| S5159 |
Doxycycline
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Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.
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Nature, 2025, 10.1038/s41586-025-09222-5
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Cell Stem Cell, 2025, S1934-5909(25)00181-X
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Nat Commun, 2025, 16(1):7898
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| S1773 |
Oxytetracycline (Terramycin)
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Oxytetracycline (Terramycin) is a broad-spectrum tetracycline antibiotic used to treat infections with bacteria.
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Sci Rep, 2018, 8(1):7653
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Front Microbiol, 2016, 7: 1765
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| E4932 |
Amikacin
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Amikacin(BAY 41-6551, Lukadin) is a semisynthetic aminoglycoside, derived from kanamycin-A, that acts as an inhibitor of the Z ring formation, leading to the inhibition of cell division. It is used to treat serious infections caused by aerobic Gram-negative bacteria, mycobacteria, Nocardia, and life-threatening infections in neonates.
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| S7417 |
Puromycin Dihydrochloride
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Puromycin 2HCl is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is an inhibitor of protein synthesis and has been used to study transcription regulatory mechanisms that control the sequential and coordinated expression of genes during cell differentiation.
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Signal Transduct Target Ther, 2025, 10(1):182
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Cell Stem Cell, 2025, S1934-5909(25)00181-X
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Nat Commun, 2025, 16(1):4792
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| S4163 |
Doxycycline Hyclate
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Doxycycline Hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP).
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Cell Discov, 2025, 11(1):41
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Adv Sci (Weinh), 2025, 12(41):e03977
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Dev Cell, 2025, S1534-5807(25)00405-8
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| S1403 |
Tigecycline
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Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. This compound induces autophagy by downregulating the PI3K-AKT-mTOR pathway.
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J Infect Dis, 2025, 232(3):e416-e420
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NPJ Antimicrob Resist, 2025, 3(1):12
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Int J Mol Sci, 2024, 25(9)4887
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| S2908 |
Hygromycin B
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Hygromycin B (Hygrovetine), a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome.
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Nat Commun, 2024, 15(1):10594
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Redox Biol, 2024, 76:103349
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Front Pharmacol, 2024, 15:1432851
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| S2572 |
Streptomycin sulfate
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Streptomycin sulfate(Phytomycin) is a sulfate salt of streptomycin that is a protein synthesis inhibitor.
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Front. Oncol, 2023-, Volume 13
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Front Oncol, 2023, 13:1118268
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Transl Oncol, 2022, 26:101502
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| S4147 |
Azithromycin Dihydrate
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Azithromycin Dihydrate(CP-62993 dihydrate) is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.
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J Cell Biochem, 2022, 10.1002/jcb.30213
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Adv Ther (Weinh), 2020, 2000034
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PLoS Comput Biol, 2020, 16(12):e1008489
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| S2555 |
Clarithromycin
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Clarithromycin (A-56268) is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections.
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Circulation, 2024, 150(7):563-576
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Microorganisms, 2022, 10(7)1421
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Cell Biol Toxicol, 2021, 10.1007/s10565-021-09646-5
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