Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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4 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MnuyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\EWVBWUUN3ME2wMlAxODByMECzOVkh|ryP M33R[3NCVkeHUh?=
MV-4-11 M3;VfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XKR2lEPTB;MD6wNFAxQTV4IN88US=> NYLnZm44W0GQR1XS
MEG-01 M3jPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMECwNVI5KM7:TR?= NG\ZWnNUSU6JRWK=
LAMA-84 M2\BVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXrTWM2OD1yLkCwNFE3PSEQvF2= M1LQTnNCVkeHUh?=
CGTH-W-1 NYrvWIJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLzbHNoUUN3ME2wMlAxOTZ7IN88US=> MWnTRW5ITVJ?
KASUMI-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjnRWVKSzVyPUCuNFAzOTdizszN NIXyU29USU6JRWK=
BE-13 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:wTWM2OD1yLkCwNlU6KM7:TR?= MorBV2FPT0WU
CTV-1 NE\DOYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTaTWM2OD1yLkCwOVIyKM7:TR?= Mk\tV2FPT0WU
NKM-1 NYW1PFg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjyW3B{UUN3ME2wMlAxPjV3IN88US=> M1rSeHNCVkeHUh?=
MONO-MAC-6 NF[xS2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn1TWM2OD1yLkCwPFM4KM7:TR?= NGfaXI5USU6JRWK=
A204 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPjemtjUUN3ME2wMlAyOjF6IN88US=> NYrOfIpEW0GQR1XS
GDM-1 NX:zTpJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnaSlZKSzVyPUCuNFE5OzNizszN M3XxfnNCVkeHUh?=
AN3-CA M1foNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHi0VXlKSzVyPUCuNFE5PzNizszN Mn3VV2FPT0WU
BL-70 MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTqTWM2OD1yLkCyNVk6KM7:TR?= NVLVcZlVW0GQR1XS
Daudi NHfBfItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEK1N|ch|ryP MnPyV2FPT0WU
KU812 NYLO[I9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMEK4OFgh|ryP M{jBdnNCVkeHUh?=
KG-1 M3uwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMEOyPVQh|ryP NUPmU2pGW0GQR1XS
DOHH-2 NEjLTo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Gz[mlEPTB;MD6wOFgxOyEQvF2= MlrhV2FPT0WU
HuO9 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrWfGZKSzVyPUCuNFU1PDhizszN NILxOFRUSU6JRWK=
EB2 NEGwcWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37Lc2lEPTB;MD6wOVU4PiEQvF2= MmnVV2FPT0WU
G-402 M3OyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\1U3pPUUN3ME2wMlA3OzRzIN88US=> MVfTRW5ITVJ?
SU-DHL-1 NVniSnNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwME[zO|kh|ryP MkjyV2FPT0WU
NCI-H719 NIKxeHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LDU2lEPTB;MD6wO|g5QCEQvF2= M3fCZnNCVkeHUh?=
MLMA NUXUXFFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi5RoZKSzVyPUCuNFkxPiEQvF2= MVHTRW5ITVJ?
KM12 NFXIO3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33ZdWlEPTB;MD6wPVc{PyEQvF2= M3\ESXNCVkeHUh?=
SUP-T1 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEm5PFIh|ryP MWrTRW5ITVJ?
MZ1-PC M1jQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTOTWM2OD1yLkGxN|M3KM7:TR?= NGHEWIlUSU6JRWK=
MFE-296 M3\xNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnziTWM2OD1yLkGxPFM6KM7:TR?= NGjOOFVUSU6JRWK=
ALL-PO NUjJNVNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHwNY5RUUN3ME2wMlEzPDR|IN88US=> NG\RV3ZUSU6JRWK=
GB-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYizVGFkUUN3ME2wMlEzPTF{IN88US=> NVPvfWtXW0GQR1XS
SIG-M5 NVTrSYZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[1SpdKSzVyPUCuNVM{PyEQvF2= M3y1RnNCVkeHUh?=
P30-OHK NH3NWHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfLXm5KSzVyPUCuNVU3PzJizszN MoTtV2FPT0WU
NCI-H716 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETOfXpKSzVyPUCuNVYzPjZizszN M2jxfHNCVkeHUh?=
MPP-89 M3Xodmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT1[YZKSzVyPUCuNVY6OzNizszN NHezXGlUSU6JRWK=
SF126 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7PT3FKSzVyPUCuNVcxPjNizszN NXPubFJTW0GQR1XS
CTB-1 M{D3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnUVm16UUN3ME2wMlE4OzF4IN88US=> NUfRb2hmW0GQR1XS
CA46 NXfxVlJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHyTWM2OD1yLkG3OFg6KM7:TR?= M4fvW3NCVkeHUh?=
NCI-H520 NFvFXZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjFVG5KSzVyPUCuNVc4OzJizszN MYrTRW5ITVJ?
CAL-85-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMUe5Nlch|ryP NVe3TpVPW0GQR1XS
NCI-H2342 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMUi1O|ch|ryP NWPjNlFPW0GQR1XS
697 MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrETWM2OD1yLkG4PFcyKM7:TR?= NFPEU3pUSU6JRWK=
NY MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3q0W2lEPTB;MD6xPVI5PyEQvF2= MlHBV2FPT0WU
T98G NX\1fow4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrSco5KSzVyPUCuNVk{OThizszN MWjTRW5ITVJ?
NCI-H1703 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXGe5lKSzVyPUCuNVk3OTVizszN M1[y[3NCVkeHUh?=
NCI-H2087 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj4SFVKSzVyPUCuNlA1OzlizszN MlixV2FPT0WU
PF-382 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPjTWM2OD1yLkKwPFc{KM7:TR?= Ml:0V2FPT0WU
HCT-116 MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zVcGlEPTB;MD6yNVA3QSEQvF2= MnnXV2FPT0WU
CAKI-1 NWTPcY5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMkG2OlYh|ryP NULjc4k4W0GQR1XS
CCF-STTG1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMkK0O|Uh|ryP MkXUV2FPT0WU
D-392MG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMkOxO|ch|ryP Mo\zV2FPT0WU
RT-112 M3m0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMkO3PVUh|ryP NITVcGlUSU6JRWK=
MES-SA M1GwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDHWYVKSzVyPUCuNlQyQDdizszN M4fxXXNCVkeHUh?=
LC-2-ad NI\Ic21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TyUmlEPTB;MD6yOFI3PSEQvF2= NYPEVGV6W0GQR1XS
NOS-1 NXOwUnc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDGTWM2OD1yLkK0N|Y4KM7:TR?= NGfa[YlUSU6JRWK=
NALM-6 M{\yUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDDTWM2OD1yLkK1OVQ{KM7:TR?= NXT3RpdDW0GQR1XS
TE-15 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILs[JFKSzVyPUCuNlYxQTFizszN NHTw[5VUSU6JRWK=
786-0 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMk[yNlgh|ryP Mnr0V2FPT0WU
IST-MES1 MmO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMk[4Nlkh|ryP NGjRPHRUSU6JRWK=
KYSE-180 NETPVXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\QWGlKSzVyPUCuNlY5QTFizszN NGfP[pVUSU6JRWK=
YT M3fCZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rie2lEPTB;MD6yOlk4PCEQvF2= M1vxbnNCVkeHUh?=
A427 NWrQS5ByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMkeyOlQh|ryP M3T5VnNCVkeHUh?=
KYSE-450 NVzvd4NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm2TWM2OD1yLkK3N|I6KM7:TR?= MWLTRW5ITVJ?
HuH-7 M2\vTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMke3OlMh|ryP NGPyXXdUSU6JRWK=
CAS-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXyPJhMUUN3ME2wMlI5OzB|IN88US=> NIP1UHlUSU6JRWK=
KURAMOCHI NI\vOnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:zW2dkUUN3ME2wMlI5PDF7IN88US=> M2HxOXNCVkeHUh?=
ACHN NV;PRZlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\hemlEPTB;MD6yPVMzOyEQvF2= M3H4eHNCVkeHUh?=
HGC-27 MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfnTWM2OD1yLkK5N|U{KM7:TR?= NUfXZYtRW0GQR1XS
A172 NEj3[IdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[xXG1KSzVyPUCuNlk2PzdizszN NGHqbnhUSU6JRWK=
SNU-449 M4XoTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HSfWlEPTB;MD6yPVk3PCEQvF2= NX74Zm5EW0GQR1XS
SW982 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H1fmlEPTB;MD6yPVk4QCEQvF2= Ml3KV2FPT0WU
EFO-21 MlLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwM{C0NVEh|ryP NIDPem5USU6JRWK=
NCI-H2030 M4DUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwM{GxOlQh|ryP MmjLV2FPT0WU
HT-144 NHzITpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjDfHdlUUN3ME2wMlMyOjhizszN NV\uN2VVW0GQR1XS
MFE-280 NH;GU3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z5NGlEPTB;MD6zNVQ2OyEQvF2= NHL6[3JUSU6JRWK=
SK-LU-1 M{Lh[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofOTWM2OD1yLkOxOFY3KM7:TR?= NGDyZXhUSU6JRWK=
NCI-H2052 NV3uOI9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjmUIpDUUN3ME2wMlMyPDh2IN88US=> MV3TRW5ITVJ?
SK-HEP-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLNXVhKSzVyPUCuN|M{PjhizszN NWfOPYszW0GQR1XS
QIMR-WIL MnHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwM{O0NlQh|ryP MYDTRW5ITVJ?
A2780 NWCweHBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTV[2hKSzVyPUCuN|Q{ODRizszN M135NnNCVkeHUh?=
ACN MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTWTWM2OD1yLkO0PFc{KM7:TR?= MXXTRW5ITVJ?
BxPC-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwM{S5PFkh|ryP MmjVV2FPT0WU
BCPAP NWjFZoV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTBTWM2OD1yLkO2NFAyKM7:TR?= MkjUV2FPT0WU
HOP-62 MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS0TWM2OD1yLkO2NVA3KM7:TR?= MkXKV2FPT0WU
SW1710 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTDTWM2OD1yLkO2OFU2KM7:TR?= NEHofFlUSU6JRWK=
OPM-2 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwM{[0O|Mh|ryP MnHqV2FPT0WU
DBTRG-05MG NYOzN5Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTCTGxKSzVyPUCuN|gxPTRizszN M3Hlc3NCVkeHUh?=
SK-MEL-24 NHjUfJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\BTWM2OD1yLkO5O|kyKM7:TR?= NVjjdI45W0GQR1XS
8305C M2D3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwM{m3PVMh|ryP NX\q[GhNW0GQR1XS
OVCAR-4 NIfDXZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnrSpN3UUN3ME2wMlQyPTh4IN88US=> MnvBV2FPT0WU
HLE NIDwOnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTiOJZKSzVyPUCuOFE5PiEQvF2= MYDTRW5ITVJ?
NCI-H747 MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXPR|BKSzVyPUCuOFIyOzdizszN M2PpNXNCVkeHUh?=
SW780 M1;HXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHRTWM2OD1yLkSyN|Q3KM7:TR?= NG\vU5lUSU6JRWK=
KYSE-150 NESweIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH4TWM2OD1yLkSyOFE2KM7:TR?= M4DsNXNCVkeHUh?=
H4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF72PJlKSzVyPUCuOFI1PTFizszN NX3Yc457W0GQR1XS
SW1088 NWThRVl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwNESzPUDPxE1? MXfTRW5ITVJ?
SF268 M2q0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFT4WI1KSzVyPUCuOFQ5PiEQvF2= M2PUXnNCVkeHUh?=
RT4 NY\GUIZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7Nc4dKSzVyPUCuOFUyOTFizszN M1[we3NCVkeHUh?=
NCI-H522 NFvaOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwNEWyO{DPxE1? NH\EOHpUSU6JRWK=
LCLC-97TM1 NWXNUYdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\PS2lEPTB;MD60OlE6PSEQvF2= NGnSb4hUSU6JRWK=
CAL-39 NYrnWZpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXNRY5KSzVyPUCuOFY2OTlizszN M{nOUHNCVkeHUh?=
CAL-120 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTXTWM2OD1yLkS3OlQ{KM7:TR?= Mo\xV2FPT0WU
ESS-1 M4TzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLQO|lKSzVyPUCuOFc5OjFizszN M1rwd3NCVkeHUh?=
KARPAS-45 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHUTWM2OD1yLkS4PVM{KM7:TR?= MYrTRW5ITVJ?
DU-4475 NEnwb41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwNEm1NVEh|ryP NFnhe2VUSU6JRWK=
VMRC-RCZ NIfDe2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzvUGZKSzVyPUCuOFk6ODRizszN MV3TRW5ITVJ?
HOS NXrQO4pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDi[3JYUUN3ME2wMlUxOzZ3IN88US=> M4nxTXNCVkeHUh?=
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NCI-H2452 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\RfGlEPTB;MT64PVA4PCEQvF2= NIDaUHlUSU6JRWK=
SK-MEL-2 NYWzTG05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHXPHBkUUN3ME2xMlkxOjdzIN88US=> MlnLV2FPT0WU
OVCAR-5 M33qUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPOOGdUUUN3ME2xMlkxPjd3IN88US=> MmDxV2FPT0WU
SNG-M NYH5blhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnMV3JKSzVyPUGuPVU5PThizszN MoC3V2FPT0WU
A673 MkPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLMeHNpUUN3ME2xMlk4PTF4IN88US=> NFvLdZdUSU6JRWK=
L-428 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnMN28{UUN3ME2xMlk6OTd7IN88US=> MlP4V2FPT0WU
KM-H2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDyfYNrUUN3ME2yMlAyODlizszN NF:4XZpUSU6JRWK=
MC-IXC NIHUSGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrNTWM2OD1{LkCyNlc{KM7:TR?= MmrzV2FPT0WU
COLO-678 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjH[ZYyUUN3ME2yMlA1OjB5IN88US=> NF\kTZpUSU6JRWK=
MEL-JUSO Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LJW2lEPTB;Mj6wO|g2OSEQvF2= NWe2SYxZW0GQR1XS
HCC38 MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXW3ZpFNUUN3ME2yMlA5PDN|IN88US=> M4jWWXNCVkeHUh?=
UACC-62 NUj6NZNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXsTWM2OD1{LkC4PFU2KM7:TR?= MWfTRW5ITVJ?
OAW-42 M{j4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXuTWM2OD1{LkC5O|EyKM7:TR?= MmrJV2FPT0WU
LB996-RCC Ml\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHuPJkxUUN3ME2yMlE{QDF5IN88US=> NIrDe3pUSU6JRWK=
COR-L105 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJwMU[zO|Mh|ryP NG\yb5hUSU6JRWK=
RCC10RGB NFuzcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWT4Vm5{UUN3ME2yMlE5PTd4IN88US=> NYHVd3U6W0GQR1XS
A431 M2fNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3McoR2UUN3ME2yMlE6ODF7IN88US=> M1m0d3NCVkeHUh?=
NCI-H292 MnH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17lSWlEPTB;Mj6yN|k2OSEQvF2= NEj2VVhUSU6JRWK=
SK-UT-1 M4XXVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[3[WtKSzVyPUKuN|MyQDRizszN Mn2yV2FPT0WU
PANC-08-13 M3XINWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXUNGdKSzVyPUKuN|MzOzVizszN M4POR3NCVkeHUh?=
ST486 M2TTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfWZmFKSzVyPUKuOFExPDhizszN NEGzcVhUSU6JRWK=
SJSA-1 MmXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJwNEGyO|Eh|ryP NEfYVItUSU6JRWK=
RKO NFXIWZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDnfY9KSzVyPUKuOFIxOjlizszN NYHqNZNDW0GQR1XS
NCI-H1793 M3vIN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi4Rmg6UUN3ME2yMlQ1ODJ7IN88US=> M1\je3NCVkeHUh?=
639-V NXyyTndHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwNEWzPFIh|ryP MnvrV2FPT0WU
ES3 NWO3eW01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJwNEm3N|ch|ryP NXfYfoFsW0GQR1XS
NCI-H1792 NWDhdm9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7aN3VKSzVyPUKuOVY5OjZizszN MofvV2FPT0WU
NCI-H1651 MlLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULmXHJOUUN3ME2yMlU5OjFizszN MYDTRW5ITVJ?
SN12C NXq2bGlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWG1cWF1UUN3ME2yMlU5PDh5IN88US=> M2LuOnNCVkeHUh?=
COLO-679 NFHS[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rKPWlEPTB;Mj61PFYxPSEQvF2= NH\tcIdUSU6JRWK=
U-118-MG MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrUfFFJUUN3ME2yMlU5QDd{IN88US=> MnvhV2FPT0WU
Ramos-2G6-4C10 M3HDNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXrdIpbUUN3ME2yMlY1QDB5IN88US=> NVnGOZU5W0GQR1XS
HCT-15 NFTBe45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;DTWM2OD1{Lk[4O|kzKM7:TR?= NYWwWY83W0GQR1XS
MDA-MB-157 NGLwT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrodHdKSzVyPUKuO|A4PDdizszN MlPqV2FPT0WU
K5 M{X0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f2R2lEPTB;Mj63NVg1PSEQvF2= M3P0bHNCVkeHUh?=
MKN45 Mm\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDxSopKSzVyPUKuO|M{PjZizszN NWTHSVJ2W0GQR1XS
DMS-273 NFHWOZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLBTWM2OD1{Lke1OlMzKM7:TR?= M3jnPHNCVkeHUh?=
C8166 M2DhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJwN{i1NVMh|ryP MYrTRW5ITVJ?
Calu-3 NYDEd3FiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfsVZRkUUN3ME2yMlc5QTZ7IN88US=> NUizTlB[W0GQR1XS
SNB75 MmjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfoTWM2OD1{Lki4OVM2KM7:TR?= NVPJfoZTW0GQR1XS
BFTC-905 NFnKdlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[2TWM2OD1{LkmwNVkyKM7:TR?= M3[2SnNCVkeHUh?=
C-4-II NYfBVWVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTJwOUGzOVMh|ryP NYjhd45pW0GQR1XS
MS-1 M4Hhbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6xTWM2OD1{Lkm2O|Y6KM7:TR?= NYjiZ44yW0GQR1XS
A375 MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDT[oR1UUN3ME2zMlA5OTh2IN88US=> NYLVe3RZW0GQR1XS
KYSE-70 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvxTWM2OD1|LkC4PFgzKM7:TR?= MX\TRW5ITVJ?
KYSE-510 NHPwd3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHiTWM2OD1|LkGwPVk2KM7:TR?= NGL2SYNUSU6JRWK=
LN-405 NWLVWno6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHSwV3NKSzVyPUOuNVM2OThizszN MUjTRW5ITVJ?
BOKU NHe2dlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVmxfndHUUN3ME2zMlE1OjV4IN88US=> M3zVZ3NCVkeHUh?=
TE-10 Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvnVm9KSzVyPUOuNVc{PjJizszN MWHTRW5ITVJ?
MKN1 NWq3XGRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTNwMUi0PFMh|ryP MUXTRW5ITVJ?
M059J MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TmOmlEPTB;Mz6yNFE4OyEQvF2= MoLBV2FPT0WU
GOTO M3jH[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\NTWM2OD1|LkKyNFM6KM7:TR?= NHn0eHhUSU6JRWK=
DK-MG Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDnSZVKSzVyPUOuNlU6PzZizszN NVHGU|JoW0GQR1XS
NCI-H727 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTNwMk[1PEDPxE1? MoruV2FPT0WU
NB12 Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nB[GlEPTB;Mz6zN|IzPCEQvF2= M1HBVHNCVkeHUh?=
DOK NWm0W2RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XZSGlEPTB;Mz6zOlE5PiEQvF2= MkDjV2FPT0WU
KYSE-410 M3j3PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfVVFFKSzVyPUOuN|YzQDdizszN NVf0NppoW0GQR1XS
AM-38 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTNwM{iwOVEh|ryP Mm\UV2FPT0WU
GR-ST M{O4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTNwNEW3N|Ih|ryP NF;rT3dUSU6JRWK=
D-247MG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TaNWlEPTB;Mz60PFI3OyEQvF2= NVXXW5VEW0GQR1XS
TE-8 NEe0XWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHaXVJtUUN3ME2zMlQ6OzN|IN88US=> Mn;IV2FPT0WU
LS-411N NXTIWlRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;GT5MzUUN3ME2zMlQ6Pjl{IN88US=> M{W3XHNCVkeHUh?=
SK-MES-1 M1\Ze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\0e2ZlUUN3ME2zMlU3PDN|IN88US=> NF\kdGVUSU6JRWK=
SF295 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TOUGlEPTB;Mz62NVU2OiEQvF2= M1O1dHNCVkeHUh?=
SK-MEL-30 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm4TWM2OD1|Lk[1PVIyKM7:TR?= MnPIV2FPT0WU
LB2241-RCC MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfI[GdKSzVyPUOuOlYzPiEQvF2= M{\GOXNCVkeHUh?=
PC-14 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13HZWlEPTB;Mz62OlQ{PyEQvF2= NYrrZZplW0GQR1XS
EW-7 NHWwbHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPu[|VKSzVyPUOuOlc3QTNizszN NGDwXoNUSU6JRWK=
NMC-G1 NXPzU4doT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTNwN{G4N|ch|ryP NUW0PGRNW0GQR1XS
TE-441-T NFr3O5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTNwN{OwNlgh|ryP M2LnNHNCVkeHUh?=
NCI-H1618 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zycGlEPTB;Mz64NVg4PSEQvF2= NWrHVmpRW0GQR1XS
PANC-03-27 NXLqXoY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGCze4FKSzVyPUOuPFE6OTZizszN NYPieFB4W0GQR1XS
NCI-H2228 NF[wS2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTNwOEOxNlYh|ryP Mon4V2FPT0WU
CAPAN-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnmRXVSUUN3ME2zMlg4ODB7IN88US=> NXTZbIVQW0GQR1XS
KLE MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTNwOUC2O{DPxE1? NHzXcYJUSU6JRWK=
Becker Ml\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTNwOUK4OFkh|ryP M3H5b3NCVkeHUh?=
SK-PN-DW M4OxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTRwMEe5O|Qh|ryP MWHTRW5ITVJ?
Hs-578-T NFyyO4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfoNldWUUN3ME20MlA5OzB4IN88US=> MlXOV2FPT0WU
RS4-11 MnfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr2TWM2OD12LkGxNlU2KM7:TR?= MYPTRW5ITVJ?
D-502MG MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTRwMU[5PVch|ryP MlL1V2FPT0WU
GI-1 M{O5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjsZWZKSzVyPUSuNlgzQTlizszN NVjoU21zW0GQR1XS
NCI-H209 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTRwM{O3PEDPxE1? NVvYXJNUW0GQR1XS
SK-OV-3 NXv6UGlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHUVmdXUUN3ME20MlQ5OTR7IN88US=> NHLDUZBUSU6JRWK=
LOUCY MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2O1UGlEPTB;ND60PFQ{OiEQvF2= MVzTRW5ITVJ?
NCI-H69 NEjaZmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\pN2VtUUN3ME20MlUyPzl|IN88US=> MYrTRW5ITVJ?
SCC-9 NYC0[|ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[2Z|BKSzVyPUSuOVMyPzJizszN MoS2V2FPT0WU
NCI-H526 NInRTHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTRwNUmyPVMh|ryP MkHHV2FPT0WU
NCI-H2170 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnRblFEUUN3ME20MlY3PzdzIN88US=> MoTkV2FPT0WU
SR MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIX4VVBKSzVyPUSuO|AxPDhizszN M3\tdHNCVkeHUh?=
CMK M{Lz[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnYTWM2OD12LkeyNVAyKM7:TR?= MYXTRW5ITVJ?
COLO-829 NFnWRmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTRwN{ewOFMh|ryP MkjiV2FPT0WU
HuO-3N1 NX\oTVJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTRwOEOyPFEh|ryP M{L3cHNCVkeHUh?=
5637 NYjqR2E4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;pVHFKSzVyPUSuPVA1QDdizszN Mn;hV2FPT0WU
A253 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\3RWlEPTB;ND65O|cxQCEQvF2= NITXWFNUSU6JRWK=
NB10 NXiwcmhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTVwMEe0PVch|ryP NYO5clhzW0GQR1XS
SF539 NY\QUZp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDMcoV7UUN3ME21MlA6QTV7IN88US=> Mk\DV2FPT0WU
HAL-01 NIf3fIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33NXmlEPTB;NT6xOFY1PSEQvF2= MmOxV2FPT0WU
MHH-ES-1 M3e2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnldXNiUUN3ME21MlE3QTJ3IN88US=> NFyyS2pUSU6JRWK=
DEL M{TuTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Pn[mlEPTB;NT6yO|U5OiEQvF2= NFPabI5USU6JRWK=
NCI-H1299 MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPrTWM2OD13LkO1NFA4KM7:TR?= NF\CfGdUSU6JRWK=
ChaGo-K-1 NFv6eY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrrbZRKSzVyPUWuN|UyODdizszN NFLTXoRUSU6JRWK=
HMV-II NUHVZ|gzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXW3WJBvUUN3ME21MlM6PDNizszN NXKzXZF3W0GQR1XS
NB69 M{DTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTVwM{m2N|Eh|ryP NEnhVW5USU6JRWK=
NCI-H1882 NITQXGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTVwNEOzOlQh|ryP MYrTRW5ITVJ?
SNU-475 Ml\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXSU41KSzVyPUWuOFcyPzFizszN NW\VSmRoW0GQR1XS
RXF393 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEewNmFKSzVyPUWuOFg1QTRizszN NWXaZXhYW0GQR1XS
CAL-51 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;Ee4VKSzVyPUWuOlI5PTNizszN MWHTRW5ITVJ?
SW1573 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjFW3JCUUN3ME21MlY{PTN2IN88US=> Moe2V2FPT0WU
GCT NGPQfnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7LSJg6UUN3ME21Mlc2QTJ7IN88US=> NUTqZYtoW0GQR1XS
COR-L88 M{PGTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPKTWM2OD13Lke2PFQ3KM7:TR?= MXXTRW5ITVJ?
MDA-MB-134-VI MmSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13zV2lEPTB;NT64O|U{PiEQvF2= M2TKVnNCVkeHUh?=
NB5 NULsNHZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTVwOUK0OEDPxE1? MWjTRW5ITVJ?
GMS-10 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PjPWlEPTB;NT65Olg3OSEQvF2= M{\qZnNCVkeHUh?=
CHP-212 M1L5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH2yN5FKSzVyPU[uOFgzPjdizszN MmCzV2FPT0WU
TE-11 NFXPR|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXZTWM2OD14LkW1NVgzKM7:TR?= Mle5V2FPT0WU
SW962 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj5V5VKSzVyPU[uOlU4PzRizszN NUDMZ45uW0GQR1XS
MZ2-MEL MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTZwOEKwNVEh|ryP NEfUU2dUSU6JRWK=
C-33-A NEjpe5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTCTWM2OD14LkmxOlg5KM7:TR?= NX;nOng5W0GQR1XS
IGR-1 NFrtWIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PS[2lEPTB;Nj65O|gzPiEQvF2= M3fzVHNCVkeHUh?=
MOLT-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTdwMUW0NFYh|ryP NGn4ToZUSU6JRWK=
NCI-H1650 M4PneGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfVXYlKSzVyPUeuNlcxPDZizszN M1HoenNCVkeHUh?=
AsPC-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfYfo9KSzVyPUeuNlg3ODVizszN MnW5V2FPT0WU
SNU-C2B M1;2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XONmlEPTB;Nz6yPVU4OSEQvF2= MonEV2FPT0WU
MKN7 NHvn[VRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W2RWlEPTB;Nz6zO|I{PSEQvF2= MkGzV2FPT0WU
SW620 NX7MNJJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTdwM{iyNFUh|ryP NVnaeJIzW0GQR1XS
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COLO-792 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTITWM2OD1{Mj63NVEyKM7:TR?= NInvfolUSU6JRWK=
CAL-62 M3O1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXEfoZ5UUN3ME2yNk44PTF5IN88US=> MmriV2FPT0WU
HCE-T NUfmOJJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJ{Lki2NFYh|ryP Mn7DV2FPT0WU
BB65-RCC NWjCWohjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO2ZmpwUUN3ME2yN{4xOzR2IN88US=> MnXVV2FPT0WU
SiHa MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPPXIZ7UUN3ME2yN{4{QTZ6IN88US=> NGPWOnBUSU6JRWK=
NCI-H2081 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj4TWM2OD1{ND6wOlQyKM7:TR?= NXfEfIhXW0GQR1XS
U251 NIr0bXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTJ2LkC2Olgh|ryP NFnPRpVUSU6JRWK=
LoVo MoP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\LSJhCUUN3ME2yOE46Ojh{IN88US=> MVLTRW5ITVJ?
GCIY M4HOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTKTWM2OD1{NT6yPFc4KM7:TR?= NFKxcpRUSU6JRWK=
NUGC-3 NILPepZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ3LkOzNVYh|ryP MWXTRW5ITVJ?
LNCaP-Clone-FGC NXm3OJlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLQZoFYUUN3ME2yOU4{PDl6IN88US=> MWnTRW5ITVJ?
PA-1 NFHXdIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJ3Lk[4N|Mh|ryP MU\TRW5ITVJ?
OE33 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJ3Lk[4OVMh|ryP M4TabXNCVkeHUh?=
HT-29 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJ3Lke4O|kh|ryP MXXTRW5ITVJ?
RCM-1 NHj6UZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmOyTWM2OD1{NT65OlU3KM7:TR?= MX7TRW5ITVJ?
NCI-H1522 NH3BZ3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEL5[XlKSzVyPUK1Mlk6OTFizszN NF7SOnJUSU6JRWK=
LB373-MEL-D NIfQ[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXRV3BKSzVyPUK2MlE4ODhizszN NGrJfotUSU6JRWK=
NCI-H1436 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn22TWM2OD1{Nj6yO|M5KM7:TR?= MkjuV2FPT0WU
COLO-824 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJ4LkSwNFIh|ryP MYDTRW5ITVJ?
CP50-MEL-B M2PGbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJ4LkW2O|Uh|ryP M33LcHNCVkeHUh?=
EGI-1 M2jWVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn23TWM2OD1{Nz6yOlk5KM7:TR?= NVrFfXJmW0GQR1XS
LAN-6 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJ5LkO1PVgh|ryP NHfKRlJUSU6JRWK=
GAK NHPrOJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;iSWlEPTB;MkeuOFIzPSEQvF2= M2\p[HNCVkeHUh?=
MDA-MB-175-VII MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUS4dVBIUUN3ME2yO{42ODV|IN88US=> M2nSc3NCVkeHUh?=
JVM-2 MkjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJ5Lk[2NlIh|ryP Mke3V2FPT0WU
UACC-257 NIXjVlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjBTWM2OD1{Nz62PFc5KM7:TR?= MkLnV2FPT0WU
SW1783 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTJ5Lke3PFMh|ryP NVfGPIo2W0GQR1XS
HT-3 NYTDd5BzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ6LkKxOlYh|ryP MoW0V2FPT0WU
RL M1rvbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojETWM2OD1{OD61PVEyKM7:TR?= NIDL[IxUSU6JRWK=
TK10 NU\YNY1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJ6Lk[1N|Uh|ryP MkXpV2FPT0WU
HT55 NFTVZoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFm0e5VKSzVyPUK5MlA2PjVizszN NUfXe5NzW0GQR1XS
BT-20 M1nm[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[3fGhKSzVyPUK5MlA2QDZizszN NFmwW|JUSU6JRWK=
TGBC24TKB NHvP[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPoTWM2OD1{OT6xPFMyKM7:TR?= MlG0V2FPT0WU
HSC-2 M3\RdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULG[5JiUUN3ME2yPU4{ODBzIN88US=> MoX4V2FPT0WU
COLO-205 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ewNGlEPTB;MkmuN|k1PCEQvF2= MYLTRW5ITVJ?
GT3TKB M{T2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\1bHdKSzVyPUK5MlY5PzdizszN NHjMSHJUSU6JRWK=
T47D MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJ7Lki1PFIh|ryP NEDM[I5USU6JRWK=
OMC-1 MmXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP2b4dGUUN3ME2zNE4yQTF7IN88US=> MYLTRW5ITVJ?
PFSK-1 NVvFZ21KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PEfGlEPTB;M{GuNlY2QSEQvF2= NVPrdZVlW0GQR1XS
JEG-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTNzLkO1OlEh|ryP MV;TRW5ITVJ?
RD NFPWTJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfBcZRKSzVyPUOxMlUyOTVizszN NI\vdIpUSU6JRWK=
NCI-H64 MkiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXOVHhWUUN3ME2zNk41OTd7IN88US=> NYTMNIplW0GQR1XS
DMS-114 NHTuS5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LTWWlEPTB;M{KuOFE5OiEQvF2= MX3TRW5ITVJ?
NCI-H661 M{XX[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTN{Lk[1NFEh|ryP MWrTRW5ITVJ?
CAL-148 MoHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi4XmFRUUN3ME2zNk43PjZ3IN88US=> NXrFd5BCW0GQR1XS
HuP-T3 M{\PfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\OeWlEPTB;M{KuPVM{QCEQvF2= NFj5dmlUSU6JRWK=
ES4 MkjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTN|LkG3NFUh|ryP MVvTRW5ITVJ?
Ca9-22 M164N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFztV|RKSzVyPUOzMlQ3ODFizszN NHTIT2RUSU6JRWK=
LP-1 M3vSUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\weJJKSzVyPUO0MlA6KM7:TR?= MV;TRW5ITVJ?
AU565 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrrPW1zUUN3ME2zOE42ODZ7IN88US=> NED3NIRUSU6JRWK=
MDA-MB-453 NX;LUnZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M330SmlEPTB;M{WuNVQzPiEQvF2= NXfRTolTW0GQR1XS
SNU-C1 NI\uUXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M375cWlEPTB;M{WuNVcyKM7:TR?= Mmi1V2FPT0WU
SW13 NY\ieW1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHmR|V4UUN3ME2zOU41ODd4IN88US=> NHq4WHpUSU6JRWK=
NCI-H2122 NHnPcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj6NoRKSzVyPUO1MlU2QThizszN MnLRV2FPT0WU
NCI-H1395 M{LnUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkK1TWM2OD1|NT62OlkyKM7:TR?= MUjTRW5ITVJ?
J-RT3-T3-5 MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjBd4FMUUN3ME2zOk4xOjl2IN88US=> M2[2SHNCVkeHUh?=
COR-L279 NXL4Z3FFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LJR2lEPTB;M{[uNVk5OSEQvF2= NFXD[29USU6JRWK=
ATN-1 Mn;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zVNGlEPTB;M{[uPFUyPiEQvF2= NXPsflU3W0GQR1XS
HCC2998 MlzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvrXlFbUUN3ME2zOk45PTdzIN88US=> Ml3NV2FPT0WU
UM-UC-3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXKeWhKSzVyPUO2Mlg3PzVizszN NFO2b2FUSU6JRWK=
DV-90 NUPjfJBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInaTXNKSzVyPUO2MlkxPjdizszN MnXNV2FPT0WU
ES8 M4LK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTN4LkmzNVgh|ryP NVTJNmR2W0GQR1XS
YAPC MnSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TscWlEPTB;M{[uPVY2PCEQvF2= NEDje2NUSU6JRWK=
HCC1599 NEDPfW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPPfVFKSzVyPUO3MlE3OThizszN MnvoV2FPT0WU
UMC-11 NV7UZlE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrRVFhlUUN3ME2zO{4zPTB|IN88US=> M1\BUXNCVkeHUh?=
THP-1 NIHZcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTN5LkK4Olgh|ryP NIPoe25USU6JRWK=
OCUB-M MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rBZmlEPTB;M{euNlg6OSEQvF2= MkHKV2FPT0WU
NCI-H1693 M4H1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;XeGlEPTB;M{euN|I{OyEQvF2= NHLiTFRUSU6JRWK=
NCI-H345 M1S2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;5TWM2OD1|Nz6zOlI1KM7:TR?= M1rxSHNCVkeHUh?=
COLO-800 M2PlR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTN5LkW2O{DPxE1? Ml3BV2FPT0WU
COLO-320-HSR M4rB[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH1e|BKSzVyPUO4MlM1QTJizszN NYHEeXhEW0GQR1XS
NCI-H596 MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;QOlFKSzVyPUO4MlQ1QDlizszN MnLvV2FPT0WU
NCI-H187 M4r6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDPPI5KSzVyPUO4Mlc{PDRizszN MnLRV2FPT0WU
ECC4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3FbIVKSzVyPUO5MlA5OTRizszN M3:wRnNCVkeHUh?=
KP-4 NWKxelFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zFfGlEPTB;M{muNVI{PSEQvF2= M33JcXNCVkeHUh?=
NCI-H2227 NGTYbIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[5OZpVUUN3ME2zPU4{QTR7IN88US=> NIrleGxUSU6JRWK=
22RV1 Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnJN4ZKSzVyPUO5Mlg{QThizszN NFjSXYZUSU6JRWK=
SAS M3XYVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvVTWM2OD12MD6wPVYh|ryP M3G2WHNCVkeHUh?=
PANC-10-05 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUe0e5I{UUN3ME20NE4yQDJ6IN88US=> NEjEempUSU6JRWK=
MDA-MB-468 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTRyLkWzOFYh|ryP NXi3XWR7W0GQR1XS
RPMI-7951 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nWeWlEPTB;NEGuNlA4PSEQvF2= NHLLXJVUSU6JRWK=
BB49-HNC MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG0dXNWUUN3ME20NU4zOTd7IN88US=> NYfMU5JyW0GQR1XS
23132-87 MlT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37vUmlEPTB;NEGuNlc{OiEQvF2= MVXTRW5ITVJ?
HCC1569 NI[4WJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn0ZXBKSzVyPUSxMlI5QDVizszN M{DtVHNCVkeHUh?=
CP66-MEL M4PTemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fKRWlEPTB;NEKuNVg5PiEQvF2= M4PFXHNCVkeHUh?=
K-562 NHeyRoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTR{LkK4OVQh|ryP MonEV2FPT0WU
OCI-AML2 NX7tdmdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\lTWM2OD12Mj64PVc1KM7:TR?= M1HaWHNCVkeHUh?=
SW756 M4K4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTtb5ByUUN3ME20N{4xOzh6IN88US=> NIj1VnRUSU6JRWK=
M14 Mmj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fMV2lEPTB;NEOuN|E5QSEQvF2= NFj2cWRUSU6JRWK=
NCI-H1623 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17JVWlEPTB;NEOuOFY1KM7:TR?= MUPTRW5ITVJ?
KNS-81-FD NUDyUpA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTR|Lke2NkDPxE1? MYfTRW5ITVJ?
TGBC1TKB MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\lUlRKSzVyPUSzMlkxQTlizszN NWnBZnJUW0GQR1XS
RERF-LC-MS M1zTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXqTWM2OD12Mz65NlgyKM7:TR?= MlTLV2FPT0WU
PC-3 NYCzfpM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPxTWM2OD12ND60N|Q4KM7:TR?= NUewSYxqW0GQR1XS
HuP-T4 NFr2eI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX63XGY4UUN3ME20OE41PDd2IN88US=> MoDQV2FPT0WU
NCI-H510A MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TxdmlEPTB;NESuO|A5KM7:TR?= NUDKcGRuW0GQR1XS
LB2518-MEL NWHXN4RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnHPGVKSzVyPUS0Mlc6OzdizszN NIHlNVFUSU6JRWK=
TE-5 M1\3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3iwc2lEPTB;NEWuPVU5OSEQvF2= NXfBS|ZsW0GQR1XS
EW-24 NFHjZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXKTWM2OD12Nj6xO|I{KM7:TR?= NUCwR5k{W0GQR1XS
LB647-SCLC MoTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTkTHZKSzVyPUS2MlIyPTVizszN NYDFbGx3W0GQR1XS
NCI-H524 M4HYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTR4LkexPFUh|ryP M1rWSHNCVkeHUh?=
EW-11 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTR4LkmzO|Mh|ryP Moq3V2FPT0WU
KALS-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnITYpKUUN3ME20O{4zODZ4IN88US=> M4W0cnNCVkeHUh?=
BT-474 NH;WSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTXVm5KSzVyPUS3MlQzOTZizszN MXzTRW5ITVJ?
SK-N-AS M13DVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq2TWM2OD12Nz64PFgh|ryP MV3TRW5ITVJ?
HCC2157 NEfqelJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrMTWM2OD12OD6wO|Yh|ryP NWK4XpIzW0GQR1XS
HCC1954 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTR6LkG3NFQh|ryP M2j0T3NCVkeHUh?=
FADU NEHTenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHQbZlKSzVyPUS4MlMxOzFizszN NIqwe2RUSU6JRWK=
S-117 M4DneGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvzTWM2OD12OD6zPFE2KM7:TR?= NEXrc41USU6JRWK=
LS-1034 NH;OV2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUT1[GxKUUN3ME20PE44ODZ5IN88US=> NYrQOZY{W0GQR1XS
CAMA-1 M3X2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[yd2lEPTB;NEmuOVU1OyEQvF2= MlK3V2FPT0WU
LU-134-A M2DXWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonoTWM2OD12OT64NFg2KM7:TR?= MWLTRW5ITVJ?
NCI-H1838 NU\reGZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i3dWlEPTB;NEmuPFA5PyEQvF2= M{XvZnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
+ Expand
  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID