TLR Activators

Cat.No.	Product Name	Information	Product Use Citations
S7850	Lipopolysaccharides (LPS)	Lipopolysaccharides (LPSs, Endotoxin,LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells. Lipopolysaccharides induces secretion of cell migrasome.	J Immunother Cancer, 2025, 13(7)e010898 Cell Rep, 2025, 44(5):115625 Biomedicines, 2025, 13(6)1320
E4998	Polyinosinic-polycytidylic acid sodium	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic double-stranded RNA (dsRNA) analogue that activates the MDA-5 receptor in the cytoplasm and TLR3 in endosomal compartments. This activation promotes the production of type I interferons and induces apoptosis in cancer cells, particularly those that lack protective anti-apoptotic mechanisms like Bcl-xL.
S9937	CU-CPD107	CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, this compound acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, it shows synergistic agonist activities, while this chemical alone is unable to influence TLR8 signaling.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7850

Lipopolysaccharides (LPS)

Lipopolysaccharides (LPSs, Endotoxin,LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells. Lipopolysaccharides induces secretion of cell migrasome.

J Immunother Cancer, 2025, 13(7)e010898

Cell Rep, 2025, 44(5):115625

Biomedicines, 2025, 13(6)1320

E4998

Polyinosinic-polycytidylic acid sodium

Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic double-stranded RNA (dsRNA) analogue that activates the MDA-5 receptor in the cytoplasm and TLR3 in endosomal compartments. This activation promotes the production of type I interferons and induces apoptosis in cancer cells, particularly those that lack protective anti-apoptotic mechanisms like Bcl-xL.

S9937

CU-CPD107

CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, this compound acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, it shows synergistic agonist activities, while this chemical alone is unable to influence TLR8 signaling.