Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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4 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NFrXfJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMECwNFAxODN3OTFOwG0> M2HWU3NCVkeHUh?=
MV-4-11 MnvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3Yd5o6UUN3ME2wMlAxODB7NU[g{txO M{XOXXNCVkeHUh?=
MEG-01 M1XGN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDCUVhPUUN3ME2wMlAxODF{ODFOwG0> M2HrbHNCVkeHUh?=
LAMA-84 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFGyV5JKSzVyPUCuNFAxOTZ3IN88US=> MXjTRW5ITVJ?
CGTH-W-1 Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3rTWM2OD1yLkCwNVY6KM7:TR?= Ml3LV2FPT0WU
KASUMI-1 NWXyOoVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nO[GlEPTB;MD6wNFIyPyEQvF2= MlPBV2FPT0WU
BE-13 M1rod2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljGTWM2OD1yLkCwNlU6KM7:TR?= MlPQV2FPT0WU
CTV-1 MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\ETWM2OD1yLkCwOVIyKM7:TR?= Ml\3V2FPT0WU
NKM-1 Mlm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfGN2FKSzVyPUCuNFA3PTVizszN NUDSeZBkW0GQR1XS
MONO-MAC-6 MlqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHxTWM2OD1yLkCwPFM4KM7:TR?= NEXXUIZUSU6JRWK=
A204 M1;wbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEGyNVgh|ryP NWryPWE6W0GQR1XS
GDM-1 M2PnT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEG4N|Mh|ryP NFWyTlFUSU6JRWK=
AN3-CA MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDkSnFLUUN3ME2wMlAyQDd|IN88US=> M{fTZnNCVkeHUh?=
BL-70 MnvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEKxPVkh|ryP MlXzV2FPT0WU
Daudi MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEK1N|ch|ryP M1zTfXNCVkeHUh?=
KU812 M4W0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7DV4FKSzVyPUCuNFI5PDhizszN MUXTRW5ITVJ?
KG-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17j[WlEPTB;MD6wN|I6PCEQvF2= MXHTRW5ITVJ?
DOHH-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMES4NFMh|ryP NH21do1USU6JRWK=
HuO9 MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2GzU2lEPTB;MD6wOVQ1QCEQvF2= M1TpWnNCVkeHUh?=
EB2 M2DUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEW1O|Yh|ryP NVfFb2VSW0GQR1XS
G-402 Moq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwME[zOFEh|ryP NULlVIlPW0GQR1XS
SU-DHL-1 Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmOzTWM2OD1yLkC2N|c6KM7:TR?= NYPHNXZ5W0GQR1XS
NCI-H719 MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2OxVGlEPTB;MD6wO|g5QCEQvF2= MVHTRW5ITVJ?
MLMA M{TxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPGTWM2OD1yLkC5NFYh|ryP M4\OOnNCVkeHUh?=
KM12 NXnXNnM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLjeFRDUUN3ME2wMlA6PzN5IN88US=> NIXzNXlUSU6JRWK=
SUP-T1 MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEm5PFIh|ryP NE\MTIlUSU6JRWK=
MZ1-PC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPJTWM2OD1yLkGxN|M3KM7:TR?= MWrTRW5ITVJ?
MFE-296 M4TGdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTkcZlsUUN3ME2wMlEyQDN7IN88US=> M2TmVnNCVkeHUh?=
ALL-PO MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoG0TWM2OD1yLkGyOFQ{KM7:TR?= NHrzN3hUSU6JRWK=
GB-1 Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\aNm1uUUN3ME2wMlEzPTF{IN88US=> NX7oU2RJW0GQR1XS
SIG-M5 M1P3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMUOzO{DPxE1? MWHTRW5ITVJ?
P30-OHK NGPIcWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMUW2O|Ih|ryP M3PXfnNCVkeHUh?=
NCI-H716 NEG1V2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;rW2ZKSzVyPUCuNVYzPjZizszN NFvJTVJUSU6JRWK=
MPP-89 M{DEemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\JbVZ6UUN3ME2wMlE3QTN|IN88US=> M{ThbnNCVkeHUh?=
SF126 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fDXmlEPTB;MD6xO|A3OyEQvF2= MkLrV2FPT0WU
CTB-1 M13nSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPXTWM2OD1yLkG3N|E3KM7:TR?= MlTjV2FPT0WU
CA46 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELZdYdKSzVyPUCuNVc1QDlizszN M{\CSHNCVkeHUh?=
NCI-H520 M4DOUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXkcZJKSzVyPUCuNVc4OzJizszN NXXQR|FCW0GQR1XS
CAL-85-1 NFrW[WJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnThTWM2OD1yLkG3PVI4KM7:TR?= NXq1VWRIW0GQR1XS
NCI-H2342 NV;PU|VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMUi1O|ch|ryP MV\TRW5ITVJ?
697 M4n6PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMUi4O|Eh|ryP MnGwV2FPT0WU
NY NVfvU45CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHNXYJKSzVyPUCuNVkzQDdizszN M2rPW3NCVkeHUh?=
T98G NULrN2ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMUmzNVgh|ryP MXPTRW5ITVJ?
NCI-H1703 MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XJV2lEPTB;MD6xPVYyPSEQvF2= NGjuZpdUSU6JRWK=
NCI-H2087 M3LQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMkC0N|kh|ryP NE[0WpRUSU6JRWK=
PF-382 MkH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfWTWM2OD1yLkKwPFc{KM7:TR?= NIDPS5ZUSU6JRWK=
HCT-116 NYDJSYtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3nVo5oUUN3ME2wMlIyODZ7IN88US=> M3X3NnNCVkeHUh?=
CAKI-1 MkjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDSfphvUUN3ME2wMlIyPjZ4IN88US=> NEjiOnhUSU6JRWK=
CCF-STTG1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnrTWM2OD1yLkKyOFc2KM7:TR?= NYjNRZU{W0GQR1XS
D-392MG NVfDZ3NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnMU5ZGUUN3ME2wMlI{OTd5IN88US=> NGWyV5RUSU6JRWK=
RT-112 Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMkO3PVUh|ryP MVzTRW5ITVJ?
MES-SA M3HWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nyNmlEPTB;MD6yOFE5PyEQvF2= NX7FcoFzW0GQR1XS
LC-2-ad MnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMkSyOlUh|ryP MnuzV2FPT0WU
NOS-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\2TWM2OD1yLkK0N|Y4KM7:TR?= MkniV2FPT0WU
NALM-6 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMkW1OFMh|ryP M3\oSXNCVkeHUh?=
TE-15 NHznZWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;UTWM2OD1yLkK2NFkyKM7:TR?= M4C1NnNCVkeHUh?=
786-0 MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHqz[Y5KSzVyPUCuNlYzOjhizszN M3TB[nNCVkeHUh?=
IST-MES1 M2PJfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP6WoFzUUN3ME2wMlI3QDJ7IN88US=> NX7LeXRPW0GQR1XS
KYSE-180 MoDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMk[4PVEh|ryP M1\0ZXNCVkeHUh?=
YT NUThU5ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvaTWM2OD1yLkK2PVc1KM7:TR?= M{fIb3NCVkeHUh?=
A427 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnXWG9KSzVyPUCuNlczPjRizszN NULZ[lYyW0GQR1XS
KYSE-450 MoHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LFUWlEPTB;MD6yO|MzQSEQvF2= MlXWV2FPT0WU
HuH-7 NYfMT3BGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMke3OlMh|ryP MYDTRW5ITVJ?
CAS-1 Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjXTWM2OD1yLkK4N|A{KM7:TR?= M4PNW3NCVkeHUh?=
KURAMOCHI M2\Gbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTEcWdMUUN3ME2wMlI5PDF7IN88US=> MV;TRW5ITVJ?
ACHN MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LB[WlEPTB;MD6yPVMzOyEQvF2= NFvjc2xUSU6JRWK=
HGC-27 NFvINotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2G1TWlEPTB;MD6yPVM2OyEQvF2= Mn7JV2FPT0WU
A172 Mki3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\5ZWlEPTB;MD6yPVU4PyEQvF2= MUPTRW5ITVJ?
SNU-449 NVLlfXZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Xkd2lEPTB;MD6yPVk3PCEQvF2= NG\lZnhUSU6JRWK=
SW982 M1LmR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\KRXNKSzVyPUCuNlk6PzhizszN MX;TRW5ITVJ?
EFO-21 MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vhUGlEPTB;MD6zNFQyOSEQvF2= NVThfoh3W0GQR1XS
NCI-H2030 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LUXGlEPTB;MD6zNVE3PCEQvF2= NXLrSJFpW0GQR1XS
HT-144 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TTeWlEPTB;MD6zNVI5KM7:TR?= MnzoV2FPT0WU
MFE-280 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\pNI1KSzVyPUCuN|E1PTNizszN NXnQUY5ZW0GQR1XS
SK-LU-1 NIfHV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwM{G0OlYh|ryP MXXTRW5ITVJ?
NCI-H2052 MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;WXlRKSzVyPUCuN|E1QDRizszN NIDEZpFUSU6JRWK=
SK-HEP-1 NH\xd|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwM{OzOlgh|ryP NYjpV4pXW0GQR1XS
QIMR-WIL NX74SZNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nrc2lEPTB;MD6zN|QzPCEQvF2= NV3NR5g{W0GQR1XS
A2780 NIjjdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvSTWM2OD1yLkO0N|A1KM7:TR?= M2Xn[nNCVkeHUh?=
ACN NGXOeFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPzV3NKSzVyPUCuN|Q5PzNizszN NUHQNHJyW0GQR1XS
BxPC-3 M2\EWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnLTWM2OD1yLkO0PVg6KM7:TR?= M4fIcnNCVkeHUh?=
BCPAP M{XPUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXqxU4pNUUN3ME2wMlM3ODBzIN88US=> NVnzeI5pW0GQR1XS
HOP-62 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGS0dodKSzVyPUCuN|YyODZizszN NHjKdFlUSU6JRWK=
SW1710 M3[0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwM{[0OVUh|ryP NIfUZW5USU6JRWK=
OPM-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTHTWM2OD1yLkO2OFc{KM7:TR?= NVXS[pdKW0GQR1XS
DBTRG-05MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1OybWlEPTB;MD6zPFA2PCEQvF2= NE\tW4FUSU6JRWK=
SK-MEL-24 M4r3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvnbnhKSzVyPUCuN|k4QTFizszN M3q5b3NCVkeHUh?=
8305C M3:1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL0ZXZKSzVyPUCuN|k4QTNizszN MUnTRW5ITVJ?
OVCAR-4 NUHHOIJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jZb2lEPTB;MD60NVU5PiEQvF2= MmH5V2FPT0WU
HLE NEfyOYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3Lc4dKSzVyPUCuOFE5PiEQvF2= MXXTRW5ITVJ?
NCI-H747 MnPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnBTXdKSzVyPUCuOFIyOzdizszN MmrFV2FPT0WU
SW780 MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPnTWM2OD1yLkSyN|Q3KM7:TR?= M{PvVnNCVkeHUh?=
KYSE-150 M12xWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrMTJJ6UUN3ME2wMlQzPDF3IN88US=> NFfkRXdUSU6JRWK=
H4 MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rtUGlEPTB;MD60NlQ2OSEQvF2= NHjMT4xUSU6JRWK=
SW1088 NWL2dHlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HVdWlEPTB;MD60OFM6KM7:TR?= M4jhTnNCVkeHUh?=
SF268 M3TKcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLQbXdKSzVyPUCuOFQ5PiEQvF2= M2fEfnNCVkeHUh?=
RT4 NVfyc5dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2D0R2lEPTB;MD60OVEyOSEQvF2= M2jYdnNCVkeHUh?=
NCI-H522 M{DuWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHMd3JKSzVyPUCuOFUzPyEQvF2= MmfTV2FPT0WU
LCLC-97TM1 NUL6PHpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fEV2lEPTB;MD60OlE6PSEQvF2= NHHDcG1USU6JRWK=
CAL-39 NETRUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\D[YhKSzVyPUCuOFY2OTlizszN NFv0R2pUSU6JRWK=
CAL-120 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnFTWM2OD1yLkS3OlQ{KM7:TR?= M{HMU3NCVkeHUh?=
ESS-1 MoP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILiXm1KSzVyPUCuOFc5OjFizszN MlnpV2FPT0WU
KARPAS-45 M2Tqfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljTTWM2OD1yLkS4PVM{KM7:TR?= NGewZpJUSU6JRWK=
DU-4475 NWSwXlM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwNEm1NVEh|ryP NYThNXplW0GQR1XS
VMRC-RCZ MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG3XJJ6UUN3ME2wMlQ6QTB2IN88US=> M3T6b3NCVkeHUh?=
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KNS-42 M2fl[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUOxS4o5UUN3ME2xMlg3OjZ4IN88US=> M1nMUHNCVkeHUh?=
NCI-H2452 Mn;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTFwOEmwO|Qh|ryP NV\GdYJSW0GQR1XS
SK-MEL-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PXU2lEPTB;MT65NFI4OSEQvF2= NUP1UmpwW0GQR1XS
OVCAR-5 NXLvNGxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[wTWM2OD1zLkmwOlc2KM7:TR?= NGP2Xm9USU6JRWK=
SNG-M M3f0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXo[opKSzVyPUGuPVU5PThizszN MUfTRW5ITVJ?
A673 MmrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfkRohDUUN3ME2xMlk4PTF4IN88US=> NYj3WYRDW0GQR1XS
L-428 M1;lT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3iwfmlEPTB;MT65PVE4QSEQvF2= MV;TRW5ITVJ?
KM-H2 NHvXZYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2SzOmlEPTB;Mj6wNVA6KM7:TR?= NETxS25USU6JRWK=
MC-IXC NX7pXm1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrRTWRnUUN3ME2yMlAzOjd|IN88US=> M4\SS3NCVkeHUh?=
COLO-678 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLITWM2OD1{LkC0NlA4KM7:TR?= M2DvVHNCVkeHUh?=
MEL-JUSO NUjnT4pFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTJwMEe4OVEh|ryP Ml:1V2FPT0WU
HCC38 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PzOGlEPTB;Mj6wPFQ{OyEQvF2= NHzKPG5USU6JRWK=
UACC-62 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJwMEi4OVUh|ryP NY[4O5RiW0GQR1XS
OAW-42 MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjve5hKSzVyPUKuNFk4OTFizszN M36ycHNCVkeHUh?=
LB996-RCC M1XRbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rnbGlEPTB;Mj6xN|gyPyEQvF2= M4\qSHNCVkeHUh?=
COR-L105 NGXDNJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHmdllKSzVyPUKuNVY{PzNizszN NHnCb2RUSU6JRWK=
RCC10RGB NWPvdWZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwMUi1O|Yh|ryP NWLhcmx6W0GQR1XS
A431 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{POOWlEPTB;Mj6xPVAyQSEQvF2= NWXrUZlEW0GQR1XS
NCI-H292 Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjIZXhKSzVyPUKuNlM6PTFizszN MVnTRW5ITVJ?
SK-UT-1 M{HxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\XbXB[UUN3ME2yMlM{OTh2IN88US=> NHXZeXVUSU6JRWK=
PANC-08-13 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJwM{OyN|Uh|ryP NEDVe3pUSU6JRWK=
ST486 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLjfWNpUUN3ME2yMlQyODR6IN88US=> M1eweHNCVkeHUh?=
SJSA-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;mTWM2OD1{LkSxNlcyKM7:TR?= M2SydnNCVkeHUh?=
RKO M4HRbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofsTWM2OD1{LkSyNFI6KM7:TR?= NVnxXGtRW0GQR1XS
NCI-H1793 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPTTWM2OD1{LkS0NFI6KM7:TR?= MlLkV2FPT0WU
639-V Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXDTWM2OD1{LkS1N|gzKM7:TR?= MXPTRW5ITVJ?
ES3 NX7NPVR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7WR4hlUUN3ME2yMlQ6PzN5IN88US=> M{GyfHNCVkeHUh?=
NCI-H1792 MoPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonuTWM2OD1{LkW2PFI3KM7:TR?= MmGzV2FPT0WU
NCI-H1651 Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJwNUiyNUDPxE1? MWfTRW5ITVJ?
SN12C Ml;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvwNZNKSzVyPUKuOVg1QDdizszN Mkn0V2FPT0WU
COLO-679 MljiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HIdWlEPTB;Mj61PFYxPSEQvF2= NU\l[YpNW0GQR1XS
U-118-MG NImwOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHi5eYJKSzVyPUKuOVg5PzJizszN M2\GS3NCVkeHUh?=
Ramos-2G6-4C10 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nV[WlEPTB;Mj62OFgxPyEQvF2= MXHTRW5ITVJ?
HCT-15 NIPHRWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoD4TWM2OD1{Lk[4O|kzKM7:TR?= MXfTRW5ITVJ?
MDA-MB-157 NWG3cWs2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[wTWM2OD1{LkewO|Q4KM7:TR?= NVW5Z|VSW0GQR1XS
K5 MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7BeHNJUUN3ME2yMlcyQDR3IN88US=> M2ize3NCVkeHUh?=
MKN45 NWPTeGJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITrcGdKSzVyPUKuO|M{PjZizszN NFrsVnFUSU6JRWK=
DMS-273 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP0TWM2OD1{Lke1OlMzKM7:TR?= NFP6XpVUSU6JRWK=
C8166 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJwN{i1NVMh|ryP NXn2VZR1W0GQR1XS
Calu-3 M1T3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkniTWM2OD1{Lke4PVY6KM7:TR?= MWjTRW5ITVJ?
SNB75 NVXaZWYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nXSWlEPTB;Mj64PFU{PSEQvF2= M{PRRXNCVkeHUh?=
BFTC-905 MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jmTWlEPTB;Mj65NFE6OSEQvF2= MmC5V2FPT0WU
C-4-II MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzRV5l6UUN3ME2yMlkyOzV|IN88US=> NELj[4NUSU6JRWK=
MS-1 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;VTGlEPTB;Mj65Olc3QSEQvF2= MoPMV2FPT0WU
A375 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3KyfGlEPTB;Mz6wPFE5PCEQvF2= MXnTRW5ITVJ?
KYSE-70 NXzSepA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkKxTWM2OD1|LkC4PFgzKM7:TR?= NHTPXGpUSU6JRWK=
KYSE-510 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWj6UG9SUUN3ME2zMlExQTl3IN88US=> Mnu3V2FPT0WU
LN-405 Mn7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTNwMUO1NVgh|ryP NFG3So9USU6JRWK=
BOKU NELXUYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS2e3ZVUUN3ME2zMlE1OjV4IN88US=> MnPtV2FPT0WU
TE-10 MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHVO3N[UUN3ME2zMlE4OzZ{IN88US=> M2DieHNCVkeHUh?=
MKN1 NWrOb|VoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTITWM2OD1|LkG4OFg{KM7:TR?= M1nOV3NCVkeHUh?=
M059J MlPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTNwMkCxO|Mh|ryP M1\QeXNCVkeHUh?=
GOTO MmO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTNwMkKwN|kh|ryP M2L1S3NCVkeHUh?=
DK-MG NUTJSpFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnL[pV3UUN3ME2zMlI2QTd4IN88US=> M{ToTXNCVkeHUh?=
NCI-H727 MlewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfoTWM2OD1|LkK2OVgh|ryP NVnwVJlkW0GQR1XS
NB12 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXXTWM2OD1|LkOzNlI1KM7:TR?= MVHTRW5ITVJ?
DOK MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4G3dWlEPTB;Mz6zOlE5PiEQvF2= M4TFb3NCVkeHUh?=
KYSE-410 NHH3e3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW3TWM2OD1|LkO2Nlg4KM7:TR?= MnTzV2FPT0WU
AM-38 NUXqNWhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\wTWM2OD1|LkO4NFUyKM7:TR?= NEft[2hUSU6JRWK=
GR-ST NGHGW2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTNwNEW3N|Ih|ryP NUPnRlFuW0GQR1XS
D-247MG NEntWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTNwNEiyOlMh|ryP NIPvUWdUSU6JRWK=
TE-8 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H1c2lEPTB;Mz60PVM{OyEQvF2= NFTRdXhUSU6JRWK=
LS-411N NU\ibmtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zPPGlEPTB;Mz60PVY6OiEQvF2= M1fJeHNCVkeHUh?=
SK-MES-1 NFHzO4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3mwTWlEPTB;Mz61OlQ{OyEQvF2= MVTTRW5ITVJ?
SF295 MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkm2TWM2OD1|Lk[xOVUzKM7:TR?= NFvSfYlUSU6JRWK=
SK-MEL-30 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTNwNkW5NlEh|ryP NVu3bpJLW0GQR1XS
LB2241-RCC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jCSmlEPTB;Mz62OlI3KM7:TR?= NYXTUIU6W0GQR1XS
PC-14 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkK3TWM2OD1|Lk[2OFM4KM7:TR?= Ml\SV2FPT0WU
EW-7 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vW[GlEPTB;Mz62O|Y6OyEQvF2= NUj3dJR2W0GQR1XS
NMC-G1 MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTNwN{G4N|ch|ryP MoXHV2FPT0WU
TE-441-T NIfyV5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvXTWM2OD1|LkezNFI5KM7:TR?= MnflV2FPT0WU
NCI-H1618 M3LIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS2TJdKSzVyPUOuPFE5PzVizszN MVzTRW5ITVJ?
PANC-03-27 MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nIdGlEPTB;Mz64NVkyPiEQvF2= NHG5UHdUSU6JRWK=
NCI-H2228 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPrd5FKSzVyPUOuPFMyOjZizszN M1fSNnNCVkeHUh?=
CAPAN-1 MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fOOGlEPTB;Mz64O|AxQSEQvF2= NUTP[VZ7W0GQR1XS
KLE MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTNwOUC2O{DPxE1? NGmzcIVUSU6JRWK=
Becker M2LLOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGSxUWNKSzVyPUOuPVI5PDlizszN MYjTRW5ITVJ?
SK-PN-DW MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvSb5pKSzVyPUSuNFc6PzRizszN Ml3rV2FPT0WU
Hs-578-T MlrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTlUVlRUUN3ME20MlA5OzB4IN88US=> MXnTRW5ITVJ?
RS4-11 MorzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXrNHFKSzVyPUSuNVEzPTVizszN MXPTRW5ITVJ?
D-502MG MmPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Xpe2lEPTB;ND6xOlk6PyEQvF2= M{PzdXNCVkeHUh?=
GI-1 MknLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX[zRlZ6UUN3ME20MlI5Ojl7IN88US=> NF;ISI1USU6JRWK=
NCI-H209 NUiwXWtjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjYTWM2OD12LkOzO|gh|ryP M2D4XHNCVkeHUh?=
SK-OV-3 NV;HfWVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDDTWM2OD12LkS4NVQ6KM7:TR?= MYnTRW5ITVJ?
LOUCY MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHyUGt[UUN3ME20MlQ5PDN{IN88US=> NUWwZYo6W0GQR1XS
NCI-H69 M2PoWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrFTWM2OD12LkWxO|k{KM7:TR?= NFHQ[HZUSU6JRWK=
SCC-9 NH7vcJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTRwNUOxO|Ih|ryP NGDPV2lUSU6JRWK=
NCI-H526 NUmwdWR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnOyTWM2OD12LkW5Nlk{KM7:TR?= NIrPXolUSU6JRWK=
NCI-H2170 M{XmVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPUTWM2OD12Lk[2O|cyKM7:TR?= MYPTRW5ITVJ?
SR M171b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3OyXWlEPTB;ND63NFA1QCEQvF2= Mn60V2FPT0WU
CMK NWHDd4J7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTRwN{KxNFEh|ryP NX[1ZXluW0GQR1XS
COLO-829 NXHSc4g5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTITWM2OD12Lke3NFQ{KM7:TR?= M1rae3NCVkeHUh?=
HuO-3N1 NEPwXHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nENmlEPTB;ND64N|I5OSEQvF2= MUDTRW5ITVJ?
5637 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILqbFdKSzVyPUSuPVA1QDdizszN NFzXRmpUSU6JRWK=
A253 NWHiSpN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3ESpVKSzVyPUSuPVc4ODhizszN NYDFT4JZW0GQR1XS
NB10 M3jXdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTVwMEe0PVch|ryP NVjjSpJTW0GQR1XS
SF539 M2PuNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nvZ2lEPTB;NT6wPVk2QSEQvF2= NFPIZ3NUSU6JRWK=
HAL-01 NEDGdohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPjS4RKSzVyPUWuNVQ3PDVizszN M3nE[nNCVkeHUh?=
MHH-ES-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH3OlVlUUN3ME21MlE3QTJ3IN88US=> M3HXTXNCVkeHUh?=
DEL MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmC4TWM2OD13LkK3OVgzKM7:TR?= M2XISHNCVkeHUh?=
NCI-H1299 M{f3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\tWotKSzVyPUWuN|UxODdizszN MmfvV2FPT0WU
ChaGo-K-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzWXGJDUUN3ME21MlM2OTB5IN88US=> NWDKclJDW0GQR1XS
HMV-II NG\MeWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTVwM{m0N{DPxE1? MVfTRW5ITVJ?
NB69 M37Xc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTJZlFKSzVyPUWuN|k3OzFizszN M4HO[XNCVkeHUh?=
NCI-H1882 MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jud2lEPTB;NT60N|M3PCEQvF2= NInwV2RUSU6JRWK=
SNU-475 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjvTWM2OD13LkS3NVcyKM7:TR?= M2f4[HNCVkeHUh?=
RXF393 MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnRblJTUUN3ME21MlQ5PDl2IN88US=> NFO5TZFUSU6JRWK=
CAL-51 NY\zPYFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTVwNkK4OVMh|ryP M4\ibHNCVkeHUh?=
SW1573 NEnFdYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzHTWM2OD13Lk[zOVM1KM7:TR?= M1u3S3NCVkeHUh?=
GCT M2niRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXURZVKSzVyPUWuO|U6OjlizszN NFXHXIVUSU6JRWK=
COR-L88 M{LiSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXzVoZOUUN3ME21Mlc3QDR4IN88US=> NV3hfY1uW0GQR1XS
MDA-MB-134-VI Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTVwOEe1N|Yh|ryP NVPsXJE4W0GQR1XS
NB5 NGTo[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTVwOUK0OEDPxE1? MlexV2FPT0WU
GMS-10 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T4V2lEPTB;NT65Olg3OSEQvF2= NXriV29YW0GQR1XS
CHP-212 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzpSpdKSzVyPU[uOFgzPjdizszN NGfteZpUSU6JRWK=
TE-11 MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn25TWM2OD14LkW1NVgzKM7:TR?= M3;JV3NCVkeHUh?=
SW962 M4nvc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrvNVg1UUN3ME22MlY2Pzd2IN88US=> NHW0TJdUSU6JRWK=
MZ2-MEL M4q2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jk[WlEPTB;Nj64NlAyOSEQvF2= MXzTRW5ITVJ?
C-33-A MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTZwOUG2PFgh|ryP MoLFV2FPT0WU
IGR-1 NYL4cYZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnCOpV{UUN3ME22Mlk4QDJ4IN88US=> NGLpZ2VUSU6JRWK=
MOLT-4 MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7KOoFWUUN3ME23MlE2PDB4IN88US=> NWXVbHlYW0GQR1XS
NCI-H1650 NWnXRXhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTdwMkewOFYh|ryP NVq0dW0zW0GQR1XS
AsPC-1 Ml3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXSzWpl6UUN3ME23MlI5PjB3IN88US=> NVe0NnpKW0GQR1XS
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CAL-62 NWLCZVFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TIOmlEPTB;MkKuO|UyPyEQvF2= NWqybYpPW0GQR1XS
HCE-T NYXt[nZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HBVWlEPTB;MkKuPFYxPiEQvF2= M2HsXnNCVkeHUh?=
BB65-RCC MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJ|LkCzOFQh|ryP NFnEZYFUSU6JRWK=
SiHa MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJ|LkO5Olgh|ryP MVzTRW5ITVJ?
NCI-H2081 Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPrO292UUN3ME2yOE4xPjRzIN88US=> MVjTRW5ITVJ?
U251 NWHURppsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXCc5F7UUN3ME2yOE4xPjZ6IN88US=> NFHY[5NUSU6JRWK=
LoVo NIXON2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDJUo1KSzVyPUK0MlkzQDJizszN NVjKcnhSW0GQR1XS
GCIY M1n5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLCbWRKSzVyPUK1MlI5PzdizszN NGX0NGJUSU6JRWK=
NUGC-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzGPFlKSzVyPUK1MlM{OTZizszN MUXTRW5ITVJ?
LNCaP-Clone-FGC NX74OZJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHNRlFKSzVyPUK1MlM1QThizszN M1T0U3NCVkeHUh?=
PA-1 MojKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3L6TWlEPTB;MkWuOlg{OyEQvF2= M2TPNHNCVkeHUh?=
OE33 MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS4TWM2OD1{NT62PFU{KM7:TR?= NEmyOmtUSU6JRWK=
HT-29 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXvTWM2OD1{NT63PFc6KM7:TR?= NUK1cpJOW0GQR1XS
RCM-1 MnWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPSSY9kUUN3ME2yOU46PjV4IN88US=> NGfFTYpUSU6JRWK=
NCI-H1522 MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJ3Lkm5NVEh|ryP MUPTRW5ITVJ?
LB373-MEL-D M4PLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rjZ2lEPTB;Mk[uNVcxQCEQvF2= MlPCV2FPT0WU
NCI-H1436 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfVSWJWUUN3ME2yOk4zPzN6IN88US=> M4rGW3NCVkeHUh?=
COLO-824 NFrGTJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3TXYhDUUN3ME2yOk41ODB{IN88US=> MY\TRW5ITVJ?
CP50-MEL-B M2LzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Py[2lEPTB;Mk[uOVY4PSEQvF2= MmjXV2FPT0WU
EGI-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnDdXd3UUN3ME2yO{4zPjl6IN88US=> NWLtbGJJW0GQR1XS
LAN-6 NFLUNVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ5LkO1PVgh|ryP M3LURnNCVkeHUh?=
GAK NWDsVHB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJ5LkSyNlUh|ryP Mn3yV2FPT0WU
MDA-MB-175-VII MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M175RWlEPTB;MkeuOVA2OyEQvF2= M4fFW3NCVkeHUh?=
JVM-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjleHhKSzVyPUK3MlY3OjJizszN NWf6bYlRW0GQR1XS
UACC-257 NGXGdVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jhNGlEPTB;MkeuOlg4QCEQvF2= M4HWR3NCVkeHUh?=
SW1783 M2XORmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PLemlEPTB;MkeuO|c5OyEQvF2= NHqyN5pUSU6JRWK=
HT-3 MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJ6LkKxOlYh|ryP MY\TRW5ITVJ?
RL M3;EXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPtNYxxUUN3ME2yPE42QTFzIN88US=> NUWxS|NwW0GQR1XS
TK10 M1fDZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJ6Lk[1N|Uh|ryP NV\BRWRKW0GQR1XS
HT55 M1zlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfZTWM2OD1{OT6wOVY2KM7:TR?= M1jlWnNCVkeHUh?=
BT-20 NF7nRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX4SHgzUUN3ME2yPU4xPTh4IN88US=> MVrTRW5ITVJ?
TGBC24TKB M4rlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJ7LkG4N|Eh|ryP NF7uUllUSU6JRWK=
HSC-2 Ml\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJ7LkOwNFEh|ryP MXXTRW5ITVJ?
COLO-205 NYnvS4lRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\IfYVzUUN3ME2yPU4{QTR2IN88US=> MXjTRW5ITVJ?
GT3TKB NGTSNFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LIOWlEPTB;MkmuOlg4PyEQvF2= MVvTRW5ITVJ?
T47D NUT5dIx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHFTWM2OD1{OT64OVgzKM7:TR?= M4HBRXNCVkeHUh?=
OMC-1 NVXxPYJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LHVGlEPTB;M{CuNVkyQSEQvF2= M2fWXnNCVkeHUh?=
PFSK-1 MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPK[mVKSzVyPUOxMlI3PTlizszN MWrTRW5ITVJ?
JEG-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TvOWlEPTB;M{GuN|U3OSEQvF2= NVi1UW1YW0GQR1XS
RD MlT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PQemlEPTB;M{GuOVEyPSEQvF2= NHjYcpZUSU6JRWK=
NCI-H64 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LvcmlEPTB;M{KuOFE4QSEQvF2= NF3QT3BUSU6JRWK=
DMS-114 MnrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjjXpFKSzVyPUOyMlQyQDJizszN NVvlOG9lW0GQR1XS
NCI-H661 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPqTWM2OD1|Mj62OVAyKM7:TR?= MnvZV2FPT0WU
CAL-148 MonuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC1VpJKSzVyPUOyMlY3PjVizszN MmS5V2FPT0WU
HuP-T3 NYrne2NiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrSb5lKSzVyPUOyMlk{OzhizszN NEHnd4xUSU6JRWK=
ES4 M3rDNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;VS|VIUUN3ME2zN{4yPzB3IN88US=> Mn:wV2FPT0WU
Ca9-22 NVXRN4EzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml71TWM2OD1|Mz60OlAyKM7:TR?= NG\6V5FUSU6JRWK=
LP-1 NWXa[YU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\GTWM2OD1|ND6wPUDPxE1? M{XjN3NCVkeHUh?=
AU565 NUjMfo02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\ES4xPUUN3ME2zOE42ODZ7IN88US=> NEH5RZpUSU6JRWK=
MDA-MB-453 NHfvPJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLXSnpmUUN3ME2zOU4yPDJ4IN88US=> NHKxWlJUSU6JRWK=
SNU-C1 NWW2dXNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGC3[IhKSzVyPUO1MlE4OSEQvF2= MXHTRW5ITVJ?
SW13 MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLMTWM2OD1|NT60NFc3KM7:TR?= MUfTRW5ITVJ?
NCI-H2122 NWXiOXpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDPVJBKSzVyPUO1MlU2QThizszN NW\aWlUzW0GQR1XS
NCI-H1395 M4\5UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjpTWM2OD1|NT62OlkyKM7:TR?= NEjvZ4xUSU6JRWK=
J-RT3-T3-5 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXMTWM2OD1|Nj6wNlk1KM7:TR?= NVrRZnJMW0GQR1XS
COR-L279 MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7uSZRXUUN3ME2zOk4yQThzIN88US=> NXztNIt[W0GQR1XS
ATN-1 NEGwUYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvxTWM2OD1|Nj64OVE3KM7:TR?= NV7QNld7W0GQR1XS
HCC2998 NXHYSpVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PM[2lEPTB;M{[uPFU4OSEQvF2= NWKyUYpCW0GQR1XS
UM-UC-3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvzS|UxUUN3ME2zOk45Pjd3IN88US=> MoLLV2FPT0WU
DV-90 MkewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTN4LkmwOlch|ryP M4TaeHNCVkeHUh?=
ES8 NHuz[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTN4LkmzNVgh|ryP MlftV2FPT0WU
YAPC M2rEeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTN4Lkm2OVQh|ryP NGry[phUSU6JRWK=
HCC1599 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfhbFZzUUN3ME2zO{4yPjF6IN88US=> NYDBPXdtW0GQR1XS
UMC-11 M3SzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\vOGVKSzVyPUO3MlI2ODNizszN NVzoU2NnW0GQR1XS
THP-1 MnrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTN5LkK4Olgh|ryP M3O2e3NCVkeHUh?=
OCUB-M NIDwcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[5TWM2OD1|Nz6yPFkyKM7:TR?= M1zQPHNCVkeHUh?=
NCI-H1693 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnQd|hKSzVyPUO3MlMzOzNizszN M2f1UHNCVkeHUh?=
NCI-H345 NVnxdZh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTN5LkO2NlQh|ryP NXnSWnBoW0GQR1XS
COLO-800 NIfGW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTN5LkW2O{DPxE1? MWXTRW5ITVJ?
COLO-320-HSR NUfKdoNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTN6LkO0PVIh|ryP NHHiXI9USU6JRWK=
NCI-H596 NHuzN5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf5RYVYUUN3ME2zPE41PDh7IN88US=> M{XhTnNCVkeHUh?=
NCI-H187 MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXBTWM2OD1|OD63N|Q1KM7:TR?= NEex[oNUSU6JRWK=
ECC4 M1HGOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\QR2lEPTB;M{muNFgyPCEQvF2= NYe4VZZZW0GQR1XS
KP-4 MoXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnkZlVmUUN3ME2zPU4yOjN3IN88US=> MYrTRW5ITVJ?
NCI-H2227 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrFTWM2OD1|OT6zPVQ6KM7:TR?= NXrYbm54W0GQR1XS
22RV1 NWnnb4V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X2fWlEPTB;M{muPFM6QCEQvF2= NFX1UFdUSU6JRWK=
SAS MoGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLIPWNwUUN3ME20NE4xQTZizszN MmLWV2FPT0WU
PANC-10-05 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3flOGlEPTB;NECuNVgzQCEQvF2= MXXTRW5ITVJ?
MDA-MB-468 NV7UV295T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTRyLkWzOFYh|ryP NHHsfYtUSU6JRWK=
RPMI-7951 Mmi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2yVo5kUUN3ME20NU4zODd3IN88US=> Mn\hV2FPT0WU
BB49-HNC Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7LWpd3UUN3ME20NU4zOTd7IN88US=> MWTTRW5ITVJ?
23132-87 M2TzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2H2PGlEPTB;NEGuNlc{OiEQvF2= M1:0R3NCVkeHUh?=
HCC1569 M2WwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofzTWM2OD12MT6yPFg2KM7:TR?= NVzWcI8zW0GQR1XS
CP66-MEL NFjCWmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTR{LkG4PFYh|ryP NWLOSGVuW0GQR1XS
K-562 NUXHbldJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTR{LkK4OVQh|ryP MYDTRW5ITVJ?
OCI-AML2 M{D5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fqSWlEPTB;NEKuPFk4PCEQvF2= M3LxTnNCVkeHUh?=
SW756 M1TNTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonlTWM2OD12Mz6wN|g5KM7:TR?= Ml35V2FPT0WU
M14 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHmdJF[UUN3ME20N{4{OTh7IN88US=> NWD6[3JxW0GQR1XS
NCI-H1623 NX;jW5B[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnCXFJ3UUN3ME20N{41PjRizszN MWPTRW5ITVJ?
KNS-81-FD MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TlXGlEPTB;NEOuO|YzKM7:TR?= Ml\EV2FPT0WU
TGBC1TKB MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTR|LkmwPVkh|ryP MoW1V2FPT0WU
RERF-LC-MS NFP0SWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWn0UWJOUUN3ME20N{46OjhzIN88US=> MlrMV2FPT0WU
PC-3 NGDx[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHCSIlKSzVyPUS0MlQ{PDdizszN NHvwTHNUSU6JRWK=
HuP-T4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIT2Oo1KSzVyPUS0MlQ1PzRizszN M{\3eXNCVkeHUh?=
NCI-H510A NYfsXXk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTR2LkewPEDPxE1? MmPlV2FPT0WU
LB2518-MEL MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTR2Lke5N|ch|ryP M1LT[HNCVkeHUh?=
TE-5 NGCwNlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHO1[JpKSzVyPUS1Mlk2QDFizszN M3TjeHNCVkeHUh?=
EW-24 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnwTWM2OD12Nj6xO|I{KM7:TR?= Mm\IV2FPT0WU
LB647-SCLC NEfsWHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHuc|lKSzVyPUS2MlIyPTVizszN M{fVUXNCVkeHUh?=
NCI-H524 NITC[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTR4LkexPFUh|ryP MXTTRW5ITVJ?
EW-11 M{G3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXCTWM2OD12Nj65N|c{KM7:TR?= NF2xfY1USU6JRWK=
KALS-1 M4Lmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrrR45QUUN3ME20O{4zODZ4IN88US=> NH7iPJdUSU6JRWK=
BT-474 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\STWM2OD12Nz60NlE3KM7:TR?= Mnm0V2FPT0WU
SK-N-AS MkDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jWcmlEPTB;NEeuPFg5KM7:TR?= NGD2WodUSU6JRWK=
HCC2157 NX;3cXZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n5[mlEPTB;NEiuNFc3KM7:TR?= M4DT[HNCVkeHUh?=
HCC1954 M2TzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[yUldKSzVyPUS4MlE4ODRizszN MmTLV2FPT0WU
FADU M1zQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jMN2lEPTB;NEiuN|A{OSEQvF2= MlzsV2FPT0WU
S-117 NEnRXm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPOS2RvUUN3ME20PE4{QDF3IN88US=> Mm\jV2FPT0WU
LS-1034 NUHLdoN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLkTWM2OD12OD63NFY4KM7:TR?= NVHSPW9FW0GQR1XS
CAMA-1 NXrIbJVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XJbWlEPTB;NEmuOVU1OyEQvF2= M1TRVHNCVkeHUh?=
LU-134-A MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3O4Z2lEPTB;NEmuPFA5PSEQvF2= NFWyXoVUSU6JRWK=
NCI-H1838 NHjxVpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTR7LkiwPFch|ryP NEnvdYFUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
+ Expand

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
+ Expand
  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
1% CMC Na
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID