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ribosome Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S1635 Erythromycin Erythromycin (E-Mycin) is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml).
Infection and Drug Resistance, July 25, 2023, 4867-4879
Autophagy, April 4, 2025, 1945-1961
Autophagy, 2025, 1945-1961
S2574 Tetracycline HCl Tetracycline HCl (NCI-c55561) is a hydrochloride salt of tetracycline that is a broad-spectrum polyketide antibiotic.
Nat Commun, 2024, 15(1):2377
Cell Cycle, 2022, 21(2):140-151
Antiviral Research, 2021 Jan, 185:104993
S1677 Chloramphenicol Chloramphenicol (Chloromycetin) is a bacteriostatic by inhibiting protein synthesis.
bioRxiv, March 26, 2026, nan
Canadian Journal of Physiology and Pharmacology, 2024, 661-671
Cell Rep, 2021, 34(3):108631
S4056 Retapamulin Retapamulin (SB-275833) is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.
Infection and Drug Resistance, 2023, 4867-4879
Infect Drug Resist, 2023, 16:4867-4879
Pediatr Infect Dis J, 2021, 40(7):637-638
S4490 Tetracycline Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.
Redox Biol, 2025, 84:103649
bioRxiv, 2025, 2025.01.08.632009
PeerJ, 2022, 10:e13719
S4279 Demeclocycline HCl Demeclocycline HCl(Demeclocycline hydrochloride) is a tetracycline antibiotic via inhibition of protein synthesis by bacteria, used for the treatment of bacterial infections.
Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433
J Biol Chem, 2020, 10.1074/jbc.RA119.011633.
Sci Rep, 2018, 8(1):7653
S2514 Tobramycin Tobramycin (NSC 180514,Deoxykanamycin B, Nebramycin Factor 6) is an aminoglycoside antibiotic with an IC50 of 9.7 μM.
Oncotarget, May 25, 2018, 26086-26095
Oncotarget, 2018 May 25, 26086-26095
Oncotarget, 2018, 9(40):26086-26095
S2315 Kanamycin sulfate Kanamycin sulfate (Kanamycin monosulfate, Ophtalmokalixan) is an aminoglycoside antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections.
Journal of Advanced Research, 2024, 481-499
Heliyon, 2024, 10(11):e32571
Heliyon, 2024, e32571
S2510 Spectinomycin 2HCl Spectinomycin 2HCl (Actinospectacin) is a new parenteral antibiotic prepared from Streptomyces spectabilis.
Cell Rep, 2020, 32(2):107897
S3496 Lefamulin acetate (Xenleta) Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. It inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.
J Biol Chem, 2022, 298(5):101909
Journal of Biological Chemistry, 2022, 101909
S5417 Spectinomycin dihydrochloride pentahydrate Spectinomycin dihydrochloride pentahydrate (Trobicin) is a widely used antibiotic that inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome.
E4867 Omadacycline Omadacycline(Amadacycline) is an oral aminomethylcycline antibacterial antibiotic used to treat moderate-to-severe infections, such as community-acquired pneumonia and acute bacterial skin and skin structure infections caused by susceptible organisms. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This compound has broad-spectrum antibacterial activity and is effective against Gram-positive and Gram-negative aerobic, anaerobic, and atypical bacteria.