Home Metabolism Casein Kinase inhibitor (E/Z)-GO289 For research use only.

(E/Z)-GO289

(E/Z)-GO289 potently and selectively inhibits casein kinase 2 (CK2) at an IC50 of 7 nM in vitro kinase assay.

(E/Z)-GO289 Chemical Structure

(E/Z)-GO289 Chemical Structure

CAS: 694522-87-7

Selleck's (E/Z)-GO289 has been cited by 1 publication

Purity & Quality Control

Batch: S985001 DMSO] 21 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.95%
99.95

(E/Z)-GO289 Related Products

Choose Selective Casein Kinase Inhibitors

Biological Activity

Description

(E/Z)-GO289 potently and selectively inhibits casein kinase 2 (CK2) at an IC50 of 7 nM in vitro kinase assay.
Targets
CK2 [1]
(in vitro kinase assay)
7 nM
In vitro
In vitro

(E/Z)-GO289 has an effectively and selectively inhibition of casein kinase-2 (CK2), especially on CK2α and CK2α′, thus regulate the phosphorylation of clock protein. .<sup><a class="sref" href="#s_ref">[1]</a></sup>
Cell Research Cell lines Bmal1-dLuc U2OS cells
Concentrations 50 μM
Incubation Time --
Method

Agarose-conjugated GO457 was incubated with a U2OS cell lysate in the presence of 0 and 50 μM GO289. Affinity-purified proteins were analyzed by LC-MS/MS. The affinity-purified proteins from a U2OS cell lysate or recombinant CK2 were analyzed by immunoblotting with specific antibodies.

Chemical Information & Solubility

Molecular Weight 419.30 Formula

C17H15BrN4O2S
CAS No. 694522-87-7 SDF --
Smiles COC1=CC(=C(Br)C=C1O)\C=N\[N]2C(=NN=C2C3=CC=CC=C3)SC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 21 mg/mL ( (50.08 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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