NXLs[2w{W0GQR1XS
CAPAN-1 Ml7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfmWGczUUN3ME2zMlg4ODB7IN88US=> MXfTRW5ITVJ?
KLE MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlr1TWM2OD1|LkmwOlch|ryP MXXTRW5ITVJ?
Becker NH3tZYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfSSIhKSzVyPUOuPVI5PDlizszN MVjTRW5ITVJ?
SK-PN-DW NIG2R3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn31TWM2OD12LkC3PVc1KM7:TR?= NWP5bZVOW0GQR1XS
Hs-578-T NYi2fmJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vvfmlEPTB;ND6wPFMxPiEQvF2= MojBV2FPT0WU
RS4-11 M{TtU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjHTWM2OD12LkGxNlU2KM7:TR?= M3nXT3NCVkeHUh?=
D-502MG Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33SbGlEPTB;ND6xOlk6PyEQvF2= NFjSRZVUSU6JRWK=
GI-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPy[o8yUUN3ME20MlI5Ojl7IN88US=> M3LSdnNCVkeHUh?=
NCI-H209 M2rDSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn34TWM2OD12LkOzO|gh|ryP NUjBbpU4W0GQR1XS
SK-OV-3 NELqdIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTRwNEixOFkh|ryP MkXJV2FPT0WU
LOUCY NFLlb5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvhdXlKSzVyPUSuOFg1OzJizszN NFvNPXZUSU6JRWK=
NCI-H69 M2HySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTRd4pVUUN3ME20MlUyPzl|IN88US=> NVeyVVhQW0GQR1XS
SCC-9 MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTRwNUOxO|Ih|ryP Mn;mV2FPT0WU
NCI-H526 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P1UGlEPTB;ND61PVI6OyEQvF2= M3nNZnNCVkeHUh?=
NCI-H2170 NX;kZpVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDoPYJuUUN3ME20MlY3PzdzIN88US=> M4PZNXNCVkeHUh?=
SR M4Sy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHVWVhbUUN3ME20MlcxODR6IN88US=> M2Px[3NCVkeHUh?=
CMK M1LyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\ZeYx3UUN3ME20MlczOTBzIN88US=> NGX4dZZUSU6JRWK=
COLO-829 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTRwN{ewOFMh|ryP NUjySZF[W0GQR1XS
HuO-3N1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTRwOEOyPFEh|ryP MUnTRW5ITVJ?
5637 M4[wSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWCyUpVCUUN3ME20MlkxPDh5IN88US=> MoX6V2FPT0WU
A253 M1nwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nnXGlEPTB;ND65O|cxQCEQvF2= NWTzPFBDW0GQR1XS
NB10 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn5cJVKSzVyPUWuNFc1QTdizszN M1fPTnNCVkeHUh?=
SF539 M3KwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PFO2lEPTB;NT6wPVk2QSEQvF2= MV;TRW5ITVJ?
HAL-01 MlfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTVwMUS2OFUh|ryP MmTrV2FPT0WU
MHH-ES-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjXS|NKSzVyPUWuNVY6OjVizszN MYTTRW5ITVJ?
DEL NHjXOlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXVTWM2OD13LkK3OVgzKM7:TR?= NH3S[49USU6JRWK=
NCI-H1299 MmL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHOzdldKSzVyPUWuN|UxODdizszN MWjTRW5ITVJ?
ChaGo-K-1 M{LhUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnHT4NyUUN3ME21MlM2OTB5IN88US=> NYK4eXFrW0GQR1XS
HMV-II Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYKxb3hKUUN3ME21MlM6PDNizszN M{XsVnNCVkeHUh?=
NB69 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPOTWM2OD13LkO5OlMyKM7:TR?= NFf3WmxUSU6JRWK=
NCI-H1882 NIPWb29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HhPGlEPTB;NT60N|M3PCEQvF2= M4DsWHNCVkeHUh?=
SNU-475 NFrEUo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorJTWM2OD13LkS3NVcyKM7:TR?= MlHHV2FPT0WU
RXF393 NYS2c4EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLIN|dKSzVyPUWuOFg1QTRizszN MoTQV2FPT0WU
CAL-51 MkO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHYTWM2OD13Lk[yPFU{KM7:TR?= MlLvV2FPT0WU
SW1573 MmTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTVwNkO1N|Qh|ryP NY\jNohvW0GQR1XS
GCT M3vP[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13RemlEPTB;NT63OVkzQSEQvF2= NVLrZ3ZtW0GQR1XS
COR-L88 M4jObmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q5[2lEPTB;NT63Olg1PiEQvF2= M1S4OXNCVkeHUh?=
MDA-MB-134-VI NE\JbZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTVwOEe1N|Yh|ryP NV\RUZhQW0GQR1XS
NB5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTVwOUK0OEDPxE1? M3T5NHNCVkeHUh?=
GMS-10 M{\EPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTVwOU[4OlEh|ryP M2Gwd3NCVkeHUh?=
CHP-212 NXzBelg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTZwNEiyOlch|ryP MnfWV2FPT0WU
TE-11 NIrQOXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTZwNUWxPFIh|ryP NWrBSG9nW0GQR1XS
SW962 M3ixXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTZwNkW3O|Qh|ryP NHf3WW5USU6JRWK=
MZ2-MEL M1jsdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXxZYJDUUN3ME22MlgzODFzIN88US=> M4HHZ3NCVkeHUh?=
C-33-A NFPTd5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzublVwUUN3ME22MlkyPjh6IN88US=> M1PjbXNCVkeHUh?=
IGR-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfpNlJKSzVyPU[uPVc5OjZizszN MX\TRW5ITVJ?
MOLT-4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r3bmlEPTB;Nz6xOVQxPiEQvF2= NXPqd2JWW0GQR1XS
NCI-H1650 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG2[4xuUUN3ME23MlI4ODR4IN88US=> M{\HbXNCVkeHUh?=
AsPC-1 M2TKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\vW2s2UUN3ME23MlI5PjB3IN88US=> MoXYV2FPT0WU
SNU-C2B M4fwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;HWHc{UUN3ME23MlI6PTdzIN88US=> MmLnV2FPT0WU
MKN7 NY\kTIRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7SOJZKSzVyPUeuN|czOzVizszN NYqwTVVvW0GQR1XS
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NCI-H630 NYPUcXFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rIOGlEPTB;MkKuOVM3OyEQvF2= MWPTRW5ITVJ?
LU-165 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[yTVlKSzVyPUKyMlU2PCEQvF2= MUjTRW5ITVJ?
COLO-792 NXPxbIY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPROI5KSzVyPUKyMlcyOTFizszN MUXTRW5ITVJ?
CAL-62 MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37yZ2lEPTB;MkKuO|UyPyEQvF2= MXPTRW5ITVJ?
HCE-T MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnziTWM2OD1{Mj64OlA3KM7:TR?= NHrQSZdUSU6JRWK=
BB65-RCC NUTFeZFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v1WmlEPTB;MkOuNFM1PCEQvF2= MXLTRW5ITVJ?
SiHa MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonVTWM2OD1{Mz6zPVY5KM7:TR?= NVra[FE{W0GQR1XS
NCI-H2081 Mln4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXHbVJKSzVyPUK0MlA3PDFizszN MoK4V2FPT0WU
U251 MoPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XqZWlEPTB;MkSuNFY3QCEQvF2= MoHLV2FPT0WU
LoVo NVHjR4hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDMN2h6UUN3ME2yOE46Ojh{IN88US=> MVvTRW5ITVJ?
GCIY NH\FeG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLldphKSzVyPUK1MlI5PzdizszN MkjMV2FPT0WU
NUGC-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFyyboVKSzVyPUK1MlM{OTZizszN Mom1V2FPT0WU
LNCaP-Clone-FGC NHTQbFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\6eWYxUUN3ME2yOU4{PDl6IN88US=> MWnTRW5ITVJ?
PA-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rZSmlEPTB;MkWuOlg{OyEQvF2= MXPTRW5ITVJ?
OE33 NYLLXlJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfNVHRKSzVyPUK1MlY5PTNizszN NYfaRmtRW0GQR1XS
HT-29 NHnqOJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LpXmlEPTB;MkWuO|g4QSEQvF2= NYDEbplHW0GQR1XS
RCM-1 NHrNfGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHVTWM2OD1{NT65OlU3KM7:TR?= NFLQfm1USU6JRWK=
NCI-H1522 NEXDXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\mTWM2OD1{NT65PVEyKM7:TR?= NETFfo5USU6JRWK=
LB373-MEL-D M165cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXJVmc4UUN3ME2yOk4yPzB6IN88US=> MYjTRW5ITVJ?
NCI-H1436 M1;yVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLaTWM2OD1{Nj6yO|M5KM7:TR?= Mn3nV2FPT0WU
COLO-824 NYXDe4VIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLuTGR{UUN3ME2yOk41ODB{IN88US=> M336WHNCVkeHUh?=
CP50-MEL-B MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXXXFlKSzVyPUK2MlU3PzVizszN M3LNb3NCVkeHUh?=
EGI-1 NGXFNVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\wW2lEPTB;MkeuNlY6QCEQvF2= Mn;pV2FPT0WU
LAN-6 NVHrd4VqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJ5LkO1PVgh|ryP MWrTRW5ITVJ?
GAK MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDT[VdKSzVyPUK3MlQzOjVizszN NF7NRVBUSU6JRWK=
MDA-MB-175-VII M3zBbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fLfWlEPTB;MkeuOVA2OyEQvF2= MmHSV2FPT0WU
JVM-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnG1TWM2OD1{Nz62OlIzKM7:TR?= MnjCV2FPT0WU
UACC-257 M1X0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfJV5piUUN3ME2yO{43QDd6IN88US=> NH7aXnpUSU6JRWK=
SW1783 M1fHVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LwUWlEPTB;MkeuO|c5OyEQvF2= MYnTRW5ITVJ?
HT-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnzTWM2OD1{OD6yNVY3KM7:TR?= MofsV2FPT0WU
RL NHPCUVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z3b2lEPTB;MkiuOVkyOSEQvF2= NF;3fZZUSU6JRWK=
TK10 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJ6Lk[1N|Uh|ryP NGDFfmRUSU6JRWK=
HT55 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnlfnJKSzVyPUK5MlA2PjVizszN M3nVe3NCVkeHUh?=
BT-20 NFHldFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTJ7LkC1PFYh|ryP MX\TRW5ITVJ?
TGBC24TKB MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojYTWM2OD1{OT6xPFMyKM7:TR?= MX7TRW5ITVJ?
HSC-2 NEXLRWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHQTWM2OD1{OT6zNFAyKM7:TR?= Mkm0V2FPT0WU
COLO-205 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJ7LkO5OFQh|ryP MYHTRW5ITVJ?
GT3TKB MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jrU2lEPTB;MkmuOlg4PyEQvF2= M17rXXNCVkeHUh?=
T47D MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX32bopWUUN3ME2yPU45PTh{IN88US=> NITVPG5USU6JRWK=
OMC-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTNyLkG5NVkh|ryP M4\Jb3NCVkeHUh?=
PFSK-1 M2DhXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPwc3hKSzVyPUOxMlI3PTlizszN NFTR[I1USU6JRWK=
JEG-3 NGrkb|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv5[IdKSzVyPUOxMlM2PjFizszN NYfrT4NMW0GQR1XS
RD NFvmcGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\XdGlEPTB;M{GuOVEyPSEQvF2= MX7TRW5ITVJ?
NCI-H64 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnRSYVNUUN3ME2zNk41OTd7IN88US=> MWnTRW5ITVJ?
DMS-114 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTnTWM2OD1|Mj60NVgzKM7:TR?= Mk\lV2FPT0WU
NCI-H661 NF63WlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzaTWM2OD1|Mj62OVAyKM7:TR?= NGjCZ2dUSU6JRWK=
CAL-148 NFf6[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M363PGlEPTB;M{KuOlY3PSEQvF2= Ml3nV2FPT0WU
HuP-T3 M3\yS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DxSWlEPTB;M{KuPVM{QCEQvF2= NGmyXFdUSU6JRWK=
ES4 Mn3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13G[GlEPTB;M{OuNVcxPSEQvF2= NHe4RYFUSU6JRWK=
Ca9-22 NFryPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTN|LkS2NFEh|ryP MYnTRW5ITVJ?
LP-1 M3z5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NID6OG5KSzVyPUO0MlA6KM7:TR?= MknjV2FPT0WU
AU565 Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfFOJBKSzVyPUO0MlUxPjlizszN MVTTRW5ITVJ?
MDA-MB-453 NFXyWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTN3LkG0NlYh|ryP NHHINpdUSU6JRWK=
SNU-C1 NXH5R|BET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\1TWM2OD1|NT6xO|Eh|ryP MXLTRW5ITVJ?
SW13 MkPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XOdWlEPTB;M{WuOFA4PiEQvF2= M4PDcHNCVkeHUh?=
NCI-H2122 M4\tbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH1SmdKSzVyPUO1MlU2QThizszN NXHuUodQW0GQR1XS
NCI-H1395 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTN3Lk[2PVEh|ryP NVn5d2dwW0GQR1XS
J-RT3-T3-5 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nuZmlEPTB;M{[uNFI6PCEQvF2= NHuxNlZUSU6JRWK=
COR-L279 NXPnUXZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnYTWM2OD1|Nj6xPVgyKM7:TR?= M3XGSXNCVkeHUh?=
ATN-1 Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHSRmJ1UUN3ME2zOk45PTF4IN88US=> MmK3V2FPT0WU
HCC2998 M3z0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN4Lki1O|Eh|ryP NYXXTVVSW0GQR1XS
UM-UC-3 NYjJWGpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nLUmlEPTB;M{[uPFY4PSEQvF2= NUDqdZh[W0GQR1XS
DV-90 M1L4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTOWGpRUUN3ME2zOk46ODZ5IN88US=> NUnneZVFW0GQR1XS
ES8 M4T2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXheFR3UUN3ME2zOk46OzF6IN88US=> M1W5OHNCVkeHUh?=
YAPC NWrEeVdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTN4Lkm2OVQh|ryP NGWwWFFUSU6JRWK=
HCC1599 NHTCdnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnjR25KSzVyPUO3MlE3OThizszN NV[1c5B1W0GQR1XS
UMC-11 NVrmO4JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\XTGlEPTB;M{euNlUxOyEQvF2= NYThPVZEW0GQR1XS
THP-1 NFjvNnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX5ZnZKSzVyPUO3MlI5PjhizszN MlraV2FPT0WU
OCUB-M NXzoPGFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3mTWM2OD1|Nz6yPFkyKM7:TR?= Mn64V2FPT0WU
NCI-H1693 M1PFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTN5LkOyN|Mh|ryP MUPTRW5ITVJ?
NCI-H345 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoWyTWM2OD1|Nz6zOlI1KM7:TR?= M3SxbHNCVkeHUh?=
COLO-800 NEPxfYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PhfGlEPTB;M{euOVY4KM7:TR?= M4jWTHNCVkeHUh?=
COLO-320-HSR NWHu[optT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LxOGlEPTB;M{iuN|Q6OiEQvF2= NYDPZVNYW0GQR1XS
NCI-H596 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULQXG9qUUN3ME2zPE41PDh7IN88US=> NH;VN4tUSU6JRWK=
NCI-H187 NHzYXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1m4SGlEPTB;M{iuO|M1PCEQvF2= NWK0WXUzW0GQR1XS
ECC4 MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fEeWlEPTB;M{muNFgyPCEQvF2= MmrpV2FPT0WU
KP-4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTN7LkGyN|Uh|ryP NUT2c29lW0GQR1XS
NCI-H2227 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y4b2lEPTB;M{muN|k1QSEQvF2= M1HK[nNCVkeHUh?=
22RV1 NUTLU5J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jKOGlEPTB;M{muPFM6QCEQvF2= M1P5b3NCVkeHUh?=
SAS NIrqNnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2njb2lEPTB;NECuNFk3KM7:TR?= MnziV2FPT0WU
PANC-10-05 NWC2T3h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLvNm1XUUN3ME20NE4yQDJ6IN88US=> M1;aU3NCVkeHUh?=
MDA-MB-468 NX7ET5FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTRyLkWzOFYh|ryP M4f4cHNCVkeHUh?=
RPMI-7951 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq1fFlSUUN3ME20NU4zODd3IN88US=> M1WwcXNCVkeHUh?=
BB49-HNC MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnK[IVKSzVyPUSxMlIyPzlizszN NYfxNGdOW0GQR1XS
23132-87 M2LlVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn72TWM2OD12MT6yO|MzKM7:TR?= MVLTRW5ITVJ?
HCC1569 NWrabGZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T0UGlEPTB;NEGuNlg5PSEQvF2= M1HM[3NCVkeHUh?=
CP66-MEL M17PO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS0S4tKSzVyPUSyMlE5QDZizszN MWTTRW5ITVJ?
K-562 NVjOPFBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3xcYt{UUN3ME20Nk4zQDV2IN88US=> MXjTRW5ITVJ?
OCI-AML2 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nrZWlEPTB;NEKuPFk4PCEQvF2= M{njXnNCVkeHUh?=
SW756 M{Do[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzITWM2OD12Mz6wN|g5KM7:TR?= M3;6d3NCVkeHUh?=
M14 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHFTWM2OD12Mz6zNVg6KM7:TR?= MVvTRW5ITVJ?
NCI-H1623 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\iTWlEPTB;NEOuOFY1KM7:TR?= MoP4V2FPT0WU
KNS-81-FD NGK0UpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3Le|FKSzVyPUSzMlc3OiEQvF2= NH23WJZUSU6JRWK=
TGBC1TKB NE[zcVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYi0SJQ{UUN3ME20N{46ODl7IN88US=> NF34dGNUSU6JRWK=
RERF-LC-MS M2n2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XreWlEPTB;NEOuPVI5OSEQvF2= MXHTRW5ITVJ?
PC-3 M4HyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvTTWM2OD12ND60N|Q4KM7:TR?= MWHTRW5ITVJ?
HuP-T4 NUiydlZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7vd|FKSzVyPUS0MlQ1PzRizszN MmH2V2FPT0WU
NCI-H510A MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M170[2lEPTB;NESuO|A5KM7:TR?= NYTKV2NIW0GQR1XS
LB2518-MEL NGHmbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTR2Lke5N|ch|ryP MnzhV2FPT0WU
TE-5 NIqyXohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXESphSUUN3ME20OU46PThzIN88US=> MVLTRW5ITVJ?
EW-24 M3W1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T1RWlEPTB;NE[uNVczOyEQvF2= NIHXXG5USU6JRWK=
LB647-SCLC NIfxeHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\FTGk3UUN3ME20Ok4zOTV3IN88US=> NHzhfphUSU6JRWK=
NCI-H524 MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvMTWM2OD12Nj63NVg2KM7:TR?= M4jwZXNCVkeHUh?=
EW-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonzTWM2OD12Nj65N|c{KM7:TR?= Mkf4V2FPT0WU
KALS-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTR5LkKwOlYh|ryP MnzOV2FPT0WU
BT-474 M{fhU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zx[WlEPTB;NEeuOFIyPiEQvF2= NX3G[FJqW0GQR1XS
SK-N-AS NXj4fXJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnKTWM2OD12Nz64PFgh|ryP M1O2XnNCVkeHUh?=
HCC2157 NXv5XllQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlexTWM2OD12OD6wO|Yh|ryP M4O5OHNCVkeHUh?=
HCC1954 M2L1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVH3NGxzUUN3ME20PE4yPzB2IN88US=> M{\OXHNCVkeHUh?=
FADU NYX1cVduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHoW2JRUUN3ME20PE4{ODNzIN88US=> M{\seHNCVkeHUh?=
S-117 MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTR6LkO4NVUh|ryP NUjrZ2d{W0GQR1XS
LS-1034 MnvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFryTGpKSzVyPUS4MlcxPjdizszN Moi1V2FPT0WU
CAMA-1 M3TMfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHtTWM2OD12OT61OVQ{KM7:TR?= NIm4[Y5USU6JRWK=
LU-134-A NXP6UmpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjKSo5KSzVyPUS5MlgxQDVizszN NV3mSmdFW0GQR1XS
NCI-H1838 NWPV[5lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7Wc5FKSzVyPUS5MlgxQDdizszN NUfnUokxW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02776605 Not yet recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02398825 Not yet recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 Phase 2
NCT02779283 Recruiting Untreated Adult Acute Myeloid Leukemia OHSU Knight Cancer Institute|National Cancer Institute (NCI) December 2015 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID