• Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1443 Zileuton <1 mg/mL 47 mg/mL 47 mg/mL
S3984 Nordihydroguaiaretic acid (NDGA) <1 mg/mL 60 mg/mL 60 mg/mL
S8236 MK-886 (L-663,536) <1 mg/mL 94 mg/mL <1 mg/mL
S4711 Esculetin <1 mg/mL 35 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations


Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma.


Nordihydroguaiaretic acid (NDGA)

Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties.


MK-886 (L-663,536)

MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.



Esculetin is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).