Chenodeoxycholic Acid

Catalog No.S1843 Synonyms: Chenodiol

Chenodeoxycholic Acid Chemical Structure

Molecular Weight(MW): 392.57

Chenodeoxycholic Acid is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines.

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In DMSO USD 130 In stock
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Biological Activity

Description Chenodeoxycholic Acid is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines.
In vitro

Chenodeoxycholic acid (CDCA) and Deoxycholic acid (DCA) both inhibits 11 beta HSD2 with IC(50) values of 22 mM and 38 mM, respectively and causes cortisol-dependent nuclear translocation and increases transcriptionalactivity of mineralocorticoid receptor (MR). [1] Chenodeoxycholic acid is able to stimulate Ishikawa cell growth by inducing a significant increase in Cyclin D1 protein and mRNA expression through the activation of the membrane G protein-coupled receptor (TGR5)-dependent pathway. [2] Chenodeoxycholic acid (CDCA) induces LDL receptor mRNA levels approximately 4 fold and mRNA levels for HMG-CoA reductase and HMG-CoA synthase two fold in a cultured human hepatoblastoma cell line, Hep G2. [3] Chenodeoxycholic acid-induced Isc is inhibited (≥67%) by Bumetanide, BaCl2, and the cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor CFTRinh-172. Chenodeoxycholic acid-stimulated Isc is decreased 43% by the adenylate cyclase inhibitor MDL12330A and Chenodeoxycholic acid increases intracellular cAMP concentration. [4] Chenodeoxycholic acid treatment activates C/EBPβ, as shown by increases in its phosphorylation, nuclear accumulation, and expression in HepG2 cells. Chenodeoxycholic acid enhances luciferase gene transcription from the construct containing -1.65-kb GSTA2 promoter, which contains C/EBP response element (pGL-1651). Chenodeoxycholic acid treatment activates AMP-activated protein kinase (AMPK), which leads to extracellular signal-regulated kinase 1/2 (ERK1/2) activation, as evidenced by the results of experiments using a dominant-negative mutant of AMPKα and chemical inhibitor. [5]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.23 mM)
Ethanol 79 mg/mL (201.23 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.57
Formula

C24H40O4

CAS No. 474-25-9
Storage powder
Synonyms Chenodiol

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02952963 Recruiting Severe Obesity Hvidovre University Hospital|University of Copenhagen October 2016 Phase 4
NCT02876484 Recruiting Severe Obesity Hvidovre University Hospital|University of Copenhagen June 2016 Phase 4
NCT02340247 Completed Severe Obesity Hvidovre University Hospital|University of Copenhagen November 2014 Phase 4
NCT01666223 Completed Type 2 Diabetes|Obesity University Hospital, Gentofte, Copenhagen November 2012 --
NCT01674946 Completed Echolocation University Hospital, Basel, Switzerland September 2011 Phase 1
NCT00465751 Completed Metabolic Syndrome|Familial Hypertriglyceridemia|Familial Combined Hyperlipidemia University Hospital, Basel, Switzerland October 2004 Early Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID