Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2zVIhoUUN3ME2wMlAxODByMECzOVkh|ryP M{HLRXNCVkeHUh?=
MV-4-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMECwNFk2PiEQvF2= NXTFeoRnW0GQR1XS
MEG-01 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXsWGZmUUN3ME2wMlAxODF{ODFOwG0> MorpV2FPT0WU
LAMA-84 NHnTZ3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMECwNVY2KM7:TR?= NEjLbIxUSU6JRWK=
CGTH-W-1 Ml;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jVNWlEPTB;MD6wNFE3QSEQvF2= NGPtelZUSU6JRWK=
KASUMI-1 M{n0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPPTWM2OD1yLkCwNlE4KM7:TR?= M4n6NnNCVkeHUh?=
BE-13 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzY[HdVUUN3ME2wMlAxOjV7IN88US=> M1rR[nNCVkeHUh?=
CTV-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEC1NlEh|ryP Mkf2V2FPT0WU
NKM-1 NGHyRVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMEC2OVUh|ryP MX\TRW5ITVJ?
MONO-MAC-6 MnvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTFTWM2OD1yLkCwPFM4KM7:TR?= Mk\jV2FPT0WU
A204 NEPnRolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEGyNVgh|ryP MoL5V2FPT0WU
GDM-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;QW2lEPTB;MD6wNVg{OyEQvF2= NY\YOVNzW0GQR1XS
AN3-CA NFPNUIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEG4O|Mh|ryP M{DGWXNCVkeHUh?=
BL-70 NWLJNoY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT2Nop1UUN3ME2wMlAzOTl7IN88US=> M2[1PHNCVkeHUh?=
Daudi M2ruS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Pkc2lEPTB;MD6wNlU{PyEQvF2= MYnTRW5ITVJ?
KU812 NHzSRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4frc2lEPTB;MD6wNlg1QCEQvF2= MXnTRW5ITVJ?
KG-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\FWGhDUUN3ME2wMlA{Ojl2IN88US=> Mn7oV2FPT0WU
DOHH-2 NHm2dHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDtTWM2OD1yLkC0PFA{KM7:TR?= NETJOnVUSU6JRWK=
HuO9 NUfoSIFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\2cYlKSzVyPUCuNFU1PDhizszN M{DXNnNCVkeHUh?=
EB2 M1T6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEW1O|Yh|ryP MUDTRW5ITVJ?
G-402 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLYTWM2OD1yLkC2N|QyKM7:TR?= NV2yO21ZW0GQR1XS
SU-DHL-1 NI\lRVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nMSWlEPTB;MD6wOlM4QSEQvF2= MYTTRW5ITVJ?
NCI-H719 NXXzU4ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\tZmlEPTB;MD6wO|g5QCEQvF2= M37rNHNCVkeHUh?=
MLMA NVvMfnUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rVbGlEPTB;MD6wPVA3KM7:TR?= NYH3bXBtW0GQR1XS
KM12 Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\VWpRKSzVyPUCuNFk4OzdizszN M{nV[nNCVkeHUh?=
SUP-T1 M{myU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3BUndKSzVyPUCuNFk6QDJizszN MnrEV2FPT0WU
MZ1-PC Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMUGzN|Yh|ryP MlnsV2FPT0WU
MFE-296 M{To[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrWTWM2OD1yLkGxPFM6KM7:TR?= M3fGTHNCVkeHUh?=
ALL-PO NFv4eHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETr[FNKSzVyPUCuNVI1PDNizszN M1PaUXNCVkeHUh?=
GB-1 M4ezWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zvOGlEPTB;MD6xNlUyOiEQvF2= NEjBOm9USU6JRWK=
SIG-M5 NEPwNnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVuwcJBEUUN3ME2wMlE{OzdizszN MYLTRW5ITVJ?
P30-OHK MkH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjmR|k{UUN3ME2wMlE2Pjd{IN88US=> NGP0bGRUSU6JRWK=
NCI-H716 NXO5OXp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7BeVRKSzVyPUCuNVYzPjZizszN NX;2Z3lJW0GQR1XS
MPP-89 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUO0W5RsUUN3ME2wMlE3QTN|IN88US=> MkDJV2FPT0WU
SF126 NXi0VXVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvETWM2OD1yLkG3NFY{KM7:TR?= MWfTRW5ITVJ?
CTB-1 M1H6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMUezNVYh|ryP NYDYboltW0GQR1XS
CA46 M2\H[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnwR2t[UUN3ME2wMlE4PDh7IN88US=> NELrfGpUSU6JRWK=
NCI-H520 NYq2TG5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnBTWM2OD1yLkG3O|MzKM7:TR?= NFXQOGtUSU6JRWK=
CAL-85-1 M1nFfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\PRVVVUUN3ME2wMlE4QTJ5IN88US=> NV\0VlR[W0GQR1XS
NCI-H2342 NVfkOVl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn6XZJKSzVyPUCuNVg2PzdizszN MmLMV2FPT0WU
697 M3nHT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1T2bmlEPTB;MD6xPFg4OSEQvF2= M{DDTnNCVkeHUh?=
NY M4fYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXkWYlKUUN3ME2wMlE6Ojh5IN88US=> NX7EOnhWW0GQR1XS
T98G MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fzS2lEPTB;MD6xPVMyQCEQvF2= NXHDSINDW0GQR1XS
NCI-H1703 NX71ZmdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULPZ2poUUN3ME2wMlE6PjF3IN88US=> NYDXTJJRW0GQR1XS
NCI-H2087 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMkC0N|kh|ryP M2T5UHNCVkeHUh?=
PF-382 NE\DRnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\VR4pKSzVyPUCuNlA5PzNizszN NH:zPYxUSU6JRWK=
HCT-116 NYDhOY9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXWNmZ1UUN3ME2wMlIyODZ7IN88US=> MmrBV2FPT0WU
CAKI-1 M4DwU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;sPGlEPTB;MD6yNVY3PiEQvF2= NEDZNoVUSU6JRWK=
CCF-STTG1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XCVGlEPTB;MD6yNlQ4PSEQvF2= M{XHTnNCVkeHUh?=
D-392MG MknCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rhZWlEPTB;MD6yN|E4PyEQvF2= NGjEdnZUSU6JRWK=
RT-112 NYDye4ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n5eWlEPTB;MD6yN|c6PSEQvF2= MWjTRW5ITVJ?
MES-SA NWXDZox7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXLTWM2OD1yLkK0NVg4KM7:TR?= NFW0[WhUSU6JRWK=
LC-2-ad M4i0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMkSyOlUh|ryP NGHNV49USU6JRWK=
NOS-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\DSGlEPTB;MD6yOFM3PyEQvF2= M4HwTHNCVkeHUh?=
NALM-6 M1S5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV33XnNLUUN3ME2wMlI2PTR|IN88US=> M2DsN3NCVkeHUh?=
TE-15 M1fXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7aTWM2OD1yLkK2NFkyKM7:TR?= MkLMV2FPT0WU
786-0 M{HlW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUezdZNpUUN3ME2wMlI3OjJ6IN88US=> MW\TRW5ITVJ?
IST-MES1 M4PoXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMk[4Nlkh|ryP M{\VdnNCVkeHUh?=
KYSE-180 NGP6VGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvNTWM2OD1yLkK2PFkyKM7:TR?= NYL5fnNuW0GQR1XS
YT NFzWZXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTITWM2OD1yLkK2PVc1KM7:TR?= NWDHNIw3W0GQR1XS
A427 NUTMfIxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\1TJRLUUN3ME2wMlI4OjZ2IN88US=> NYnr[pBEW0GQR1XS
KYSE-450 NEPFXlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn2W2ZKSzVyPUCuNlc{OjlizszN NGXTb5FUSU6JRWK=
HuH-7 NW\uR|RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHZOHdKSzVyPUCuNlc4PjNizszN MkmzV2FPT0WU
CAS-1 M3e4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMkizNFMh|ryP NULvNYJDW0GQR1XS
KURAMOCHI MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMki0NVkh|ryP NXXEZ4p4W0GQR1XS
ACHN M2TTNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\EUFRKSzVyPUCuNlk{OjNizszN Mn63V2FPT0WU
HGC-27 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW2OINKSzVyPUCuNlk{PTNizszN MUPTRW5ITVJ?
A172 Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvMdm93UUN3ME2wMlI6PTd5IN88US=> M4DZR3NCVkeHUh?=
SNU-449 MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{i4RmlEPTB;MD6yPVk3PCEQvF2= MorQV2FPT0WU
SW982 NH\CVmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojsTWM2OD1yLkK5PVc5KM7:TR?= MVHTRW5ITVJ?
EFO-21 NF;VUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nMVGlEPTB;MD6zNFQyOSEQvF2= M1fFfXNCVkeHUh?=
NCI-H2030 NGnIboFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnCWVZKSzVyPUCuN|EyPjRizszN Mmm4V2FPT0WU
HT-144 NUXnbXpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjpd5NKSzVyPUCuN|EzQCEQvF2= MXjTRW5ITVJ?
MFE-280 NGTLUnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHXVpprUUN3ME2wMlMyPDV|IN88US=> NFTBXpdUSU6JRWK=
SK-LU-1 M2fsRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXFXFdbUUN3ME2wMlMyPDZ4IN88US=> M1j5eHNCVkeHUh?=
NCI-H2052 M1SxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37BRWlEPTB;MD6zNVQ5PCEQvF2= MXfTRW5ITVJ?
SK-HEP-1 MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV60VVl5UUN3ME2wMlM{OzZ6IN88US=> MkjxV2FPT0WU
QIMR-WIL MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwM{O0NlQh|ryP MlrLV2FPT0WU
A2780 NFnv[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[4Z4pKSzVyPUCuN|Q{ODRizszN NEGyO4dUSU6JRWK=
ACN MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnmZWJGUUN3ME2wMlM1QDd|IN88US=> MUjTRW5ITVJ?
BxPC-3 NH\sPJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjITWM2OD1yLkO0PVg6KM7:TR?= MYPTRW5ITVJ?
BCPAP NIqxcFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnFdVJKSzVyPUCuN|YxODFizszN M4HMe3NCVkeHUh?=
HOP-62 M37jV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzub5pFUUN3ME2wMlM3OTB4IN88US=> Ml21V2FPT0WU
SW1710 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS3ZYFKSzVyPUCuN|Y1PTVizszN MkXOV2FPT0WU
OPM-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnSTWM2OD1yLkO2OFc{KM7:TR?= NYHofGE2W0GQR1XS
DBTRG-05MG NVHKOJB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwM{iwOVQh|ryP MVvTRW5ITVJ?
SK-MEL-24 MnXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwM{m3PVEh|ryP MkHMV2FPT0WU
8305C MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnZTWM2OD1yLkO5O|k{KM7:TR?= M1vwTHNCVkeHUh?=
OVCAR-4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwNEG1PFYh|ryP NFXGS5ZUSU6JRWK=
HLE Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P1NGlEPTB;MD60NVg3KM7:TR?= Mnv6V2FPT0WU
NCI-H747 NF3HV4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrTTWM2OD1yLkSyNVM4KM7:TR?= NFTpVWdUSU6JRWK=
SW780 NHXVbJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwNEKzOFYh|ryP NIH1NGhUSU6JRWK=
KYSE-150 NF;5NY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\mU5pzUUN3ME2wMlQzPDF3IN88US=> MUTTRW5ITVJ?
H4 M3zI[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwNEK0OVEh|ryP M33QTnNCVkeHUh?=
SW1088 NEHrfZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTh[o5KSzVyPUCuOFQ{QSEQvF2= M{HMNXNCVkeHUh?=
SF268 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwNES4OkDPxE1? NHnFNZdUSU6JRWK=
RT4 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWiwZ45FUUN3ME2wMlQ2OTFzIN88US=> NGfDc2NUSU6JRWK=
NCI-H522 NV\yVYJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCyTmFxUUN3ME2wMlQ2OjdizszN MV;TRW5ITVJ?
LCLC-97TM1 M1PHT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwNE[xPVUh|ryP M1\XPHNCVkeHUh?=
CAL-39 M2rnWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwNE[1NVkh|ryP M{XGN3NCVkeHUh?=
CAL-120 NEPXeIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH1TWM2OD1yLkS3OlQ{KM7:TR?= MknFV2FPT0WU
ESS-1 NWDMTplmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnr6TWM2OD1yLkS3PFIyKM7:TR?= NHjQ[nNUSU6JRWK=
KARPAS-45 NYfTU|FOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILhdZRKSzVyPUCuOFg6OzNizszN M1rvUHNCVkeHUh?=
DU-4475 MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLiTWM2OD1yLkS5OVEyKM7:TR?= Mn;wV2FPT0WU
VMRC-RCZ NV;C[IZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITrcmhKSzVyPUCuOFk6ODRizszN MknwV2FPT0WU
HOS M3XocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPEV5B7UUN3ME2wMlUxOzZ3IN88US=> NIDpcnRUSU6JRWK=
MOLT-16 M4HTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwNUG4NFgh|ryP M{nyRnNCVkeHUh?=
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D-542MG MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPi[IFbUUN3ME2xMlg2QDVzIN88US=> M3;qVnNCVkeHUh?=
KNS-42 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH0XYtwUUN3ME2xMlg3OjZ4IN88US=> MX7TRW5ITVJ?
NCI-H2452 M4XDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XUTmlEPTB;MT64PVA4PCEQvF2= NYXYXFM6W0GQR1XS
SK-MEL-2 M{PkV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTHPYdKSzVyPUGuPVAzPzFizszN M1f4T3NCVkeHUh?=
OVCAR-5 NIDFW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTFwOUC2O|Uh|ryP NYTDfm06W0GQR1XS
SNG-M Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f3cWlEPTB;MT65OVg2QCEQvF2= NHjESIZUSU6JRWK=
A673 Ml6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFwOUe1NVYh|ryP NFrSbYdUSU6JRWK=
L-428 NGjRSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHTR4pOUUN3ME2xMlk6OTd7IN88US=> NFzjUJJUSU6JRWK=
KM-H2 M1jnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TCNGlEPTB;Mj6wNVA6KM7:TR?= MnKzV2FPT0WU
MC-IXC NV\GVnExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\lT5g2UUN3ME2yMlAzOjd|IN88US=> NE\oPJhUSU6JRWK=
COLO-678 NWTLSG4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLoTWM2OD1{LkC0NlA4KM7:TR?= MX3TRW5ITVJ?
MEL-JUSO NHzLWFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjrTWM2OD1{LkC3PFUyKM7:TR?= MoLIV2FPT0WU
HCC38 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TpOmlEPTB;Mj6wPFQ{OyEQvF2= MVHTRW5ITVJ?
UACC-62 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\CfJVGUUN3ME2yMlA5QDV3IN88US=> MknLV2FPT0WU
OAW-42 MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTITWM2OD1{LkC5O|EyKM7:TR?= Ml;QV2FPT0WU
LB996-RCC M3nzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fuSmlEPTB;Mj6xN|gyPyEQvF2= M4[z[3NCVkeHUh?=
COR-L105 NGG0RmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvKOZNOUUN3ME2yMlE3Ozd|IN88US=> M2LtW3NCVkeHUh?=
RCC10RGB NU\xcmE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzFZlNwUUN3ME2yMlE5PTd4IN88US=> NFTDXmhUSU6JRWK=
A431 NX72PWhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPjTWM2OD1{LkG5NFE6KM7:TR?= NGHQXFlUSU6JRWK=
NCI-H292 M1LDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH4dWdKSzVyPUKuNlM6PTFizszN MXzTRW5ITVJ?
SK-UT-1 NFX5[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;OU29KSzVyPUKuN|MyQDRizszN M1i2SHNCVkeHUh?=
PANC-08-13 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln5TWM2OD1{LkOzNlM2KM7:TR?= MXPTRW5ITVJ?
ST486 NYO5TnE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HPXmlEPTB;Mj60NVA1QCEQvF2= M1Xk[HNCVkeHUh?=
SJSA-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nucmlEPTB;Mj60NVI4OSEQvF2= M3vOcnNCVkeHUh?=
RKO MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2i4[GlEPTB;Mj60NlAzQSEQvF2= NXHWe2tWW0GQR1XS
NCI-H1793 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\CWmlEPTB;Mj60OFAzQSEQvF2= Mnr6V2FPT0WU
639-V MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXOTWM2OD1{LkS1N|gzKM7:TR?= MVjTRW5ITVJ?
ES3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELxcYpKSzVyPUKuOFk4OzdizszN NEPPbodUSU6JRWK=
NCI-H1792 NWHwV5VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTyTWM2OD1{LkW2PFI3KM7:TR?= MmfkV2FPT0WU
NCI-H1651 NIDWZWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nld2lEPTB;Mj61PFIyKM7:TR?= MmmyV2FPT0WU
SN12C MmXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LNRWlEPTB;Mj61PFQ5PyEQvF2= NEHPOlhUSU6JRWK=
COLO-679 NFLldo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHQUGx1UUN3ME2yMlU5PjB3IN88US=> MlzKV2FPT0WU
U-118-MG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmK2TWM2OD1{LkW4PFczKM7:TR?= NUTPToJsW0GQR1XS
Ramos-2G6-4C10 M1;MfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O2d2lEPTB;Mj62OFgxPyEQvF2= M17BXXNCVkeHUh?=
HCT-15 NUjtSmFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnOzTWM2OD1{Lk[4O|kzKM7:TR?= NH;0RYRUSU6JRWK=
MDA-MB-157 NVu3V3lYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTEWXpKSzVyPUKuO|A4PDdizszN M2nZVXNCVkeHUh?=
K5 NXPnSJRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\tfm9iUUN3ME2yMlcyQDR3IN88US=> MkjVV2FPT0WU
MKN45 NEf2RZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HjUWlEPTB;Mj63N|M3PiEQvF2= MVfTRW5ITVJ?
DMS-273 NVnlTJlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHmO2pFUUN3ME2yMlc2PjN{IN88US=> MnWyV2FPT0WU
C8166 NYnKU4V7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf2TWM2OD1{Lke4OVE{KM7:TR?= NH:2S3pUSU6JRWK=
Calu-3 M1jsdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJwN{i5Olkh|ryP M1rDSnNCVkeHUh?=
SNB75 NUjOfYJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTYRYNjUUN3ME2yMlg5PTN3IN88US=> NEjwSIxUSU6JRWK=
BFTC-905 NITCdXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XzZWlEPTB;Mj65NFE6OSEQvF2= Ml3qV2FPT0WU
C-4-II M3OzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED3WXlKSzVyPUKuPVE{PTNizszN MlrFV2FPT0WU
MS-1 NW\RPZlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJwOU[3Olkh|ryP M4n5ZXNCVkeHUh?=
A375 NULuTlRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLwbnZYUUN3ME2zMlA5OTh2IN88US=> MojkV2FPT0WU
KYSE-70 NH3Fd|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvqR4RKSzVyPUOuNFg5QDJizszN NIDPbJBUSU6JRWK=
KYSE-510 NYDydWlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTNwMUC5PVUh|ryP MX3TRW5ITVJ?
LN-405 MmjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnhUI8yUUN3ME2zMlE{PTF6IN88US=> MkD6V2FPT0WU
BOKU M4fXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlruTWM2OD1|LkG0NlU3KM7:TR?= M4T3TnNCVkeHUh?=
TE-10 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULrSYFxUUN3ME2zMlE4OzZ{IN88US=> NHnGZnVUSU6JRWK=
MKN1 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfHfI1KSzVyPUOuNVg1QDNizszN NGDmO4hUSU6JRWK=
M059J MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfzcpNoUUN3ME2zMlIxOTd|IN88US=> MXvTRW5ITVJ?
GOTO MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTNwMkKwN|kh|ryP M{HBfXNCVkeHUh?=
DK-MG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjSTFdrUUN3ME2zMlI2QTd4IN88US=> M2fqdHNCVkeHUh?=
NCI-H727 M3\oV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\PdHpKSzVyPUOuNlY2QCEQvF2= M4nBXnNCVkeHUh?=
NB12 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fEVWlEPTB;Mz6zN|IzPCEQvF2= M{LKNXNCVkeHUh?=
DOK NFr3bYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DNfmlEPTB;Mz6zOlE5PiEQvF2= NHvFNlVUSU6JRWK=
KYSE-410 NUCxVXFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK0d5hKSzVyPUOuN|YzQDdizszN NUPnWVFoW0GQR1XS
AM-38 M1PNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP4NlBqUUN3ME2zMlM5ODVzIN88US=> MnzjV2FPT0WU
GR-ST NWD2[HpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\NUGJNUUN3ME2zMlQ2PzN{IN88US=> M2m0[HNCVkeHUh?=
D-247MG NHrNNpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTDNJFKSzVyPUOuOFgzPjNizszN MkHKV2FPT0WU
TE-8 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:yOIFPUUN3ME2zMlQ6OzN|IN88US=> NYjBXVNqW0GQR1XS
LS-411N MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzHTWM2OD1|LkS5OlkzKM7:TR?= NFK0dmpUSU6JRWK=
SK-MES-1 MkP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLsN5ZKSzVyPUOuOVY1OzNizszN M3jXcXNCVkeHUh?=
SF295 NIPuOVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rDcGlEPTB;Mz62NVU2OiEQvF2= NXHXdWwzW0GQR1XS
SK-MEL-30 NYDGfYhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrBfYtbUUN3ME2zMlY2QTJzIN88US=> MWnTRW5ITVJ?
LB2241-RCC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTNwNk[yOkDPxE1? NFXJWoxUSU6JRWK=
PC-14 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrK[mw5UUN3ME2zMlY3PDN5IN88US=> NIjjVHVUSU6JRWK=
EW-7 NF3JTYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7ITWM2OD1|Lk[3Olk{KM7:TR?= M2LuZ3NCVkeHUh?=
NMC-G1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjaTWM2OD1|LkexPFM4KM7:TR?= MXHTRW5ITVJ?
TE-441-T MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTNwN{OwNlgh|ryP MWDTRW5ITVJ?
NCI-H1618 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTNwOEG4O|Uh|ryP NFXwRm5USU6JRWK=
PANC-03-27 NVvmd3RnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqwWHRxUUN3ME2zMlgyQTF4IN88US=> M3yw[HNCVkeHUh?=
NCI-H2228 NGDkU3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTNwOEOxNlYh|ryP NVuxU5ZKW0GQR1XS
CAPAN-1 M2PXWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zYTWlEPTB;Mz64O|AxQSEQvF2= NGPqVnVUSU6JRWK=
KLE MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\TXYFKSzVyPUOuPVA3PyEQvF2= MUPTRW5ITVJ?
Becker M2PXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;XXmlEPTB;Mz65Nlg1QSEQvF2= NFnablVUSU6JRWK=
SK-PN-DW Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnWSJd[UUN3ME20MlA4QTd2IN88US=> NWexdFRiW0GQR1XS
Hs-578-T M1fENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfpTWM2OD12LkC4N|A3KM7:TR?= MorTV2FPT0WU
RS4-11 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS5TWM2OD12LkGxNlU2KM7:TR?= NHL3T3RUSU6JRWK=
D-502MG MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvJVGtKSzVyPUSuNVY6QTdizszN NIi4Z2lUSU6JRWK=
GI-1 NGDzOnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzacoU5UUN3ME20MlI5Ojl7IN88US=> MoTWV2FPT0WU
NCI-H209 NWDRcpVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\mWYhyUUN3ME20MlM{PzhizszN NEC2To1USU6JRWK=
SK-OV-3 NWPoT3ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTRwNEixOFkh|ryP NYDHUGNIW0GQR1XS
LOUCY M2PYbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPpSIFKSzVyPUSuOFg1OzJizszN NXnWNmx7W0GQR1XS
NCI-H69 M2TBVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoSzTWM2OD12LkWxO|k{KM7:TR?= MlnMV2FPT0WU
SCC-9 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkX5TWM2OD12LkWzNVczKM7:TR?= M3jjcHNCVkeHUh?=
NCI-H526 NH36PIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;QPWlEPTB;ND61PVI6OyEQvF2= NV7OUnVJW0GQR1XS
NCI-H2170 MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTRwNk[3O|Eh|ryP MkXnV2FPT0WU
SR NWrESJZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e4e2lEPTB;ND63NFA1QCEQvF2= NH;zPI9USU6JRWK=
CMK Mn\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjaWnNKSzVyPUSuO|IyODFizszN MWfTRW5ITVJ?
COLO-829 NXzsWZZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLueXFKSzVyPUSuO|cxPDNizszN NGfwWWxUSU6JRWK=
HuO-3N1 NE\QW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonwTWM2OD12LkizNlgyKM7:TR?= NFzuVJJUSU6JRWK=
5637 NHzNV3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\Q[JZGUUN3ME20MlkxPDh5IN88US=> MlXZV2FPT0WU
A253 NEXJPYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLqTWM2OD12Lkm3O|A5KM7:TR?= M1XHR3NCVkeHUh?=
NB10 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVK2OW5jUUN3ME21MlA4PDl5IN88US=> M1nhWHNCVkeHUh?=
SF539 Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2ybHhmUUN3ME21MlA6QTV7IN88US=> MVnTRW5ITVJ?
HAL-01 NV;6TYpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvaNZhnUUN3ME21MlE1PjR3IN88US=> Ml:2V2FPT0WU
MHH-ES-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDVZZNKSzVyPUWuNVY6OjVizszN MkTEV2FPT0WU
DEL MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGOxeGZKSzVyPUWuNlc2QDJizszN M{P3UnNCVkeHUh?=
NCI-H1299 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDsWW06UUN3ME21MlM2ODB5IN88US=> MYDTRW5ITVJ?
ChaGo-K-1 MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jFZmlEPTB;NT6zOVExPyEQvF2= NXf0XZFDW0GQR1XS
HMV-II M{jLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7Bb|NKSzVyPUWuN|k1OyEQvF2= M2nCeXNCVkeHUh?=
NB69 MoDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDsdHJUUUN3ME21MlM6PjNzIN88US=> NWLQT3J1W0GQR1XS
NCI-H1882 NXe2XWdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XtN2lEPTB;NT60N|M3PCEQvF2= NEPyU2xUSU6JRWK=
SNU-475 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTVwNEexO|Eh|ryP MXjTRW5ITVJ?
RXF393 NFT6e4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HWbmlEPTB;NT60PFQ6PCEQvF2= M{Hr[3NCVkeHUh?=
CAL-51 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnxVolKSzVyPUWuOlI5PTNizszN MnS4V2FPT0WU
SW1573 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz2UIh3UUN3ME21MlY{PTN2IN88US=> MmX4V2FPT0WU
GCT MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Xm[WlEPTB;NT63OVkzQSEQvF2= NUfzcVNOW0GQR1XS
COR-L88 NFzabHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHCfpFKSzVyPUWuO|Y5PDZizszN NYHUN4xNW0GQR1XS
MDA-MB-134-VI NEDKdZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rFR2lEPTB;NT64O|U{PiEQvF2= MVLTRW5ITVJ?
NB5 M{jSfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTVwOUK0OEDPxE1? M2P1dXNCVkeHUh?=
GMS-10 MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jSVmlEPTB;NT65Olg3OSEQvF2= MoT2V2FPT0WU
CHP-212 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:1SWlEPTB;Nj60PFI3PyEQvF2= M3zLWXNCVkeHUh?=
TE-11 M1nYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTZwNUWxPFIh|ryP NXPCbmxuW0GQR1XS
SW962 NIe0c3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P6TWlEPTB;Nj62OVc4PCEQvF2= MXHTRW5ITVJ?
MZ2-MEL NUTJPXVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LLc2lEPTB;Nj64NlAyOSEQvF2= MUTTRW5ITVJ?
C-33-A MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXQTWM2OD14LkmxOlg5KM7:TR?= M1HoOnNCVkeHUh?=
IGR-1 NX;B[4xwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXrfJpKSzVyPU[uPVc5OjZizszN Mo\hV2FPT0WU
MOLT-4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:yT2ZzUUN3ME23MlE2PDB4IN88US=> M1HrXXNCVkeHUh?=
NCI-H1650 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq4SlN3UUN3ME23MlI4ODR4IN88US=> NWHjT|BGW0GQR1XS
AsPC-1 NX7ublBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XrSWlEPTB;Nz6yPFYxPSEQvF2= MUHTRW5ITVJ?
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LU-165 MnTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTJ{LkW1OEDPxE1? MmnGV2FPT0WU
COLO-792 NUjWT5hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTpd5JYUUN3ME2yNk44OTFzIN88US=> NG\2e2tUSU6JRWK=
CAL-62 M33BWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTsTWM2OD1{Mj63OVE4KM7:TR?= MXPTRW5ITVJ?
HCE-T M3:5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojlTWM2OD1{Mj64OlA3KM7:TR?= NUPYZ3VuW0GQR1XS
BB65-RCC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3OTWM2OD1{Mz6wN|Q1KM7:TR?= NH;4R3ZUSU6JRWK=
SiHa M{O1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;STWM2OD1{Mz6zPVY5KM7:TR?= MXrTRW5ITVJ?
NCI-H2081 Mmm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnkXnVKSzVyPUK0MlA3PDFizszN M2i3PHNCVkeHUh?=
U251 NYe2N5BUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTMOFBtUUN3ME2yOE4xPjZ6IN88US=> M{nKcHNCVkeHUh?=
LoVo M3nPXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJ2LkmyPFIh|ryP MmD6V2FPT0WU
GCIY NVLlOHhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7zTWM2OD1{NT6yPFc4KM7:TR?= MVHTRW5ITVJ?
NUGC-3 Mo\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PEe2lEPTB;MkWuN|MyPiEQvF2= MonSV2FPT0WU
LNCaP-Clone-FGC NGO0c4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\FVIhKSzVyPUK1MlM1QThizszN NFzPW|NUSU6JRWK=
PA-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jzTWlEPTB;MkWuOlg{OyEQvF2= M1XZNHNCVkeHUh?=
OE33 NX6wTpBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTFTFlmUUN3ME2yOU43QDV|IN88US=> NWqwV2w4W0GQR1XS
HT-29 M4TZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfOTXJuUUN3ME2yOU44QDd7IN88US=> MnjwV2FPT0WU
RCM-1 NXixSG9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJ3Lkm2OVYh|ryP NX7KdJU5W0GQR1XS
NCI-H1522 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJ3Lkm5NVEh|ryP NV3idVcxW0GQR1XS
LB373-MEL-D MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJ4LkG3NFgh|ryP NFO3bZZUSU6JRWK=
NCI-H1436 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJ4LkK3N|gh|ryP M2fST3NCVkeHUh?=
COLO-824 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\JSXlzUUN3ME2yOk41ODB{IN88US=> MoDrV2FPT0WU
CP50-MEL-B MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHRc|BHUUN3ME2yOk42Pjd3IN88US=> MmXuV2FPT0WU
EGI-1 NHrUfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PsXGlEPTB;MkeuNlY6QCEQvF2= MVLTRW5ITVJ?
LAN-6 NX62T4xJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJ5LkO1PVgh|ryP NUWyepdwW0GQR1XS
GAK NXSx[|RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DTWmlEPTB;MkeuOFIzPSEQvF2= MmTLV2FPT0WU
MDA-MB-175-VII Mof6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zxR2lEPTB;MkeuOVA2OyEQvF2= NGS0Z4tUSU6JRWK=
JVM-2 NGfweVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPGPGU6UUN3ME2yO{43PjJ{IN88US=> M4PNOnNCVkeHUh?=
UACC-257 NGf3ZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{j6SGlEPTB;MkeuOlg4QCEQvF2= NGj1SnRUSU6JRWK=
SW1783 NHr2ZlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDqTWM2OD1{Nz63O|g{KM7:TR?= Mlu3V2FPT0WU
HT-3 M2m3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DCdmlEPTB;MkiuNlE3PiEQvF2= Mn\1V2FPT0WU
RL Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJ6LkW5NVEh|ryP NXPuNWpjW0GQR1XS
TK10 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfJOFhQUUN3ME2yPE43PTN3IN88US=> NVXRVJVlW0GQR1XS
HT55 NWTFWZpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLnTWM2OD1{OT6wOVY2KM7:TR?= M4DYUnNCVkeHUh?=
BT-20 MkLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJ7LkC1PFYh|ryP NF35O2lUSU6JRWK=
TGBC24TKB MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojQTWM2OD1{OT6xPFMyKM7:TR?= M2TlUnNCVkeHUh?=
HSC-2 M1vCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjoO4pKSzVyPUK5MlMxODFizszN M1TRUnNCVkeHUh?=
COLO-205 NGHPeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELIPXhKSzVyPUK5MlM6PDRizszN MljsV2FPT0WU
GT3TKB NG\RWHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnMTWM2OD1{OT62PFc4KM7:TR?= MlXtV2FPT0WU
T47D MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXtXGVKSzVyPUK5Mlg2QDJizszN MkXYV2FPT0WU
OMC-1 M{LwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTmWFhRUUN3ME2zNE4yQTF7IN88US=> NF7QNW5USU6JRWK=
PFSK-1 NYjEWpBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPJephXUUN3ME2zNU4zPjV7IN88US=> MWTTRW5ITVJ?
JEG-3 MlfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL5eXFJUUN3ME2zNU4{PTZzIN88US=> MnvSV2FPT0WU
RD NXvzOpk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjNTWM2OD1|MT61NVE2KM7:TR?= MkfxV2FPT0WU
NCI-H64 M2P5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\aTWM2OD1|Mj60NVc6KM7:TR?= MXfTRW5ITVJ?
DMS-114 M4W0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK3[ZNvUUN3ME2zNk41OTh{IN88US=> M1THSHNCVkeHUh?=
NCI-H661 M324dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jHeWlEPTB;M{KuOlUxOSEQvF2= NF7OOZVUSU6JRWK=
CAL-148 NXW4OXRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWSzVlBVUUN3ME2zNk43PjZ3IN88US=> NVrR[3ZOW0GQR1XS
HuP-T3 M{HwWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHGfm5KSzVyPUOyMlk{OzhizszN M{PMW3NCVkeHUh?=
ES4 NVrXOGs4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fGNGlEPTB;M{OuNVcxPSEQvF2= NGj3SodUSU6JRWK=
Ca9-22 M3zGbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLTWIczUUN3ME2zN{41PjBzIN88US=> M4\Bc3NCVkeHUh?=
LP-1 NIrxS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfTZmdKSzVyPUO0MlA6KM7:TR?= MVPTRW5ITVJ?
AU565 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LBc2lEPTB;M{SuOVA3QSEQvF2= NV[zRWhHW0GQR1XS
MDA-MB-453 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;yVWQzUUN3ME2zOU4yPDJ4IN88US=> MkPRV2FPT0WU
SNU-C1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LlNmlEPTB;M{WuNVcyKM7:TR?= NVWxZ|kzW0GQR1XS
SW13 MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3YSYlKSzVyPUO1MlQxPzZizszN NUXwZXJrW0GQR1XS
NCI-H2122 NU[0flZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXmSGhKSzVyPUO1MlU2QThizszN MmjPV2FPT0WU
NCI-H1395 M4DOTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGqzRXRKSzVyPUO1MlY3QTFizszN MYLTRW5ITVJ?
J-RT3-T3-5 NGPKT3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2P2b2lEPTB;M{[uNFI6PCEQvF2= NHnXU5pUSU6JRWK=
COR-L279 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[3UGlEPTB;M{[uNVk5OSEQvF2= NYO1UpBSW0GQR1XS
ATN-1 NHnEO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzjTWM2OD1|Nj64OVE3KM7:TR?= MWfTRW5ITVJ?
HCC2998 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGS5W5RKSzVyPUO2Mlg2PzFizszN M2rhPHNCVkeHUh?=
UM-UC-3 M2HNSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTaTWM2OD1|Nj64Olc2KM7:TR?= M2PKTHNCVkeHUh?=
DV-90 M1W4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjlW3NKSzVyPUO2MlkxPjdizszN MULTRW5ITVJ?
ES8 NV\EV4JFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[zdGlEPTB;M{[uPVMyQCEQvF2= MVfTRW5ITVJ?
YAPC NFPzfVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLQTWM2OD1|Nj65OlU1KM7:TR?= M4L1VXNCVkeHUh?=
HCC1599 M2PSWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTN5LkG2NVgh|ryP NV6zRXpPW0GQR1XS
UMC-11 NIS0VnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnuXmpxUUN3ME2zO{4zPTB|IN88US=> NXHp[HBDW0GQR1XS
THP-1 M{XQVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;wc|U6UUN3ME2zO{4zQDZ6IN88US=> NUe2cY9PW0GQR1XS
OCUB-M NH;LZmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLFcVFKSzVyPUO3MlI5QTFizszN MlfNV2FPT0WU
NCI-H1693 NEXMSXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3KR4dKSzVyPUO3MlMzOzNizszN NGLEdFNUSU6JRWK=
NCI-H345 NXjRXolqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnpNmxKSzVyPUO3MlM3OjRizszN M3LmWHNCVkeHUh?=
COLO-800 NUTMXmJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDMTWM2OD1|Nz61Olch|ryP M17GeXNCVkeHUh?=
COLO-320-HSR NFjpZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTN6LkO0PVIh|ryP MVXTRW5ITVJ?
NCI-H596 NIfnU2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrjTWM2OD1|OD60OFg6KM7:TR?= MYXTRW5ITVJ?
NCI-H187 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPaTWM2OD1|OD63N|Q1KM7:TR?= MVfTRW5ITVJ?
ECC4 MmjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUSzcHVyUUN3ME2zPU4xQDF2IN88US=> MnrqV2FPT0WU
KP-4 MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTN7LkGyN|Uh|ryP MmTlV2FPT0WU
NCI-H2227 M2faTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;2TWM2OD1|OT6zPVQ6KM7:TR?= M1qwTXNCVkeHUh?=
22RV1 M4fldGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mke3TWM2OD1|OT64N|k5KM7:TR?= MXjTRW5ITVJ?
SAS NILHTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7rTWM2OD12MD6wPVYh|ryP NUjCVo81W0GQR1XS
PANC-10-05 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrI[JpKSzVyPUSwMlE5OjhizszN NUfpOZVMW0GQR1XS
MDA-MB-468 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TwVWlEPTB;NECuOVM1PiEQvF2= M3\OSHNCVkeHUh?=
RPMI-7951 NXT4fmJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHXUpZKSzVyPUSxMlIxPzVizszN NVnsTVdZW0GQR1XS
BB49-HNC NGHzeVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13ReGlEPTB;NEGuNlE4QSEQvF2= MYnTRW5ITVJ?
23132-87 Mk\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTRzLkK3N|Ih|ryP NUHCPIlJW0GQR1XS
HCC1569 NUHBVGJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTRzLkK4PFUh|ryP NFX1bohUSU6JRWK=
CP66-MEL M4HHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnaTWM2OD12Mj6xPFg3KM7:TR?= MX7TRW5ITVJ?
K-562 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXux[XRqUUN3ME20Nk4zQDV2IN88US=> MVXTRW5ITVJ?
OCI-AML2 Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTR{Lki5O|Qh|ryP MY\TRW5ITVJ?
SW756 NUPnZoJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTR|LkCzPFgh|ryP MnvQV2FPT0WU
M14 NF;JfY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTR|LkOxPFkh|ryP NULoWFJLW0GQR1XS
NCI-H1623 NYmxWZp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4i5e2lEPTB;NEOuOFY1KM7:TR?= NHTZ[VFUSU6JRWK=
KNS-81-FD M3PxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH73UWZKSzVyPUSzMlc3OiEQvF2= MYrTRW5ITVJ?
TGBC1TKB NYf4XpJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7KTWM2OD12Mz65NFk6KM7:TR?= NFHiN2VUSU6JRWK=
RERF-LC-MS M3\id2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn0TlRqUUN3ME20N{46OjhzIN88US=> MYjTRW5ITVJ?
PC-3 MmTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:4TWM2OD12ND60N|Q4KM7:TR?= NFjmfIRUSU6JRWK=
HuP-T4 NHXzSplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHCOIVKSzVyPUS0MlQ1PzRizszN NVfvdpg2W0GQR1XS
NCI-H510A NX3mOZJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITFWpFKSzVyPUS0MlcxQCEQvF2= NV7O[5JUW0GQR1XS
LB2518-MEL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXZNm9KSzVyPUS0Mlc6OzdizszN NGjJRpVUSU6JRWK=
TE-5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6zbJNKSzVyPUS1Mlk2QDFizszN MWfTRW5ITVJ?
EW-24 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Tve2lEPTB;NE[uNVczOyEQvF2= MXrTRW5ITVJ?
LB647-SCLC M1vn[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH0T4NwUUN3ME20Ok4zOTV3IN88US=> Ml;aV2FPT0WU
NCI-H524 NIPUPHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTo[npKUUN3ME20Ok44OTh3IN88US=> NInZWYNUSU6JRWK=
EW-11 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFG4bppKSzVyPUS2Mlk{PzNizszN NHPXNodUSU6JRWK=
KALS-1 Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\VdYk{UUN3ME20O{4zODZ4IN88US=> Mn:xV2FPT0WU
BT-474 M1r1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzrTWM2OD12Nz60NlE3KM7:TR?= MonDV2FPT0WU
SK-N-AS MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:yR3VKSzVyPUS3Mlg5QCEQvF2= MmnIV2FPT0WU
HCC2157 M2PGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDqXYhOUUN3ME20PE4xPzZizszN NV;FXWdNW0GQR1XS
HCC1954 NULYcoRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDG[Y94UUN3ME20PE4yPzB2IN88US=> NUf6UJhyW0GQR1XS
FADU MoOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33RTGlEPTB;NEiuN|A{OSEQvF2= MorDV2FPT0WU
S-117 NVXKc2NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX5WXhKSzVyPUS4MlM5OTVizszN MnrKV2FPT0WU
LS-1034 NE\CfXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTR6LkewOlch|ryP MYDTRW5ITVJ?
CAMA-1 NGXsRWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofoTWM2OD12OT61OVQ{KM7:TR?= MYnTRW5ITVJ?
LU-134-A NUHyeGhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnjbnc4UUN3ME20PU45ODh3IN88US=> NUDlXHg1W0GQR1XS
NCI-H1838 NX3pSppYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrzZZRKSzVyPUS5MlgxQDdizszN NInX[nJUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
+ Expand

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
+ Expand
  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID