Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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4 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NYTWe|QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf3TWM2OD1yLkCwNFAxODB|NUmg{txO MYTTRW5ITVJ?
MV-4-11 NWDPRnFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfwZXhKSzVyPUCuNFAxODl3NjFOwG0> NXLqUVV7W0GQR1XS
MEG-01 MnvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn20TWM2OD1yLkCwNFEzQCEQvF2= NEXMdG5USU6JRWK=
LAMA-84 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn6N3BKSzVyPUCuNFAxOTZ3IN88US=> NHflWpNUSU6JRWK=
CGTH-W-1 MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\wTWM2OD1yLkCwNVY6KM7:TR?= NIe0fJRUSU6JRWK=
KASUMI-1 NF;nVm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjWUpZKSzVyPUCuNFAzOTdizszN NIL6dmpUSU6JRWK=
BE-13 NV7KXmFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMECyOVkh|ryP NXXiRlhbW0GQR1XS
CTV-1 NYTVS2NYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HKW2lEPTB;MD6wNFUzOSEQvF2= MVXTRW5ITVJ?
NKM-1 MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV72XGZHUUN3ME2wMlAxPjV3IN88US=> NV3IV3BVW0GQR1XS
MONO-MAC-6 M2L4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPx[pFKSzVyPUCuNFA5OzdizszN NFfG[XNUSU6JRWK=
A204 NX7TVHl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq2e5R3UUN3ME2wMlAyOjF6IN88US=> M2LiS3NCVkeHUh?=
GDM-1 NH\HWIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G4VGlEPTB;MD6wNVg{OyEQvF2= MYDTRW5ITVJ?
AN3-CA MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfsfGZKSzVyPUCuNFE5PzNizszN MnvzV2FPT0WU
BL-70 NWniOZdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi2eGptUUN3ME2wMlAzOTl7IN88US=> MWnTRW5ITVJ?
Daudi MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjlXGZKSzVyPUCuNFI2OzdizszN MULTRW5ITVJ?
KU812 NWDxcGdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGqwe25KSzVyPUCuNFI5PDhizszN MWHTRW5ITVJ?
KG-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;vTWM2OD1yLkCzNlk1KM7:TR?= M4\5d3NCVkeHUh?=
DOHH-2 Ml\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\1bGQ3UUN3ME2wMlA1QDB|IN88US=> NXH1doNDW0GQR1XS
HuO9 MnPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{mweGlEPTB;MD6wOVQ1QCEQvF2= NUfQOXp2W0GQR1XS
EB2 NUe5NVJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vPZWlEPTB;MD6wOVU4PiEQvF2= NV3zVVRGW0GQR1XS
G-402 NXO3R412T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\mUpoxUUN3ME2wMlA3OzRzIN88US=> NEPCSoNUSU6JRWK=
SU-DHL-1 NYqwTFRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwME[zO|kh|ryP NF64XIhUSU6JRWK=
NCI-H719 NXnRcI1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW5VXlKSzVyPUCuNFc5QDhizszN NFfLVXhUSU6JRWK=
MLMA NWT6VmJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjwXmQ1UUN3ME2wMlA6ODZizszN MnjSV2FPT0WU
KM12 NFnLVIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHyTWM2OD1yLkC5O|M4KM7:TR?= NFzSfIhUSU6JRWK=
SUP-T1 NFziO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEm5PFIh|ryP MofhV2FPT0WU
MZ1-PC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjTS4ZKSzVyPUCuNVE{OzZizszN NIPN[pFUSU6JRWK=
MFE-296 M2HleWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G5fmlEPTB;MD6xNVg{QSEQvF2= NHHoW4pUSU6JRWK=
ALL-PO NHP3N2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnFZVd3UUN3ME2wMlEzPDR|IN88US=> M3TWTHNCVkeHUh?=
GB-1 M3Ly[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2G3TmlEPTB;MD6xNlUyOiEQvF2= M3jnWXNCVkeHUh?=
SIG-M5 M2jMWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMUOzO{DPxE1? MmXsV2FPT0WU
P30-OHK NGra[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHGxNlVKSzVyPUCuNVU3PzJizszN MYPTRW5ITVJ?
NCI-H716 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMU[yOlYh|ryP NVXBd|IzW0GQR1XS
MPP-89 MkTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\DS3RwUUN3ME2wMlE3QTN|IN88US=> NVjNUoxHW0GQR1XS
SF126 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17obWlEPTB;MD6xO|A3OyEQvF2= MX3TRW5ITVJ?
CTB-1 NXvaWGY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMUezNVYh|ryP NHTON4ZUSU6JRWK=
CA46 NHzlc|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrNPYhLUUN3ME2wMlE4PDh7IN88US=> NY[wO2FHW0GQR1XS
NCI-H520 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3T5OmlEPTB;MD6xO|c{OiEQvF2= MXfTRW5ITVJ?
CAL-85-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnqwTWM2OD1yLkG3PVI4KM7:TR?= NGjZOYNUSU6JRWK=
NCI-H2342 NULHRpVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PHZ2lEPTB;MD6xPFU4PyEQvF2= NUPlOXh3W0GQR1XS
697 NIq5c2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnITWM2OD1yLkG4PFcyKM7:TR?= NF3o[nhUSU6JRWK=
NY M1ezWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMUmyPFch|ryP MVPTRW5ITVJ?
T98G MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nGUWlEPTB;MD6xPVMyQCEQvF2= NUjWSWZHW0GQR1XS
NCI-H1703 NWS1Xnc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDaTWM2OD1yLkG5OlE2KM7:TR?= MULTRW5ITVJ?
NCI-H2087 MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMkC0N|kh|ryP MU\TRW5ITVJ?
PF-382 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3xTWM2OD1yLkKwPFc{KM7:TR?= NYW1U29OW0GQR1XS
HCT-116 M1LPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjuN2RoUUN3ME2wMlIyODZ7IN88US=> NX7tUJV3W0GQR1XS
CAKI-1 NGTFfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MomxTWM2OD1yLkKxOlY3KM7:TR?= MmjHV2FPT0WU
CCF-STTG1 M4jETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfqTWM2OD1yLkKyOFc2KM7:TR?= MnXaV2FPT0WU
D-392MG NICzc45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe1eFRyUUN3ME2wMlI{OTd5IN88US=> NFPWUmFUSU6JRWK=
RT-112 MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HJemlEPTB;MD6yN|c6PSEQvF2= NWTObWFyW0GQR1XS
MES-SA NFi4VYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHGwTYVKSzVyPUCuNlQyQDdizszN NWnxZXhzW0GQR1XS
LC-2-ad M1vEU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO1XGZKSzVyPUCuNlQzPjVizszN M1HFV3NCVkeHUh?=
NOS-1 NUPQWnRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMkSzOlch|ryP M2TpPHNCVkeHUh?=
NALM-6 NVLVR4E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfNTWM2OD1yLkK1OVQ{KM7:TR?= NGSwXYJUSU6JRWK=
TE-15 NHXMeoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i1NWlEPTB;MD6yOlA6OSEQvF2= MmLoV2FPT0WU
786-0 MlPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMk[yNlgh|ryP MV7TRW5ITVJ?
IST-MES1 NGLOSYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TTTWlEPTB;MD6yOlgzQSEQvF2= NEXkV21USU6JRWK=
KYSE-180 M{fvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXO2e2xFUUN3ME2wMlI3QDlzIN88US=> NIPkeGhUSU6JRWK=
YT MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjFfGM{UUN3ME2wMlI3QTd2IN88US=> NFf1dmxUSU6JRWK=
A427 Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\jNmlEPTB;MD6yO|I3PCEQvF2= MnL4V2FPT0WU
KYSE-450 NF3venJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXKyTGVYUUN3ME2wMlI4OzJ7IN88US=> NFjXR3VUSU6JRWK=
HuH-7 NVW1WWhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf6emhKSzVyPUCuNlc4PjNizszN NYW5enpOW0GQR1XS
CAS-1 MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMkizNFMh|ryP NIfR[lFUSU6JRWK=
KURAMOCHI NX7mTm9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3Mbm53UUN3ME2wMlI5PDF7IN88US=> M1T0U3NCVkeHUh?=
ACHN NGfLTnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHLU3RKSzVyPUCuNlk{OjNizszN M1\TUXNCVkeHUh?=
HGC-27 M{OzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3uTWM2OD1yLkK5N|U{KM7:TR?= NYLMZ4lyW0GQR1XS
A172 M4frdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMkm1O|ch|ryP Mmn2V2FPT0WU
SNU-449 NXi5c5BvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn25TWM2OD1yLkK5PVY1KM7:TR?= NFjJR5FUSU6JRWK=
SW982 M3qxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMkm5O|gh|ryP NGPyV2JUSU6JRWK=
EFO-21 NF;zWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TiUWlEPTB;MD6zNFQyOSEQvF2= MUDTRW5ITVJ?
NCI-H2030 MmLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHLZ3RvUUN3ME2wMlMyOTZ2IN88US=> NW[4SoxLW0GQR1XS
HT-144 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Hrb2lEPTB;MD6zNVI5KM7:TR?= MVvTRW5ITVJ?
MFE-280 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHJTWM2OD1yLkOxOFU{KM7:TR?= M1rmfXNCVkeHUh?=
SK-LU-1 MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXyz[ZVMUUN3ME2wMlMyPDZ4IN88US=> M2e2VXNCVkeHUh?=
NCI-H2052 NEKyXVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwM{G0PFQh|ryP NX3QTHJyW0GQR1XS
SK-HEP-1 Mor3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml2wTWM2OD1yLkOzN|Y5KM7:TR?= MV\TRW5ITVJ?
QIMR-WIL NIjkXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwM{O0NlQh|ryP MnnWV2FPT0WU
A2780 M1L5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwM{SzNFQh|ryP M3[xcHNCVkeHUh?=
ACN NFPoSZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwM{S4O|Mh|ryP NUXZd4ExW0GQR1XS
BxPC-3 MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzQTWM2OD1yLkO0PVg6KM7:TR?= MoTnV2FPT0WU
BCPAP NX3vT4VLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfmTWM2OD1yLkO2NFAyKM7:TR?= NYXiXWpiW0GQR1XS
HOP-62 M1\KfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPV[nVPUUN3ME2wMlM3OTB4IN88US=> NGGxdWxUSU6JRWK=
SW1710 M{L2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\HPYlKSzVyPUCuN|Y1PTVizszN NUDD[HpTW0GQR1XS
OPM-2 NXjSTJhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH31TIJKSzVyPUCuN|Y1PzNizszN MU\TRW5ITVJ?
DBTRG-05MG M3H2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoD2TWM2OD1yLkO4NFU1KM7:TR?= NIHlPW1USU6JRWK=
SK-MEL-24 M2LYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj1OW46UUN3ME2wMlM6PzlzIN88US=> NHPJO29USU6JRWK=
8305C MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Xnb2lEPTB;MD6zPVc6OyEQvF2= Ml23V2FPT0WU
OVCAR-4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPCV4hKSzVyPUCuOFE2QDZizszN MVnTRW5ITVJ?
HLE MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrrS5lKSzVyPUCuOFE5PiEQvF2= MX\TRW5ITVJ?
NCI-H747 M4XNVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwNEKxN|ch|ryP MYPTRW5ITVJ?
SW780 MkH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHDRW9GUUN3ME2wMlQzOzR4IN88US=> NGnQ[nNUSU6JRWK=
KYSE-150 NHXpXplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrJfWZuUUN3ME2wMlQzPDF3IN88US=> M2Htb3NCVkeHUh?=
H4 NGfJXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\B[m5KSzVyPUCuOFI1PTFizszN NFHEN3FUSU6JRWK=
SW1088 M2f6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFiyRXNKSzVyPUCuOFQ{QSEQvF2= M1L4OnNCVkeHUh?=
SF268 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHoTWM2OD1yLkS0PFYh|ryP MoTQV2FPT0WU
RT4 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G1fGlEPTB;MD60OVEyOSEQvF2= NYHORmhYW0GQR1XS
NCI-H522 M4LFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwNEWyO{DPxE1? NXrDPJZxW0GQR1XS
LCLC-97TM1 MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwNE[xPVUh|ryP NXPvbXFXW0GQR1XS
CAL-39 NUPXb3dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwNE[1NVkh|ryP NHK2PVhUSU6JRWK=
CAL-120 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17BfWlEPTB;MD60O|Y1OyEQvF2= Mnr3V2FPT0WU
ESS-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwNEe4NlEh|ryP NVnCWZZSW0GQR1XS
KARPAS-45 NYqxSndrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLSN|VKSzVyPUCuOFg6OzNizszN NF\3cZlUSU6JRWK=
DU-4475 NVezUHo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfkTWM2OD1yLkS5OVEyKM7:TR?= NXXB[lE4W0GQR1XS
VMRC-RCZ MlO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT6TWM2OD1yLkS5PVA1KM7:TR?= MXHTRW5ITVJ?
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KNS-42 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTHR4t[UUN3ME2xMlg3OjZ4IN88US=> NIrufG5USU6JRWK=
NCI-H2452 NULqSmh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTFwOEmwO|Qh|ryP M1TaXnNCVkeHUh?=
SK-MEL-2 NUWyWIhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjBO5dKSzVyPUGuPVAzPzFizszN NF7IdYFUSU6JRWK=
OVCAR-5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTFwOUC2O|Uh|ryP M1XF[nNCVkeHUh?=
SNG-M NFHYclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXpNZdKSzVyPUGuPVU5PThizszN MmnoV2FPT0WU
A673 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP4T3ZKSzVyPUGuPVc2OTZizszN M4D4RnNCVkeHUh?=
L-428 M2\2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjmWJV2UUN3ME2xMlk6OTd7IN88US=> NGjQXWVUSU6JRWK=
KM-H2 M3;Tcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLoZ5hUUUN3ME2yMlAyODlizszN M4XsUnNCVkeHUh?=
MC-IXC M4PMWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3QbJZKSzVyPUKuNFIzPzNizszN MX7TRW5ITVJ?
COLO-678 M{PKU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTJwMESyNFch|ryP MWXTRW5ITVJ?
MEL-JUSO MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULBRmI1UUN3ME2yMlA4QDVzIN88US=> NUjnb4cyW0GQR1XS
HCC38 M4fpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TXdGlEPTB;Mj6wPFQ{OyEQvF2= M3P2NXNCVkeHUh?=
UACC-62 NFfXVmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrvPFhKSzVyPUKuNFg5PTVizszN M1nUV3NCVkeHUh?=
OAW-42 NX3PeY9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJwMEm3NVEh|ryP NWnXWlhLW0GQR1XS
LB996-RCC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDZR25KSzVyPUKuNVM5OTdizszN MV3TRW5ITVJ?
COR-L105 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJwMU[zO|Mh|ryP MnTpV2FPT0WU
RCC10RGB M3\kWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPtTWM2OD1{LkG4OVc3KM7:TR?= MWDTRW5ITVJ?
A431 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjOS2xKSzVyPUKuNVkxOTlizszN NHuwWnpUSU6JRWK=
NCI-H292 Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7iXWwzUUN3ME2yMlI{QTVzIN88US=> Mnj6V2FPT0WU
SK-UT-1 NU\kNFZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDibIo{UUN3ME2yMlM{OTh2IN88US=> NXrK[IxWW0GQR1XS
PANC-08-13 M3z2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TLOmlEPTB;Mj6zN|I{PSEQvF2= NULqOGlCW0GQR1XS
ST486 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H0XWlEPTB;Mj60NVA1QCEQvF2= M{[yUXNCVkeHUh?=
SJSA-1 M3jqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D6cWlEPTB;Mj60NVI4OSEQvF2= NX22fo9[W0GQR1XS
RKO MnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHNTWM2OD1{LkSyNFI6KM7:TR?= NIfNSlhUSU6JRWK=
NCI-H1793 NYDPT29HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJwNESwNlkh|ryP NWe3eldZW0GQR1XS
639-V MlPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTrTWM2OD1{LkS1N|gzKM7:TR?= NULFO2lWW0GQR1XS
ES3 M4Lo[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{WxVGlEPTB;Mj60PVc{PyEQvF2= NHzCPVBUSU6JRWK=
NCI-H1792 NHjxe5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoflTWM2OD1{LkW2PFI3KM7:TR?= M2rlN3NCVkeHUh?=
NCI-H1651 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLKTWM2OD1{LkW4NlEh|ryP NHHrZWFUSU6JRWK=
SN12C Mlu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnZfWZnUUN3ME2yMlU5PDh5IN88US=> NWH4N5ZLW0GQR1XS
COLO-679 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXSTWM2OD1{LkW4OlA2KM7:TR?= Mof0V2FPT0WU
U-118-MG Moe2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJwNUi4O|Ih|ryP NEmxeFJUSU6JRWK=
Ramos-2G6-4C10 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jaSWlEPTB;Mj62OFgxPyEQvF2= M1zKdHNCVkeHUh?=
HCT-15 M{O1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTveINQUUN3ME2yMlY5Pzl{IN88US=> NF7XXndUSU6JRWK=
MDA-MB-157 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVG5NHlNUUN3ME2yMlcxPzR5IN88US=> MVHTRW5ITVJ?
K5 MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJwN{G4OFUh|ryP MYfTRW5ITVJ?
MKN45 NHO1[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXZR4tDUUN3ME2yMlc{OzZ4IN88US=> MkPVV2FPT0WU
DMS-273 NFPHe|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jvfmlEPTB;Mj63OVY{OiEQvF2= NWrKeo5vW0GQR1XS
C8166 NHrNbZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX1S5ZKSzVyPUKuO|g2OTNizszN NX;2XHZ2W0GQR1XS
Calu-3 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJwN{i5Olkh|ryP NUXWTlVPW0GQR1XS
SNB75 MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPGOGxGUUN3ME2yMlg5PTN3IN88US=> NH\3SFRUSU6JRWK=
BFTC-905 NVPzT2hwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPPVnZKSzVyPUKuPVAyQTFizszN M1ThXnNCVkeHUh?=
C-4-II M2f6Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XOOGlEPTB;Mj65NVM2OyEQvF2= M1fDfXNCVkeHUh?=
MS-1 MoqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJwOU[3Olkh|ryP Mom4V2FPT0WU
A375 M1\XXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7UTWM2OD1|LkC4NVg1KM7:TR?= NX7XeoFCW0GQR1XS
KYSE-70 M1r3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC5TWM2OD1|LkC4PFgzKM7:TR?= M2nLNnNCVkeHUh?=
KYSE-510 NH3QWZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXxNFBKSzVyPUOuNVA6QTVizszN MXzTRW5ITVJ?
LN-405 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[1TWM2OD1|LkGzOVE5KM7:TR?= MmLkV2FPT0WU
BOKU M3jlR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;HTWM2OD1|LkG0NlU3KM7:TR?= MmrkV2FPT0WU
TE-10 MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTNwMUezOlIh|ryP NIrpZYJUSU6JRWK=
MKN1 NGjtfnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rHfmlEPTB;Mz6xPFQ5OyEQvF2= NHPNbYVUSU6JRWK=
M059J NVeyW4Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\3PZVKSzVyPUOuNlAyPzNizszN NUDZWVNTW0GQR1XS
GOTO NWKxN3RnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnr4TWM2OD1|LkKyNFM6KM7:TR?= NYfybHJQW0GQR1XS
DK-MG M2Tudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfv[FJKSzVyPUOuNlU6PzZizszN MYHTRW5ITVJ?
NCI-H727 NWLPOmFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTNwMk[1PEDPxE1? NXjsUYYxW0GQR1XS
NB12 NVvBUmpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OwdGlEPTB;Mz6zN|IzPCEQvF2= NFq2PGZUSU6JRWK=
DOK MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTNwM{[xPFYh|ryP NI\NSZhUSU6JRWK=
KYSE-410 MmTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3IOmNKSzVyPUOuN|YzQDdizszN NVj6eGZPW0GQR1XS
AM-38 NI\CXZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nybGlEPTB;Mz6zPFA2OSEQvF2= M2ezenNCVkeHUh?=
GR-ST M{HGWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHuyPZRKSzVyPUOuOFU4OzJizszN M2TwS3NCVkeHUh?=
D-247MG MoX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLrTWM2OD1|LkS4NlY{KM7:TR?= MXPTRW5ITVJ?
TE-8 NW\3S|YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HyO2lEPTB;Mz60PVM{OyEQvF2= NVnqdZV[W0GQR1XS
LS-411N MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzmcZNKSzVyPUOuOFk3QTJizszN MoHWV2FPT0WU
SK-MES-1 NFHINY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnsTWM2OD1|LkW2OFM{KM7:TR?= NUHNe4lkW0GQR1XS
SF295 MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTNwNkG1OVIh|ryP MV7TRW5ITVJ?
SK-MEL-30 NUP6UoxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjyNlJKSzVyPUOuOlU6OjFizszN NH;tPJhUSU6JRWK=
LB2241-RCC NGrYbmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTNwNk[yOkDPxE1? MUHTRW5ITVJ?
PC-14 NEXme2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TyVGlEPTB;Mz62OlQ{PyEQvF2= NXzjTHd6W0GQR1XS
EW-7 NIXqZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLRNo5KSzVyPUOuOlc3QTNizszN MlXwV2FPT0WU
NMC-G1 MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD6[oNKSzVyPUOuO|E5OzdizszN Mn\rV2FPT0WU
TE-441-T NIHoUHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX6TWM2OD1|LkezNFI5KM7:TR?= NYXCO5FGW0GQR1XS
NCI-H1618 MoXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvvTWM2OD1|LkixPFc2KM7:TR?= MV\TRW5ITVJ?
PANC-03-27 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HOe2lEPTB;Mz64NVkyPiEQvF2= M3Tvd3NCVkeHUh?=
NCI-H2228 NGrUR|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTNwOEOxNlYh|ryP M2T3THNCVkeHUh?=
CAPAN-1 NVPxd5Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;QNpJMUUN3ME2zMlg4ODB7IN88US=> MXHTRW5ITVJ?
KLE NVrMb2MzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTNwOUC2O{DPxE1? NWDP[nFvW0GQR1XS
Becker MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzYR4hKSzVyPUOuPVI5PDlizszN M2WwSHNCVkeHUh?=
SK-PN-DW NGnucpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XudGlEPTB;ND6wO|k4PCEQvF2= M{XqWnNCVkeHUh?=
Hs-578-T M1HhSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m3R2lEPTB;ND6wPFMxPiEQvF2= M2jTPXNCVkeHUh?=
RS4-11 MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfETI1KSzVyPUSuNVEzPTVizszN M2\qO3NCVkeHUh?=
D-502MG MmS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\SR5RoUUN3ME20MlE3QTl5IN88US=> Mnu0V2FPT0WU
GI-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzOTWM2OD12LkK4Nlk6KM7:TR?= NXvhZZRTW0GQR1XS
NCI-H209 NWq4bmd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrHPZRKSzVyPUSuN|M4QCEQvF2= NYO3XmZNW0GQR1XS
SK-OV-3 Mn:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTRwNEixOFkh|ryP NEe4fJBUSU6JRWK=
LOUCY NFnmNI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\6ZXlkUUN3ME20MlQ5PDN{IN88US=> M2jHcXNCVkeHUh?=
NCI-H69 NH7acZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfyTWM2OD12LkWxO|k{KM7:TR?= Mn;yV2FPT0WU
SCC-9 NV7rOVlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfk[opKSzVyPUSuOVMyPzJizszN MXTTRW5ITVJ?
NCI-H526 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnsPHlyUUN3ME20MlU6Ojl|IN88US=> MX;TRW5ITVJ?
NCI-H2170 MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHXNYl5UUN3ME20MlY3PzdzIN88US=> MX;TRW5ITVJ?
SR NUTOc5pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnncpN2UUN3ME20MlcxODR6IN88US=> M2PMbXNCVkeHUh?=
CMK M1\JTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoOzTWM2OD12LkeyNVAyKM7:TR?= NI\VcHlUSU6JRWK=
COLO-829 MmTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXUTWM2OD12Lke3NFQ{KM7:TR?= M4\2[XNCVkeHUh?=
HuO-3N1 M4LaUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT6dHpKSzVyPUSuPFMzQDFizszN MYPTRW5ITVJ?
5637 M2jVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PPe2lEPTB;ND65NFQ5PyEQvF2= NVnH[Gd4W0GQR1XS
A253 NXTSPHV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTRwOUe3NFgh|ryP M{K5b3NCVkeHUh?=
NB10 NUjsT4s{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\IZ2lEPTB;NT6wO|Q6PyEQvF2= NHLTS4dUSU6JRWK=
SF539 M2frOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTVwMEm5OVkh|ryP MkfqV2FPT0WU
HAL-01 MonZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLHTWM2OD13LkG0OlQ2KM7:TR?= NHLofnZUSU6JRWK=
MHH-ES-1 NETCT3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHQTWM2OD13LkG2PVI2KM7:TR?= Mn3lV2FPT0WU
DEL NWrhSXBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrEbGdbUUN3ME21MlI4PTh{IN88US=> M13rZXNCVkeHUh?=
NCI-H1299 M1Wzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTYbJhKSzVyPUWuN|UxODdizszN NUD6NW5uW0GQR1XS
ChaGo-K-1 MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PLUWlEPTB;NT6zOVExPyEQvF2= NWjUVJBYW0GQR1XS
HMV-II MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfKTWM2OD13LkO5OFMh|ryP MV7TRW5ITVJ?
NB69 NIG3U2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTVwM{m2N|Eh|ryP MXTTRW5ITVJ?
NCI-H1882 NGXwNHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTVwNEOzOlQh|ryP MmXkV2FPT0WU
SNU-475 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3S2TWlEPTB;NT60O|E4OSEQvF2= NX2xO49XW0GQR1XS
RXF393 NVnNbohxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTVwNEi0PVQh|ryP NWroN4c1W0GQR1XS
CAL-51 MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTVwNkK4OVMh|ryP MlrFV2FPT0WU
SW1573 M1Pyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTHTWM2OD13Lk[zOVM1KM7:TR?= MUDTRW5ITVJ?
GCT MoPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmi0TWM2OD13Lke1PVI6KM7:TR?= NH\hc41USU6JRWK=
COR-L88 M1PRVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTVwN{[4OFYh|ryP NYS3eXE{W0GQR1XS
MDA-MB-134-VI Ml;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL3V5BKSzVyPUWuPFc2OzZizszN M1jISXNCVkeHUh?=
NB5 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTVwOUK0OEDPxE1? NXzxeZU6W0GQR1XS
GMS-10 NGW3UXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV70OpozUUN3ME21Mlk3QDZzIN88US=> MUnTRW5ITVJ?
CHP-212 NV3yTI1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnl[nRKSzVyPU[uOFgzPjdizszN NWHLSZlRW0GQR1XS
TE-11 M33yV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTZwNUWxPFIh|ryP M{PkUHNCVkeHUh?=
SW962 NVvHXIRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2qxb2lEPTB;Nj62OVc4PCEQvF2= NFvleI1USU6JRWK=
MZ2-MEL M3jFOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDW[npbUUN3ME22MlgzODFzIN88US=> MX3TRW5ITVJ?
C-33-A NHn6[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDRTmZNUUN3ME22MlkyPjh6IN88US=> MnLQV2FPT0WU
IGR-1 NWTVc5k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPUTWM2OD14Lkm3PFI3KM7:TR?= NXXseGN6W0GQR1XS
MOLT-4 NX;TSXRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\0fGdKSzVyPUeuNVU1ODZizszN NIm1PWVUSU6JRWK=
NCI-H1650 NHfMfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTdwMkewOFYh|ryP M{DrPHNCVkeHUh?=
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NCI-H630 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj2fnBKSzVyPUKyMlU{PjNizszN M4HEfHNCVkeHUh?=
LU-165 M3zXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:5TWM2OD1{Mj61OVQh|ryP Ml\DV2FPT0WU
COLO-792 M3;i[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvWTWM2OD1{Mj63NVEyKM7:TR?= NFLSe2pUSU6JRWK=
CAL-62 NH2zNGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXSWpZKSzVyPUKyMlc2OTdizszN NGm4SFBUSU6JRWK=
HCE-T NXnOemFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUi5Z2k6UUN3ME2yNk45PjB4IN88US=> NY\qVnZkW0GQR1XS
BB65-RCC NH6xTm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TaWmlEPTB;MkOuNFM1PCEQvF2= NVLabJVUW0GQR1XS
SiHa M3fadmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJ|LkO5Olgh|ryP NGf4W4hUSU6JRWK=
NCI-H2081 NIns[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXGTWM2OD1{ND6wOlQyKM7:TR?= MXzTRW5ITVJ?
U251 MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPDTWM2OD1{ND6wOlY5KM7:TR?= MnfnV2FPT0WU
LoVo M{LrXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTJ2LkmyPFIh|ryP M3voNHNCVkeHUh?=
GCIY MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHQcoNiUUN3ME2yOU4zQDd5IN88US=> M{myXHNCVkeHUh?=
NUGC-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJ3LkOzNVYh|ryP MknrV2FPT0WU
LNCaP-Clone-FGC NYTGXo56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H2cWlEPTB;MkWuN|Q6QCEQvF2= NXmyVXlDW0GQR1XS
PA-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvJNoNCUUN3ME2yOU43QDN|IN88US=> NWrCWml5W0GQR1XS
OE33 NELXc|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvwTWM2OD1{NT62PFU{KM7:TR?= NYDjdoZGW0GQR1XS
HT-29 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPtTWM2OD1{NT63PFc6KM7:TR?= MUfTRW5ITVJ?
RCM-1 M17YXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJ3Lkm2OVYh|ryP M1\tWnNCVkeHUh?=
NCI-H1522 NYDITHdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvZTFZKSzVyPUK1Mlk6OTFizszN NUP4VWhpW0GQR1XS
LB373-MEL-D NVHXOXRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJ4LkG3NFgh|ryP MYHTRW5ITVJ?
NCI-H1436 MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXy5UohqUUN3ME2yOk4zPzN6IN88US=> MmPIV2FPT0WU
COLO-824 NFP2R3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfJTWM2OD1{Nj60NFAzKM7:TR?= NY\iW4d5W0GQR1XS
CP50-MEL-B NYLieZVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jQOWlEPTB;Mk[uOVY4PSEQvF2= M{fVenNCVkeHUh?=
EGI-1 NFj3UXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LldWlEPTB;MkeuNlY6QCEQvF2= MVHTRW5ITVJ?
LAN-6 NXrve2Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvwTWM2OD1{Nz6zOVk5KM7:TR?= MXnTRW5ITVJ?
GAK MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\2THJkUUN3ME2yO{41OjJ3IN88US=> MlvxV2FPT0WU
MDA-MB-175-VII MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJ5LkWwOVMh|ryP NEL6dGJUSU6JRWK=
JVM-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7wfVBKSzVyPUK3MlY3OjJizszN MVTTRW5ITVJ?
UACC-257 MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLKboJKSzVyPUK3MlY5PzhizszN NXv0eHNyW0GQR1XS
SW1783 M1S3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTJ5Lke3PFMh|ryP NULRW29JW0GQR1XS
HT-3 NF[0d5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\zVWlEPTB;MkiuNlE3PiEQvF2= MmXqV2FPT0WU
RL NUfRNoY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP4TWM2OD1{OD61PVEyKM7:TR?= NWe3XVBRW0GQR1XS
TK10 NELWSJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ6Lk[1N|Uh|ryP NX3RfnY5W0GQR1XS
HT55 NEXaWYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1i5[2lEPTB;MkmuNFU3PSEQvF2= NGXrSmtUSU6JRWK=
BT-20 M3;wdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETyOIRKSzVyPUK5MlA2QDZizszN MUXTRW5ITVJ?
TGBC24TKB Mm\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLTUZlKSzVyPUK5MlE5OzFizszN MWfTRW5ITVJ?
HSC-2 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFriZYFKSzVyPUK5MlMxODFizszN M3PXd3NCVkeHUh?=
COLO-205 Mlu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXO1R206UUN3ME2yPU4{QTR2IN88US=> NIPVfHhUSU6JRWK=
GT3TKB M3y3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1i0WGlEPTB;MkmuOlg4PyEQvF2= MY\TRW5ITVJ?
T47D M{fpcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;2bWlEPTB;MkmuPFU5OiEQvF2= NVzqT24xW0GQR1XS
OMC-1 NGn6d4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXtb2dKSzVyPUOwMlE6OTlizszN MV;TRW5ITVJ?
PFSK-1 NFLWOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTNzLkK2OVkh|ryP NGLQUWRUSU6JRWK=
JEG-3 M1P6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvrPI5KSzVyPUOxMlM2PjFizszN NGPB[ZJUSU6JRWK=
RD M{HV[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTNzLkWxNVUh|ryP MlLvV2FPT0WU
NCI-H64 NIm2W|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37FWWlEPTB;M{KuOFE4QSEQvF2= M{XlcHNCVkeHUh?=
DMS-114 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\JVmlEPTB;M{KuOFE5OiEQvF2= M2nTR3NCVkeHUh?=
NCI-H661 NHfYdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDSN|ZKSzVyPUOyMlY2ODFizszN NGDJTmRUSU6JRWK=
CAL-148 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[4UGhKSzVyPUOyMlY3PjVizszN Mo\UV2FPT0WU
HuP-T3 MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrtd|RKSzVyPUOyMlk{OzhizszN MWXTRW5ITVJ?
ES4 NVuw[4V6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTN|LkG3NFUh|ryP MljGV2FPT0WU
Ca9-22 M1XRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3KycWlEPTB;M{OuOFYxOSEQvF2= MnLlV2FPT0WU
LP-1 MmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTN2LkC5JO69VQ>? NFPZcYZUSU6JRWK=
AU565 NHXxNFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDn[mxKSzVyPUO0MlUxPjlizszN MWjTRW5ITVJ?
MDA-MB-453 M1PafWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLkZVA2UUN3ME2zOU4yPDJ4IN88US=> NWT5T5VvW0GQR1XS
SNU-C1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7yXnpKSzVyPUO1MlE4OSEQvF2= NVXROGJyW0GQR1XS
SW13 M4DXZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfrTWM2OD1|NT60NFc3KM7:TR?= MWXTRW5ITVJ?
NCI-H2122 MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTN3LkW1PVgh|ryP M{LyWXNCVkeHUh?=
NCI-H1395 M4mw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTN3Lk[2PVEh|ryP Mne2V2FPT0WU
J-RT3-T3-5 NWfKSpZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;KW2ZKSzVyPUO2MlAzQTRizszN M2TJTHNCVkeHUh?=
COR-L279 NFXIWVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWT6UIVCUUN3ME2zOk4yQThzIN88US=> MVjTRW5ITVJ?
ATN-1 M1f1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rrfGlEPTB;M{[uPFUyPiEQvF2= MYTTRW5ITVJ?
HCC2998 M1TBbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTN4Lki1O|Eh|ryP MnLQV2FPT0WU
UM-UC-3 NFzFVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnMbFhPUUN3ME2zOk45Pjd3IN88US=> MUDTRW5ITVJ?
DV-90 NVrwR41wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrPTWM2OD1|Nj65NFY4KM7:TR?= NXKwd|JDW0GQR1XS
ES8 M3HsT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTxSYVKSzVyPUO2Mlk{OThizszN NV:wNY9uW0GQR1XS
YAPC NFHhXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS0SXZKSzVyPUO2Mlk3PTRizszN Mo\yV2FPT0WU
HCC1599 Mk\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLzdZlPUUN3ME2zO{4yPjF6IN88US=> M1;0OXNCVkeHUh?=
UMC-11 Ml3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T4UmlEPTB;M{euNlUxOyEQvF2= MW\TRW5ITVJ?
THP-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTN5LkK4Olgh|ryP MU\TRW5ITVJ?
OCUB-M M1H4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTN5LkK4PVEh|ryP NV60V5N5W0GQR1XS
NCI-H1693 NILzd2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3vTWM2OD1|Nz6zNlM{KM7:TR?= M2\KZXNCVkeHUh?=
NCI-H345 M2m1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTN5LkO2NlQh|ryP NWfifZZEW0GQR1XS
COLO-800 M1;zV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLRRphPUUN3ME2zO{42PjdizszN MkTZV2FPT0WU
COLO-320-HSR MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTN6LkO0PVIh|ryP NICzeINUSU6JRWK=
NCI-H596 M3nFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTN6LkS0PFkh|ryP NFz2W3pUSU6JRWK=
NCI-H187 M1n4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTN6LkezOFQh|ryP M2mxW3NCVkeHUh?=
ECC4 NYHweXdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTN7LkC4NVQh|ryP NFX1R|lUSU6JRWK=
KP-4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PGZWlEPTB;M{muNVI{PSEQvF2= NWPue4hJW0GQR1XS
NCI-H2227 M332RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTKPYI6UUN3ME2zPU4{QTR7IN88US=> NF3FRVRUSU6JRWK=
22RV1 NF;DfJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjJTHVKSzVyPUO5Mlg{QThizszN NFXmepZUSU6JRWK=
SAS MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HZSGlEPTB;NECuNFk3KM7:TR?= MXnTRW5ITVJ?
PANC-10-05 NFXBZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4mzW2lEPTB;NECuNVgzQCEQvF2= MVXTRW5ITVJ?
MDA-MB-468 NHXtSmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHGSohKSzVyPUSwMlU{PDZizszN NWPUOId1W0GQR1XS
RPMI-7951 NELjVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\vXmlEPTB;NEGuNlA4PSEQvF2= M4TXeHNCVkeHUh?=
BB49-HNC NIDoPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zOSWlEPTB;NEGuNlE4QSEQvF2= MnzrV2FPT0WU
23132-87 NHLRWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PGdmlEPTB;NEGuNlc{OiEQvF2= MUDTRW5ITVJ?
HCC1569 M4LOU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDoTWM2OD12MT6yPFg2KM7:TR?= NIXyU2pUSU6JRWK=
CP66-MEL NWLN[XloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;PV|dKSzVyPUSyMlE5QDZizszN NFv0epZUSU6JRWK=
K-562 NGK1XppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTkTWM2OD12Mj6yPFU1KM7:TR?= MnL3V2FPT0WU
OCI-AML2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTR{Lki5O|Qh|ryP NIO0co5USU6JRWK=
SW756 M1jlZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPRTWM2OD12Mz6wN|g5KM7:TR?= NHjBPG5USU6JRWK=
M14 NGrHe41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTR|LkOxPFkh|ryP NHLVdWNUSU6JRWK=
NCI-H1623 NG\Bc4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWzTWM2OD12Mz60OlQh|ryP NIjPSZVUSU6JRWK=
KNS-81-FD MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLITWM2OD12Mz63OlIh|ryP NECxXZpUSU6JRWK=
TGBC1TKB NY[4cIN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTSTWM2OD12Mz65NFk6KM7:TR?= MXPTRW5ITVJ?
RERF-LC-MS MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP0TWM2OD12Mz65NlgyKM7:TR?= NXLYUmpqW0GQR1XS
PC-3 M{Dpe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfuTWM2OD12ND60N|Q4KM7:TR?= NX\XVGJLW0GQR1XS
HuP-T4 M4LrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW5S4tCUUN3ME20OE41PDd2IN88US=> M331TnNCVkeHUh?=
NCI-H510A MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTMTWM2OD12ND63NFgh|ryP MnfwV2FPT0WU
LB2518-MEL MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\ac2JKSzVyPUS0Mlc6OzdizszN MXjTRW5ITVJ?
TE-5 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHFeHNKSzVyPUS1Mlk2QDFizszN NYfSenBQW0GQR1XS
EW-24 MnHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXPTWM2OD12Nj6xO|I{KM7:TR?= NGW3bo1USU6JRWK=
LB647-SCLC MmC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MormTWM2OD12Nj6yNVU2KM7:TR?= MX3TRW5ITVJ?
NCI-H524 M{DaeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfXU2hKUUN3ME20Ok44OTh3IN88US=> NG\vV2VUSU6JRWK=
EW-11 Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\lTmlEPTB;NE[uPVM4OyEQvF2= NGq4bYdUSU6JRWK=
KALS-1 M{ixeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Xq[mlEPTB;NEeuNlA3PiEQvF2= MmCxV2FPT0WU
BT-474 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnGendWUUN3ME20O{41OjF4IN88US=> NYC1TFZ1W0GQR1XS
SK-N-AS NIKxUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTR5Lki4PEDPxE1? M4[0PXNCVkeHUh?=
HCC2157 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfCTWM2OD12OD6wO|Yh|ryP M4LI[nNCVkeHUh?=
HCC1954 M4nEdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHjWnNKSzVyPUS4MlE4ODRizszN NXPvSplTW0GQR1XS
FADU NITxSWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rHfWlEPTB;NEiuN|A{OSEQvF2= Ml7KV2FPT0WU
S-117 NFf4WYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTR6LkO4NVUh|ryP MUDTRW5ITVJ?
LS-1034 MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M325emlEPTB;NEiuO|A3PyEQvF2= M2nzeHNCVkeHUh?=
CAMA-1 NFTnbGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[zTWM2OD12OT61OVQ{KM7:TR?= NX\xWJZUW0GQR1XS
LU-134-A NXW1[2JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjSfFBIUUN3ME20PU45ODh3IN88US=> NWO2OG1RW0GQR1XS
NCI-H1838 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;vV2lEPTB;NEmuPFA5PyEQvF2= NUH1UoIyW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID