CAS No. 748810-28-8

Batch: Purity:99.84
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Vernakalant (RSD1235) Hydrochloride Chemical Structure
Chemical Structure
Check the Vernakalant (RSD1235) Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol;hydrochloride
CAS Number 748810-28-8
Molecular Formula

C20H31NO4.ClH
Molecular Weight (MW) 385.93
SMILES Cl.COC1=C(OC)C=C(CCOC2CCCCC2N3CCC(O)C3)C=C1
InChIKey JMHYCBFEEFHTMK-IIUXMCBISA-N

Ordering Information

Biological Activity

Vernakalant Hydrochloride is a frequency-dependent sodium channel blocker and early-activating potassium channel blocker that selectively prolongs the atrial refractory period. By inhibiting cardiac sodium and ultrarapid delayed-rectifier potassium currents, it modulates electrical signaling in atrial myocytes and suppresses arrhythmia perpetuation. This ion channel blockade reduces electrical heterogeneity and slows rate-dependent conduction to restore normal cardiac sinus rhythm. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 77 mg/mL (199.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 77 mg/mL
Ethanol 77 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.