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ribosome Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S1773 Oxytetracycline (Terramycin) Oxytetracycline (Terramycin) is a broad-spectrum tetracycline antibiotic used to treat infections with bacteria.
Sci Rep, 2018, 8(1):7653
Front Microbiol, 2016, 7: 1765
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S7417 Puromycin Dihydrochloride Puromycin 2HCl is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is an inhibitor of protein synthesis and has been used to study transcription regulatory mechanisms that control the sequential and coordinated expression of genes during cell differentiation.
Autophagy, October 6, 2021, 1-12
Nucleic Acids Research, March 20, 2025, gkaf200
Nature Communications, December 5, 2024, 10594
S5159 Doxycycline Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.
Nature, 2025, 10.1038/s41586-025-09222-5
Cell Stem Cell, 2025, S1934-5909(25)00181-X
Nat Commun, 2025, 16(1):7898
S4163 Doxycycline Hyclate Doxycycline Hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP).
Cell Discov, 2025, 11(1):41
Adv Sci (Weinh), 2025, 12(41):e03977
Dev Cell, 2025, S1534-5807(25)00405-8
S1403 Tigecycline Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. This compound induces autophagy by downregulating the PI3K-AKT-mTOR pathway.
J Infect Dis, 2025, 232(3):e416-e420
NPJ Antimicrob Resist, 2025, 3(1):12
Int J Mol Sci, 2024, 25(9)4887
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S2908 Hygromycin B Hygromycin B (Hygrovetine), a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome.
Redox Biology, 2024 Oct, 76:103349
Acta Pharmacologica Sinica, 2024 Aug, 45(8):1644-1659
Preprint (ResearchGate), 2024 Apr, nan
S2572 Streptomycin sulfate Streptomycin sulfate(Phytomycin) is a sulfate salt of streptomycin that is a protein synthesis inhibitor.
Front. Oncol, 2023-, Volume 13
Front Oncol, 2023, 13:1118268
Transl Oncol, 2022, 26:101502
S2555 Clarithromycin Clarithromycin (A-56268) is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections.
Circulation, 2024, 150(7):563-576
Microorganisms, 2022, 10(7)1421
Cell Biol Toxicol, 2021, 10.1007/s10565-021-09646-5
S1635 Erythromycin Erythromycin (E-Mycin) is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml).
Infection and Drug Resistance, July 25, 2023, 4867-4879
Autophagy, April 4, 2025, 1945-1961
Autophagy, 2025, 1945-1961
S2574 Tetracycline HCl Tetracycline HCl (NCI-c55561) is a hydrochloride salt of tetracycline that is a broad-spectrum polyketide antibiotic.
Nat Commun, 2024, 15(1):2377
Cell Cycle, 2022, 21(2):140-151
Antiviral Research, 2021 Jan, 185:104993
S1677 Chloramphenicol Chloramphenicol (Chloromycetin) is a bacteriostatic by inhibiting protein synthesis.
bioRxiv, March 26, 2026, nan
Canadian Journal of Physiology and Pharmacology, 2024, 661-671
Cell Rep, 2021, 34(3):108631
S4490 Tetracycline Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.
Redox Biol, 2025, 84:103649
bioRxiv, 2025, 2025.01.08.632009
PeerJ, 2022, 10:e13719
S2514 Tobramycin Tobramycin (NSC 180514,Deoxykanamycin B, Nebramycin Factor 6) is an aminoglycoside antibiotic with an IC50 of 9.7 μM.
Oncotarget, May 25, 2018, 26086-26095
Oncotarget, 2018 May 25, 26086-26095
Oncotarget, 2018, 9(40):26086-26095
S2315 Kanamycin sulfate Kanamycin sulfate (Kanamycin monosulfate, Ophtalmokalixan) is an aminoglycoside antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections.
Journal of Advanced Research, 2024, 481-499
Heliyon, 2024, 10(11):e32571
Heliyon, 2024, e32571
S2510 Spectinomycin 2HCl Spectinomycin 2HCl (Actinospectacin) is a new parenteral antibiotic prepared from Streptomyces spectabilis.
Cell Rep, 2020, 32(2):107897
S3496 Lefamulin acetate (Xenleta) Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. It inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.
J Biol Chem, 2022, 298(5):101909
Journal of Biological Chemistry, 2022, 101909
E4867 Omadacycline Omadacycline(Amadacycline) is an oral aminomethylcycline antibacterial antibiotic used to treat moderate-to-severe infections, such as community-acquired pneumonia and acute bacterial skin and skin structure infections caused by susceptible organisms. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This compound has broad-spectrum antibacterial activity and is effective against Gram-positive and Gram-negative aerobic, anaerobic, and atypical bacteria.