Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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3 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f6OmlEPTB;MD6wNFAxODByM{W5JO69VQ>? MkO1V2FPT0WU
MV-4-11 NW\5[|dKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\4TWM2OD1yLkCwNFA6PTZizszN NF73W4hUSU6JRWK=
MEG-01 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMECwNVI5KM7:TR?= MYLTRW5ITVJ?
LAMA-84 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILLWohKSzVyPUCuNFAxOTZ3IN88US=> MlLXV2FPT0WU
CGTH-W-1 NGHySG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\LTWM2OD1yLkCwNVY6KM7:TR?= M1TRRnNCVkeHUh?=
KASUMI-1 MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMECyNVch|ryP M4HQfnNCVkeHUh?=
BE-13 MnHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\0OGlEPTB;MD6wNFI2QSEQvF2= NYDEUFdzW0GQR1XS
CTV-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\B[ZhKSzVyPUCuNFA2OjFizszN NXvmV|VvW0GQR1XS
NKM-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkezTWM2OD1yLkCwOlU2KM7:TR?= NHvENHRUSU6JRWK=
MONO-MAC-6 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEC4N|ch|ryP NILwNnhUSU6JRWK=
A204 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvyUpJoUUN3ME2wMlAyOjF6IN88US=> M{f4Z3NCVkeHUh?=
GDM-1 M4PwSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknWTWM2OD1yLkCxPFM{KM7:TR?= NXfaZ4pTW0GQR1XS
AN3-CA NESyUldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X5d2lEPTB;MD6wNVg4OyEQvF2= M{LQVHNCVkeHUh?=
BL-70 NGHEVZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILX[FNKSzVyPUCuNFIyQTlizszN NWXRZpl1W0GQR1XS
Daudi NXf5PHpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofzTWM2OD1yLkCyOVM4KM7:TR?= Ml3FV2FPT0WU
KU812 NG\XR4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHieVVkUUN3ME2wMlAzQDR6IN88US=> NWrjU4N3W0GQR1XS
KG-1 M2PseWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEOyPVQh|ryP NVLSNVl4W0GQR1XS
DOHH-2 NYnEZ2hvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M36zU2lEPTB;MD6wOFgxOyEQvF2= M{WxTXNCVkeHUh?=
HuO9 MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYqzdFR6UUN3ME2wMlA2PDR6IN88US=> NFO5b5pUSU6JRWK=
EB2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33X[WlEPTB;MD6wOVU4PiEQvF2= M17VdnNCVkeHUh?=
G-402 NGS5TWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PZdmlEPTB;MD6wOlM1OSEQvF2= NWP0[FhQW0GQR1XS
SU-DHL-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\1U2VKSzVyPUCuNFY{PzlizszN MUfTRW5ITVJ?
NCI-H719 MmXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrCTWM2OD1yLkC3PFg5KM7:TR?= MVLTRW5ITVJ?
MLMA NVnYNJltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEmwOkDPxE1? M2XENHNCVkeHUh?=
KM12 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEm3N|ch|ryP M1XTTHNCVkeHUh?=
SUP-T1 NHLHU2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMEm5PFIh|ryP MVrTRW5ITVJ?
MZ1-PC NFLqcmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEW5T41KSzVyPUCuNVE{OzZizszN NEDGW3VUSU6JRWK=
MFE-296 MnnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPDdmF3UUN3ME2wMlEyQDN7IN88US=> MlrmV2FPT0WU
ALL-PO MnzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGKydmNKSzVyPUCuNVI1PDNizszN M{S4enNCVkeHUh?=
GB-1 MlvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\1O25KSzVyPUCuNVI2OTJizszN NY[2VWhHW0GQR1XS
SIG-M5 NFzqVlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXv0O5pVUUN3ME2wMlE{OzdizszN M2DDOHNCVkeHUh?=
P30-OHK MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\OflFKSzVyPUCuNVU3PzJizszN NIr6XVNUSU6JRWK=
NCI-H716 NIfDO|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTKTWM2OD1yLkG2NlY3KM7:TR?= NIm5eGZUSU6JRWK=
MPP-89 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7HTWM2OD1yLkG2PVM{KM7:TR?= NHPpXotUSU6JRWK=
SF126 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXOe3VKSzVyPUCuNVcxPjNizszN NV\DZ2JwW0GQR1XS
CTB-1 M4XjW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\hOGlEPTB;MD6xO|MyPiEQvF2= MVvTRW5ITVJ?
CA46 NXHCUXdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMUe0PFkh|ryP NVzZNZRZW0GQR1XS
NCI-H520 NWnRRWhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;OXY5VUUN3ME2wMlE4PzN{IN88US=> MonEV2FPT0WU
CAL-85-1 M2\wWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq4PHZKSzVyPUCuNVc6OjdizszN M1jpO3NCVkeHUh?=
NCI-H2342 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nhWmlEPTB;MD6xPFU4PyEQvF2= M3;6THNCVkeHUh?=
697 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\pT2lEPTB;MD6xPFg4OSEQvF2= NV;aNlNJW0GQR1XS
NY NWfGUolMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHwRVlKSzVyPUCuNVkzQDdizszN Mkm3V2FPT0WU
T98G NFXXfWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17yNWlEPTB;MD6xPVMyQCEQvF2= NUCwZ5NyW0GQR1XS
NCI-H1703 NGezTphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M161dmlEPTB;MD6xPVYyPSEQvF2= MWLTRW5ITVJ?
NCI-H2087 NH7vcopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXCTndwUUN3ME2wMlIxPDN7IN88US=> M1fUOHNCVkeHUh?=
PF-382 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[xOpJKSzVyPUCuNlA5PzNizszN NUTJTWtZW0GQR1XS
HCT-116 MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojNTWM2OD1yLkKxNFY6KM7:TR?= NYfGNZJ5W0GQR1XS
CAKI-1 NGHnOGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjQcVBKSzVyPUCuNlE3PjZizszN NWT2PHJQW0GQR1XS
CCF-STTG1 NFjPbWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnX2TWM2OD1yLkKyOFc2KM7:TR?= M{O0[nNCVkeHUh?=
D-392MG Ml;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3FbVJKSzVyPUCuNlMyPzdizszN MVLTRW5ITVJ?
RT-112 MmD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO0TWM2OD1yLkKzO|k2KM7:TR?= NFraPHdUSU6JRWK=
MES-SA MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMkSxPFch|ryP MWjTRW5ITVJ?
LC-2-ad MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LOWWlEPTB;MD6yOFI3PSEQvF2= NWnsOndoW0GQR1XS
NOS-1 MlzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\xNGlEPTB;MD6yOFM3PyEQvF2= NULhUZFwW0GQR1XS
NALM-6 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPmV3BpUUN3ME2wMlI2PTR|IN88US=> NWHqUWViW0GQR1XS
TE-15 NHvOb|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XCR2lEPTB;MD6yOlA6OSEQvF2= NX3EXIYzW0GQR1XS
786-0 M4Xy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnyWZA3UUN3ME2wMlI3OjJ6IN88US=> NIm2SpBUSU6JRWK=
IST-MES1 NGnRemhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGOzVFVKSzVyPUCuNlY5OjlizszN NVvLcWp[W0GQR1XS
KYSE-180 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofmTWM2OD1yLkK2PFkyKM7:TR?= M17ONHNCVkeHUh?=
YT M1jnWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMk[5O|Qh|ryP NGXOfYdUSU6JRWK=
A427 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMkeyOlQh|ryP M2fQUHNCVkeHUh?=
KYSE-450 Mlq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojZTWM2OD1yLkK3N|I6KM7:TR?= NGfQenpUSU6JRWK=
HuH-7 NVHi[Zg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTOT3JRUUN3ME2wMlI4PzZ|IN88US=> NWXT[IkzW0GQR1XS
CAS-1 M{C3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LwUWlEPTB;MD6yPFMxOyEQvF2= NVmyWpB3W0GQR1XS
KURAMOCHI MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvEc2VKSzVyPUCuNlg1OTlizszN NWnLeWVNW0GQR1XS
ACHN M4fFNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLvR41oUUN3ME2wMlI6OzJ|IN88US=> NFTFNnBUSU6JRWK=
HGC-27 M3zDN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjPdVUzUUN3ME2wMlI6OzV|IN88US=> M3zTb3NCVkeHUh?=
A172 NEPIdIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\FdZNKSzVyPUCuNlk2PzdizszN NV36SJRjW0GQR1XS
SNU-449 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMkm5OlQh|ryP MXjTRW5ITVJ?
SW982 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMkm5O|gh|ryP MoXzV2FPT0WU
EFO-21 M2TaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGOydo9KSzVyPUCuN|A1OTFizszN M4[yWHNCVkeHUh?=
NCI-H2030 NVi2NGFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX4N4dyUUN3ME2wMlMyOTZ2IN88US=> MVfTRW5ITVJ?
HT-144 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwM{GyPEDPxE1? M1TrUnNCVkeHUh?=
MFE-280 NWraZZpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ywTWlEPTB;MD6zNVQ2OyEQvF2= M1f4RnNCVkeHUh?=
SK-LU-1 Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj0RpJKSzVyPUCuN|E1PjZizszN MnvyV2FPT0WU
NCI-H2052 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwM{G0PFQh|ryP Mn7zV2FPT0WU
SK-HEP-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwM{OzOlgh|ryP NVT4NWRbW0GQR1XS
QIMR-WIL MkXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7UZZBoUUN3ME2wMlM{PDJ2IN88US=> NWLoe|FtW0GQR1XS
A2780 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP1R3RKSzVyPUCuN|Q{ODRizszN NEPqcHRUSU6JRWK=
ACN NWHwOI5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\0TWM2OD1yLkO0PFc{KM7:TR?= NU[5eHJnW0GQR1XS
BxPC-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki2TWM2OD1yLkO0PVg6KM7:TR?= NXPT[FZ3W0GQR1XS
BCPAP Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnk[YVrUUN3ME2wMlM3ODBzIN88US=> M4PsSXNCVkeHUh?=
HOP-62 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3GwbWlEPTB;MD6zOlExPiEQvF2= MWDTRW5ITVJ?
SW1710 NHPZbJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfPTWM2OD1yLkO2OFU2KM7:TR?= MoLWV2FPT0WU
OPM-2 NVvqRoc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHm[VRyUUN3ME2wMlM3PDd|IN88US=> M{\abXNCVkeHUh?=
DBTRG-05MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjGR5FoUUN3ME2wMlM5ODV2IN88US=> NYK1OVZQW0GQR1XS
SK-MEL-24 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\wc4pKSzVyPUCuN|k4QTFizszN MVzTRW5ITVJ?
8305C MlnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzNPVdKSzVyPUCuN|k4QTNizszN MU\TRW5ITVJ?
OVCAR-4 NHjHV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHhSlJKUUN3ME2wMlQyPTh4IN88US=> M4PacXNCVkeHUh?=
HLE MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfmTWM2OD1yLkSxPFYh|ryP M2LxfXNCVkeHUh?=
NCI-H747 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7ROIJKSzVyPUCuOFIyOzdizszN MVPTRW5ITVJ?
SW780 NUK2XIllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[4VG54UUN3ME2wMlQzOzR4IN88US=> MV;TRW5ITVJ?
KYSE-150 NHnGW4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwNEK0NVUh|ryP MXjTRW5ITVJ?
H4 NW\yZY5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vifWlEPTB;MD60NlQ2OSEQvF2= MnK1V2FPT0WU
SW1088 NHy4d|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC1UFRKSzVyPUCuOFQ{QSEQvF2= MUTTRW5ITVJ?
SF268 NYr4[mo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX4TWM2OD1yLkS0PFYh|ryP Mlf6V2FPT0WU
RT4 NHjVNZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDoUZRKSzVyPUCuOFUyOTFizszN MXvTRW5ITVJ?
NCI-H522 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;YRmxKSzVyPUCuOFUzPyEQvF2= NIGwfHVUSU6JRWK=
LCLC-97TM1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrLeoZuUUN3ME2wMlQ3OTl3IN88US=> M3n5SHNCVkeHUh?=
CAL-39 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz6UWRKSzVyPUCuOFY2OTlizszN NULIOZVbW0GQR1XS
CAL-120 MkjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HaZ2lEPTB;MD60O|Y1OyEQvF2= NGPzdIxUSU6JRWK=
ESS-1 Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDBTmxKSzVyPUCuOFc5OjFizszN NHruSXFUSU6JRWK=
KARPAS-45 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\zTWM2OD1yLkS4PVM{KM7:TR?= NGLFdmdUSU6JRWK=
DU-4475 MmKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfTS|c2UUN3ME2wMlQ6PTFzIN88US=> NIrofGhUSU6JRWK=
VMRC-RCZ NHvyem9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LjWWlEPTB;MD60PVkxPCEQvF2= NVzlb|RyW0GQR1XS
HOS NHfMVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWxVWhVUUN3ME2wMlUxOzZ3IN88US=> MkS2V2FPT0WU
MOLT-16 MmrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm4TWM2OD1yLkWxPFA5KM7:TR?= NYPWe4VDW0GQR1XS
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SK-MEL-2 MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zPUGlEPTB;MT65NFI4OSEQvF2= NUTBXHh5W0GQR1XS
OVCAR-5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4n6eWlEPTB;MT65NFY4PSEQvF2= NXvJeHFFW0GQR1XS
SNG-M NUX0fJVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[1TWM2OD1zLkm1PFU5KM7:TR?= M17TWnNCVkeHUh?=
A673 Ml\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTBV4tKSzVyPUGuPVc2OTZizszN MWrTRW5ITVJ?
L-428 NGPHOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DteGlEPTB;MT65PVE4QSEQvF2= MYjTRW5ITVJ?
KM-H2 M1nqVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTJwMEGwPUDPxE1? NX\u[JlzW0GQR1XS
MC-IXC NFyxN45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn5TWM2OD1{LkCyNlc{KM7:TR?= MYnTRW5ITVJ?
COLO-678 M3T6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\qPVVKSzVyPUKuNFQzODdizszN NH\pXYJUSU6JRWK=
MEL-JUSO NYjDWI53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDpTWM2OD1{LkC3PFUyKM7:TR?= MXLTRW5ITVJ?
HCC38 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHZco5KSzVyPUKuNFg1OzNizszN M3\NT3NCVkeHUh?=
UACC-62 NFrnbnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\jZmhFUUN3ME2yMlA5QDV3IN88US=> MVLTRW5ITVJ?
OAW-42 MlTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{S4OGlEPTB;Mj6wPVcyOSEQvF2= NFLTTmZUSU6JRWK=
LB996-RCC MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL5TWM2OD1{LkGzPFE4KM7:TR?= NFvxbHJUSU6JRWK=
COR-L105 NVrVSpdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP1fJhTUUN3ME2yMlE3Ozd|IN88US=> MnjQV2FPT0WU
RCC10RGB MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rYfmlEPTB;Mj6xPFU4PiEQvF2= M1;GeHNCVkeHUh?=
A431 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIra[WtKSzVyPUKuNVkxOTlizszN MWrTRW5ITVJ?
NCI-H292 M3jjb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HjWWlEPTB;Mj6yN|k2OSEQvF2= NFzJNVdUSU6JRWK=
SK-UT-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJwM{OxPFQh|ryP Mn[xV2FPT0WU
PANC-08-13 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;T[ZZXUUN3ME2yMlM{OjN3IN88US=> MVHTRW5ITVJ?
ST486 NVzpeWtzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTJwNEGwOFgh|ryP MX\TRW5ITVJ?
SJSA-1 NGLuWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\xc2lEPTB;Mj60NVI4OSEQvF2= MYXTRW5ITVJ?
RKO NY\vRYZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJwNEKwNlkh|ryP NFzDOlRUSU6JRWK=
NCI-H1793 MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU[5[2ZVUUN3ME2yMlQ1ODJ7IN88US=> NWfPNYY1W0GQR1XS
639-V NEXGemJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJwNEWzPFIh|ryP Ml;uV2FPT0WU
ES3 NHXzN4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr3eJJZUUN3ME2yMlQ6PzN5IN88US=> M4ToOXNCVkeHUh?=
NCI-H1792 MnSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3PcYxKSzVyPUKuOVY5OjZizszN MUnTRW5ITVJ?
NCI-H1651 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYewSHF7UUN3ME2yMlU5OjFizszN MoDzV2FPT0WU
SN12C NGD1[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fNPWlEPTB;Mj61PFQ5PyEQvF2= NWK1TVFkW0GQR1XS
COLO-679 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3u4VmlEPTB;Mj61PFYxPSEQvF2= NELwWHVUSU6JRWK=
U-118-MG MoP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEe0RW5KSzVyPUKuOVg5PzJizszN NITUPHNUSU6JRWK=
Ramos-2G6-4C10 NX7yXFRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLrO3BbUUN3ME2yMlY1QDB5IN88US=> MUTTRW5ITVJ?
HCT-15 MlKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M171OGlEPTB;Mj62PFc6OiEQvF2= MVTTRW5ITVJ?
MDA-MB-157 NX\RNGVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zHWmlEPTB;Mj63NFc1PyEQvF2= M3rPfXNCVkeHUh?=
K5 NYL0boFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q2TGlEPTB;Mj63NVg1PSEQvF2= NXq2VYFtW0GQR1XS
MKN45 NX3QOmVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;xdGJKSzVyPUKuO|M{PjZizszN Mo\KV2FPT0WU
DMS-273 NVrzTmU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vGW2lEPTB;Mj63OVY{OiEQvF2= M1zOdXNCVkeHUh?=
C8166 NWLHOm9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPqfllKSzVyPUKuO|g2OTNizszN MXfTRW5ITVJ?
Calu-3 NWrPZ5JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XQTmlEPTB;Mj63PFk3QSEQvF2= MYLTRW5ITVJ?
SNB75 NGPyUoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzUb5M1UUN3ME2yMlg5PTN3IN88US=> MmX1V2FPT0WU
BFTC-905 NXHHUohTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJwOUCxPVEh|ryP NIHWZVZUSU6JRWK=
C-4-II NYfzRZlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLJeIl3UUN3ME2yMlkyOzV|IN88US=> MVPTRW5ITVJ?
MS-1 Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{S3PGlEPTB;Mj65Olc3QSEQvF2= NFH1Vo9USU6JRWK=
A375 M2rjcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvPO2k2UUN3ME2zMlA5OTh2IN88US=> M3S2W3NCVkeHUh?=
KYSE-70 NIfz[YZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;se2o{UUN3ME2zMlA5QDh{IN88US=> M1jE[HNCVkeHUh?=
KYSE-510 M3fRNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjtbppKSzVyPUOuNVA6QTVizszN NHzuUZRUSU6JRWK=
LN-405 M4fmVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HReGlEPTB;Mz6xN|UyQCEQvF2= MUHTRW5ITVJ?
BOKU MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTNwMUSyOVYh|ryP NH;SOlZUSU6JRWK=
TE-10 NXO4e3p{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MliwTWM2OD1|LkG3N|YzKM7:TR?= MoP5V2FPT0WU
MKN1 NXLDOlVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTNwMUi0PFMh|ryP NWK2dY5[W0GQR1XS
M059J MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHXTWM2OD1|LkKwNVc{KM7:TR?= M3\HSnNCVkeHUh?=
GOTO M1;yZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jxbmlEPTB;Mz6yNlA{QSEQvF2= MonrV2FPT0WU
DK-MG M{HCcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTNwMkW5O|Yh|ryP NVTDVJB4W0GQR1XS
NCI-H727 MlLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PpZ2lEPTB;Mz6yOlU5KM7:TR?= MkjWV2FPT0WU
NB12 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTNwM{OyNlQh|ryP NHfke4xUSU6JRWK=
DOK NYPafnN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3y5WWlEPTB;Mz6zOlE5PiEQvF2= MlPrV2FPT0WU
KYSE-410 MkP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXQSYhqUUN3ME2zMlM3Ojh5IN88US=> NXL4U5RCW0GQR1XS
AM-38 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPZdW9FUUN3ME2zMlM5ODVzIN88US=> MlrJV2FPT0WU
GR-ST MlzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHxZVFKSzVyPUOuOFU4OzJizszN M4T1WnNCVkeHUh?=
D-247MG MoS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVmzR2x5UUN3ME2zMlQ5OjZ|IN88US=> MoHHV2FPT0WU
TE-8 NXnHZVZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTtTWM2OD1|LkS5N|M{KM7:TR?= MmfrV2FPT0WU
LS-411N NGXt[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEH2N2dKSzVyPUOuOFk3QTJizszN MoPnV2FPT0WU
SK-MES-1 MnzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Pq[mlEPTB;Mz61OlQ{OyEQvF2= MWDTRW5ITVJ?
SF295 NEXOWoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPTTWM2OD1|Lk[xOVUzKM7:TR?= NE\O[WlUSU6JRWK=
SK-MEL-30 NXTLdWVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTNwNkW5NlEh|ryP Mk[4V2FPT0WU
LB2241-RCC NX;JZ3pET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNwNk[yOkDPxE1? NFfNR4FUSU6JRWK=
PC-14 Moe4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PhWGlEPTB;Mz62OlQ{PyEQvF2= NV\ITWxmW0GQR1XS
EW-7 NFLUPJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIf0fpJKSzVyPUOuOlc3QTNizszN NWT1doZ3W0GQR1XS
NMC-G1 Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTIS49KSzVyPUOuO|E5OzdizszN M2TXSnNCVkeHUh?=
TE-441-T M4O4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXvUmFKSzVyPUOuO|MxOjhizszN M1rHc3NCVkeHUh?=
NCI-H1618 MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTNwOEG4O|Uh|ryP NFjWS|NUSU6JRWK=
PANC-03-27 NWXRbmlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHBPIN5UUN3ME2zMlgyQTF4IN88US=> NWnWfFJOW0GQR1XS
NCI-H2228 NVTzUG1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3aelhKSzVyPUOuPFMyOjZizszN MVHTRW5ITVJ?
CAPAN-1 NEfkdlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PGeWlEPTB;Mz64O|AxQSEQvF2= NInJdJBUSU6JRWK=
KLE Mki2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHoepNKSzVyPUOuPVA3PyEQvF2= NWrpZYVDW0GQR1XS
Becker MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTNwOUK4OFkh|ryP M2PueXNCVkeHUh?=
SK-PN-DW MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHrTWM2OD12LkC3PVc1KM7:TR?= M1Pr[HNCVkeHUh?=
Hs-578-T NVu2W49VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zPN2lEPTB;ND6wPFMxPiEQvF2= MmDmV2FPT0WU
RS4-11 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPSXHRKSzVyPUSuNVEzPTVizszN NEjxPGxUSU6JRWK=
D-502MG NH3KW2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTRR2dKSzVyPUSuNVY6QTdizszN MWHTRW5ITVJ?
GI-1 NUjuWVJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmW2TWM2OD12LkK4Nlk6KM7:TR?= M1PBbHNCVkeHUh?=
NCI-H209 NH64RnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnTNIFKSzVyPUSuN|M4QCEQvF2= NUjo[JB[W0GQR1XS
SK-OV-3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTRwNEixOFkh|ryP NHq5[4VUSU6JRWK=
LOUCY MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Syd2lEPTB;ND60PFQ{OiEQvF2= M2WybXNCVkeHUh?=
NCI-H69 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HlSWlEPTB;ND61NVc6OyEQvF2= NWHpU3FHW0GQR1XS
SCC-9 NUPzfYJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj3XW1KSzVyPUSuOVMyPzJizszN NVHSfGpFW0GQR1XS
NCI-H526 MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXFTWM2OD12LkW5Nlk{KM7:TR?= NFPudG1USU6JRWK=
NCI-H2170 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTRwNk[3O|Eh|ryP NETsSGNUSU6JRWK=
SR NGHoSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnVTWM2OD12LkewNFQ5KM7:TR?= M2q5NnNCVkeHUh?=
CMK NGDxbZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTRwN{KxNFEh|ryP M12yOnNCVkeHUh?=
COLO-829 MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTrV5hZUUN3ME20Mlc4ODR|IN88US=> Mkf0V2FPT0WU
HuO-3N1 MmHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHCVndKSzVyPUSuPFMzQDFizszN MlvPV2FPT0WU
5637 M4D0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTRwOUC0PFch|ryP NIfCOWVUSU6JRWK=
A253 MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPv[IFKSzVyPUSuPVc4ODhizszN M3vITnNCVkeHUh?=
NB10 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrXS3dlUUN3ME21MlA4PDl5IN88US=> NXXPb5EyW0GQR1XS
SF539 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTVwMEm5OVkh|ryP MUXTRW5ITVJ?
HAL-01 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVq3cXVMUUN3ME21MlE1PjR3IN88US=> NXvYbnNRW0GQR1XS
MHH-ES-1 NF\E[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTVwMU[5NlUh|ryP NV;IW45mW0GQR1XS
DEL MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTVwMke1PFIh|ryP NW[xclFWW0GQR1XS
NCI-H1299 NVvIXWZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInBNWlKSzVyPUWuN|UxODdizszN MVXTRW5ITVJ?
ChaGo-K-1 MkHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTVwM{WxNFch|ryP MmX5V2FPT0WU
HMV-II MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrWRVFVUUN3ME21MlM6PDNizszN NXLKUVZ4W0GQR1XS
NB69 NEmzNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTtTWM2OD13LkO5OlMyKM7:TR?= NX;2R2hKW0GQR1XS
NCI-H1882 NELvPJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTVwNEOzOlQh|ryP Ml3HV2FPT0WU
SNU-475 NEC5PIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjMTWM2OD13LkS3NVcyKM7:TR?= NWL0UFh[W0GQR1XS
RXF393 NE\pNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTVwNEi0PVQh|ryP MWXTRW5ITVJ?
CAL-51 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTVwNkK4OVMh|ryP M1HTTnNCVkeHUh?=
SW1573 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi3TWM2OD13Lk[zOVM1KM7:TR?= NUHQWXRwW0GQR1XS
GCT MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDaTXE1UUN3ME21Mlc2QTJ7IN88US=> Mn;yV2FPT0WU
COR-L88 MnTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXQO3BxUUN3ME21Mlc3QDR4IN88US=> MkjiV2FPT0WU
MDA-MB-134-VI M3[1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TO[mlEPTB;NT64O|U{PiEQvF2= NUjOZVN3W0GQR1XS
NB5 MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTVwOUK0OEDPxE1? M4nTUHNCVkeHUh?=
GMS-10 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\OTWM2OD13Lkm2PFYyKM7:TR?= NF7qUXlUSU6JRWK=
CHP-212 M3nvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXo[3hKSzVyPU[uOFgzPjdizszN M{XLdXNCVkeHUh?=
TE-11 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlL6TWM2OD14LkW1NVgzKM7:TR?= M4XVXnNCVkeHUh?=
SW962 NXPuTGdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlT6TWM2OD14Lk[1O|c1KM7:TR?= MnvnV2FPT0WU
MZ2-MEL M33Vcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W0UGlEPTB;Nj64NlAyOSEQvF2= M3n2cXNCVkeHUh?=
C-33-A MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnCNVNKSzVyPU[uPVE3QDhizszN Mmn0V2FPT0WU
IGR-1 NI\PSYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTZwOUe4NlYh|ryP M{fQe3NCVkeHUh?=
MOLT-4 NHfBb4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rwemlEPTB;Nz6xOVQxPiEQvF2= Mn\MV2FPT0WU
NCI-H1650 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HlSGlEPTB;Nz6yO|A1PiEQvF2= MnXvV2FPT0WU
AsPC-1 M{TpVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTdwMki2NFUh|ryP NXHRdldxW0GQR1XS
SNU-C2B MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTdwMkm1O|Eh|ryP MW\TRW5ITVJ?
MKN7 NFO4WYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHwZ4FKSzVyPUeuN|czOzVizszN M2HoTXNCVkeHUh?=
SW620 NH;hZ5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPheJhKSzVyPUeuN|gzODVizszN NHXwRnNUSU6JRWK=
SK-MEL-28 NHLH[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DRV2lEPTB;Nz60NFc6QCEQvF2= NGHGW4RUSU6JRWK=
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CAL-62 NVLVVGtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJ{Lke1NVch|ryP NX\QSFN3W0GQR1XS
HCE-T MkjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n3N2lEPTB;MkKuPFYxPiEQvF2= NFzCb|dUSU6JRWK=
BB65-RCC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrzbZdKSzVyPUKzMlA{PDRizszN MVfTRW5ITVJ?
SiHa M{HtZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3oPFBQUUN3ME2yN{4{QTZ6IN88US=> Mn7zV2FPT0WU
NCI-H2081 NFmyTlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID3e49KSzVyPUK0MlA3PDFizszN M3zHVnNCVkeHUh?=
U251 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzQ[Hl7UUN3ME2yOE4xPjZ6IN88US=> M4D3SXNCVkeHUh?=
LoVo NGH1bGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\Q[2o5UUN3ME2yOE46Ojh{IN88US=> NF;0WZNUSU6JRWK=
GCIY M1vORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojKTWM2OD1{NT6yPFc4KM7:TR?= MlG4V2FPT0WU
NUGC-3 NEPB[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2qwTWlEPTB;MkWuN|MyPiEQvF2= Ml\sV2FPT0WU
LNCaP-Clone-FGC NHLQVnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEH1NHlKSzVyPUK1MlM1QThizszN M1zWRXNCVkeHUh?=
PA-1 M2m5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjQbGFDUUN3ME2yOU43QDN|IN88US=> NYHKfHZ3W0GQR1XS
OE33 MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojpTWM2OD1{NT62PFU{KM7:TR?= NGH2PI5USU6JRWK=
HT-29 M3LwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjvOGFKSzVyPUK1Mlc5PzlizszN NIrMfJlUSU6JRWK=
RCM-1 NEi1V21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;YXZFVUUN3ME2yOU46PjV4IN88US=> NY\ufFN5W0GQR1XS
NCI-H1522 M1XE[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTJ3Lkm5NVEh|ryP MU\TRW5ITVJ?
LB373-MEL-D NYHxNnpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TybGlEPTB;Mk[uNVcxQCEQvF2= Mk[1V2FPT0WU
NCI-H1436 NWqzeVNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTnfFh7UUN3ME2yOk4zPzN6IN88US=> NVPOZ|A3W0GQR1XS
COLO-824 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT0VXlGUUN3ME2yOk41ODB{IN88US=> MULTRW5ITVJ?
CP50-MEL-B NVezc4Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HKZmlEPTB;Mk[uOVY4PSEQvF2= M1e2UHNCVkeHUh?=
EGI-1 NHrCUpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTJ5LkK2PVgh|ryP NFX4WXpUSU6JRWK=
LAN-6 M3fXbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJ5LkO1PVgh|ryP M2rocnNCVkeHUh?=
GAK NI[3NGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrrO4RCUUN3ME2yO{41OjJ3IN88US=> MWTTRW5ITVJ?
MDA-MB-175-VII Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT3TWM2OD1{Nz61NFU{KM7:TR?= MUfTRW5ITVJ?
JVM-2 M3\JUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjaWVFyUUN3ME2yO{43PjJ{IN88US=> NHXOOVNUSU6JRWK=
UACC-257 NVrIUm13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;lS4lrUUN3ME2yO{43QDd6IN88US=> MlXtV2FPT0WU
SW1783 MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJ5Lke3PFMh|ryP NXjwW49DW0GQR1XS
HT-3 NYTsR244T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfY[4pKSzVyPUK4MlIyPjZizszN M{DifHNCVkeHUh?=
RL NFi1b2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljpTWM2OD1{OD61PVEyKM7:TR?= MUTTRW5ITVJ?
TK10 NY\RSIp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLSd3ozUUN3ME2yPE43PTN3IN88US=> M3fvfHNCVkeHUh?=
HT55 M{\JfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXscHU4UUN3ME2yPU4xPTZ3IN88US=> MV;TRW5ITVJ?
BT-20 MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJ7LkC1PFYh|ryP M{nEXXNCVkeHUh?=
TGBC24TKB NHnVZ|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPkTWM2OD1{OT6xPFMyKM7:TR?= Mm\2V2FPT0WU
HSC-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3tTWM2OD1{OT6zNFAyKM7:TR?= MoLaV2FPT0WU
COLO-205 NEnScmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NECycJFKSzVyPUK5MlM6PDRizszN Ml7kV2FPT0WU
GT3TKB MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHM[YhKSzVyPUK5MlY5PzdizszN MYnTRW5ITVJ?
T47D NITWZ|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PJZWlEPTB;MkmuPFU5OiEQvF2= NGTqSXdUSU6JRWK=
OMC-1 M{PPeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P3SWlEPTB;M{CuNVkyQSEQvF2= NUjuPZRKW0GQR1XS
PFSK-1 M4nqdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTNzLkK2OVkh|ryP Ml7XV2FPT0WU
JEG-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjHZ25KSzVyPUOxMlM2PjFizszN M3:5XHNCVkeHUh?=
RD NWDWeI9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfjTWM2OD1|MT61NVE2KM7:TR?= MVvTRW5ITVJ?
NCI-H64 NHTXUGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TVR2lEPTB;M{KuOFE4QSEQvF2= NFPCOodUSU6JRWK=
DMS-114 NVLCeHZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HBZWlEPTB;M{KuOFE5OiEQvF2= M3roN3NCVkeHUh?=
NCI-H661 NEfpflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LQSWlEPTB;M{KuOlUxOSEQvF2= NYS3UJZqW0GQR1XS
CAL-148 NWXKR2ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTN{Lk[2OlUh|ryP NVflTJVsW0GQR1XS
HuP-T3 NXLJVGk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\vTWM2OD1|Mj65N|M5KM7:TR?= NEj4RZhUSU6JRWK=
ES4 NGrpOIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTN|LkG3NFUh|ryP M2fzOXNCVkeHUh?=
Ca9-22 Mn30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFP2e4JKSzVyPUOzMlQ3ODFizszN MmjsV2FPT0WU
LP-1 M4PPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTN2LkC5JO69VQ>? NF\Vb2ZUSU6JRWK=
AU565 MkHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3P[XNvUUN3ME2zOE42ODZ7IN88US=> NI\RRZBUSU6JRWK=
MDA-MB-453 NVLySFQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLKTWM2OD1|NT6xOFI3KM7:TR?= MmLZV2FPT0WU
SNU-C1 NEnoVI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fyWWlEPTB;M{WuNVcyKM7:TR?= NUDjPY02W0GQR1XS
SW13 Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LRRmlEPTB;M{WuOFA4PiEQvF2= MVTTRW5ITVJ?
NCI-H2122 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTN3LkW1PVgh|ryP M2G2d3NCVkeHUh?=
NCI-H1395 NWrBN442T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\T[nNwUUN3ME2zOU43PjlzIN88US=> M2OwNnNCVkeHUh?=
J-RT3-T3-5 NV7DNHFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH5fpBKSzVyPUO2MlAzQTRizszN M3Ow[nNCVkeHUh?=
COR-L279 NITDNmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XP[2lEPTB;M{[uNVk5OSEQvF2= NGnZcoNUSU6JRWK=
ATN-1 NFnPTHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PJR2lEPTB;M{[uPFUyPiEQvF2= MXnTRW5ITVJ?
HCC2998 M4TtZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkD5TWM2OD1|Nj64OVcyKM7:TR?= M4XLRXNCVkeHUh?=
UM-UC-3 MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHr5WW1KSzVyPUO2Mlg3PzVizszN MnvkV2FPT0WU
DV-90 NUXR[Il4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTUTWM2OD1|Nj65NFY4KM7:TR?= M13PdHNCVkeHUh?=
ES8 Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL2PWRVUUN3ME2zOk46OzF6IN88US=> NFTtN5dUSU6JRWK=
YAPC Ml[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DIVGlEPTB;M{[uPVY2PCEQvF2= Ml7KV2FPT0WU
HCC1599 M1LGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\FUFlpUUN3ME2zO{4yPjF6IN88US=> MYHTRW5ITVJ?
UMC-11 NUnMVWw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moq1TWM2OD1|Nz6yOVA{KM7:TR?= MnXtV2FPT0WU
THP-1 M{PhWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjiOY1DUUN3ME2zO{4zQDZ6IN88US=> NXvUW3hFW0GQR1XS
OCUB-M NXjMWVRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTN5LkK4PVEh|ryP M3XCbHNCVkeHUh?=
NCI-H1693 NUT5OFkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;2VohNUUN3ME2zO{4{OjN|IN88US=> NXz1c4RwW0GQR1XS
NCI-H345 MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGT0dWtKSzVyPUO3MlM3OjRizszN MoDFV2FPT0WU
COLO-800 MkjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjLV4VwUUN3ME2zO{42PjdizszN MkDWV2FPT0WU
COLO-320-HSR NGTqfXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXReG5UUUN3ME2zPE4{PDl{IN88US=> NXPk[Hd1W0GQR1XS
NCI-H596 MniwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3pTWM2OD1|OD60OFg6KM7:TR?= MVzTRW5ITVJ?
NCI-H187 NEmwO5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvYPFVKSzVyPUO4Mlc{PDRizszN NWX3PZRHW0GQR1XS
ECC4 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTN7LkC4NVQh|ryP NUnWO4NIW0GQR1XS
KP-4 NUDRNnp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHMWFlKSzVyPUO5MlEzOzVizszN NHLr[|FUSU6JRWK=
NCI-H2227 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXMTWM2OD1|OT6zPVQ6KM7:TR?= MVzTRW5ITVJ?
22RV1 MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7zVJBKSzVyPUO5Mlg{QThizszN MlzuV2FPT0WU
SAS NULXT3F{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4G1[mlEPTB;NECuNFk3KM7:TR?= MX3TRW5ITVJ?
PANC-10-05 NEe2c2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mom3TWM2OD12MD6xPFI5KM7:TR?= NHWx[pRUSU6JRWK=
MDA-MB-468 NETFeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzWeXNZUUN3ME20NE42OzR4IN88US=> NH;jfGtUSU6JRWK=
RPMI-7951 NWrkPYhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDKbHJKSzVyPUSxMlIxPzVizszN NEnKWIpUSU6JRWK=
BB49-HNC M{jvRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXzTWM2OD12MT6yNVc6KM7:TR?= MoS3V2FPT0WU
23132-87 NV24fpZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonNTWM2OD12MT6yO|MzKM7:TR?= NHHLb5FUSU6JRWK=
HCC1569 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTRzLkK4PFUh|ryP NXfrZ3k5W0GQR1XS
CP66-MEL M33nUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33TfmlEPTB;NEKuNVg5PiEQvF2= MofjV2FPT0WU
K-562 NVTQdpk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DoXmlEPTB;NEKuNlg2PCEQvF2= NYra[olCW0GQR1XS
OCI-AML2 M121TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTR{Lki5O|Qh|ryP MYfTRW5ITVJ?
SW756 NU\tPFFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDGTYpYUUN3ME20N{4xOzh6IN88US=> MlHqV2FPT0WU
M14 NHPZdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULKZppXUUN3ME20N{4{OTh7IN88US=> MVHTRW5ITVJ?
NCI-H1623 NFLhUpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TlcWlEPTB;NEOuOFY1KM7:TR?= MlHyV2FPT0WU
KNS-81-FD Ml7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TjZmlEPTB;NEOuO|YzKM7:TR?= NXXtboFSW0GQR1XS
TGBC1TKB NUnTe5J2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWri[|JmUUN3ME20N{46ODl7IN88US=> MWTTRW5ITVJ?
RERF-LC-MS M4P2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3viVWlEPTB;NEOuPVI5OSEQvF2= Mnq0V2FPT0WU
PC-3 NXmx[29KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkiyTWM2OD12ND60N|Q4KM7:TR?= MVHTRW5ITVJ?
HuP-T4 NFj4ZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTR2LkS0O|Qh|ryP MmDOV2FPT0WU
NCI-H510A NX7BZ3pST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHYTWM2OD12ND63NFgh|ryP MUnTRW5ITVJ?
LB2518-MEL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTR2Lke5N|ch|ryP NV3CW49pW0GQR1XS
TE-5 M1PGOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTR3Lkm1PFEh|ryP MWLTRW5ITVJ?
EW-24 NVvnT2xTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrJVGZKSzVyPUS2MlE4OjNizszN M2r1VXNCVkeHUh?=
LB647-SCLC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPYPZZKSzVyPUS2MlIyPTVizszN M1HT[HNCVkeHUh?=
NCI-H524 NInUfGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrrTWM2OD12Nj63NVg2KM7:TR?= MX;TRW5ITVJ?
EW-11 NIDU[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLic|VKSzVyPUS2Mlk{PzNizszN M2LiSXNCVkeHUh?=
KALS-1 NIPMbVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLvTWM2OD12Nz6yNFY3KM7:TR?= MmLHV2FPT0WU
BT-474 MmDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTR5LkSyNVYh|ryP M1XMV3NCVkeHUh?=
SK-N-AS NVPUfIhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTR5Lki4PEDPxE1? NXvlRnFtW0GQR1XS
HCC2157 MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTR6LkC3OkDPxE1? NVPvVZV2W0GQR1XS
HCC1954 NF76fZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\4TWM2OD12OD6xO|A1KM7:TR?= Mn;TV2FPT0WU
FADU MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rkfGlEPTB;NEiuN|A{OSEQvF2= Ml3qV2FPT0WU
S-117 NWHQfHRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXYVHVKSzVyPUS4MlM5OTVizszN NEXwb4ZUSU6JRWK=
LS-1034 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j2O2lEPTB;NEiuO|A3PyEQvF2= NXfRXJRvW0GQR1XS
CAMA-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPLTWM2OD12OT61OVQ{KM7:TR?= M1\3d3NCVkeHUh?=
LU-134-A NYjrbVJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7UU|Q4UUN3ME20PU45ODh3IN88US=> M4Oyb3NCVkeHUh?=
NCI-H1838 NFfSSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTRTWM2OD12OT64NFg4KM7:TR?= NUDOSGNkW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
+ Expand

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
+ Expand
  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID