- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S1443||Zileuton||<1 mg/mL||47 mg/mL||47 mg/mL|
|S3984||Nordihydroguaiaretic acid (NDGA)||<1 mg/mL||60 mg/mL||60 mg/mL|
|S8236||MK-886 (L-663,536)||<1 mg/mL||94 mg/mL||<1 mg/mL|
|S5122||Abietic Acid||-1 mg/mL||60 mg/mL||-1 mg/mL|
|S4711||Esculetin||<1 mg/mL||35 mg/mL||<1 mg/mL|
- Lipoxygenase Inhibitors (5)
- New Lipoxygenase Products
|Catalog No.||Information||Product Use Citations||Product Validations|
Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma.
CD19+ B cells (A) or PBMCs (B) from a healthy donor were treated with zileuton (10 μM) prior to 17-HDHA or RvD1 treatment, followed by stimulation with the IgE-inducing cocktail. Cell culture supernatants were collected at day 7, and IgE levels were measured. The experiment was done in one representative donor (mean ± SEM). Data were analyzed by 1-way ANOVA with Tukey’s post test, **P ≤ 0.01, ***P ≤ 0.001. PBMC, peripheral blood mononuclear cell.
Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties.
MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
Abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.
Esculetin is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).