LIT-927

LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma.

LIT-927 Chemical Structure

LIT-927 Chemical Structure

CAS No. 2172879-52-4

Purity & Quality Control

LIT-927 Related Products

Signaling Pathway

Biological Activity

Description LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma.
Targets
CXCR4 [1] CXCL12 [1]
267 nM(Ki)
In vitro
In vitro

LIT-927 is able to bind selectively CXCL12 and to inhibit CXCL12-CXCR4 interaction[1].

In Vivo
In vivo

In a murine model of hypereosinophilia, LIT-927 shows a large and statistically reliable inhibition of eosinophil recruitment. It inhibits allergic eosinophilic airway inflammation in mice when administered orally or locally[1].

Chemical Information & Solubility

Molecular Weight 328.75 Formula

C17H13ClN2O3

CAS No. 2172879-52-4 SDF --
Smiles COC1=C(C=CC(=C1)C2=NC(=O)NC(=C2)C3=CC=C(C=C3)Cl)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 66 mg/mL ( (200.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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