Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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4 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj0TWM2OD1yLkCwNFAxODB|NUmg{txO NES1VHhUSU6JRWK=
MV-4-11 M1;USGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf0dJlZUUN3ME2wMlAxODB7NU[g{txO MV7TRW5ITVJ?
MEG-01 NXLoUnIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPDTY1KSzVyPUCuNFAxOTJ6IN88US=> MoPsV2FPT0WU
LAMA-84 M2q3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMECwNVY2KM7:TR?= NX2ySphCW0GQR1XS
CGTH-W-1 NVKydW16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P3OWlEPTB;MD6wNFE3QSEQvF2= NXq3SI17W0GQR1XS
KASUMI-1 NH7uSZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3HTWM2OD1yLkCwNlE4KM7:TR?= MYrTRW5ITVJ?
BE-13 MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fBWGlEPTB;MD6wNFI2QSEQvF2= NEDqOYlUSU6JRWK=
CTV-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXKb4ttUUN3ME2wMlAxPTJzIN88US=> M1jtcHNCVkeHUh?=
NKM-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\RTWM2OD1yLkCwOlU2KM7:TR?= NGLtTmhUSU6JRWK=
MONO-MAC-6 NXezRpFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13BdmlEPTB;MD6wNFg{PyEQvF2= M4DIbXNCVkeHUh?=
A204 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPydWlKSzVyPUCuNFEzOThizszN MVTTRW5ITVJ?
GDM-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljUTWM2OD1yLkCxPFM{KM7:TR?= MWfTRW5ITVJ?
AN3-CA MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvvR3VKSzVyPUCuNFE5PzNizszN MlvEV2FPT0WU
BL-70 NG\XW|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMEKxPVkh|ryP NIrxPGtUSU6JRWK=
Daudi NYXabXVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X3fWlEPTB;MD6wNlU{PyEQvF2= M3TzVXNCVkeHUh?=
KU812 M4GxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3BZYdKSzVyPUCuNFI5PDhizszN NFPGc4dUSU6JRWK=
KG-1 MofYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\yTWM2OD1yLkCzNlk1KM7:TR?= M4Ps[XNCVkeHUh?=
DOHH-2 NVXCeHBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHtTWM2OD1yLkC0PFA{KM7:TR?= MUHTRW5ITVJ?
HuO9 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLtTWM2OD1yLkC1OFQ5KM7:TR?= MWHTRW5ITVJ?
EB2 NVO4OIZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMEW1O|Yh|ryP MmrvV2FPT0WU
G-402 M{Dme2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfFTW9KSzVyPUCuNFY{PDFizszN M4KzZXNCVkeHUh?=
SU-DHL-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnJSmlKSzVyPUCuNFY{PzlizszN MlPYV2FPT0WU
NCI-H719 M{PETmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvmeXRzUUN3ME2wMlA4QDh6IN88US=> M1;m[nNCVkeHUh?=
MLMA NX22RnlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEmwOkDPxE1? NULEdo11W0GQR1XS
KM12 NU[xSo5vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHQTWM2OD1yLkC5O|M4KM7:TR?= M3;lO3NCVkeHUh?=
SUP-T1 MnfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4WwOWlEPTB;MD6wPVk5OiEQvF2= M1;Zd3NCVkeHUh?=
MZ1-PC NU\odHV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvVXGhmUUN3ME2wMlEyOzN4IN88US=> M{HGXXNCVkeHUh?=
MFE-296 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDiTWM2OD1yLkGxPFM6KM7:TR?= M1j3dXNCVkeHUh?=
ALL-PO MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rsXmlEPTB;MD6xNlQ1OyEQvF2= MmPGV2FPT0WU
GB-1 NWC2XnFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\qSmtKSzVyPUCuNVI2OTJizszN M1ewVnNCVkeHUh?=
SIG-M5 NY\TdoNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf1cWlwUUN3ME2wMlE{OzdizszN NUPHcGx7W0GQR1XS
P30-OHK NWi4NG9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFziXFZKSzVyPUCuNVU3PzJizszN MWTTRW5ITVJ?
NCI-H716 M2TRbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMU[yOlYh|ryP MXjTRW5ITVJ?
MPP-89 NH7YS2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPCVYRJUUN3ME2wMlE3QTN|IN88US=> NGKwfJJUSU6JRWK=
SF126 NGi4TWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3lVJMzUUN3ME2wMlE4ODZ|IN88US=> MnvwV2FPT0WU
CTB-1 M2\KNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXKWYJKSzVyPUCuNVc{OTZizszN MWHTRW5ITVJ?
CA46 M2DpPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMUe0PFkh|ryP M2jQXnNCVkeHUh?=
NCI-H520 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{H6R2lEPTB;MD6xO|c{OiEQvF2= NV[0d2Y1W0GQR1XS
CAL-85-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7QTWM2OD1yLkG3PVI4KM7:TR?= MYrTRW5ITVJ?
NCI-H2342 M1j4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMUi1O|ch|ryP M3j4PHNCVkeHUh?=
697 NVXuSGVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH1UGVGUUN3ME2wMlE5QDdzIN88US=> M1TtZXNCVkeHUh?=
NY MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTJWFNUUUN3ME2wMlE6Ojh5IN88US=> NFTjRmVUSU6JRWK=
T98G NHzPc45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\kVmlEPTB;MD6xPVMyQCEQvF2= NEC2WFRUSU6JRWK=
NCI-H1703 MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HLcWlEPTB;MD6xPVYyPSEQvF2= MVHTRW5ITVJ?
NCI-H2087 NH\lWnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHlTWM2OD1yLkKwOFM6KM7:TR?= M1\kNXNCVkeHUh?=
PF-382 NEXmU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMkC4O|Mh|ryP M1rWe3NCVkeHUh?=
HCT-116 M2ezXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\xcWlEPTB;MD6yNVA3QSEQvF2= M4LWN3NCVkeHUh?=
CAKI-1 NXvSe3NYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITRe2lKSzVyPUCuNlE3PjZizszN MYjTRW5ITVJ?
CCF-STTG1 NHTzeVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMkK0O|Uh|ryP NYXFcXU5W0GQR1XS
D-392MG MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojnTWM2OD1yLkKzNVc4KM7:TR?= NFe0U2NUSU6JRWK=
RT-112 M13tRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMkO3PVUh|ryP NEDBZ4FUSU6JRWK=
MES-SA NGjjOJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;qVnBtUUN3ME2wMlI1OTh5IN88US=> MnWxV2FPT0WU
LC-2-ad MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTxPJB7UUN3ME2wMlI1OjZ3IN88US=> NHzydlNUSU6JRWK=
NOS-1 NXLR[Io4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmCwTWM2OD1yLkK0N|Y4KM7:TR?= MkDQV2FPT0WU
NALM-6 MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMkW1OFMh|ryP M3jjbXNCVkeHUh?=
TE-15 NIfrZmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTLPWlGUUN3ME2wMlI3ODlzIN88US=> NI\TcolUSU6JRWK=
786-0 NXPifnRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;iTWM2OD1yLkK2NlI5KM7:TR?= M2fOUXNCVkeHUh?=
IST-MES1 NFjMc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXkR3NKSzVyPUCuNlY5OjlizszN NELLWVZUSU6JRWK=
KYSE-180 NEnPPW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG3TWM2OD1yLkK2PFkyKM7:TR?= M4\x[nNCVkeHUh?=
YT M1vBNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILSO4hKSzVyPUCuNlY6PzRizszN NIPMNmJUSU6JRWK=
A427 NGS5[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vwOmlEPTB;MD6yO|I3PCEQvF2= M4jlcXNCVkeHUh?=
KYSE-450 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMkezNlkh|ryP Ml\GV2FPT0WU
HuH-7 MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoS1TWM2OD1yLkK3O|Y{KM7:TR?= MVjTRW5ITVJ?
CAS-1 NWLhZlFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXsRZpKSzVyPUCuNlg{ODNizszN MmG0V2FPT0WU
KURAMOCHI NEHGNmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37aXWlEPTB;MD6yPFQyQSEQvF2= NF:0OWtUSU6JRWK=
ACHN MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjUUYlKSzVyPUCuNlk{OjNizszN MnXBV2FPT0WU
HGC-27 NIDrTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jvOWlEPTB;MD6yPVM2OyEQvF2= NIX4blFUSU6JRWK=
A172 NHvkVlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXmVIo1UUN3ME2wMlI6PTd5IN88US=> MXXTRW5ITVJ?
SNU-449 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT1eotKSzVyPUCuNlk6PjRizszN M3fjb3NCVkeHUh?=
SW982 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C0O2lEPTB;MD6yPVk4QCEQvF2= MoH4V2FPT0WU
EFO-21 M1jNXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwM{C0NVEh|ryP MVLTRW5ITVJ?
NCI-H2030 Mn\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P1[GlEPTB;MD6zNVE3PCEQvF2= MYTTRW5ITVJ?
HT-144 NIrIXlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrmenJKSzVyPUCuN|EzQCEQvF2= MmDvV2FPT0WU
MFE-280 NH[yXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TJNGlEPTB;MD6zNVQ2OyEQvF2= M2\FUXNCVkeHUh?=
SK-LU-1 M3jnXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrwWo5KSzVyPUCuN|E1PjZizszN NXfPOYo6W0GQR1XS
NCI-H2052 M2\rPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnjTWM2OD1yLkOxOFg1KM7:TR?= NGnwTldUSU6JRWK=
SK-HEP-1 MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTMOW9RUUN3ME2wMlM{OzZ6IN88US=> M33PXnNCVkeHUh?=
QIMR-WIL NFv5[lVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXhNotKSzVyPUCuN|M1OjRizszN Mlj2V2FPT0WU
A2780 Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrZTnRKSzVyPUCuN|Q{ODRizszN MYjTRW5ITVJ?
ACN MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwM{S4O|Mh|ryP NEjGWHRUSU6JRWK=
BxPC-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDyTWM2OD1yLkO0PVg6KM7:TR?= M2TMbXNCVkeHUh?=
BCPAP M1jibGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvJTWM2OD1yLkO2NFAyKM7:TR?= MkmwV2FPT0WU
HOP-62 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfvRpdKSzVyPUCuN|YyODZizszN MX3TRW5ITVJ?
SW1710 NYfmUXp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV2zd4xHUUN3ME2wMlM3PDV3IN88US=> NFXXVJVUSU6JRWK=
OPM-2 NGPNbXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwM{[0O|Mh|ryP MoixV2FPT0WU
DBTRG-05MG NHvMXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NECyWZpKSzVyPUCuN|gxPTRizszN MmrWV2FPT0WU
SK-MEL-24 M1\CTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXUZo9DUUN3ME2wMlM6PzlzIN88US=> Ml;QV2FPT0WU
8305C MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rYWmlEPTB;MD6zPVc6OyEQvF2= MmLaV2FPT0WU
OVCAR-4 NHPXfXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33GNmlEPTB;MD60NVU5PiEQvF2= NH\XToZUSU6JRWK=
HLE NVHwXmQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUO3[4lTUUN3ME2wMlQyQDZizszN M1q4OHNCVkeHUh?=
NCI-H747 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPy[mhKSzVyPUCuOFIyOzdizszN NEPZdGlUSU6JRWK=
SW780 M{PXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3sTWM2OD1yLkSyN|Q3KM7:TR?= NETreJpUSU6JRWK=
KYSE-150 M4n0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHPTWM2OD1yLkSyOFE2KM7:TR?= MnnkV2FPT0WU
H4 NH7kVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D5OGlEPTB;MD60NlQ2OSEQvF2= NILhN5NUSU6JRWK=
SW1088 NW\2RY5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULTNmtVUUN3ME2wMlQ1OzlizszN M4DSUHNCVkeHUh?=
SF268 NH[1ZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrXXIc4UUN3ME2wMlQ1QDZizszN NEX3SlhUSU6JRWK=
RT4 MmjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXOTWM2OD1yLkS1NVEyKM7:TR?= MV7TRW5ITVJ?
NCI-H522 MlvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrmbGpRUUN3ME2wMlQ2OjdizszN M1nSSnNCVkeHUh?=
LCLC-97TM1 NYf6O|h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPMNWhKSzVyPUCuOFYyQTVizszN NWfS[nIyW0GQR1XS
CAL-39 MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljQTWM2OD1yLkS2OVE6KM7:TR?= M2i3fXNCVkeHUh?=
CAL-120 MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwNEe2OFMh|ryP NUPnTIk1W0GQR1XS
ESS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TJN2lEPTB;MD60O|gzOSEQvF2= NFH6SW9USU6JRWK=
KARPAS-45 MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:2cphkUUN3ME2wMlQ5QTN|IN88US=> NH6z[HJUSU6JRWK=
DU-4475 NFvvbWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{D6Z2lEPTB;MD60PVUyOSEQvF2= NUDUdFFtW0GQR1XS
VMRC-RCZ MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfjSYtnUUN3ME2wMlQ6QTB2IN88US=> M{H6d3NCVkeHUh?=
HOS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHuyZ3ZKSzVyPUCuOVA{PjVizszN M3v4O3NCVkeHUh?=
MOLT-16 NHrnTppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwNUG4NFgh|ryP NXzPV3BiW0GQR1XS
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MHH-NB-11 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwMUWzOlgh|ryP NIDYTpVUSU6JRWK=
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NCI-H838 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV25TnN3UUN3ME2xMlMxPjF3IN88US=> MlTtV2FPT0WU
HEC-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXOTWM2OD1zLkOzO|U2KM7:TR?= M1u5PHNCVkeHUh?=
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SIMA MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlryTWM2OD1zLkS4Olg4KM7:TR?= M163bHNCVkeHUh?=
NCI-H1770 NX7hTlI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zFWWlEPTB;MT61NlA2PCEQvF2= MUPTRW5ITVJ?
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SW48 NHrW[mVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTFwNUSyOFMh|ryP MX\TRW5ITVJ?
KYSE-140 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zjRWlEPTB;MT61OVc1OSEQvF2= MoXRV2FPT0WU
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LB831-BLC MlGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTFwNkm4OVQh|ryP MV;TRW5ITVJ?
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NCI-H2009 NInNd4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDZTWM2OD1zLke5O|IyKM7:TR?= Mn;3V2FPT0WU
A498 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzDTWM2OD1zLkixNlgzKM7:TR?= NH3wPGdUSU6JRWK=
NCI-H810 MmLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjjTZNCUUN3ME2xMlgyPjB4IN88US=> NXHKZ5lZW0GQR1XS
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KNS-42 NF;oZ2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:1WGlEPTB;MT64OlI3PiEQvF2= NY\JcVFlW0GQR1XS
NCI-H2452 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfHdG1NUUN3ME2xMlg6ODd2IN88US=> NIrTUmxUSU6JRWK=
SK-MEL-2 NXGzXppOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\ETWM2OD1zLkmwNlcyKM7:TR?= M1;nNXNCVkeHUh?=
OVCAR-5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHoTWM2OD1zLkmwOlc2KM7:TR?= NX3u[ZFlW0GQR1XS
SNG-M MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLkTWM2OD1zLkm1PFU5KM7:TR?= NWXiN5VHW0GQR1XS
A673 MnfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFwOUe1NVYh|ryP MYXTRW5ITVJ?
L-428 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HTe2lEPTB;MT65PVE4QSEQvF2= MonOV2FPT0WU
KM-H2 Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fSdmlEPTB;Mj6wNVA6KM7:TR?= MWrTRW5ITVJ?
MC-IXC MlK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4P3UWlEPTB;Mj6wNlI4OyEQvF2= MYHTRW5ITVJ?
COLO-678 M4DMfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\tXWlEPTB;Mj6wOFIxPyEQvF2= M1z0VHNCVkeHUh?=
MEL-JUSO MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDxTWM2OD1{LkC3PFUyKM7:TR?= Mn3KV2FPT0WU
HCC38 MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJwMEi0N|Mh|ryP NV7weVNPW0GQR1XS
UACC-62 M33YSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGzfWNKSzVyPUKuNFg5PTVizszN MXHTRW5ITVJ?
OAW-42 Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJwMEm3NVEh|ryP MULTRW5ITVJ?
LB996-RCC MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHW0VJNKSzVyPUKuNVM5OTdizszN MnjjV2FPT0WU
COR-L105 NXKyV5VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDOdGVKSzVyPUKuNVY{PzNizszN MkDDV2FPT0WU
RCC10RGB NFyxfZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nwdmlEPTB;Mj6xPFU4PiEQvF2= MkXCV2FPT0WU
A431 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7IT4tSUUN3ME2yMlE6ODF7IN88US=> MU\TRW5ITVJ?
NCI-H292 M{HDc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLmZZVKSzVyPUKuNlM6PTFizszN Mk\tV2FPT0WU
SK-UT-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWwTWM2OD1{LkOzNVg1KM7:TR?= MWjTRW5ITVJ?
PANC-08-13 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJwM{OyN|Uh|ryP NIXid|ZUSU6JRWK=
ST486 M1TRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHz[XdLUUN3ME2yMlQyODR6IN88US=> M{nzdXNCVkeHUh?=
SJSA-1 NHm1bY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFftUFZKSzVyPUKuOFEzPzFizszN MkTuV2FPT0WU
RKO NYj6XZk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXNTmdDUUN3ME2yMlQzODJ7IN88US=> NIOxdW9USU6JRWK=
NCI-H1793 M37xV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzmTWM2OD1{LkS0NFI6KM7:TR?= NHO1XGRUSU6JRWK=
639-V NULL[2dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HRPGlEPTB;Mj60OVM5OiEQvF2= M3S5S3NCVkeHUh?=
ES3 NXnVO|BST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i1[WlEPTB;Mj60PVc{PyEQvF2= NEDFOWlUSU6JRWK=
NCI-H1792 M1XTPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrrNY9KSzVyPUKuOVY5OjZizszN MX\TRW5ITVJ?
NCI-H1651 M3XiTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36xd2lEPTB;Mj61PFIyKM7:TR?= MnHSV2FPT0WU
SN12C NHL6dXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLWXY1KSzVyPUKuOVg1QDdizszN M4fFPXNCVkeHUh?=
COLO-679 NWTNdFgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJwNUi2NFUh|ryP NYWyc3VNW0GQR1XS
U-118-MG NITzRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PId2lEPTB;Mj61PFg4OiEQvF2= MV3TRW5ITVJ?
Ramos-2G6-4C10 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXUTWM2OD1{Lk[0PFA4KM7:TR?= NInrVI9USU6JRWK=
HCT-15 MoDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfQ[YlZUUN3ME2yMlY5Pzl{IN88US=> NE\nVYpUSU6JRWK=
MDA-MB-157 MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LrXWlEPTB;Mj63NFc1PyEQvF2= MVjTRW5ITVJ?
K5 NYPKfVlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIGzXmtKSzVyPUKuO|E5PDVizszN M4jKV3NCVkeHUh?=
MKN45 M335Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;pdZVLUUN3ME2yMlc{OzZ4IN88US=> MW\TRW5ITVJ?
DMS-273 NH;wT2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX74bmxwUUN3ME2yMlc2PjN{IN88US=> M2HEU3NCVkeHUh?=
C8166 NYLGR5B2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTJwN{i1NVMh|ryP NVvGVldmW0GQR1XS
Calu-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPXTWM2OD1{Lke4PVY6KM7:TR?= MnTlV2FPT0WU
SNB75 NFX0bFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzkTWM2OD1{Lki4OVM2KM7:TR?= NIO5cnlUSU6JRWK=
BFTC-905 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfq[XVIUUN3ME2yMlkxOTlzIN88US=> MVrTRW5ITVJ?
C-4-II MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S4WmlEPTB;Mj65NVM2OyEQvF2= M2jMXXNCVkeHUh?=
MS-1 NEj6dY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m5[GlEPTB;Mj65Olc3QSEQvF2= MlXHV2FPT0WU
A375 NGLRe2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVezVXl7UUN3ME2zMlA5OTh2IN88US=> MnzpV2FPT0WU
KYSE-70 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYSzS3NNUUN3ME2zMlA5QDh{IN88US=> M4\UdnNCVkeHUh?=
KYSE-510 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDsWIhpUUN3ME2zMlExQTl3IN88US=> NUP1d|JRW0GQR1XS
LN-405 NF\MeXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nqfmlEPTB;Mz6xN|UyQCEQvF2= NU\xNIE3W0GQR1XS
BOKU MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfycI9HUUN3ME2zMlE1OjV4IN88US=> NXj2c3k2W0GQR1XS
TE-10 M1TjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Hpb2lEPTB;Mz6xO|M3OiEQvF2= NWju[2p5W0GQR1XS
MKN1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LQNWlEPTB;Mz6xPFQ5OyEQvF2= MkTRV2FPT0WU
M059J MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrtTWM2OD1|LkKwNVc{KM7:TR?= MlPWV2FPT0WU
GOTO NXrrfJFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;s[ZNKSzVyPUOuNlIxOzlizszN NIC0W5BUSU6JRWK=
DK-MG NGDZO5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTNwMkW5O|Yh|ryP NHvqTXZUSU6JRWK=
NCI-H727 M1vPN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\zTWM2OD1|LkK2OVgh|ryP M1X1cXNCVkeHUh?=
NB12 M13z[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\rbJJKSzVyPUOuN|MzOjRizszN NIHMUVZUSU6JRWK=
DOK NUG3d2dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPIPXdLUUN3ME2zMlM3OTh4IN88US=> MV7TRW5ITVJ?
KYSE-410 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XNcWlEPTB;Mz6zOlI5PyEQvF2= MW\TRW5ITVJ?
AM-38 NWLiepNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XYfWlEPTB;Mz6zPFA2OSEQvF2= NV7ae3BKW0GQR1XS
GR-ST MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTNwNEW3N|Ih|ryP MlPVV2FPT0WU
D-247MG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPxRYJSUUN3ME2zMlQ5OjZ|IN88US=> MWnTRW5ITVJ?
TE-8 NH7hOHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrNPINKSzVyPUOuOFk{OzNizszN NGXzTJJUSU6JRWK=
LS-411N MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTyXpdnUUN3ME2zMlQ6Pjl{IN88US=> MnXsV2FPT0WU
SK-MES-1 Ml;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTNwNU[0N|Mh|ryP NGS2XJNUSU6JRWK=
SF295 M{PYNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TlbGlEPTB;Mz62NVU2OiEQvF2= M2jHTHNCVkeHUh?=
SK-MEL-30 NXnNWWRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzSenpUUUN3ME2zMlY2QTJzIN88US=> M3TFdHNCVkeHUh?=
LB2241-RCC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe2RmpsUUN3ME2zMlY3OjZizszN M2ryO3NCVkeHUh?=
PC-14 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW5dWVKSzVyPUOuOlY1OzdizszN MXzTRW5ITVJ?
EW-7 Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LFPGlEPTB;Mz62O|Y6OyEQvF2= MkHCV2FPT0WU
NMC-G1 MmfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon1TWM2OD1|LkexPFM4KM7:TR?= MmC2V2FPT0WU
TE-441-T NVzYZ4VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHpXodKSzVyPUOuO|MxOjhizszN NH\0fYJUSU6JRWK=
NCI-H1618 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNwOEG4O|Uh|ryP Ml;LV2FPT0WU
PANC-03-27 Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\6[GlEPTB;Mz64NVkyPiEQvF2= MXjTRW5ITVJ?
NCI-H2228 NYfTfGRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljMTWM2OD1|LkizNVI3KM7:TR?= NETUSG1USU6JRWK=
CAPAN-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvNTWM2OD1|Lki3NFA6KM7:TR?= M3rZN3NCVkeHUh?=
KLE NITudJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33HeGlEPTB;Mz65NFY4KM7:TR?= MmDRV2FPT0WU
Becker M4PIfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrUe|BKSzVyPUOuPVI5PDlizszN MXvTRW5ITVJ?
SK-PN-DW M3PON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LYdmlEPTB;ND6wO|k4PCEQvF2= MlzVV2FPT0WU
Hs-578-T NXHreWlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHHTWM2OD12LkC4N|A3KM7:TR?= M2jhTXNCVkeHUh?=
RS4-11 NEDwN|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrwVVhKSzVyPUSuNVEzPTVizszN MknsV2FPT0WU
D-502MG M33FXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\Qem9QUUN3ME20MlE3QTl5IN88US=> NHjnfoJUSU6JRWK=
GI-1 Mon5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nmfGlEPTB;ND6yPFI6QSEQvF2= NV3hVXp[W0GQR1XS
NCI-H209 NE\wdXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLnR4dtUUN3ME20MlM{PzhizszN MU\TRW5ITVJ?
SK-OV-3 NYDEPFZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV33cHlCUUN3ME20MlQ5OTR7IN88US=> MlLDV2FPT0WU
LOUCY NF;ndoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HNTmlEPTB;ND60PFQ{OiEQvF2= NXWyS3lDW0GQR1XS
NCI-H69 M1e1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTRwNUG3PVMh|ryP MlL6V2FPT0WU
SCC-9 MoPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX0[VFKSzVyPUSuOVMyPzJizszN MVHTRW5ITVJ?
NCI-H526 NGHmR41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHPRZFkUUN3ME20MlU6Ojl|IN88US=> NILHbJpUSU6JRWK=
NCI-H2170 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\zTWM2OD12Lk[2O|cyKM7:TR?= MlzOV2FPT0WU
SR NVjiW|hIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTRwN{CwOFgh|ryP NEnOV2pUSU6JRWK=
CMK MkHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETSUlJKSzVyPUSuO|IyODFizszN MoLkV2FPT0WU
COLO-829 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K3e2lEPTB;ND63O|A1OyEQvF2= NYrSbYpKW0GQR1XS
HuO-3N1 NG[yWnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorjTWM2OD12LkizNlgyKM7:TR?= MY\TRW5ITVJ?
5637 NWjlbFF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH4TWM2OD12LkmwOFg4KM7:TR?= NXjJ[XBNW0GQR1XS
A253 MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPlOG9[UUN3ME20Mlk4PzB6IN88US=> NHz5fIVUSU6JRWK=
NB10 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTVwMEe0PVch|ryP NHfsV3pUSU6JRWK=
SF539 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTVwMEm5OVkh|ryP MX;TRW5ITVJ?
HAL-01 NWfnPZk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37IVGlEPTB;NT6xOFY1PSEQvF2= M2DBZXNCVkeHUh?=
MHH-ES-1 NVXRenJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i5NGlEPTB;NT6xOlkzPSEQvF2= NID6S|RUSU6JRWK=
DEL MlvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvTTWM2OD13LkK3OVgzKM7:TR?= MWrTRW5ITVJ?
NCI-H1299 M4LQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTVwM{WwNFch|ryP NF;PRYZUSU6JRWK=
ChaGo-K-1 MkDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mli4TWM2OD13LkO1NVA4KM7:TR?= NYDoOoJVW0GQR1XS
HMV-II NH7TXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljnTWM2OD13LkO5OFMh|ryP M4rYPXNCVkeHUh?=
NB69 NGPtNWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHoTWM2OD13LkO5OlMyKM7:TR?= NGL1VI9USU6JRWK=
NCI-H1882 MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXLZW1KSzVyPUWuOFM{PjRizszN M{Dp[3NCVkeHUh?=
SNU-475 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nxXWlEPTB;NT60O|E4OSEQvF2= MmfxV2FPT0WU
RXF393 NV3z[2NoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrHTWM2OD13LkS4OFk1KM7:TR?= M3rNUnNCVkeHUh?=
CAL-51 M3HI[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3Gd3BHUUN3ME21MlYzQDV|IN88US=> NEHEW2FUSU6JRWK=
SW1573 Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzSTWM2OD13Lk[zOVM1KM7:TR?= NGSyTmlUSU6JRWK=
GCT NVXiTI5RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTVwN{W5Nlkh|ryP NXfBWWhjW0GQR1XS
COR-L88 NWPFbXh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYi2NplkUUN3ME21Mlc3QDR4IN88US=> NFnm[3hUSU6JRWK=
MDA-MB-134-VI NI\QU3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P6dmlEPTB;NT64O|U{PiEQvF2= NH7XO2dUSU6JRWK=
NB5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XGZ2lEPTB;NT65NlQ1KM7:TR?= NYfhRpZqW0GQR1XS
GMS-10 M33KRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjXV3ZKSzVyPUWuPVY5PjFizszN MXHTRW5ITVJ?
CHP-212 MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTZwNEiyOlch|ryP MkTUV2FPT0WU
TE-11 NXjXVlVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;rOGlEPTB;Nj61OVE5OiEQvF2= M4XGU3NCVkeHUh?=
SW962 M2\ES2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvSTWM2OD14Lk[1O|c1KM7:TR?= M3\xSHNCVkeHUh?=
MZ2-MEL MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XYXGlEPTB;Nj64NlAyOSEQvF2= M{S1S3NCVkeHUh?=
C-33-A NHezXVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfqTWVJUUN3ME22MlkyPjh6IN88US=> NHjDcZBUSU6JRWK=
IGR-1 M3Xwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTZwOUe4NlYh|ryP NXTS[Wp{W0GQR1XS
MOLT-4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;hTWM2OD15LkG1OFA3KM7:TR?= MY\TRW5ITVJ?
NCI-H1650 NYnrOYtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW1TWM2OD15LkK3NFQ3KM7:TR?= NWTLXIFKW0GQR1XS
AsPC-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PMSWlEPTB;Nz6yPFYxPSEQvF2= NXXpT2tSW0GQR1XS
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COLO-792 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHOTWM2OD1{Mj63NVEyKM7:TR?= MlfGV2FPT0WU
CAL-62 NXHw[mhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmizTWM2OD1{Mj63OVE4KM7:TR?= NX;LSWlXW0GQR1XS
HCE-T M{LNdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TlZmlEPTB;MkKuPFYxPiEQvF2= M{O4XnNCVkeHUh?=
BB65-RCC MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW0RmdJUUN3ME2yN{4xOzR2IN88US=> MWfTRW5ITVJ?
SiHa NF32PXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDweXpPUUN3ME2yN{4{QTZ6IN88US=> MWjTRW5ITVJ?
NCI-H2081 M4G0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rU[2lEPTB;MkSuNFY1OSEQvF2= NVPJ[GFxW0GQR1XS
U251 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkWwTWM2OD1{ND6wOlY5KM7:TR?= NEDVZ5NUSU6JRWK=
LoVo M3W3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzvPZdKSzVyPUK0MlkzQDJizszN MmTqV2FPT0WU
GCIY MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3YTWM2OD1{NT6yPFc4KM7:TR?= NUfDcVNMW0GQR1XS
NUGC-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r5RWlEPTB;MkWuN|MyPiEQvF2= MX;TRW5ITVJ?
LNCaP-Clone-FGC NGrPc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGxZodbUUN3ME2yOU4{PDl6IN88US=> NH3ESYtUSU6JRWK=
PA-1 MofWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X5UGlEPTB;MkWuOlg{OyEQvF2= NX3udXpzW0GQR1XS
OE33 NF;1XXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\ON4RyUUN3ME2yOU43QDV|IN88US=> MYrTRW5ITVJ?
HT-29 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj0Wm4{UUN3ME2yOU44QDd7IN88US=> M1HsOnNCVkeHUh?=
RCM-1 Mn;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ewSGlEPTB;MkWuPVY2PiEQvF2= NWXIc5dJW0GQR1XS
NCI-H1522 NGjCem1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHaTWM2OD1{NT65PVEyKM7:TR?= NV;ZeXFJW0GQR1XS
LB373-MEL-D M{TyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ4LkG3NFgh|ryP M3j5[nNCVkeHUh?=
NCI-H1436 NV;qU3pOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LuWWlEPTB;Mk[uNlc{QCEQvF2= NX;ubVlKW0GQR1XS
COLO-824 M1nHcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJ4LkSwNFIh|ryP M{\VTXNCVkeHUh?=
CP50-MEL-B NUm5TFJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfqNWFKSzVyPUK2MlU3PzVizszN NGHEb3pUSU6JRWK=
EGI-1 M3X0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJ5LkK2PVgh|ryP MmnkV2FPT0WU
LAN-6 NWDEOHdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rlSGlEPTB;MkeuN|U6QCEQvF2= MWrTRW5ITVJ?
GAK NInze3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJ5LkSyNlUh|ryP NXzzeHQxW0GQR1XS
MDA-MB-175-VII NUTUbpBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYqwSVlPUUN3ME2yO{42ODV|IN88US=> M1nGSXNCVkeHUh?=
JVM-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT2TWM2OD1{Nz62OlIzKM7:TR?= MWjTRW5ITVJ?
UACC-257 NYr6VIxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzqTWM2OD1{Nz62PFc5KM7:TR?= MoLzV2FPT0WU
SW1783 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33ZWmlEPTB;MkeuO|c5OyEQvF2= M3HufHNCVkeHUh?=
HT-3 MkGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3PNnVKSzVyPUK4MlIyPjZizszN MYrTRW5ITVJ?
RL NIHYcIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DTcGlEPTB;MkiuOVkyOSEQvF2= M{GzUHNCVkeHUh?=
TK10 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnWTWM2OD1{OD62OVM2KM7:TR?= MYLTRW5ITVJ?
HT55 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkeyTWM2OD1{OT6wOVY2KM7:TR?= NHrHT3VUSU6JRWK=
BT-20 NHq2WnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHXeItKSzVyPUK5MlA2QDZizszN NYn4TYRbW0GQR1XS
TGBC24TKB M37IPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfTU4ZKSzVyPUK5MlE5OzFizszN NYDuT3JyW0GQR1XS
HSC-2 M4\GNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1q1fGlEPTB;MkmuN|AxOSEQvF2= MXvTRW5ITVJ?
COLO-205 M2PhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTJ7LkO5OFQh|ryP M3;jTnNCVkeHUh?=
GT3TKB NIrvWGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJ7Lk[4O|ch|ryP MmnQV2FPT0WU
T47D NH34[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7jTWM2OD1{OT64OVgzKM7:TR?= M2q0WXNCVkeHUh?=
OMC-1 M4PMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nnXGlEPTB;M{CuNVkyQSEQvF2= Mn;zV2FPT0WU
PFSK-1 NI\aXY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVu4TWZNUUN3ME2zNU4zPjV7IN88US=> NIPvc|BUSU6JRWK=
JEG-3 NYPKfWF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTNzLkO1OlEh|ryP NVHFT2tmW0GQR1XS
RD NHTtRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO3TWM2OD1|MT61NVE2KM7:TR?= M4XNN3NCVkeHUh?=
NCI-H64 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HLemlEPTB;M{KuOFE4QSEQvF2= MorxV2FPT0WU
DMS-114 NFWxdpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTsTWlYUUN3ME2zNk41OTh{IN88US=> M{H1U3NCVkeHUh?=
NCI-H661 NVzvS4cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PiW2lEPTB;M{KuOlUxOSEQvF2= NH3idFVUSU6JRWK=
CAL-148 M1zyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XjXGlEPTB;M{KuOlY3PSEQvF2= MX\TRW5ITVJ?
HuP-T3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP4dXhlUUN3ME2zNk46OzN6IN88US=> NGjoZWNUSU6JRWK=
ES4 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTN|LkG3NFUh|ryP MljvV2FPT0WU
Ca9-22 NXX2TlBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nqPWlEPTB;M{OuOFYxOSEQvF2= MYfTRW5ITVJ?
LP-1 NVnSd2JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTN2LkC5JO69VQ>? MX3TRW5ITVJ?
AU565 MlvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXWR3ZuUUN3ME2zOE42ODZ7IN88US=> NUHEcYxUW0GQR1XS
MDA-MB-453 Mm\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPhTWM2OD1|NT6xOFI3KM7:TR?= MVvTRW5ITVJ?
SNU-C1 NHnEcWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzhUWVKSzVyPUO1MlE4OSEQvF2= MX;TRW5ITVJ?
SW13 NULHV3NjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33OdGlEPTB;M{WuOFA4PiEQvF2= MnnkV2FPT0WU
NCI-H2122 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTN3LkW1PVgh|ryP MVTTRW5ITVJ?
NCI-H1395 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\hXYdKSzVyPUO1MlY3QTFizszN NHLKNWtUSU6JRWK=
J-RT3-T3-5 MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED3ZlVKSzVyPUO2MlAzQTRizszN NUHWcWhjW0GQR1XS
COR-L279 NVLyZnRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHzNVhJUUN3ME2zOk4yQThzIN88US=> NWr4O5N6W0GQR1XS
ATN-1 MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mli4TWM2OD1|Nj64OVE3KM7:TR?= M4HseHNCVkeHUh?=
HCC2998 NEWxPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTN4Lki1O|Eh|ryP MXHTRW5ITVJ?
UM-UC-3 NXzaSYdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK0foFKSzVyPUO2Mlg3PzVizszN MV;TRW5ITVJ?
DV-90 NIXZXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWf0doU5UUN3ME2zOk46ODZ5IN88US=> M2fpZnNCVkeHUh?=
ES8 MoPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTN4LkmzNVgh|ryP M4PZTnNCVkeHUh?=
YAPC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTN4Lkm2OVQh|ryP Mmm4V2FPT0WU
HCC1599 M3\heGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDWTWM2OD1|Nz6xOlE5KM7:TR?= MkW5V2FPT0WU
UMC-11 M3vHcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTN5LkK1NFMh|ryP NVLO[WZSW0GQR1XS
THP-1 MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXaOXlKSzVyPUO3MlI5PjhizszN M2W3RnNCVkeHUh?=
OCUB-M NUTHVmF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTN5LkK4PVEh|ryP MkXWV2FPT0WU
NCI-H1693 NGL6ZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPNUIVKSzVyPUO3MlMzOzNizszN NULhd2U1W0GQR1XS
NCI-H345 NGnUeVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq2blhKSzVyPUO3MlM3OjRizszN NFTuRXlUSU6JRWK=
COLO-800 MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnyyTWM2OD1|Nz61Olch|ryP NGPBTGdUSU6JRWK=
COLO-320-HSR M3HlWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzvV2pKSzVyPUO4MlM1QTJizszN M13JbHNCVkeHUh?=
NCI-H596 NIDzenZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTN6LkS0PFkh|ryP Mk\yV2FPT0WU
NCI-H187 NGPWd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTN6LkezOFQh|ryP M4HBfnNCVkeHUh?=
ECC4 NUfteXBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nkNmlEPTB;M{muNFgyPCEQvF2= NXvydW1yW0GQR1XS
KP-4 NX\HNFJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITJXmFKSzVyPUO5MlEzOzVizszN NHLFSHNUSU6JRWK=
NCI-H2227 NYDlWI11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXBTWM2OD1|OT6zPVQ6KM7:TR?= NHPYZ5lUSU6JRWK=
22RV1 MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTN7LkizPVgh|ryP M1jmcXNCVkeHUh?=
SAS NUTZRol2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTRyLkC5OkDPxE1? M3ridXNCVkeHUh?=
PANC-10-05 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3pOmo5UUN3ME20NE4yQDJ6IN88US=> M1fyb3NCVkeHUh?=
MDA-MB-468 M{XuSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XmNmlEPTB;NECuOVM1PiEQvF2= MYrTRW5ITVJ?
RPMI-7951 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLGTWM2OD12MT6yNFc2KM7:TR?= Mk\jV2FPT0WU
BB49-HNC M{L3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfHTWM2OD12MT6yNVc6KM7:TR?= M{\0SnNCVkeHUh?=
23132-87 NHHrNXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PrcmlEPTB;NEGuNlc{OiEQvF2= NWTsRVJuW0GQR1XS
HCC1569 NIG3OIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\4[VhnUUN3ME20NU4zQDh3IN88US=> NH\O[nRUSU6JRWK=
CP66-MEL MlezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1yzbmlEPTB;NEKuNVg5PiEQvF2= MnXYV2FPT0WU
K-562 NFPMfmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj2TWM2OD12Mj6yPFU1KM7:TR?= M37EXXNCVkeHUh?=
OCI-AML2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHmN3dEUUN3ME20Nk45QTd2IN88US=> Mn;OV2FPT0WU
SW756 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPMOpRKSzVyPUSzMlA{QDhizszN MmPqV2FPT0WU
M14 NUjv[|JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\5OmlEPTB;NEOuN|E5QSEQvF2= M{KwN3NCVkeHUh?=
NCI-H1623 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHoPJllUUN3ME20N{41PjRizszN NV;HfoNLW0GQR1XS
KNS-81-FD MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTR|Lke2NkDPxE1? M{j4fnNCVkeHUh?=
TGBC1TKB MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYj2fGZmUUN3ME20N{46ODl7IN88US=> NGn4fG1USU6JRWK=
RERF-LC-MS NYrQSYJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjmTWM2OD12Mz65NlgyKM7:TR?= M2PINnNCVkeHUh?=
PC-3 NIDI[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEntWm9KSzVyPUS0MlQ{PDdizszN MWnTRW5ITVJ?
HuP-T4 MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHTV4M1UUN3ME20OE41PDd2IN88US=> NWjxTJZkW0GQR1XS
NCI-H510A MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f6fWlEPTB;NESuO|A5KM7:TR?= MmXEV2FPT0WU
LB2518-MEL NXvJN4g5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTR2Lke5N|ch|ryP NHzJVYNUSU6JRWK=
TE-5 NV7hNWRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLxVI1xUUN3ME20OU46PThzIN88US=> M4jkPHNCVkeHUh?=
EW-24 M4HFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7WTWM2OD12Nj6xO|I{KM7:TR?= MXTTRW5ITVJ?
LB647-SCLC MnrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XBemlEPTB;NE[uNlE2PSEQvF2= NFfsTFlUSU6JRWK=
NCI-H524 NYW1SXRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT0flNwUUN3ME20Ok44OTh3IN88US=> MWTTRW5ITVJ?
EW-11 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3u4N2lEPTB;NE[uPVM4OyEQvF2= NUX6[G9WW0GQR1XS
KALS-1 NYD0WJFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPiNHhiUUN3ME20O{4zODZ4IN88US=> MkfMV2FPT0WU
BT-474 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTR5LkSyNVYh|ryP MYPTRW5ITVJ?
SK-N-AS MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYT6SXNuUUN3ME20O{45QDhizszN Mn61V2FPT0WU
HCC2157 NXfPcJpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3u4SmlEPTB;NEiuNFc3KM7:TR?= NGPkb3RUSU6JRWK=
HCC1954 NVzMS3NQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHoU5NKSzVyPUS4MlE4ODRizszN NYG4Nmc6W0GQR1XS
FADU MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTR6LkOwN|Eh|ryP NHfaV3VUSU6JRWK=
S-117 NGDDTphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTR6LkO4NVUh|ryP Mof3V2FPT0WU
LS-1034 NVzHeGh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTR6LkewOlch|ryP MnTmV2FPT0WU
CAMA-1 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXPTWM2OD12OT61OVQ{KM7:TR?= M1H3S3NCVkeHUh?=
LU-134-A MlrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjsfZNKSzVyPUS5MlgxQDVizszN M{WxR3NCVkeHUh?=
NCI-H1838 M33oN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G3cWlEPTB;NEmuPFA5PyEQvF2= M1XqUnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID