Catalog No.S8134 Synonyms: IY-5511
Molecular Weight(MW): 530.50
Radotinib is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia.
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Choose Selective Bcr-Abl Inhibitors
|Description||Radotinib is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia.|
In vitro, Radotinib binds BCR-ABL1 and reduces phosphorylation of CrkL, a BCR-ABL1 target protein. Radotinib also effectively inhibits the proliferation of common mutant clones of BCR-ABL1, with the exception of T315I.  In AML cells, radotinib significantly decreases the cell viability, promotes differentiation, and induces CD11b expression and apoptosis. In NB4, THP-1, and Kasumi-1 cells, radotinib also induces CD11b expression, and decreases the viability. 
|In vitro||DMSO||100 mg/mL (188.5 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02422719||Recruiting||Chronic Myeloid Leukemia||Ulsan University Hospital||April 2015||Phase 2|
|NCT02421926||Withdrawn||Leukemia, Myelogenous, Chronic, BCR-ABL Positive||Asan Medical Center||October 2014||--|
|NCT01511289||Completed||Leukemia|Leukemia, Myeloid|Leukemia, Myelogenous, Chronic, BCR-ABL Positive|Philadelphia Chromosome|Bone Marrow Diseases|Hematologic Diseases||Il-Yang Pharm. Co., Ltd.||August 2011||Phase 3|
|NCT01602952||Active, not recruiting||Leukemia|Leukemia, Myeloid|Leukemia, Myelogenous, Chronic, BCR-ABL Positive|Philadelphia Chromosome|Hematologic Diseases||Il-Yang Pharm. Co., Ltd.||July 2008||Phase 1|Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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